CN103169783A

CN103169783A - Medicine for treating anovulatory dysfunctional uterine bleeding

Info

Publication number: CN103169783A
Application number: CN2013100968728A
Authority: CN
Inventors: 薛洪喜
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-03-25
Filing date: 2013-03-25
Publication date: 2013-06-26

Abstract

The invention relates to a medicine for treating anovulatory dysfunctional uterine bleeding. Common symptom of anovulatory dysfunctional uterine bleeding is irregular metrorrhagia and is represented by irregular menstrual periods, unequal menstrual periods, indefinite or increased menstrual blood volume, and even excessive bleeding. No stomachache or other discomforts are available in the full bleeding period, secondary anemia always occurs when the amount of bleeding is great or the time is long, and excessive bleeding leads to shock. No abnormalities are found in general check-up and gynecologic examination, so that organic lesions of reproductive organ and general lesions are excluded. Ovulation is stopped through endometrium sample pathological examination, progesterone test in luteal phase and examination of basal body temperature. Through long-term research and clinical verification, the inventor finally finds a traditional Chinese medicine oral preparation for treating anovulatory dysfunctional uterine bleeding with better curative effect. The use level of medical components are found by the inventer, and the medicine comprises the components in parts by weight as follows: 10 parts of angelica sinensis, 10 parts of ligusticum wallichii, 10 parts of myrrh, 10 parts of trogopterus dung, 3 parts of pseudo-ginseng, 12 parts of the root bark of the peony tree, 10 parts of the root of red-rooted salvia, 6 parts of donkey-hide gelatin, 15 parts of fried folium artemisiae argyi, 20 parts of cuttle bone, 20 parts of keel and 15 parts of oyster. The medicines are combined, so that the medicines have the synergistic effect, and have the functions of promoting blood circulation to remove blood stasis, nourishing the blood and hemoslasis and regulating menstruation and relieving pain, so that the medicine can effectively treat anovulatory dysfunctional uterine bleeding.

Description

A kind of medicine for the treatment of the anovulatory anovulatory dysfunctional uterine hemorrhage

Technical field

The present invention relates to a kind of Chinese herbal medicine, especially a kind of Chinese herbal medicine for the treatment of the anovulatory anovulatory dysfunctional uterine hemorrhage.

Background technology

The anovulatory anovulatory dysfunctional uterine hemorrhage is apt to occur in adolescence and climacteric, and common sympton is metrorrhagia, shows as the confusion of the menstrual cycle, and menstrual period are different in size, through measuring indefinite or increasing, even bleeds profusely.Hemorrhage general without stomachache or other discomforts during complete, the many or normal secondary anemia of time long time of amount of bleeding, bleeding profusely to cause shock.General physical checkup and gynecologial examination are got rid of genitals and general organic disease without extremely.Endometrial sampling pathologic finding, luteal phase, progesterone was measured or the examination of basal body temperature anovulation, and treatment is take the hormone hemostasis as main, easily repeatedly at present; The operative treatment such as dilatation and curettage or endometrectomy, uterectomy, both bring very large misery to the patient in case of necessity.

Summary of the invention

The inventor is through studying for a long period of time, and the checking repeatedly by clinical trial, finally found the extract oral medicine that is used for the treatment of the anovulatory anovulatory dysfunctional uterine hemorrhage that better curative effect is arranged, and this medicine has the effects such as blood circulation promoting and blood stasis dispelling, nourishing blood and hemoslasis, menstruction regulating and pain relieving.

Technical assignment of the present invention is to provide a kind of Chinese medicine composition of more efficiently treatment anovulatory anovulatory dysfunctional uterine hemorrhage.Medicament selection Radix Angelicae Sinensis Rhizoma Chuanxiong Myrrha Oletum Trogopterori Radix Notoginseng Cortex Moutan Radix Salviae Miltiorrhizae Colla Corii Asini Folium Artemisiae Argyi (parched) Os Sepiae Os Draconis Concha Ostreae of the present invention makes up, and makes each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the anovulatory anovulatory dysfunctional uterine hemorrhage.Wherein: Radix Angelicae Sinensis: be the root of Umbelliferae herbaceos perennial Radix Angelicae Sinensis.Property is sweet, hot, temperature.Return liver, suffering, spleen, large intestine channel.Have and enrich blood, invigorate blood circulation, pain relieving, regulating menstruation, the effect of loosening bowel to relieve constipation.

Rhizoma Chuanxiong: be the rhizome of Umbelliferae herbaceos perennial Rhizoma Chuanxiong.The property hot, temperature.GUIXIN, Liver Channel.Has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.

Myrrha: the oleo-gum-resin of oozing out for Burseraceae shrub or arbor myrrh skin zone.The property hot, bitter, flat.GUIXIN, liver, spleen channel.Promoting blood circulation and stopping pain, detumescence and promoting granulation.

Oletum Trogopterori: be the feces of the trogopterus xanthipes Milne-Edwards of flying squirrel section animal.Property is bitter, salty, sweet, temperature.Return Liver Channel.Promoting blood circulation and stopping pain, removing stasis to stop bleeding.

Radix Notoginseng:Root for Araliaceae herbaceos perennial Radix Notoginseng.Property is hot, sweet, little puckery, temperature.Return liver, heart channel.Hemostasia and dissipation blood stasis, reducing swelling and alleviating pain.Main chemical compositions: arasaponin class, dencichine, flavone, saccharide etc.Arasaponin class, flavone have the effect of blood circulation promoting and blood stasis dispelling, improve blood and stick, gather, coagulate state, to endometrial hyperplasia person successful.

Cortex Moutan: be the root bark of Ranunculaceae undershrub plant Paeonia suffruticosa.The property bitter, hot, be slightly cold.Return kidney, liver, heart channel.Has clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, the effect of reducing the asthenic fever.

Radix Salviae Miltiorrhizae: be the root of Labiatae herbaceos perennial Radix Salviae Miltiorrhizae.The property hot, bitter, be slightly cold.GUIXIN, Liver Channel.Has blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, the effect that relieving restlessness is calmed the nerves.

Colla Corii Asini: for the skin of equine species donkey through decoct, the concentrated solid gum of making.The property sweet, flat.Return lung, liver, kidney, heart channel.Enrich blood, lung conscience kidney yin is grown in hemostasis.

Folium Artemisiae Argyi: be the leaf of Compositae herbaceos perennial Chinese mugwort.The property bitter, hot, warm.Return the liver,kidney,spleen warp.Has warming the meridian for stopping bleeding, the effect of dispersing cold for relieving pain.

The Inner shell of Os Sepiae: Wei Wu Quarry section's animal sepiella maindroni de Rochebrune or golden cuttlefish.Property is salty, puckery, tepor.Return liver, kidney channel.Treating spontaneous emission and leukorrhagia, astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.

Os Draconis: for ancient times multiple large mammal such as deer class, bovine, resemble the Skeletal Fossils of class etc. or resemble the fossil of class front tooth.The property sweet, puckery, flat.GUIXIN, liver, kidney channel.Tranquillizing the mind by relieving convulsion, suppressing the hyperactive liver and subsiding YANG is restrained astringent or styptic treatment for spontaneous sweating.

Concha Ostreae: for Ostreidae animal Concha Ostreae shell.Property is salty, puckery, is slightly cold.Return liver, kidney channel.Suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.

Radix Angelicae Sinensis, Rhizoma Chuanxiong: nourshing blood and promoting blood circulation.Myrrha, Oletum Trogopterori: promoting blood circulation to disperse blood clots and relieves pain.Radix Notoginseng, Cortex Moutan, Radix Salviae Miltiorrhizae: promoting blood flow and remove blood stasis and stop bleeding.Colla Corii Asini, Folium Artemisiae Argyi (parched) nourishing blood and hemoslasis.Os Sepiae, Os Draconis, Concha Ostreae: astringent or styptic treatment for spontaneous sweating hemostasis.

The consumption of drug component of the present invention is also groped to draw through the inventor in a large number, and each amounts of components is for to have curative effect preferably in the following weight proportioning: Radix Angelicae Sinensis 5-15 part, Rhizoma Chuanxiong 3-10 part, Myrrha 3-10 part, Oletum Trogopterori 3-10 part, Radix Notoginseng 3-12 part, Cortex Moutan 6-12 part, Radix Salviae Miltiorrhizae 5-15 part, Colla Corii Asini 5-15 part, Folium Artemisiae Argyi (parched) 3-15 part, Os Sepiae 6-20 part, Os Draconis 15-30 part, Concha Ostreae 10-30 part.

Its best proportioning is: 10 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 10 parts of Myrrhas, 10 parts of Oletum Trogopteroris, 3 parts of Radix Notoginseng, 12 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 6 parts, Colla Corii Asini, 15 parts of Folium Artemisiae Argyi (parched), 20 parts of Os Sepiae, 20 parts of Os Draconis, 15 parts of Concha Ostreaes.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Can use decocting, get after filtration filtrate, make oral liquid; Also can directly take decoction in case of necessity.

Medicine of the present invention has the effects such as blood circulation promoting and blood stasis dispelling, nourishing blood and hemoslasis, menstruction regulating and pain relieving, and short treating period is evident in efficacy, without any side effects, according to clinical 200 routine patients being observed statistics, takes 80%, two of one of the medicine of the present invention obvious effective rate course for the treatment of obvious effective rate course for the treatment of 86%.

The specific embodiment

Take following each medicine:

10 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 10 parts of Myrrhas, 10 parts of Oletum Trogopteroris, 3 parts of Radix Notoginseng, 12 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 6 parts, Colla Corii Asini, 15 parts of Folium Artemisiae Argyi (parched), 20 parts of Os Sepiae, 20 parts of Os Draconis, 15 parts of Concha Ostreaes.

Said medicine is put in mortar successively grind well, cross 100 mesh sieves, then packing two pouches; When taking one day twice, once a bag, ten days was a course for the treatment of.

The below is the clinical data that the patient uses medicine of the present invention:

One, physical data

Accept patient's totally 200 examples for medical treatment, all make a definite diagnosis through gynecologial examination and ultrasonic examination, its age 20-49 year, average 32 years old.

Two, diagnostic criteria

1, be apt to occur in adolescence and climacteric, common sympton is metrorrhagia, shows as the confusion of the menstrual cycle, and menstrual period are different in size, through measuring indefinite or increasing, even bleeds profusely.Hemorrhage general without stomachache or other discomforts during complete, the many or normal secondary anemia of time long time of amount of bleeding, bleeding profusely to cause shock.2, general physical checkup and gynecologial examination without extremely, are got rid of genitals and general organic disease.3, Endometrial sampling pathologic finding, luteal phase, progesterone was measured or the examination of basal body temperature anovulation.

Three, Therapeutic Method

The patient takes medicine of the present invention, and one day twice, once a bag.

Four, efficacy assessment standard

Produce effects: after finishing the course for the treatment of, clinical symptoms disappears fully.

Take a turn for the better: symptom is alleviated substantially.

Invalid: remission is not obvious.

Five, therapeutic outcome

Treatment time	Produce effects (example)	Obvious effective rate %	Take a turn for the better (example)	Improvement rate %	Invalid (example)	Inefficiency %
							One course for the treatment of	160	80	32	16	8	4
Two courses for the treatment of	172	86	10	20	8	4

Model case:

One, Mrs Li, 20 years old, unmarried, the From Shandong Rizhao people, more than patient's the confusion of the menstrual cycle half a year, menorrhagia, dizzy weak, pale complexion, general physical checkup and anus are looked into no abnormality seen, and luteal phase, progesterone was measured or examination of basal body temperature prompting anovulation.Be diagnosed as the anovulatory anovulatory dysfunctional uterine hemorrhage.

Take medicine of the present invention after course for the treatment of, the patient feels symptom obviously to be alleviated, and menstrual cycle transfers to normally, reduces through amount.Continue to take medicine of the present invention after course for the treatment of, menses are normal, continue a course for the treatment of.

Two, Mrs Wang, 45 years old, people from Linyi, Shandong, polymenorrhea companion be through measuring many 3 months, and general physical checkup and gynecologial examination be without extremely, agenosomia official and general organic disease, Endometrial sampling pathologic finding prompting anovulation.Be diagnosed as the anovulatory anovulatory dysfunctional uterine hemorrhage.

Take medicine of the present invention after course for the treatment of, symptom obviously alleviates, and continues to consolidate a course for the treatment of curative effect.

Claims

1. medicine for the treatment of the anovulatory anovulatory dysfunctional uterine hemorrhage is characterized in that it is made by the crude drug of following weight proportion: Radix Angelicae Sinensis 5-15 part, Rhizoma Chuanxiong 3-10 part, Myrrha 3-10 part, Oletum Trogopterori 3-10 part, Radix Notoginseng 3-12 part, Cortex Moutan 6-12 part, Radix Salviae Miltiorrhizae 5-15 part, Colla Corii Asini 5-15 part, Folium Artemisiae Argyi (parched) 3-15 part, Os Sepiae 6-20 part, Os Draconis 15-30 part, Concha Ostreae 10-30 part.

2. medicine according to claim 1 is characterized in that it is made by the crude drug of following weight proportion: 10 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 10 parts of Myrrhas, 10 parts of Oletum Trogopteroris, 3 parts of Radix Notoginseng, 12 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 6 parts, Colla Corii Asini, 15 parts of Folium Artemisiae Argyi (parched), 20 parts of Os Sepiae, 20 parts of Os Draconis, 15 parts of Concha Ostreaes.