CN103278618A - Biochip information reading device and information analyzing method - Google Patents
Biochip information reading device and information analyzing method Download PDFInfo
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- CN103278618A CN103278618A CN2013101700355A CN201310170035A CN103278618A CN 103278618 A CN103278618 A CN 103278618A CN 2013101700355 A CN2013101700355 A CN 2013101700355A CN 201310170035 A CN201310170035 A CN 201310170035A CN 103278618 A CN103278618 A CN 103278618A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
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- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to a biochip information reading device and an information analyzing method, discloses a biochip information reading instrument and belongs to the technical field of clinical diagnosis instruments. The traditional 'gold standard' for diagnosing the flora-imbalanced bacterial vaginitis is difficult in actual operation, and is also rough and complicated to operate although certain new technologies are adopted. According to the biochip information reading instrument, a liquid crystal display is arranged on a casing; a mainboard is arranged in the casing below the display; a photoelectric signal processing and data storing chip, a circuit system, a light source and a photoelectric sensor are fixedly arranged on the mainboard; a biochip detecting channel passing from the instrument in the front-back direction is arranged below the mainboard; and a cutter-shaped telescopic clamping tongue is respectively arranged at two sides of a position below the photoelectric sensor in the biochip detecting channel. A mechanical transmission component and a motor are not arranged in the biochip information reading instrument, so that the biochip information reading instrument is small in volume. The biochip information reading instrument can be used for rapidly obtaining multi-index comprehensive judgment results, thereby being comprehensive, accurate and convenient. Thus, the biochip information reading instrument is suitable for the bedside operation by outpatient service doctors in hospitals or the household use by patients.
Description
Technical field
The present invention relates to a kind of biochip information read device, particularly relate to a kind of microecology in vaginas environmentally sensitive chip information reading device, belong to the clinical diagnosis Instrument technology field.
Background technology
Normal child-bearing period women, under the estrogen action of ovarian secretion, uterine neck and vagina squamous cell receive glycogen and ripe gradually, the intracellular glycogen in back that comes off discharges, be conducive to the growth of lactobacillus and reduce pH value in the vagina, suppressed the growth of other pathogenic bacteria, formed a normal ecologic equilibrium at vagina, the secretion of cervix gland has formed the specific micro-ecological environment of resisting pathogenic microorganism invasion and attack, the state of keeping fit in addition.When the human body decrease in estrogen, a large amount of use microbiotic or with the excessive washing vagina of akaline liquid, paathogenic factors such as unhealthy sexuality suppress to produce the growth of hydrogen ion lactobacillus, cause Grain stain variation coccobacillus (gardnerella vaginalis, bacteroid), anaerobion (Mobiluncus, Fusobacterium, the fertile Pseudomonas of Prey and peptostreptococcus), fusobacterium (atropic ripple bacterium) and mycoplasma genitalium pathogen such as (mycoplasma hominis and ureaplasma urealyticums) increase unusually, cause the microecology in vaginas dysequilibrium, clinical be referred to as bacterial vaginosis BV (bacterial vaginosis, BV).
This shows that the microecology in vaginas dysequilibrium is reason and the early stage state of many gynemetrics serious disease, becomes in close relations with vaginitis, cervicitis, salpingitis, pelvic infecton, gynaecology's postoperative infection, urinary tract infections, mould, trichomonas infection and cervical intraepithelial neoplasia; Can increase the HIV (human immunodeficiency virus) infection probability; Increase infection in infertile, ectopic pregnancy, miscarriage, premature labor, premature rupture of fetal membranes, chorioamnionitis, the caesarean section seraglio, pregnancy badness and complications of pregnancy, infant of low-birth weight's equivalent risk.
The typical clinical of bacterial vaginosis BV shows as vagina abnormal secretion thing showed increased, is lean homogeneous charge shape or scattered paste shape, and canescence, lark or milk yellow have the stench flavor of special fish, and vulva has sense of discomfort, comprises in various degree pruritus vulvue or burning heat sensation.Infect if merge other specific pathogen, clinical manifestation can have specific variations and different, and as when merging gonococcal infection, vaginal fluid can show as obvious purulence shape, and urinary tract infection symptoms such as odynuria, dysuria can occur; When merging trichomonas infection, the spumescence vaginal fluid can appear, and the itch aggravation; When merging monilial infection, vaginal fluid can be rendered as curdy or bean curd slag specimen.
Bacterial vaginosis BV is one of modal vagina infection disease of the women of child-bearing age.Infection rate is at 30-50%, and the incidence of disease is at 10-20%, and number of patients is higher than the number of the infected of Trichomonas vaginalis, mould etc. far away, and easily recurrence.In addition, about 50% bacterial vaginosis BV patient is not affected adversely diagnosis and treatment because there being obvious clinical symptoms.
Amsel standard and Nugent standard are the what is called " goldstandard " of the two big diagnosing bacterial vagina diseases of generally acknowledging in the world.The Amsel standard namely can be diagnosed as bacterial vaginosis BV for three of having in the following four indices simultaneously: (1) vagina has even matter, thin, white secretion; (2) vagina pH〉4.5; (3) the amine test positive; (4) the clues cell positive.The Nugent standard is by different shape classification of flora and integration in the vaginal fluid are diagnosed BV.
In clinical practice, the Amsel standard has the following disadvantages: 1.pH pH-value determination pH inconvenience, and 2. the vaginal fluid proterties judges that subjectivity is strong, and 3. olfactory test staff compliance and objectivity are poor, and 4. clues cell is circumstantial evidence; The Nugent standard also exists needs smear, Gram, then under oily mirror the kind to single bacterium differentiate, counting and integration, professional experiences is strong, and is loaded down with trivial details, time-consuming.
Along with to the pathogenetic understanding that deepens continuously of BV, produced based on the diagnostic method that detects the metabolic product of peculiar microorganism in BV patient's vaginal fluid and some commercial reagents boxes occurred, be " the gynaecologic multi-item dry chemical united detection test paper bar " of CN201247244 and " a kind of bacterial vaginosis BV device for fast detecting; test strip and detection method " that publication number is CN101975852A such as China Intellectual Property Office's publication number, these methods are objective and be suitable for batch operation than said method, but also need naked eyes to judge change color, all need to gather vaginal fluid with examination, the wash-out dilution, be added drop-wise to process such as develop the color on reaction utensil or the test strips then, the pH pH-value determination pH requires directly contact secretion colour developing to observe, and other reaction is through the wash-out dilution, can not samely operate, detect more indirect through the dilution back simultaneously, also can desensitization, operation steps is many, poor accuracy.
Summary of the invention
The object of the present invention is to provide a kind of microecology in vaginas environmental information to read instrument, can read microecology in vaginas environmentally sensitive chip information, quantize, quick, portable.
Technical solution of the present invention is as follows:
In order to achieve the above object, technical scheme of the present invention is: described information reads supportive device, tested chip positioning device, data input-output unit, software systems, power-supply system and the detected biochip that instrument comprises image capturing system, Photoelectric Signal Processing and data handling system, shell and Qi Nei.This information has LCD above reading the instrument shell, in the shell below described display mainboard is arranged, Photoelectric Signal Processing and data storage chip are fixedly arranged on this mainboard, Circuits System, on this mainboard one side down light source is arranged fixedly, photoelectric sensor, the sense channel that described chip arranged below this mainboard penetrates into the back from the front of this instrument, window in position in this passage below described photoelectric sensor, it is tested chip detection position, this detecting position has described chip positioning device, this device respectively has a knife-edge block tongue that can stretch in described passage both sides, there is the knife-edge draw-in groove described tested chip both sides, this draw-in groove is corresponding with described knife-edge block tongue, forms a negative and positive kayser.
As improvement of the present invention, at the next semiconductor heat booster that is equipped with in described tested chip detection position.
As improvement of the present invention, there are USB interface and outer computer or network to carry out exchanges data in the both sides of described shell.
As improvement of the present invention, be built-in with the WIFI device and network carries out exchanges data at this instrument.
As a further improvement on the present invention, between described photoelectric sensor and described chip, optical amplifier is arranged.
As a further improvement on the present invention, the present invention adopts dry cell or lithium battery power supply.
As a further improvement on the present invention, described light source is led light source, and described photoelectric sensor is imageing sensor, comprises CCD or CMOS.
As a further improvement on the present invention, the present invention has bar code or two-dimension code scanner, built-in printer.
As a further improvement on the present invention, built-in a plurality of sense channels and optical sensor system in described shell can detect a plurality of chips simultaneously.
As a further improvement on the present invention, on the tested chip of the present invention bar code or two-dimension code are arranged, corresponding with the unique coding of patient's sample as described chip unique identification and anti-counterfeiting mark, also carry the reference information of data analyses such as reagent and typical curve simultaneously.
Another object of the present invention is to provide a kind of vagina microenvironment sensing chip information of using to read the method that instrument carries out microecology in vaginas environmental change analysis, and described method step comprises:
A. switch power supply implements to make zero setting to the described instrument that reads;
B. described chip is pushed from detecting entrance, up to blocking;
C. extract the chip handle out, software is analyzed the data that read automatically, obtains the microecology in vaginas environmental statement;
D. push next chip, previous chip is ejected described sense channel.
The present invention is built-in led light source, imageing sensor, data processing single chip, when inserting the detection position of detected biochip arrival imageing sensor below, described knife-edge block tongue blocks this chip, extraction chip handle exposes the detection faces of this chip, photoelectric sensor reads described chip color or luminance brightness information, this information is converted into electronic signal, conversion, processing through data processing chip and data storage chip, through built-in application software system analysis and judgement, the result is presented on the liquid crystal touch screen or through built-in printer and gets the result again; The cloud data center that also data can be sent in the network carries out data processing and exchange; If need the detected chip of heating, then the described chip of heating reads described chip color or luminance brightness information again behind preset time automatically, and when the tested chip of the next one pushed, a last chip was ejected the detection position, spues from described channel outlet.
The present invention not only can be used for reading vagina microenvironment sensing chip information, and the information that also can be used for the immunochemistry chip of genetic chip, protein chip, cell chip, organization chip and various marks reads.
Beneficial effect of the present invention:
The present invention can read vagina microenvironment sensing chip information and other chip informations by high flux, inside does not have mechanical transmission component and motor, compact volume and convenience is carried, in medical inspection, can obtain the comprehensive judged result of many indexs at once, fast, objective, and can be by network and medical center swap data, being suitable for the operation of hospital outpatient doctor bedside or patient family uses, use in the area that also is fit to outlying medical skill condition difference, be laboratory medicine bedsideization and simplification trend (point of care testing, embodiment POCT).
Description of drawings
Fig. 1 reads instrument surface structure synoptic diagram for biochip information of the present invention;
Fig. 2 reads instrument inner structure front-view schematic diagram for biochip information of the present invention;
Fig. 3 looks synoptic diagram for biochip information of the present invention reads on the instrument inner structure;
Fig. 4 reads the instrument fundamental diagram for biochip information of the present invention;
Fig. 5 reads block tongue and draw-in groove synoptic diagram in the instrument locating device for biochip information of the present invention;
Fig. 6 reads block tongue front-end view in the instrument locating device for biochip information of the present invention.
Among the figure:
100, shell; 110, heelpiece; 120, loam cake; 130, touch screen; 140, chip inserts mouth; 141, chip discharge opening; 150, printer paper outlet; 160, two-dimension code scanner scanning mouth; 170, power switch; 180, digit punch; 190, power hole; 200, tested chip positioning device; 210, snib; 220, chip under test sense channel; 300, heat block; 410, circuit main board; 420, imageing sensor; 430, light source; 440, data processing module; 450, data reservoir module; 460, lens combination; 500, printer; 600, bar code or two-dimension code scanister; 700, tested chip; 710, draw-in groove.
Embodiment
Read instrument for a kind of microecology in vaginas environmentally sensitive chip information as depicted in figs. 1 and 2, comprise the supportive device of image capturing system, photoelectric signal processing circuit system, mobile network's terminal system, shell and Qi Nei, tested chip positioning device, data input-output system, software systems, power-supply system, heating system and detected biochip.The supportive device of described shell and Qi Nei comprises heelpiece 110 and loam cake 120, this is embedded with touch screen 130 as output input device above loam cake, there are printer paper outlet 150, bar code or two-dimension code scanner scanning mouth 160 and power switch 170 in the next door, and the side has chip to insert mouth 140, chip discharge opening 141, digit punch 180 and power hole 190; Position, the right is mounted with semiconductor heat block 300 over against described imageing sensor lower position above the described heelpiece, this is that described chip under test sense channel 220 is through described entrance and described discharge opening above heat block, this passage is windowed the position on described heat block, it is described chip under test detecting position, this detecting position has described tested chip positioning device 200, this locating device comprises snib 210 and at this segment chip passage, described snib front end is the knife-edge block tongue (Fig. 5) that can stretch, corresponding with the draw-in groove 610 of described chip under test 600 sides, form a negative and positive kayser, be positioned this when making described chip slide into this, chip can continue to stay original position and after next described chip enters this position when drawing back the handle of described chip, before this chip being pushed to; Described passage partly is grooved at described detecting position, and remainder is tubular, connects described chip and inserts mouth and described chip discharge opening; Cmos image sensor 420 is arranged above described detecting position, between this sensor and described chip, lens combination 460 is arranged as optical amplifier, in these sensor both sides led light source 430 is arranged, on the circuit main board 410 that this imageing sensor and led light source are fixed thereon, be integrated with photosignal and binary data processing module 440, data reservoir module 450 at this mainboard, operation and analysis software are stored in this reservoir module; There are bar code or two-dimension code scanister 600 in the front portion on the left side on described heelpiece, in this device left side power-supply system is arranged, settle power supply adaptor that commercially available alternating current is become low-voltage DC, also can adopt powered battery, then leave battery compartment, there is built-in printer 500 at the rear portion on the left side on described heelpiece.
Fig. 3 is principle of work block diagram of the present invention.Described chip information read instrument built-in led light source, imageing sensor, data processing single chip, post patient's identification and information code on the chip under test, this chip reads patient information and sample coding back in the scanning of described bar code or two-dimension code scanner and inserts chip and insert mouthful, when operation arrives detecting position below the imageing sensor in chip channel, described knife-edge block tongue blocks this chip, photoelectric sensor reads in this chip bar code or 2 D code information, and this information is unique ID of this chip and carries technology for detection such as typical curve and analyze reference data; Extraction chip handle exposes the detection faces of this chip, imageing sensor reads described chip image color or luminance brightness information, this information is converted into electronic signal and is sent to data and handles and storage unit, conversion, processing through data processing chip and data storage chip, through built-in application software system analysis and judgement, the result is presented on the liquid crystal touch screen or through built-in printer and gets the result again; Also can such as the WIFI device cloud data center that data are sent in the network be carried out data processing and exchange by wired or wireless network system, in conjunction with data such as patient's medical history taking and sundry item assay, pathological diagnosis result and diagnostic imaging results, obtain the expert system auxiliary diagnosis in real time; If need the detected chip of heating, then the described chip of heating reads described chip color or luminance brightness information again behind preset time automatically, and when the tested chip of the next one pushed, a last chip was ejected the detection position, spues from described channel outlet.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, also not exclusively be equal to industrial manufacture process, though the present invention discloses as above with preferred embodiment, but be not in order to limit the present invention, any those skilled in the art, in the spirit and scope that do not break away from technical solution of the present invention, when the technology contents that can utilize above-mentioned disclosure is made some changes and is modified to the equivalent embodiment of equivalent variations, every spirit that does not break away from technical solution of the present invention, any simple modification that foundation technical spirit of the present invention is done above embodiment, equivalent variations and modification and used raw-material change all still belong in the scope of technical solution of the present invention.
Claims (9)
1. a biochip information reads instrument, comprise the light signal collection system, Photoelectric Signal Processing and data handling system, the supportive device of shell and Qi Nei, the data input-output unit, tested biochip locating device, software systems, power-supply system and detected biochip, it is characterized in that: described information has LCD above reading the instrument shell, in the shell below described display mainboard is arranged, fixedly there are data to handle and the data storage chip on this mainboard, Circuits System, light source, photoelectric sensor, the sense channel that described chip arranged below this mainboard penetrates into the back from the front of this instrument, window in position in this passage below described photoelectric sensor, it is described tested chip detection position, there is tested chip positioning device this position, this device respectively has a knife-edge block tongue that can stretch in described passage both sides, below described detecting position semiconductor heat booster is arranged; There is the knife-edge draw-in groove described tested biochip both sides.
2. read instrument according to claim 1 described biochip information, it is characterized in that: between described photoelectric sensor and described detecting position, optical amplifier is arranged.
3. read instrument according to claim 1 described biochip information, it is characterized in that: described light source is led light source, and described photoelectric sensor is cmos image sensor.
4. read instrument according to claim 1 described biochip information, it is characterized in that: this reads the instrument built-in printer, is built-in with bar code or two-dimension code reading device, is built-in with mobile terminal apparatus.
5. read instrument according to any described biochip information of claim 1-4, it is characterized in that: described biochip is the immunochemistry chip of dry chemical chip, genetic chip, protein chip, cell chip, organization chip and various marks.
6. read instrument according to claim 5 described biochip information, it is characterized in that: described dry chemical chip is microecology in vaginas environmentally sensitive chip.
7. read instrument according to any described biochip information of claim 1-4, it is characterized in that: the present invention adopts powered battery.
8. an exercise of power requires 5 described biochip information to read the method that instrument carries out analysis of biological information, comprises step:
A. switch power supply implements to make zero setting to the described instrument that reads;
B. described chip is pushed from detecting entrance, up to blocking;
C. photoelectric sensor reads described biochip optical information, and software is analyzed the data that read automatically, obtains analysis report;
D. push next chip, previous chip is ejected described sense channel.
9. read the method that instrument carries out analysis of biological information according to claim 8 described biochip information, it is characterized in that: described biochip is microecology in vaginas environmentally sensitive chip, and the concrete operations step is:
A. switch power supply, zeroing arranges;
B. microecology in vaginas environmentally sensitive chip is inserted and detect entrance up to blocking;
C. extract the chip handle out;
D. photoelectric sensor reads described chip information, and software is analyzed the data that read automatically; The screen display result, the printer print result;
E. push next chip, previous chip is ejected described sense channel.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101700355A CN103278618A (en) | 2013-05-09 | 2013-05-09 | Biochip information reading device and information analyzing method |
| PCT/CN2014/076924 WO2014180308A1 (en) | 2013-05-09 | 2014-05-07 | Biochip testing device and use method therefor |
| CN201480024841.4A CN105814437A (en) | 2013-05-09 | 2014-05-07 | Biochip testing device and use method therefor |
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| CN108567413A (en) * | 2018-03-02 | 2018-09-25 | 黑龙江中医药大学 | A kind of multi-functional disease examination equipment of gynaecology of hospital and inspection system |
| CN109142252A (en) * | 2018-09-29 | 2019-01-04 | 重庆迈联医疗科技有限公司 | A kind of modular lipids detection instrument |
| CN110180811A (en) * | 2019-05-07 | 2019-08-30 | 王海山 | A kind of chip detecting equipment that the clarity with dehumidification function is high |
| CN110779923A (en) * | 2019-12-03 | 2020-02-11 | 华侨大学 | Bacterial vaginosis detector and detection method |
| CN111693471A (en) * | 2020-07-17 | 2020-09-22 | 中国农业大学 | Food safety fast-check multi-object monitoring device |
| CN112515777A (en) * | 2020-10-26 | 2021-03-19 | 中国人民解放军空军军医大学 | Special surgical instrument box for field emergency rescue |
| CN114137195A (en) * | 2021-12-03 | 2022-03-04 | 南京大学 | High-flux biochemical detection system and method based on image shooting analysis |
| CN114137195B (en) * | 2021-12-03 | 2023-12-12 | 南京大学 | High-flux biochemical detection system and method based on image shooting analysis |
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| CN105814437A (en) | 2016-07-27 |
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