CN103222523A - Food health preserving tea electuary for nourishing brain - Google Patents
Food health preserving tea electuary for nourishing brain Download PDFInfo
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Abstract
一种养脑的食品养生茶冲剂,属营养食品领域;其目的是效果好、见效快;本发明采用茶氨酸、党参、刺五加、白芍、甲壳等原料制成;它具有扶正培本、益气养血、活血化瘀养脑的作用,具有效果好、见效快的优点。A brain-nourishing food and health-preserving tea granule, which belongs to the field of nutritious food; its purpose is to have good effect and quick effect; This medicine has the effects of nourishing qi and nourishing blood, promoting blood circulation, removing blood stasis and nourishing the brain, and has the advantages of good effect and quick effect.
Description
技术领域 technical field
本发明属于营养食品领域。 The invention belongs to the field of nutritional food.
背景技术 Background technique
由于人类寿命的延长,老年人数目日益增多,老年痴呆的发病率逐渐增多。目前的老年人,大脑的衰老衰退日益明显,主要表现为智力减退、记忆力下降、思维紊乱、反应迟钝等。家族有老年痴呆遗传史者,更为脑痴呆的苗头和倾向忧心忡忡。众所周知,大脑神经细胞的抗衰防老除了必须的药品以外,经常的大量的还是要靠食品营养,以此推迟衰老的时间,减轻衰老的程度,让老年痴呆来得更晚一些,疾病更轻一些。但是,目前市场上很少有营养大脑、预防痴呆的营养食品,极少数养脑食品也存在这效果不够明显、见效比较迟缓的问题,大家对此不满意。 Due to the prolongation of human life expectancy, the number of elderly people is increasing day by day, and the incidence of Alzheimer's disease is gradually increasing. In the current elderly, the aging and decline of the brain is becoming more and more obvious, mainly manifested as mental decline, memory loss, thinking disorder, and slow response. People with a family history of Alzheimer's disease are more worried about the signs and tendencies of dementia. As we all know, in addition to the necessary medicines, the anti-aging and anti-aging of brain nerve cells often rely on food nutrition in large quantities, so as to delay the time of aging, reduce the degree of aging, and make the onset of Alzheimer's later and the disease lighter. However, currently there are few nutritious foods on the market that nourish the brain and prevent dementia, and very few brain-nourishing foods also have the problem that the effect is not obvious enough and the effect is relatively slow, and everyone is not satisfied with this.
针对以上提出的问题,本发明提供一种养脑的食品养生茶冲剂,它能解决以往此类产品中效果不够明显、见效比较迟缓的问题,具有扶正培本,益气养血,活血化瘀养脑的作用,具有效果好,见效快的优点。 Aiming at the problems raised above, the present invention provides a brain-nourishing food and health-preserving tea granule, which can solve the problems that the effects of such products in the past are not obvious enough and the effect is relatively slow. The function of nourishing the brain has the advantages of good effect and quick effect.
发明内容 Contents of the invention
本发明是通过以下技术方案来实现的: The present invention is achieved through the following technical solutions:
1、一种养脑的食品养生茶冲剂,采用中药原料和食品原料制备,配方按重量配比为: 1. A brain-nourishing food and health-preserving tea granule, which is prepared from traditional Chinese medicine raw materials and food raw materials, and the formula is in proportion by weight:
茶氨酸3—5份 党参30—50份 刺五加20—30份 3-5 parts of theanine 30-50 parts of Codonopsis 20-30 parts of Acanthopanax
白芍20—30份 甲壳80—120份 20-30 parts of white peony root 80-120 parts of carapace
这种养脑的食品养生茶冲剂是由下列方法制成的: This brain-nourishing food and health tea granule is made by the following methods:
(1)按上述重量配比,将甲壳提取壳聚糖,制作工艺是:将甲壳粉碎,按液料质量比2:1加入稀碱液,使蛋白质和不溶物分离;在不溶物中按液料质量比3:1加浓度10%稀盐酸,使其中磷酸钙溶解成氯化钙,离心分离、水洗、干燥,得粗甲壳素;按液料质量比8:1加入浓度50%浓氢氧化钠液,110℃,1h,以脱去乙酰基,过滤、水洗、真空干燥,得提取物壳聚糖细粉; (1) According to the above weight ratio, extract chitosan from the carapace. The production process is: crush the carapace, add dilute lye according to the mass ratio of liquid to material 2:1, to separate the protein from the insoluble matter; press the liquid in the insoluble matter Add dilute hydrochloric acid with a concentration of 10% at a material mass ratio of 3:1 to dissolve calcium phosphate into calcium chloride, centrifuge, wash with water, and dry to obtain crude chitin; add 50% concentrated hydrogen for oxidation at a liquid-to-material mass ratio of 8:1 Sodium solution, 110°C, 1h, to remove the acetyl group, filter, wash with water, and dry in vacuum to obtain chitosan fine powder as the extract;
(2)按上述重量配比,将党参进行提取,工艺方法是:将党参粉碎为干燥粉末,按料液质量比1:10加入浓度95%乙醇回流6h,回收乙醇,残渣加9倍量的水,水煮3次,每次20min,过滤,合并滤液,浓缩制成浸膏,烘干粉碎,得党参提取物细粉; (2) According to the above weight ratio, extract Codonopsis pilosula, the process method is: crush Codonopsis pilosula into dry powder, add 95% ethanol to reflux for 6 hours according to the mass ratio of material to liquid at 1:10, recover ethanol, add 9 times the amount of water, boiled in water for 3 times, each time for 20 minutes, filtered, combined the filtrates, concentrated to make an extract, dried and pulverized to obtain a fine powder of Codonopsis pilosula extract;
(3)按上述重量配比,将刺五加、白芍经常规水提取工艺提取,制成浸膏,烘干粉碎,得提取物细粉; (3) According to the above weight ratio, the Acanthopanax senticosus and Radix Paeoniae Alba are extracted through a conventional water extraction process to make an extract, dried and pulverized to obtain a fine powder of the extract;
(4)按上述重量配比,将茶氨酸与上述(1)、(2)、(3)提取物细粉混合,搅拌均匀,制成细小颗粒,装入小袋,每小袋内含提取物3克,制成养脑的食品养生茶冲剂。 (4) According to the above weight ratio, mix theanine with the above (1), (2) and (3) extract fine powder, stir evenly, make fine particles, put them into small bags, and each small bag contains the extract 3 grams, made into a brain-nourishing food health tea granule.
本配方中的原料都是卫生部公布的药食两用品种和食品可用品种。茶氨酸为浙江衢州卓尔化学有限公司生产,含量为99%。 The raw materials in this formula are both medicinal and edible varieties and food-available varieties announced by the Ministry of Health. Theanine is produced by Zhejiang Quzhou Zhuoer Chemical Co., Ltd., with a content of 99%.
本发明根据民间传统配方,根据中医益气养血、活血化瘀养脑的理论,精心研制而成。中医认为,脑血管供血不足,脑微循环不畅,导致脑细胞神经元缺血缺氧,出现一定程度的脑萎缩,是脑痴呆形成的根本性原因。预防脑痴呆,益气养血、活血化瘀当为根本大法。方中刺五加是扶正名品,益气健脾,补肾安神,增强机体免疫力;白芍生血养血,化阴补血,滋润肝脾,刺五加与白芍相须为用扶正培本、增强机体免疫力更为有效,免疫力的“清除”作用清除血液中多余的脂质、盐分、尿酸等垃圾,使血液清洁,黏稠度下降,流动性变好,这是改善脑供血不足,使之供血充盈的关键;臣以茶氨酸旨在保护脑神经细胞,茶氨酸对脑组织有保护作用,可避免由脑缺血所致神经细胞死亡,短暂的一过性脑缺血在中老年人中并不少见,是造成脑痴呆的重要条件,茶氨酸的这种作用——在缺血过程中减轻由缺血再灌流所造成的神经细胞伤害,非常重要;伍以党参意在改善记忆能力,按中医的观点,党参补气、益血、生津,营养学家发现其有改善记忆力的功能,党参的20%乙醇提取液可拮抗东莨菪碱造成的小鼠记忆获得不良,改善亚硝酸钠造成的小鼠记忆巩固障碍,以及40%乙醇造成的小鼠记忆再现缺损,茶氨酸与党参相伍为用,前者保护脑细胞,后者改善记忆力,作用叠加,养脑效果更为显著;辅以甲壳提取之壳聚糖,意在降血脂,高血脂是脑痴呆、脑动脉硬化的基础,壳聚糖的作用在于降低血清总胆固醇,增加高密度脂蛋白胆固醇,降低低密度脂蛋白,防止脂质过多地沉淀在脑血管壁加剧脑组织萎缩。纵观整个配方,诸药配伍,相得益彰,共奏扶正培本、益气养血、活血化瘀养脑之功,具有效果好、见效快的优点。 The present invention is elaborately developed according to traditional folk formulas and the theory of traditional Chinese medicine for nourishing qi and nourishing blood, promoting blood circulation, removing blood stasis and nourishing the brain. Traditional Chinese medicine believes that insufficient blood supply to the brain and poor cerebral microcirculation lead to ischemia and hypoxia of brain cells and neurons, and a certain degree of brain atrophy, which is the fundamental cause of the formation of dementia. To prevent dementia, nourishing qi and blood, promoting blood circulation and removing blood stasis are the fundamental methods. Acanthopanax in the prescription is a famous product of Fuzheng, which can nourish qi and spleen, invigorate the kidney and calm the nerves, and enhance the body's immunity; white peony produces blood and nourishes blood, transforms yin and nourishes blood, nourishes the liver and spleen. It is more effective to enhance the body's immunity. The "clearing" effect of immunity removes excess lipids, salt, uric acid and other garbage in the blood, making the blood clean, reducing the viscosity and improving the fluidity. This is to improve the insufficient blood supply to the brain and make the blood The key to the filling of blood supply; the subject uses theanine to protect brain nerve cells, theanine has a protective effect on brain tissue, and can avoid the death of nerve cells caused by cerebral ischemia. It is not uncommon in the elderly, and it is an important condition for dementia. The effect of theanine—reducing nerve cell damage caused by ischemia and reperfusion during ischemia is very important; Improve memory ability. According to traditional Chinese medicine, Codonopsis pilosula nourishes qi, nourishes blood, and promotes body fluids. Nutritionists have found that it has the function of improving memory. The 20% ethanol extract of Codonopsis pilosula can antagonize the poor memory acquisition caused by scopolamine in mice and improve nitrous acid. The memory consolidation disorder in mice caused by sodium, and the memory reproduction defect in mice caused by 40% ethanol, theanine and codonopsis are used together. The former protects brain cells, and the latter improves memory. The effects are superimposed, and the effect of nourishing the brain is more significant. ; Supplemented with chitosan extracted from carapace, it is intended to lower blood lipids. Hyperlipidemia is the basis of brain dementia and cerebral arteriosclerosis. The role of chitosan is to reduce serum total cholesterol, increase high-density lipoprotein cholesterol, and reduce low-density lipoprotein. , prevent excessive deposition of lipids in the walls of cerebral blood vessels and aggravate brain tissue atrophy. Looking at the whole formula, all the medicines are compatible and complement each other, and play the functions of strengthening the body, nourishing qi and nourishing blood, promoting blood circulation, removing blood stasis and nourishing the brain, and have the advantages of good effect and quick effect.
具体实施方式 Detailed ways
通过以下实施方式对本发明做具体说明: The present invention is specifically described by the following embodiments:
1、取以下配方(重量按克为单位): 1. Take the following formula (weight in grams):
茶氨酸300克 党参3000克 刺五加2000克 Theanine 300 grams Codonopsis 3000 grams Acanthopanax 2000 grams
白芍2000克 甲壳8000克 2000 grams of white peony root 8000 grams of carapace
按规定重量,用本发明内容(1)、(2)的方法将甲壳、党参分别进行提取,得提取物细粉;用本发明内容(3)的方法将刺五加、白芍进行提取,得提取物细粉,将茶氨酸与(1)、(2)、(3)提取物细粉混合,搅拌均匀,共1240克,制成细小颗粒,装入小袋,每小袋内含提取物3克,制成养脑的食品养生茶冲剂413小袋。 According to the specified weight, the carapace and Codonopsis pilosula are extracted respectively by the method of content (1) and (2) of the present invention to obtain fine powder of the extract; To get the fine powder of the extract, mix theanine with (1), (2), and (3) fine powder of the extract, stir evenly, a total of 1240 grams, make fine particles, put it into a small bag, and each small bag contains the extract 3 grams, made into 413 sachets of brain-nourishing food and health tea granules.
2、取以下配方(重量按克为单位) 2. Take the following formula (the weight is in grams)
茶氨酸500克 党参5000克 刺五加3000克 Theanine 500 grams Codonopsis 5000 grams Acanthopanax 3000 grams
白芍3000克 甲壳12000克 Paeoniae Alba 3000 grams Carapace 12000 grams
按上述同样的方法,制成养脑的食品养生茶冲剂653小袋,每小袋内含提取物3克。 By the same method as above, 653 sachets of food and health tea granules for nourishing the brain were made, and each sachet contained 3 grams of extract.
3、取以下配方(按重量比): 3. Take the following formula (by weight ratio):
茶氨酸4份 党参32份 刺五加22份 4 parts of theanine 32 parts of Codonopsis 22 parts of Acanthopanax
白芍22份 甲壳90份 22 parts of white peony root 90 parts of carapace
按上述同样的方法,制成养脑的食品养生茶冲剂,每小袋内含提取物3克。 By the same method as above, the brain-nourishing food and health-preserving tea granule is made, and each sachet contains 3 grams of extract.
4、取以下配方(按重量比): 4. Take the following formula (by weight ratio):
茶氨酸4份 党参45份 刺五加28份 4 parts of theanine 45 parts of Codonopsis 28 parts of Acanthopanax
白芍28份 甲壳110份 28 parts of white peony root 110 parts of carapace
按上述同样的方法,制成养脑的食品养生茶冲剂,每小袋内含提取物3克。 By the same method as above, the brain-nourishing food and health-preserving tea granule is made, and each sachet contains 3 grams of extract.
临床资料:clinical information:
本发明以中医老年轻度脑痴呆为例,经16例临床观察。选择中医老年痴呆为标准:60岁以上老年,精神呆滞,语言表达障碍,善忘,出现记忆障碍——记忆近事及远事的能力减退,心算、倒述数字的能力减退。如上症状,即可确诊。在确诊观察的对象中,男性9例,女性7例,无其它严重疾病,年龄为61岁~92岁,平均年龄79.5岁。 The present invention takes TCM senile mild dementia as an example, through clinical observation of 16 cases. Elderly dementia in traditional Chinese medicine is selected as the standard: elderly over 60 years old, mentally sluggish, language barriers, forgetfulness, memory impairment - the ability to remember recent and distant events is diminished, and the ability to mentally calculate and count backwards is diminished. The above symptoms can be diagnosed. Among the objects under confirmed observation, there were 9 males and 7 females, without other serious diseases, ranging in age from 61 to 92 years old, with an average age of 79.5 years.
疗效判定: Judgment of curative effect:
1、显效:精神呆滞明显改善;语言表达能力增强;记忆远事近事的能力明显恢复;判定人、时、地及心算、倒述数字的能力增强。 1. Significant effect: Mental sluggishness is significantly improved; language expression ability is enhanced; the ability to remember distant and recent events is obviously restored; the ability to judge people, time, place, and mental arithmetic and reverse numbers is enhanced.
2、有效:神情呆滞、语言表达能力有所改善,记忆、心算、倒述数字能力有所提高。 2. Effective: The expression is sluggish, the language expression ability is improved, and the ability of memory, mental calculation, and counting backwards is improved.
3、无效:症状无变化。 3. Ineffective: no change in symptoms.
临床试验时,停服其它药物和营养保健品。服用本发明实施方式2制作的养脑的食品养生茶冲剂,观察6个月为1个周期。服用方法:每日1次,每次1小袋,每小袋内含提取物3克,饭后温开水送服;2个月后症状即有缓解,服用6个月后,症状明显改善。临床实验的16人中,显效5人,有效9人,无效2人,总有效率87.5%。 During clinical trials, stop taking other drugs and nutritional health products. Take the brain-nourishing food and health-preserving tea granule prepared in Embodiment 2 of the present invention, and observe for 6 months as a cycle. How to take it: once a day, 1 sachet each time, each sachet contains 3 grams of extract, take it with warm water after meals; the symptoms will be relieved after 2 months, and the symptoms will be significantly improved after 6 months of taking. Among the 16 people in the clinical trial, 5 people were markedly effective, 9 people were effective, and 2 people were ineffective, with a total effective rate of 87.5%.
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CN103392871A (en) * | 2013-08-03 | 2013-11-20 | 北京绿源求证科技发展有限责任公司 | Food-grade health tea soluble granules capable of promoting lead excreting |
CN103404673A (en) * | 2013-08-28 | 2013-11-27 | 北京绿源求证科技发展有限责任公司 | Food brain-nourishing tee granule |
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CN101461433A (en) * | 2008-11-07 | 2009-06-24 | 健士星生物技术研发(上海)有限公司 | Tea extract and preparation method thereof |
CN102302149A (en) * | 2011-07-02 | 2012-01-04 | 赵锐 | Multi-panax healthcare food and preparation method thereof |
CN102423072A (en) * | 2011-11-24 | 2012-04-25 | 陕西方舟制药有限公司 | Health food for improving memory and preparation method thereof |
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CN101190269A (en) * | 2006-12-01 | 2008-06-04 | 张作光 | A set of medicinal compositions for improving cognitive impairment and treating senile dementia |
CN101461433A (en) * | 2008-11-07 | 2009-06-24 | 健士星生物技术研发(上海)有限公司 | Tea extract and preparation method thereof |
CN102302149A (en) * | 2011-07-02 | 2012-01-04 | 赵锐 | Multi-panax healthcare food and preparation method thereof |
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CN103392871A (en) * | 2013-08-03 | 2013-11-20 | 北京绿源求证科技发展有限责任公司 | Food-grade health tea soluble granules capable of promoting lead excreting |
CN103404673A (en) * | 2013-08-28 | 2013-11-27 | 北京绿源求证科技发展有限责任公司 | Food brain-nourishing tee granule |
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