CN103392715B - A kind of bactericidal composition containing cyprodinil and captan - Google Patents
A kind of bactericidal composition containing cyprodinil and captan Download PDFInfo
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- CN103392715B CN103392715B CN201310323431.7A CN201310323431A CN103392715B CN 103392715 B CN103392715 B CN 103392715B CN 201310323431 A CN201310323431 A CN 201310323431A CN 103392715 B CN103392715 B CN 103392715B
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Abstract
One that what a kind of bactericidal composition containing cyprodinil and captan of the present invention related to is comprises cyprodinil (Cyprodinil) and captan (Captan) bactericidal composition as active component.The invention still further relates to a kind of bactericidal composition comprising cyprodinil and captan prevent and treat cereal, fruit, vegetables, flowers, lawn, economic crops germ harm purposes.Contain a bactericidal composition for cyprodinil and captan, it is characterized in that: containing active component cyprodinil and captan.Wherein the weight proportion of cyprodinil and captan is 1:100-100:1.The present invention, by cyprodinil and captan are carried out binary built, makes the bactericidal composition obtained have gain effect in control efficiency, and expands fungicidal spectrum, plays the effect of a medicine multiple-effect.In addition, because cyprodinil is different with the captan mechanism of action, therefore can improve protection effect, germ is not easily developed immunity to drugs.
Description
Technical field
One that what a kind of bactericidal composition containing cyprodinil and captan of the present invention related to is comprises cyprodinil (Cyprodinil) and captan (Captan) bactericidal composition as active component.The invention still further relates to a kind of bactericidal composition comprising cyprodinil and captan prevent and treat cereal, fruit, vegetables, flowers, lawn, economic crops germ harm purposes.
Background technology
In horticultural crop and dry-land crop production, crop can run into multiple fungi or infecting of bacterium and various disease, also normal because of in soil multiple cause a disease or saprophytic fungi (as mould in corruption, epidemic disease is mould, Rhizoctonia solani Kuhn, sickle-like bacteria, botrytis cinerea etc.) and bacterium (soft-rot fungi etc.) infect harm, cause rotten kind, rotten, extremely seedling.
Cyprodinil (Cyprodinil), its chemical name is: 4-cyclopropyl-6-Methyl-N-phenyl pyrimidine-2-amine, and its structural formula is:
Cyprodinil is aminopyrimidine bactericide, is methionine biosynthesis inhibitor.Same triazole type, imidazoles, morpholine class, phenylpyrrole class etc. are without cross resistance.There is protection, treatment, blade penetrate and root systemic activity, can foliar spray or seed treatment, also can do the medication of barley seed coat agent.Be applicable to wheat, barley, grape, strawberry, fruit tree, vegetables, ornamental plants etc., be mainly used in preventing and treating gray mold, powdery mildew, scab, to be full of rot and wheat eyeprint sick etc.
Captan (captan), Chinese another name is called Gai Pudan, and its chemical name is: N-(trichloro-methylthio)-hexamethylene-4-alkene-1,2-dicarboximide; 1,2,3,6-tetrahydrochysene-N-(trichloro-methylthio) phthalimide, its structural formula is:
Captan is a kind of organic sulfur class broad spectrum activity low toxicity bactericide; based on protective effect, have certain therapeutic action concurrently, use safer; to many kinds of fungal diseases in various crop, all there is good preventive effect, be specially adapted to the crop to copper agent agricultural chemicals sensitivity.This medicine is permeable to the cell membrane of germ, and not only can disturb the respiratory of germ, but also can disturb its cell division, have multiple bactericidal action site, continuous several times uses extremely difficult induction germ to develop immunity to drugs, and sprays protection effect continuously more obvious.It mainly makes spray application, also can make seed treatment, dip product after results, and sowing is front or carry out soil treatment before planting.General use about 0.1% concentration liquid spraying, the scab, downy mildew, powdery mildew, anthracnose, gray mold, early blight, late blight etc. of control fruit tree, vegetables, flowers and other economic crops etc.By the 0.3-0.5% process seed of seed weight, Cereal smut can be prevented and treated, disease in cotton seedling stage etc.The activity of this compound is good, but, its when low rate of application sometimes and unsatisfactory.
Summary of the invention
The object of the invention is for solving at least one problem above-mentioned or its at least one aspect, especially effectively control plant disease, and/or reduce costs or application dosage, through large number of biological test screen, provide a kind of and contain bactericidal composition of cyprodinil and captan and uses thereof.
The present invention relates to a kind of bactericidal composition containing cyprodinil and captan.
A kind of bactericidal composition containing cyprodinil and captan of the present invention and uses thereof takes following technical scheme to realize:
Contain a bactericidal composition for cyprodinil and captan, it is characterized in that containing active component cyprodinil and captan.
The present invention is a kind of is Synergistic effective dose containing cyprodinil and captan in the bactericidal composition of cyprodinil and captan, described in a kind of bactericidal composition containing cyprodinil and captan of the present invention, the weight proportion of active component cyprodinil and captan is 1:100 to 100:1, preferred 1:50-50:1, preferred 1:20-20:1 again, more preferably 1:10-10:1, most preferably 1:5-5:1.
Of the present invention a kind of containing in the bactericidal composition of cyprodinil and captan, the weight percentage that described active component cyprodinil and captan account for composition is 5-90%, preferred 10%-80%, more preferably 20%-60%.
Described a kind of containing in the bactericidal composition of cyprodinil and captan, described active component cyprodinil and captan mix with liquid or solid carrier and/or surfactant.
Above-mentioned a kind of bactericidal composition containing cyprodinil and captan of the present invention only can comprise active ingredient, also can mix together with additive, therefore a kind of bactericidal composition containing cyprodinil and captan of the present invention can be prepared into various formulation, and the formulation of described bactericidal composition is suspending agent, seed coat agent, wetting powder, water dispersible granules, micro-capsule granules, paste, aerosol, ZC, coated granule, extrude granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet.
Contain a bactericidal composition for cyprodinil and captan, it is characterized in that: also comprise one or more other active components.
A kind of bactericidal composition containing cyprodinil and captan of the present invention is used for preventing and treating cereal, fruit, vegetables, flowers, lawn, economic crops.
A kind of bactericidal composition containing cyprodinil and captan of the present invention is for the protection of plant propagation material and the purposes of plant organ that grows subsequently.
The place control soil that the bactericidal composition that a kind of use of the present invention contains cyprodinil and captan is applied to required control causes a disease or the purposes of saprophytic fungus and bacterium.
Detailed Description Of The Invention
The invention provides a kind of bactericidal composition with synergistic function containing cyprodinil and captan.
Cyprodinil and captan creatively unite two into one by the present invention, not only can prevent and treat the germ harm of cereal, fruit, vegetables, flowers, lawn, economic crops, doublely can also control the fungus and bacterium disease in soil, there is a medicine multiplex, widen diseases prevention spectrum.And plant for soil treatment or leaching (mixing), the rotten kind that soil disease can be prevented to cause, rotten, ensure full stand, alleviate sprout term disease, better effects if.
The invention provides a kind of bactericidal composition containing cyprodinil and captan.
Concrete scheme of the present invention is: a kind of bactericidal composition containing active component cyprodinil and captan, is made up of following component: the suspending agent that cyprodinil, captan bactericide and insecticides adjuvant form, seed coat agent, wetting powder, water dispersible granules, micro-capsule granules, paste, aerosol, ZC, coated granule, extrude granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet.
In composition of the present invention, cyprodinil bactericide and captan bactericide are Synergistic effective dosies, in the present composition, the weight proportion of compound cyprodinil and captan is 1:100-100:1, preferred 1:50-50:1, preferred 1:20-20:1 again, more preferably 1:10-10:1, most preferably 1:5 to 5:1.
In composition of the present invention, active component cyprodinil and captan bactericide account for the 5-90% of composition, preferred 10%-80%, more preferably 20-60%.
Above-mentioned composition of the present invention only can comprise active ingredient, also can mix together with additive, therefore composition of the present invention can be prepared into various formulation, such as the liquor, wetting powder, water dispersible granules, suspending agent, seed coat agent, aerosol, coated granule, effervescent tablet, aqueous emulsion, microemulsion etc. of cyprodinil, captan bactericide and insecticides adjuvant composition.According to the character of these compositions and use the object and ambient conditions that composition will reach, composition can be selected to use with spraying, immersion, atomizing, the method for broadcasting sowing, pouring, fill with root etc. and so on.
These preparations are produced by known method.Such as, when selectively using surfactant, prepare preparation by being mixed with filler by reactive compound, described filler is the diluent or carrier of liquid or liquid gas or solid, said surfactant is emulsifier, dispersant, wetting agent.When using water as filler, also with an organic solvent, such as, organic solvent can be used as cosolvent.
According to the present invention, term " carrier " refers to can be combined with reactive compound or combine to make it be easier to the organic or inorganic compound being administered to the natural of object (such as plant, crop or careless class) or synthesizing.Therefore, described carrier is preferably inertia, at least to should be agricultural acceptable.Described carrier can be solid or liquid.
In the present invention, operable nonactive medium both can be solid also can be liquid, can have such as solid media materials'use: phyteral powdery type (the such as particle of soybean meal, starch, grain dust, wood powder, bark powder, sawdust, walnut shell powder, wheat bran, cellulose powder, coconut husk, corncob and tobacco stem, extract the residue etc. after plant essence), paper, sawdust, pulverize synthesized polymer body, clay class (such as kaolin, bentonite, acid china clay etc.), the talcum powder class of synthetic resin etc.Silica (such as diatomite, silica sand, mica, moisture silicic acid, calcium silicates), active carbon, natural mineral matter class (float stone, attapulgite and zeolite etc.), fire chemical fertilizer, the clay fertilizer of inorganic mineral powder, ammonium sulfate, ammonium phosphate, urea, greening ammonium etc. of diatomite, sand, plastics medium etc. (such as polyethylene, polypropylene, polyvinylidene chloride etc.), potassium chloride, calcium carbonate, calcium phosphate etc., these materials can be used alone or two or more is used with.
Can can select in llowing group of materials as liquid media materials'use, such as water, alcohol type (such as methyl alcohol, ethanol, isopropyl alcohol, butanols, ethylene glycol etc.), ketone (such as acetone, methyl ethyl ketone, isobutyrone, cyclohexanone etc.), ethers (such as ether, dioxanes, methylcellulose, oxolane etc.), aliphatic hydrocarbon class (such as kerosene, mineral wet goods), aromatic hydrocarbons class (such as benzene, toluene, dimethylbenzene, solvent naphtha, Fluhyzon, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbon, chlorobenzene, Deng), halogenated hydrocarbon class, amide-type, sulfone class, dimethyl sulfoxide (DMSO), mineral and vegetable oil, animal wet goods.
Can carry out choice for use according to application target as other adjuvants, also can be used alone, share at two or more adjuvant of some occasion, or some occasion can not use adjuvant completely.For making the emulsification of active ingredient compound, dispersion, solubilized, and/or wetting surfactant can be used such as can to enumerate fatty alcohol-polyoxyethylene ether, polyoxyethylene alkylaryl ether, polyoxyethylene higher fatty acid esters, the phosphate of polyoxyethylene alcohol or phenol, the fatty acid ester of polyalcohol, alkane aromatic sulfonic acid, naphthalene sulfonic acid polymer, lignosulfonates, a dress copolymer of macromolecule comb shape, butyl naphthalene sulfonate, alkylaryl sulfonates, sodium alkylsulfosuccinates, grease, fatty alcohol and ethylene oxide condensate, the polyacrylates such as alkyltaurate, protein hydrolysate.Suitable oligosaccharide thing or polymer, such as, based on the combination of independent vinyl monomer, acrylic acid, EO and/or PO or itself and such as (polynary) alcohol or (polynary) amine.
For making active ingredient compound decentralized stabilization, attachment and/or combination, such as xanthans, aluminium-magnesium silicate, gelatin, starch, methyl cellulose, polyvinyl alcohol, polyvinyl acetate and the adjuvant such as natural phospholipid (as cephalin and lecithin) and synthetic phospholipid, bentonite, sodium lignin sulfonate can be used.
The wherein optional spent glycol of antifreezing agent, propane diols, glycerine, sorbierite.Deflocculant as suspension product can use the adjuvant of such as naphthalene sulfonic acid polymer, polymeric phosphate etc.
Defoamer can use silicone defoaming agent.
Operable colouring agent, such as inorganic pigment, as iron oxide, titanium oxide and Prussian blue; And organic pigment/dyestuff: alizarin dyes, azo dyes and metallized phthalocyanine dye; And trace element, such as molysite, manganese salt, boron salt, mantoquita, cobalt salt, molybdenum salt and zinc salt.
Optionally, also can comprise other annexing ingredient, such as protecting colloid, adhesive, thickener, thixotropic agent, bleeding agent, stabilizing agent, screening agent.
Described a kind of formulation containing the composition pesticide of cyprodinil and captan is: aerosol, suspending agent, microcapsulated granule, granula subtilis, can be flowed concentrate, ready to use solution agent, pulvis, aqueous emulsion, oil emu, fine granule, oil dispersion pulvis, the miscible mobility concentrate of oil, oil miscible liquids, foaming agent, paste, suspending concentrate, suspension emulsion, solubility concentrate, soluble powder, granule, water-soluble granular and/or tablet, water solube powder, wetting powder, through the natural or synthetic material of reactive compound dipping, microcapsules in polymeric material and water-dispersible granule.In preferred embodiments, described composition pesticide is suspending agent, water dispersible granules, wetting powder, suspension emulsion and/or microcapsule suspending agent.
Described reactive compound mixes with conventional additives by known way and prepares by described preparation of the present invention.Described conventional additives is as conventional extender and solvent or thinner, emulsifier, dispersant and/or adhesive or fixative, wetting agent, waterproofing agent, if needed, drier and colouring agent, stabilizing agent, pigment, defoamer, preservative, thickener, water and other processing aid can also be comprised.
These compositions not only comprise can by suitable equipment as spraying or dusting equipment be applicable to pending object immediately, but also be included in be applied to object before need the concentrated commercial composition that carries out diluting.
Composition of the present invention can make with the form of the composition of its active compound component the preparation being suitable for using, and also can use with the form of the combination of the commercial preparation of its suitable dosage.
Composition of the present invention can also be used with other active ingredient combination, other active component described such as fungicide, bactericide, attractant, insecticide, miticide, nematocide, growth regulator, weed killer herbicide, safener, fertilizer or semiochemical etc.
Composition of the present invention or combination can also be presented as the form of kit, and it comprises cyprodinil and captan.On the other hand, the invention still further relates to described kit for preventing and treating the germ harm of cereal, fruit, vegetables, flowers, lawn, economic crops.The invention still further relates to described kit for the protection of plant propagation material and the plant organ that grows subsequently.The invention still further relates to the place control soil that described kit is applied to required control to cause a disease or saprophytic fungus and bacterium.
Described a kind of composition pesticide containing cyprodinil and captan is used for preventing and treating cereal, fruit, vegetables, flowers, lawn, economic crops.Common germ has stem canker, leaf rust, smut, bunt, rust, stem rot, gray mold, southern blight, anthracnose, bud rot, Brown patch disease, huge pinta, fairy ring, red thread, false smut, spot defoliation, leaf spot, epidemic disease, head blight, downy mildew, banded sclerotial blight, powdery mildew, phytophthora rot, anthracnose, brown spot, tar spot, balck shank, soft rot, canker, purple spot, damping off, stem wilt, damping off, seedling epidemic disease, leaf blight, rust, black spot, scab.
The useful plant of bactericidal composition of the present invention can be used to comprise a lot, such as: paddy rice, peanut, cotton, beet, potato, lawn, wheat, barley, cucumber, grape, mango, wax-apple, strawberry, apple, banana, tomato, sunflower, pears, potato, corn, pear tree, coffee, ornamental plants class.
Described a kind of composition pesticide comprising cyprodinil and captan is for preventing or controlling multiple in soil causing a disease or the purposes of saprophytic fungus and bacterium.The example of soilborne aquacultural fungal pathogen comprises Alternaria (Alternaria spp.), Ascochyta (Ascochyta spp.), Botrytis cinerea (Botrytis cinerea), Cercospora (Cercospora spp.), ergot (Claviceps purpurea), standing grain cochliobolus (Cochliobolus sativus), Colletotrichum (colletotrichum spp.), Epicoccum (Epicoccum spp.), F.graminearum schw (Fusarium graminearum), rice dislikes seedling chain spore (Fusarium moniliforme), fusarium oxysporum (Fusarium oxysporum), fusarium moniliforme (Fusarium proliferatum), fusariun solani (Fusarium solani), dimension glue chain spore (Fusarium subglitinans), Helminthosporium (Helminthosporium spp), avenge rotten microtorr bacterium (Microdochium nivale), Penicillium (Pencillium spp), Phoma (Phoma spp.), wheat class nuclear cavity bacteria (Pyrenophora graminea), rice blast Pyricularia Sacc. (Pyricularia oryzae), Rhizoctonia solani Kuhn (Rhizoctonia solani), Rhizoctonia cerealis (Rhizoctonia cerealis), Sclerotinia (Sclerotinia spp.), Septoria (Septoria spp.), , silk axle smut (Sphacelotheca reilliana), Tilletia (Tilletia spp.), meat spore core coral bacterium (Typhula incarnate), hidden bar smut (Urocystis occulta), Ustilago (Ustilago spp.) or Verticillium (Verticillium spp.).
Soil germ has rhizoctonia solani, sickle-like bacteria, pythium spp, phytophthora, bacterium of dampinging off, root rot, pythium spp, botrytis cinerea, soft-rot fungi etc.In the ordinary course of things, soil germ can produce a large amount of thalline, as long as condition is grown favourable to pathogen growth and host is susceptible, germ just also can infect host by amount reproduction, under susceptible host exists, these germs just can enter the lasting pathogenic phase, the amount reproduction diffusion along with the continuous cropping of crop, but afterwards nutrient be consumed or soil condition is as unfavorable to germ in temperature, humidity etc. time, germ can enter resting stage again.When susceptible host does not exist, soil-borne disease bacterium also can survive in soil, except soil germ has widely except host range, can also survive, have saprophytic competitive ability be undivided with it on the root table face of non-host or the broken branches and fallen leaves.But different germ is discrepant, almost can survive indefinite duration in soil as sickle-like bacteria.
When using method of the present invention is implemented said plant soil or cultivation medium refer to the supporter that crops can be made to take root, grow, such as: soil, water etc., concrete raw material can use such as sand, float stone, vermiculite, diatomite, agar-agar, gelling material, polymer substance, asbestos, wood chip, bark etc.
The method of medicament is used in soil, such as liquid preparation be diluted in water or do not dilute the medium method in rice seedling bed of root or the seedling being directly applied to plant corpus, method granule is disseminated in the root of plant corpus or the rice seedling bed of seedling have prior to seeding pulvis, water dispersible granules etc. are sprayed in soil and with the method that mixes of soil entirety, be sprayed in implantation hole, seed furrow by after pulvis, water-dispersible grain dilution agent, in the method etc. of carrying out sowing before sowing or before serike body.
Described a kind of composition pesticide comprising cyprodinil and captan is for the protection of plant propagation material and the purposes of plant organ that grows subsequently.
Term " plant propagation material " is interpreted as referring to all plant parts having fertility, and such as seed, it can be used for breeding the latter, and vegetable matter such as cuttage bar or stem tuber (such as potato).Therefore, plant part used herein comprises plant propagation material.Can it is mentioned that such as seed (in the narrow sense), root, fruit, stem tuber, bulb, rhizome and plant part.The germination plant suppressed after germinateing from soil or after emerging and effective plant also can be mentioned.Young plant can be undertaken all by dipping before transplantation or Local treatment is protected.
Plant part and the plant organ grown subsequently are any parts of the plant that oily plant propagation material such as seed produces.Plant part, plant organ and plant also can benefit from the cause of disease infringement protection obtained by composition pesticide being applied to plant propagation material.In a specific embodiment, after certain plants part and some institute, the plant organ that grows also can regard plant propagation material as, himself can use with composition pesticide (or process); Thus the plant produced by treated plant part and treated plant organ, other plant part and other plant organ also can be benefited from the cause of disease obtained by composition pesticide being applied to certain plants part and certain plants organ and damage protection.
Preferably, propagating materials is seed, the method of seed treatment, include, for example, the medicament of diluent liquid or solid shape or need not dilute directly seed is immersed in liquid condition solution make medicament soak into seed method, solid chemicals or liquid preparation are mixed with seed, carry out Cotton seeds make the surface of the seed adhere to medicament method, while planting, near seed, the method such as to spray.
Method of the present invention additionally provides with separately, successively or the co-administered described reactive compound of simultaneous system.In one embodiment, use cyprodinil and captan simultaneously.In another embodiment, cyprodinil and captan is used successively.In still another embodiment, separate administration cyprodinil and captan.
In a preferred embodiment, method of the present invention comprises the present composition comprising cyprodinil and captan is administered to object.
Bactericidal composition of the present invention can be made into common dosage form, the dosage form such as such as missible oil, wetting powder, suspending agent, liquor, granule, seed coat agent use, its amount of application, according to mixing ratio, meteorological condition, dosage form, Dressing date, the application process of active ingredient, use place, prevent and kill off the difference of object noxious livings, objective crop etc. and variant:
-usually leaf portion is processed: 0.1-10000g/ha, preferred 10-1000 g/ha, more preferably 50-300 g/ha; For dipping or instillation are used, described dosage even can also reduce, particularly when using inert base as asbestos or pearl rock;
-for seed treatment: 2-200 g/100kg seed, preferred 3-150 g/100kg seed;
-for soil treatment: 0.1-10000 g/ha, preferred 1-5000 g/ha.
Above-mentioned dosage is only general exemplary dose, and actual those skilled in the art can according to actual conditions and needs when using, especially according to pending plant or the character of crop and the seriousness adjustment rate of application of germ.
It should be pointed out that in meaning of the present invention, term " cyprodinil combines with captan/combines " comprises and separates, uses cyprodinil and captan successively or simultaneously.Preferably, described cyprodinil and captan are combined as the form of the composition comprising cyprodinil and captan.
The present invention is a kind of contains bactericidal composition of cyprodinil and captan and uses thereof, by cyprodinil and captan composite, there is synergistic function, not only can prevent and treat the germ harm of cereal, fruit, vegetables, flowers, lawn, economic crops, doublely can also control the fungus and bacterium disease in soil, there is a medicine multiplex, widen diseases prevention spectrum.And plant for soil treatment or leaching (mixing), the rotten kind that soil disease can be prevented to cause, rotten, ensure full stand, alleviate sprout term disease, better effects if.
Embodiment
Example of formulations
Embodiment 1 water dispersible granules
Cyprodinil 1%
Captan 50%
Polyvinyl alcohol 5%
Lauryl sodium sulfate 7%
Sodium lignin sulfonate 11%
Kaolin complements to 100%
By above-mentioned substance Homogeneous phase mixing, grind, mix suitable quantity of water and granulation, after drying, namely obtain said preparation.
Embodiment 2 wetting powder (gross weight of preparation is 100 parts)
Cyprodinil 50%
Captan 10%
Alkylnaphthalene sulfonate formaldehyde condensation products 5%
Sodium alkyl benzene sulfonate 3%
Sodium lignin sulfonate 11%
Kaolin complements to 100%
The ratio in formula such as active component, various auxiliary agent and filler is fully mixed, after ultra-fine pulverizer disintegrating, obtains said preparation.
Embodiment 3 suspending agent (gross weight of preparation is 100 parts)
Cyprodinil 50%
Captan 1%
Propane diols 5%
Phosphoric acid ester 3.5%
Xanthans 0.2%
Dioctyl succinate disulfonate acid 0.7%
Water complements to 100%
Take the microbicide compositions that there is synergistic effect high according to the above ratio and prepare material, load weighted above-mentioned raw material except xanthans is fully mixed, after sand mill grinds, mixing with a certain proportion of xanthans configured, obtain said preparation.
Embodiment 4 wetting powder (gross weight of preparation is 100 parts)
Cyprodinil 0.5%
Captan 50%
Alkylnaphthalene sulfonate formaldehyde condensation products 5%
Alkyl polyoxyethylene ether sulfonate 4%
NONIN HS 240 3%
(8-9 moles of ethylene oxide)
Kaolin complements to 100%
The ratio in formula such as active component, various auxiliary agent and filler is fully mixed, after ultra-fine pulverizer disintegrating, obtains said preparation.
Embodiment 5 water dispersible granules (gross weight of preparation is 100 parts)
Cyprodinil 20%
Captan 1%
Polyvinyl alcohol 5%
Lauryl sodium sulfate 7%
Sodium lignin sulfonate 11%
Kaolin complements to 100%
By above-mentioned substance Homogeneous phase mixing, grind, mix suitable quantity of water and granulation, after drying, namely obtain said preparation.
Embodiment 6 wetting powder (gross weight of preparation is 100 parts)
Cyprodinil 2%
Captan 40%
Alkylnaphthalene sulfonate formaldehyde condensation products 5%
Alkyl polyoxyethylene ether sulfonate 4%
NONIN HS 240 3%
(8-9 moles of ethylene oxide)
Kaolin complements to 100%
The ratio in formula such as active component, various auxiliary agent and filler is fully mixed, after ultra-fine pulverizer disintegrating, obtains said preparation.
Embodiment 7 wetting powder (gross weight of preparation is 100 parts)
Cyprodinil 20%
Captan 40%
Alkylnaphthalene sulfonate formaldehyde condensation products 5%
Alkyl polyoxyethylene ether sulfonate 4%
NONIN HS 240 3%
(8-9 moles of ethylene oxide)
Kaolin complements to 100%
The ratio in formula such as active component, various auxiliary agent and filler is fully mixed, after ultra-fine pulverizer disintegrating, obtains said preparation.
Embodiment 8 water dispersible granules (gross weight of preparation is 100 parts)
Cyprodinil 20%
Captan 10%
Polyvinyl alcohol 5%
Lauryl sodium sulfate 7%
Sodium lignin sulfonate 6%
Kaolin complements to 100%
By above-mentioned substance Homogeneous phase mixing, grind, mix suitable quantity of water and granulation, after drying, namely obtain said preparation.
Embodiment 9 seed coat agent (gross weight of preparation is 100 parts)
Cyprodinil 5%
Captan 50%
Propane diols 5%
Phosphoric acid ester 3.5%
Xanthans 0.2%
Dioctyl succinate disulfonate acid 0.7%
Water complements to 100%
Take the microbicide compositions that there is synergistic effect high according to the above ratio and prepare material, load weighted above-mentioned raw material except xanthans is fully mixed, after sand mill grinds, mixing with a certain proportion of xanthans configured, obtain said preparation.
Embodiment 10 aerosol (gross weight of preparation is 100 parts)
Cyprodinil 50%
Captan 5%
Propane diols 5%
Phosphoric acid ester 3.5%
The castor oil (EL-40) 2.0% of ethoxylation
Solvesso 100 complements to 100%
First by antifreezing agent propane diols, thinner SOLVESSO 100 mixes, and adds cyprodinil and captan under stirring; Surfactant is added wherein, under agitation pulverized by a breaking plant colloid mill, will the suspension after colloid mill be passed through, then through a micronizer.Move in circles to the particle diameter≤2um of solids.
Embodiment 11 ZC
Atlox 4913 4%
Citric acid 0.05%
Catalyzer 0.1%
Water 13%
Cyprodinil 10%
PAPI 1.35%
Solvesso 200 10%
Atlox4913 16%
Dispersant LFH 0.3%
Defoamer 0.16%
Urea 8.4%
Captan 50%
Water complements to 100%
By PAPI, the oil phase that captan and Solvesso 100 are formed adds in the aqueous solution containing Atlox4913, forms emulsion.Then heat and be incubated 50
ocatalyst reaction is added 2 hours under C.The microcapsules of captan is obtained after cooling.Atlox 4913, dispersant LFH, defoamer, urea, cyprodinil and water mix in proportion, and through sand milling, are prepared into suspending agent.The microcapsules of the captan obtained is added in the aqueous suspension agent of cyprodinil, stirs and obtain 10% cyprodinil+50% captan ZC.
Embodiment 12 extrudes granule
Cyprodinil 45%
Captan 45%
Sodium lignin sulfonate 4%
Carboxymethyl cellulose 2%
Kaolin complements to 100%
Active component is mixed with auxiliary agent and grinds, mixture water-wet.This mixture is extruded, then dry in the air stream.
Embodiment 13 coated granule
Cyprodinil 20%
Captan 60%
Polyethylene glycol 3%
The silicic acid 1% of high degree of dispersion
Calcium carbonate complements to 100%
In a mixer, by levigate active component even spread on the carrier soaked by polyethylene glycol.Dust-free coated granules agent can be obtained in this way.
Embodiment 14 missible oil
Cyprodinil 50%
Captan 0.5%
Ethoxylated castor oil 10%
Calcium dodecyl benzene sulfonate 6%
Solvesso 100 complements to 100%
By active ingredient, auxiliary agent and stirring solvent to the phase of transparent and homogeneous, namely obtain missible oil.
Embodiment 15 effervescent tablet
Cyprodinil 1%
Captan 4%
Polyvinyl alcohol 2.0 %
Sodium Laurylsulfate 4.0%
Calcium carbonate 5.0%
White carbon complements to 100%
By above-mentioned substance Homogeneous phase mixing, grind, mix suitable quantity of water and granulation, after drying, namely obtain said preparation.
Embodiment 16 paste
Cyprodinil 5%
Captan 5%
Lignosulfonates 10.0%
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0%
Water complements to 100%
Above-mentioned substance is mixed to homogeneous phase, namely obtains paste.
Embodiment 17 microemulsion
Cyprodinil 20.0 %
Captan 20.0%
Polyvinyl alcohol 10.0 %
Calcium dodecyl benzene sulfonate 5.0%
Water complements to 100%
The solution of clear is obtained after being stirred by above-mentioned substance.
Embodiment 18 aqueous emulsion
Cyprodinil 15%
Captan 5.0 %
1-METHYLPYRROLIDONE 15.0%
Ethoxylated castor oil 4.0%
Calcium dodecyl benzene sulfonate 3.0%
Water complements to 100%
Cyprodinil, captan are dissolved completely in 1-METHYLPYRROLIDONE, add in the solution of ethoxylated castor oil, calcium dodecyl benzene sulfonate, after high shear, obtain aqueous emulsion.
Above embodiment proportioning is weight per distribution ratio.
The in vitro synergy test of biological test example measures
The toxicity index of each medicament and the co-toxicity coefficient (CTC value) of mixture is calculated according to the abundant method of Sun Yun, when CTC≤80, then compositions table reveals antagonism, work as 80<CTC<120, then compositions table reveals summation action, when CTC >=120, then compositions table reveals synergistic effect.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
In theoretical toxicity index (TTI)=A medicament toxicity index * mixture A percentage composition+B medicament toxicity index * mixture in the percentage composition of B
Co-toxicity coefficient (CTC)=[theoretical toxicity index (TTI) * 100 of mixture actual measurement toxicity index (ATI)/mixture
Test one: the toxicity test of wheat powdery mildew
Be selected from three to the four leaf phase wheat seedlings that growing way is consistent, each process selects 3 basins for examination wheat seeding, and with potter spray tower in the spraying of 50PSI pressure column, the about 5mL of every basin, each medicament arranges 12 concentration gradients.After chemicals treatment, 24h connects bacterium, the wheat powdery mildew leaf picking up from field is evenly shaken off conidium above wheat seedling and inoculates, then wheat seeding is put into greenhouse and cultivate.According to the morbidity grade scale complete stool investigation disease index of wheat powdery mildew after 7d, and calculate control efficiency, then calculate concentration EC in suppression by method of least squares
50, then calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.
Table one: the virulence test result of the present invention on control wheat powdery mildew
From table one, when cyprodinil and captan are in the scope of proportioning 1:100 ~ 100:1 of preventing and treating wheat powdery mildew, co-toxicity coefficient is all greater than 120, the mixture of both explanations within the scope of this all shows as gain effect, especially, when both ratios are in 1:5, gain effect is particularly outstanding.
Test two: the toxicity test of potato cinerea
Be selected from the potato set that growing way is consistent, each process selects 3 basins for examination leaf seedling, and with potter spray tower in the spraying of 50PSI pressure column, the about 5mL of every basin, each medicament arranges 12 concentration gradients.After chemicals treatment, 24h connects bacterium, the potato cinerea leaf picking up from field is evenly shaken off conidium above potato set and inoculates, then potato set is put into greenhouse and cultivate.According to the morbidity grade scale complete stool investigation disease index of potato cinerea after 7d, and calculate control efficiency, then calculate concentration EC in suppression by method of least squares
50, then calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.
Table two: the virulence test result of the present invention on control potato cinerea
From table two, when cyprodinil and captan are in the scope of proportioning 1:100 ~ 100:1 of preventing and treating potato cinerea, co-toxicity coefficient is all greater than 120, the mixture of both explanations within the scope of this all shows as gain effect, especially, when both ratios are in 5:1, gain effect is particularly outstanding.
Test three: the toxicity test of cucumber fusarium axysporum
Be selected from the cucumber leaf seedling that growing way is consistent, each process selects 3 basins for examination leaf seedling, and with potter spray tower in the spraying of 50PSI pressure column, the about 5mL of every basin, each medicament arranges 12 concentration gradients.After chemicals treatment, 24h connects bacterium, sick for the cucumber of picking up from field leaf is evenly shaken off conidium above cucumber seedling and inoculates, then cucumber leaf seedling is put into greenhouse and cultivate.According to the morbidity grade scale complete stool investigation disease index of cucumber fusarium axysporum after 7d, and calculate control efficiency, then calculate concentration EC in suppression by method of least squares
50, then calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.
Table three: the virulence test result of the present invention on control cucumber fusarium axysporum
From table three, when cyprodinil and captan are in the scope of proportioning 1:100 ~ 100:1 of preventing and treating cucumber fusarium axysporum, co-toxicity coefficient is all greater than 120, and the mixture of both explanations within the scope of this all shows as gain effect, especially, when both ratios are in 1:1, gain effect is particularly outstanding.
Test four
When the effect of active compound combinations exceedes the summation of the effect when each reactive compound is used separately, there is synergistic function.The predictive role of the particular combination of two kinds of reactive compounds can use so-called " Colby formula " (see S.R. Colby, " Calculating Synergistic and Antagonistic Responses of Herbicide Combinations ", Weeds 1967,15,20-22) calculate as follows: if
X is the activity when using the reactive compound A that consumption is mppm for mg/ha or concentration;
Y is the activity when using the reactive compound B that consumption is nppm for ng/ha or concentration, is expressed as the percentage accounting for untreated control;
E is when using consumption for activity during m and n g/ha or the concentration reactive compound A and B that is m and n ppm,
So
If the activity of actual observation (O) is greater than expection active (E), so said composition [l1], namely has synergistic effect.
Following biological test example is in order to illustrate the present invention.But the present invention is not limited to these embodiments.
To the prolection of potato cinerea
By the aqueous suspension spraying with above activity compound concentration of specifying of the leaf of potted plant potato set.Second day by the spore suspension of the plant inoculating potato cinerea of process.Then basin is placed on to have in the room of high atmospheric humidity (90-95%) 24 hours under 20-22oC.In secondary period, spore-germination and germ tube infiltrate in leaf texture.Second day, test plants to be back in greenhouse and under 20-220C and 65-70% relative atmospheric humidity, to cultivate other 7 days.Then the degree of botrytis cinerea development on leaf is estimated.
Claims (7)
1. the bactericidal composition containing cyprodinil and captan is for preventing and treating the purposes of germ harm on cereal, fruit, vegetables, flowers, lawn, it is characterized in that described active component cyprodinil and captan weight proportion are 5:1, described germ is potato cinerea.
2. the bactericidal composition containing cyprodinil and captan is for preventing and treating the purposes of germ harm on cereal, fruit, vegetables, flowers, lawn, it is characterized in that described active component cyprodinil and captan weight proportion are 1:1, described germ is cucumber fusarium axysporum.
3. purposes according to claim 1 and 2, the weight percentage that described active component cyprodinil and captan account for described composition is 5%-90%.
4. purposes according to claim 1 and 2, the weight percentage that described active component cyprodinil and captan account for described composition is 10%-80%.
5. purposes according to claim 1 and 2, the weight percentage that described active component cyprodinil and captan account for described composition is 20%-60%.
6. purposes according to claim 1 and 2, the formulation of described bactericidal composition is suspending agent, seed coat agent, wetting powder, water dispersible granules, micro-capsule granules, paste, aerosol, ZC, coated granule, extrude granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet.
7. purposes according to claim 1 and 2, described bactericidal composition is for the protection of plant propagation material and the plant organ that grows subsequently.
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| CN1099220A (en) * | 1993-06-28 | 1995-03-01 | 希巴-盖吉股份公司 | A plant-microbicidal composition having synergistic action, comprising at least two active ingredient components, eherein...... |
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