CN103071010B - Traditional Chinese medicine preparation for treating disorders of gastrointestinal motility - Google Patents
Traditional Chinese medicine preparation for treating disorders of gastrointestinal motility Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating disorders of gastrointestinal motility, in particular to a traditional Chinese medicine preparation prepared from mangnolia officinalis, radix ophiopogonis, dried tangerine or orange peel, raw radix aucklandiae, the root of three-nerved spicebush, pericarpium arecae, codonopsis pilosula, raw bighead atractylodes rhizome and endothelium corneum gigeriae galli as raw materials. The invention further relates to a preparation method of the traditional Chinese medicine.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation for the treatment of gastrointestinal motility disorders, in particular to the Chinese medicine preparation prepared for raw material with Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, the raw Radix Aucklandiae, the Radix Linderae, Pericarpium Arecae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Raphani, Radix Glycyrrhizae Preparata, the invention still further relates to the preparation method of this medicine.
Background technology:
Gastrointestinal motility disorders is the modal disease of digestive system, and recent statistics shows, the prevalence of Chinese gastrointestinal motility disorders is 10% ~ 30%, and the outpatients caused by it accounts for 50% of Gastroenterology dept.'s outpatient service.The gastroenteropathy being clinical manifestation with various symptom of digestive tract that main finger causes because of gastrointestinal motility disorders.Such disease is the general name of one group of gastrointestinal syndrome, is the main cause causing functional dyspepsia.Clinical main manifestations is the glutted discomfort of epigastrium, is often main manifestations with belch, inappetence, heartburn, the symptom such as pantothenic acid and retrosternal pain, can with other functional symptoms.
" gastric motility " is the power of the digesting and emptying motor function of stomach, with the electrical activity of pipe smooth muscle, and the regulatory mechanism of neural and hormone, the secretion of Digestive system, at the bottom of stomach, the result of the common coordination exercise of gastric antrum, pylorus, duodenum and small intestinal; Be participated in by multi viscera, multisystem, and remain overall harmony.The clinical treatment to functional dyspepsia at present mainly gives gastro-kinetic agent, acid inhibitor and the Hp symptomatic treatment that goes out.Full digestive tract power reinforcing medicine obviously can improve clinical symptoms, but life-time service has and causes compared with side effect such as severe arrhythmia and diarrhoea, borborygmus, transient stomachache.
So find a kind of curative effect short digestive tract power Chinese medicine that is high, that have no side effect from tcm field to become one of study hotspot.
Prior art comprises the Chinese medicine that some improve gastric motility, but some uses expensive raw material of Chinese medicine, and some interrupts because uncertain therapeutic efficacy is cut using.
The present invention, through years of researches, finds a kind of brand-new Chinese medicine formula, develops the short digestive tract power Chinese medicine preparation that a kind of curative effect is high, have no side effect.
Summary of the invention:
The invention discloses a kind of Chinese medicine preparation for the treatment of gastrointestinal motility disorders.
The present invention also provides the preparation method of this Chinese medicine preparation.
Chinese medicine of the present invention, prepares for raw material with Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, the raw Radix Aucklandiae, the Radix Linderae, Pericarpium Arecae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Raphani, Radix Glycyrrhizae Preparata,
Chinese medicine preparation of the present invention, is prepared from by the raw material of Chinese medicine medicine of following weight proportion:
Cortex Magnoliae Officinalis 9-20 grams, Fructus Aurantii Immaturus 9-20 grams, Pericarpium Citri Reticulatae 9-25 grams, the raw Radix Aucklandiae 3-10 grams,
The Radix Linderae 5-15 grams, Pericarpium Arecae 9-25 grams, Radix Codonopsis 9-30 grams, Rhizoma Atractylodis Macrocephalae 9-20 grams,
Endothelium Corneum Gigeriae Galli 9-30 grams.
Preferably, Chinese medicine preparation of the present invention, is prepared from by the raw material of Chinese medicine medicine of following weight proportion:
Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the raw Radix Aucklandiae 5 grams, the Radix Linderae 10 grams,
Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams.
More than in composition, weight calculates with crude drug, and above composition can be made into the dose of pharmaceutical preparation 1-3 days.
More than composition is by weight as proportioning, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or in units of ton, small-scale production also can in units of milligram, weight can increase or reduce, but the constant rate of raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion is through that science screening obtains, for special circumstances, as serious symptom or mild, fat or modest, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is constant.
Single medicinal material more than in composition, especially ministerial drug and adjuvant drug, also can be replaced by the suitable Chinese medicine with the identical property of medicine, its drug effect of the Chinese medicine preparation after replacement is constant.
Chinese medicine preparation of the present invention, being that the raw material of Chinese medicine by being formed by above-mentioned formula is processed through extraction or other modes, making pharmaceutically active substance, subsequently, with this material for raw material, when needing, add medicine acceptable carrier, make according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can be obtained by the common raw material of Chinese medicine that extracts, also can obtain by other means, as: by pulverizing, squeezing, calcine, grind, sieve, percolation, extraction, water extraction, alcohol extraction, ester carry, the material that method obtains, these active substances can be extractum form such as ketone is carried, chromatography, can be dry extract also can be fluid extract, need to determine to make different concentration according to the difference of preparation.
Pharmaceutically active substance in Chinese medicine preparation of the present invention, its in the formulation shared percentage by weight can be 0.1-99.9%, all the other are medicine acceptable carrier.Pharmaceutical preparation of the present invention, exists in a unit, and described unit dosage form refers to the unit of preparation, as every sheet of tablet, and every capsules of capsule, every bottle of oral liquid, granule every bag etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, granule, pill, powder, unguentum, sublimed preparation, powder, solution, injection, suppository, spray, drop, patch.Preparation of the present invention, preferably peroral dosage form, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.
Chinese medicine preparation of the present invention, the preparation of its oral administration can containing conventional excipient, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent.
The filler be suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, such as sodium starch glycollate.Suitable lubricant comprises, such as magnesium stearate.The suitable acceptable wetting agent of medicine comprises sodium lauryl sulphate.
By mixing, fill, the method that tabletting etc. are conventional prepares solid oral composition.Repeatedly mix and active substance can be made to be distributed in those compositionss of a large amount of filler of whole use.
The form of oral liquid can be such as aqueous or oily suspensions, solution, Emulsion, syrup or elixir, or can be the composite dry products of a kind of available water before use or other suitable carrier.This liquid preparation can containing conventional additive, such as suspending agent, such as sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats, emulsifying agent, such as lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), the oily ester of the such as ester of almond oil, fractionated coconut oil, such as glycerol, propylene glycol or ethanol; Antiseptic, such as para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if need, can containing conventional flavouring agent or coloring agent.
Injection contains active substance of the present invention and sterile carrier.According to carrier and concentration, this compound can be suspended or dissolve.The preparation of solution is normally by being dissolved in a kind of carrier by active substance, filter-sterilized before being loaded a kind of suitable bottle or ampoule, then seals.Adjuvant such as a kind of local anesthetic, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, by freezing for this compositions after loading bottle, and under vacuo water can be removed.
Chinese medicine preparation of the present invention, applicable medicine acceptable carrier is optionally added when being prepared into medicament, adjunct ingredient as conventional: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention, in use according to condition determination usage and dosage, can take three every day, each 1-20 agent, as: 1-20 bag or grain or sheet.
The preparation method of Chinese medicine preparation of the present invention is as follows:
Whole medical material decocts with water, and obtains decoction liquor, is condensed into extractum, obtains pharmaceutically active substance, adds adjuvant and makes pharmaceutical preparation according to galenic pharmacy routine techniques, obtain Chinese medicine preparation of the present invention.
Preferably, preparation method of the present invention is as follows:
Whole medical material adds soak by water 1-3 time of 2-10 times amount, each 1-3h, merges decoction liquor, is concentrated into relative density 1-1.5(60 DEG C) extractum, add adjuvant and make pharmaceutical preparation according to galenic pharmacy routine techniques, obtain Chinese medicine preparation of the present invention.
Beneficial effect of the present invention is further illustrated below by way of test data:
The present invention uses the method in embodiment 1 to extract and obtains extractum and be called " stomach function regulating drink extract " or " Hwy ", carries out the experiment of following animal and human's body with extractum as Experimental agents
Material one: the impact that embodiment 1 extract is emptying on Mouse Stomach
Summary: the impact that object research stomach function regulating drink extract is emptying on Mouse Stomach.Method adopts different instrument recurrence due to taking drug Mouse Stomach air emptying function Disorder Model, observes the administration of various dose stomach function regulating drink extract oral to the impact of gastric emptying.Result stomach function regulating drink extract obviously can resist the Mouse Stomach gastric emptying disability in gastric that atropine and dopamine cause.
Experimental result
Hwy causes the impact of Mouse Stomach gastric emptying disability in gastric to atropine sulfate
Compare with blank group, model group gastric pigment residue rate obviously raises (p<0.05), shows that mouse peritoneal injecting atropine gastric emptying is suppressed; Compare with model group, Hwy respectively organizes gastric pigment residue rate and obviously reduces (p<0.05).
Hwy causes the impact of gastric emptying disorder to dopamine
Compare with blank group, model group gastric pigment residue rate obviously raises (p<0.05), shows that mouse peritoneal Injection of Dopamine gastric emptying is suppressed; Compare with model group, in Hwy, dosage and high dose gastric pigment residue rate obviously reduce (p<0.05).
Hwy causes the emptying hyperfunction impact of Mouse Stomach to neostigmine
Compare with blank group, model group gastric pigment residue rate obviously reduces (p<0.05), shows that mouse peritoneal injection neostigmine gastric emptying is hyperfunction; The each dosage group of Hwy compares with model group (p>0.05), Hwy is described and causes emptying hyperfunction without antagonism of Mouse Stomach to neostigmine.
Material two: embodiment 1 extract is on the impact of rat isolated stomach smooth muscle contractility
Summary: object research stomach function regulating drink extract is on the impact of rat isolated stomach smooth muscle contractility.Method utilizes isolated rat pellets floating in stomach, observes stomach function regulating drink extract to the impact of pipe smooth muscle activity in vitro under normal and dopamine, Action of Isoproterenol.It is movable that result stomach function regulating drink extract obviously can strengthen the normal in vitro pipe smooth muscle of rat, and resist dopamine and isoproterenol to the inhibitory action of rat isolated stomach smooth muscle activity.
Experimental result
The impact that Hwy shrinks pipe smooth muscle in vitro under normal and different inhibitor effect
Blank group compares, and Hwy can significantly improve the amplitude (p<0.05) of pipe smooth muscle, and (2.60 × 10
-4, 3.85 × 10
-4, 5.06 × 10
-4); And significantly can increase the tension force (p<0.05) of pipe smooth muscle, (3.85 × 10
-4, 5.06 × 10
-4).
The impact that Hwy suppresses rat isolated stomach smooth muscle contraction caused by dopamine
Compare with blank group, model group obviously can reduce pipe smooth muscle amplitude and tension force (p<0.05); Compare with model group, each concentration group of Hwy all can significantly improve pipe smooth muscle amplitude and tension force (p<0.05); Concentration is 3.85 × 10
-4amplitude and 1.32 × 10
-4comparing difference significantly (p<0.05); Concentration is 5.06 × 10
-4tension force and 1.32 × 10
-4., 2.60 × 10
-4relatively (p<0.05), show dose dependence; Model group frequency compares (p<0.05) with blank group; The each concentration class frequency of Hwy compares (p<0.05) with model group frequency.
The impact that Hwy suppresses rat isolated stomach smooth muscle contraction caused by isoproterenol
Compare with blank group, model group obviously can reduce pipe smooth muscle amplitude and tension force (p<0.05); With model group ratio, each concentration group of Hwy all can significantly improve pipe smooth muscle amplitude and tension force (p<0.05); Concentration 3.85 × 10
-4, 5.06 × 10
-4amplitude and 1.32 × 10
-4amplitude Comparison (p<0.05), show dose dependence; Model group frequency compares (p<0.05) with blank group; The each concentration class frequency of Hwy compares with model group (p<0.05).
Material three: embodiment 1 extract is on the impact of functional dyspepsia rat stomach motion frequency
Summary: object research stomach function regulating drinks extract to the impact of functional dyspepsia rat at body stomach motion frequency and general state.Method adopts and enrages method copy function dyspepsia rat model, observes stomach function regulating drink extract to animal general status and the impact at body stomach motion frequency.Result stomach function regulating drink extract obviously can improve functional dyspepsia rat functional status, increases functional dyspepsia rat stomach motion frequency.
Experimental result
Hwy is to functional dyspepsia rat stomach contraction frequency fixed point record
Compare with blank group, model group contraction frequency obviously slows down (p<0.05); Compare with model group, Hwy high dose contraction frequency is obviously accelerated (p<0.05); And high dose compares with low dosage (p<0.05), show dose dependency.
Material four: model case
Case one: Wang male 56 years old
2010.2.1 first visit
Main suit: gastral cavilty distension, belch, in heartburn more than 10 years of pantothenic acid recurrent exerbation, increases the weight of more than the moon.
Before 10 years, this trouble recurrent exerbation vague epigastralgia, taking " omeprazole " can alleviate, therefore non-systems inspection and treatment.Nearly January aggravation, time hungry, epigastric upset is uncomfortable, then gastral cavilty distension of taking food, early full, belch, heartburn pantothenic acid, and companion feels sick, and does not imitate and the traditional Chinese medical science of seeing a doctor from clothes " omeprazole ".Gastral cavity abdomen fear of cold usually, still can sleep by just rare 1 times/day, the dark red white and thin fur of tongue, stringy pulse.
2010.1.23 Attached Hospital No.1, dalian Medical Univ.:
Gastroscope: HP+ chronic superficial gastritis (moderate)
Pathology: gastric antrum chronic gastritis, moderate inflammation
2010.1.28 the hospital of traditional Chinese hospital of Daliang City:
Barium bar gastric emptying rate detects: gastric emptying weakens, and prompting gastric motility declines.
Clectrogastrogram detects: Gastric gysrhythmia, and prompting gastric motility declines.
Diagnosis: doctor trained in Western medicine: the functional dyspepsia traditional Chinese medical science: feeling of fullness
Take " granule of the present invention " 2 weeks
2010.2.15 two examine
After medicine, heartburn pantothenic acid is alleviated, and flatulence alleviates after the meal, has just been shaped 1 times/day, receive can, in more than 10 years of chronic pharyngitis, feel sick when morning rises, the dark red white and thin fur of tongue, stringy pulse.
Continue to take " granule of the present invention " 2 weeks
2010.2.28 three examine
Throat, without discomfort, is felt sick and is disappeared, and flatulence is even after the meal does, even pantothenic acid, and improper diet is still heartburn, receive can, just adjust, peace of sleeping, the dark red white and thin fur of tongue, stringy pulse.
Continue to take " granule of the present invention " 2 weeks
2010.3.14 the four diagnostic methods
Heartburn pantothenic acid disappears, and gastral cavilty, without discomfort, receives increasing, just adjusts, the dark red white and thin fur of tongue, stringy pulse.
Continue to take " granule of the present invention " 2 weeks
2010.3.28 five examine
Recently eating peppery idol has heartburn, without pantothenic acid, and the dark red white and thin fur of tongue, stringy pulse.
Continue to take " granule of the present invention ", after treatment 1 month.
2010.4.11 six examine
Withdraw medicine, advise it to keep on a diet, fasting is pungent, fry.
Visit: 2010.9.19 Attached Hospital No.1, dalian Medical Univ. checks:
Gastroscope: HP-, chronic superficial gastritis (slightly)
Barium bar gastric emptying rate detects and clectrogastrogram detects all normal.
Case two: poplar women 51 years old
2011.4.15 first visit
Main suit: gastral cavilty distension, anorexia is early full, belch pantothenic acid 3 months.
Because feelings will is unsuccessful before 3 months, occur gastral cavilty distension, decreased food intake of receiving is few, increase the weight of gradually, and occur early full, belch pantothenic acid, be hard and dry as sheep stool shape 1 time/3 days, abdominal distention, anus drops, just unclean, vexed bitter taste, dormancy is felt unwell, menstruation 13 tide the beginning of the year, passes through 3 days for every 25 days, and the few color of amount is dark red, the dark red white and thin fur of tongue, stringy and thready pulse.
History of past illness: gallbladder Polypus 96 years operation gallbladders are extractd, more than 10 years of iron deficiency anemia, calculus of intrahepatic duct 6 years.Once suffered from " barratt esophagus " before 4 years, take Chinese medicine and cure.
2011.3.30 Attached Hospital No.1, dalian Medical Univ.: gastroscope: HP: positive, chronic superficial gastritis.
2011.4.7 the Dalian hospital of traditional Chinese hospital:
Barium bar gastric emptying rate detects: gastric emptying weakens, and prompting gastric motility declines.
Clectrogastrogram detects: Total Fundoplication is slightly disorderly, and prompting gastric motility declines.
Diagnosis: doctor trained in Western medicine: the functional dyspepsia traditional Chinese medical science: feeling of fullness
Take " granule of the present invention " after 4 weeks, symptom is obviously improved, and adheres to again taking 1 month, and food of receiving is normal, and gastral cavilty symptom all disappears, just still not smooth 1 time/2 days, the dark red white and thin fur of tongue, stringy and thready pulse.
Visit after 6 months, gastral cavilty discomfort without exception.Check in the 2011.6.24 Dalian hospital of traditional Chinese hospital: gastrin detects, clectrogastrogram detects all normal.
Case three: female Lee 50 years old
2012.4.10 first visit
Main suit: gastral cavilty blocks up swollen recurrent exerbation 3 years, more than 10 years of constipation.
Gastral cavilty blocks up swollen, and anorexia is early full, and feed increases the weight of, and belch is done frequently, without heartburn pantothenic acid, is hard and dry 1 time/4-5 day, insomnia difficulty is slept, dreaming often and waking easily, and morning rises weak, dizzy profound, backache, Hypomenorrhea, every 30 days a line, pass through 3-4 days, and color is red in clot, painless warp, and the large white and thin fur of enlarged tongue has indentation, thready pulse.
Gastroscope: chronic superficial gastritis
B ultrasonic: gallbladder Polypus
Clectrogastrogram: Gastric gysrhythmia, prompting gastric motility declines.
Barium bar gastric emptying rate detects: gastric emptying weakens, and prompting gastric motility declines.
Diagnosis: doctor trained in Western medicine: the functional dyspepsia traditional Chinese medical science: feeling of fullness
Take " granule of the present invention " after 4 weeks, food of receiving increases, early full disappearance, and gastral cavilty distension obviously reduces, and belch alleviates, and defecation improves, and 1 time/2 days, remaining disease was steady.Following the service is after 4 weeks, and flatulence belch disappears, and feed is normal, defecates 1 time/2 days.Check clectrogastrogram, barium bar gastric emptying rate detect all normal.
Visit after half a year, gastral cavilty distension is not repeatedly.
Case four: female Lee 29 years old
2012.7.21 first visit
Main suit: gastral cavilty distension, uncomfortable after companion's breastbone, swallow and freely do not feel more than recurrent exerbation January.
Flatulence, anorexia, uncomfortable after breastbone, swallow not smooth, belch after taking food, throat is arrested tight uncomfortable, occasionally has burning sensation after gastral cavilty and breastbone, but without pantothenic acid, be just shaped 1 times/day, dormancy can, vexed, psychentonia, plays xerostomia hardship morning, body was thin, menstruation every 37 days a line, through row 7 days, amount can color be red has clot, the dark red fat large yellow and greasy fur of tongue, stringy and thready pulse.
History of past illness: once because esophagitis, chronic superficial gastritis companion bile reflux come to go to a doctor before 1 year, check gastroscope after treatment by Chinese herbs: esophagitis is cured, bile reflux disappears.Gastroptosis medical history 5 years.
2012.7.14 Attached Hospital No.1, dalian Medical Univ.:
Esophagus pressure measurement: hypomere power dropping in esophagus.
Clectrogastrogram: Total Fundoplication is slightly disorderly, prompting gastric motility declines.
Diagnosis: doctor trained in Western medicine: the functional dyspepsia traditional Chinese medical science: feeling of fullness
Take " granule of the present invention " 4 weeks, food of receiving increases, and after breastbone, discomfort alleviates, and flatulence belch reduces, heartburn disappearance, and following the service is after 2 weeks, and transference cure, after treatment 2 weeks, checks esophagus pressure measurement: no abnormality seen.Clectrogastrogram: normal.
Cortex Magnoliae Officinalis pungent drugs can disperse and bitter drugs can descend in the present invention, enters taste lung large intestine channel, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, relieving distension and oppression, and being the key medicine for the treatment of stagnation of QI in spleen and stomach, is be monarch drug.Get it pleasant stagnant except completely going, logical effect of falling three burnt mechanisms of qi, and kindly treat stagnation of QI in spleen and stomach with Fructus Aurantii Immaturus compatibility and demonstrate,prove.Pericarpium Citri Reticulatae invigorating the spleen and regulating the stomach, regulating QI and lowering the adverseness.Compendium of Material Medica opinion Pericarpium Citri Reticulatae: " then mending with tonic, then rush down with cathartic, then rise with Hydrargyri Oxydum Rubrum, then falling with falling medicine." Fructus Aurantii Immaturus and Pericarpium Citri Reticulatae 5 strengthen Cortex Magnoliae Officinalis relieving distension and oppression mutually, hold along the descending merit of gastric qi, and be ministerial drug.Radix Aucklandiae pungent drugs can disperse and bitter drugs can purge temperature is led to, and the stagnant gas of benefaction taste large intestine, as Compendium of Material Medica institute cloud: " Radix Aucklandiae is the medicine of three burnt edema caused by disorder of QI, can open and fall all gas." Radix Linderae reaches spleen lung, descending Liver and kidney, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, evacuate not smooth, Li Shizhen (1518-1593 A.D.) claims the Radix Linderae " can fall apart all gas ", " hold concurrently in falling and rise, rush down middle band benefit ".Modern aerofluxus soup (Radix Linderae, the Radix Aucklandiae are main component) has promotion creeping effect to intestinal tube in place.Pericarpium Arecae promoting the circulation of QI to alleviate the stagnation in middle-JIAO, is applicable to gastral cavity abdomen feeling of fullness, the belch acid regurgitation of stagnation of QI in spleen and stomach, the disease such as not well of defecating, and helps monarch drug altogether with the Radix Aucklandiae, the Radix Linderae.Radix Codonopsis is gentle, gas in spleen reinforcing nourishing the stomach, strong fortune, spleen invigorating fortune and not dry, grows spleen cloudy and do not wet.Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, raw with especially strengthening its moist merit.Shi Shoutang calls: " medication is cured the disease, and open and must help less to close, conjunction must be helped out less; Rise and must help less to fall, fall and must help less to rise.Or just helping into auxiliary merit, or using corrigent is to be used as guide, and, there is person like this in the road of negative and positive mutual reinforcement between." Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae just helping all qi-activating drugs to become auxiliary merit, residence is mended in letting out simultaneously, and tonification gas is cloudy in case dryization; Residence rises in falling, and rises spleen and transports in falling among gastric qi, is that negative and positive mutual reinforcement between is for using.Endothelium Corneum Gigeriae Galli is sweet puts down into stomach warp, and invigorating the stomach and promoting digestion helps fortune, and grain millingization is stagnant, and drawing that all medicines go directly in stomach is guiding drug.All medicine compatibilities, have method in method, Fang Zhongyou side, unimpeded taste mechanism of qi, circulation of qi promoting relieving distension and oppression, give altogether and along the power of gastric qi.
Modern pharmacological research Cortex Magnoliae Officinalis can stimulate the sense of taste, reflexive cause saliva, gastric secretion, gastrointestinal peristalsis accelerate.Fructus Aurantii Immaturus can make gastrointestinal shrink the rhythm and pace of moving things to be increased.Pericarpium Citri Reticulatae promotes the discharge of gastric secretion and gastrointestinal pneumatosis.The Radix Aucklandiae can make enterokinesia increase, and myenteron contraction frequency and amplitude all increase.The Radix Linderae has dual regulation to gastrointestinal smooth muscle, the secretion of energy facilitating digestion liquid.Radix Linderae water decoction makes In The Rabbit Stomach electricity amplitude obviously increase, and contraction of stomach strengthens.The excited gastrointestinal smooth muscle of Pericarpium Arecae energy, short digestive tract power, and have promotion fibrinolysis.Radix Codonopsis has regulating action to gastrointestinal motility, and has the merit of anti-gastric mucosa injury.The Rhizoma Atractylodis Macrocephalae has dual regulation to gastrointestinal activity.Endothelium Corneum Gigeriae Galli can make gastric motility function obviously strengthen, and gastric emptying rate is accelerated greatly.
It one month is a course for the treatment of that the present invention takes.In Long-term clinical use procedure, cure rate more than 85%, total effective rate reaches 95%.The present invention obtains satisfied curative effect in the clinical and course of disease, and has again the effect of adjustment gastrointestinal motility; Be pure Chinese medicinal preparation, without toxicity, for vast gastrointestinal motility disorders Disease brings Gospel.
Detailed description of the invention:
Embodiment 1:
Get the Chinese crude drug of following weight parts: Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the raw Radix Aucklandiae 5 grams, the Radix Linderae 10 grams, Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams.
Whole medical material adds the soak by water 3 times of 8 times amount, each 3h, merges decoction liquor, is concentrated into relative density 1-1.5(60 DEG C) extractum, add starch, dextrin, the adjuvants such as magnesium stearate make tablet according to galenic pharmacy routine techniques.
Embodiment 2:
Get the Chinese crude drug of following weight parts: Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the raw Radix Aucklandiae 5 grams, the Radix Linderae 10 grams, Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams.
Whole medical material decocts with water, soak by water 2 times, each 2h, merge decoction liquor, be concentrated into relative density 1-1.5(60 DEG C) extractum, add starch, dextrin, the adjuvants such as magnesium stearate make capsule according to galenic pharmacy routine techniques.
Embodiment 3:
Get the Chinese crude drug of following weight parts: Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the raw Radix Aucklandiae 5 grams, the Radix Linderae 10 grams, Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams.
Whole medical material decocts with water, soak by water 1 time, each 1h, merge decoction liquor, be concentrated into relative density 1-1.5(60 DEG C) extractum, add sucrose, dextrin, the adjuvants such as magnesium stearate make granule according to galenic pharmacy routine techniques.
Embodiment 4:
Get the Chinese crude drug of following weight parts: Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the raw Radix Aucklandiae 5 grams, the Radix Linderae 10 grams, Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams.
Whole medical material decocts with water, soak by water 3 times, each 2h, merge decoction liquor, be concentrated into relative density 1-1.5(60 DEG C) extractum, add the adjuvants such as sucrose and make oral solutions according to galenic pharmacy routine techniques.
Embodiment 5:
Cortex Magnoliae Officinalis 9 grams, Fructus Aurantii Immaturus 9 grams, Pericarpium Citri Reticulatae 9 grams, the raw Radix Aucklandiae 3 grams, the Radix Linderae 5 grams, Pericarpium Arecae 9 grams, Radix Codonopsis 9 grams, Rhizoma Atractylodis Macrocephalae 9 grams, Endothelium Corneum Gigeriae Galli 9 grams.
Preparation method:
The first step, by the Chinese crude drug of above-mentioned weight portion, is divided into the first and second 2 groups according to the ester dissolubility of its composition and water miscible difference;
First and second liang of group Chinese medicines are ground into coarse powder by second step respectively;
3rd step, first medicine coarse powder is placed in percolation vat ethanol obtains first medicated powder ethanol percolate by the contained percolation diafiltration of Chinese Pharmacopoeia annex, recovered alcohol becomes thick paste;
4th step, second medicine coarse powder is by volume added the pure water of ten times amount, boil and keep boiling to filter for 30 minutes, then in medicinal residues, add the pure water of 5 times amount, boil and keep boiling 15 minutes to filter, merge twice filtrate and add the thick paste that under reduced pressure control temperature is condensed into;
5th step, adds the thick paste that first medicine group recovered alcohol becomes, makes into 1 gram of Chinese medicine/milliliter and get final product by second medicine thick paste.For making oral liquid, granulated quickly dissolving.
Embodiment 6:
Cortex Magnoliae Officinalis 20 grams, Fructus Aurantii Immaturus 20 grams, Pericarpium Citri Reticulatae 25 grams, the raw Radix Aucklandiae 10 grams, the Radix Linderae 15 grams, Pericarpium Arecae 25 grams, Radix Codonopsis 30 grams, Rhizoma Atractylodis Macrocephalae 20 grams, Endothelium Corneum Gigeriae Galli 30 grams.
Preparation method:
The first step, by the Chinese crude drug of above-mentioned weight portion, is divided into the first and second 2 groups according to the ester dissolubility of its composition and water miscible difference;
First and second liang of group Chinese medicines are ground into coarse powder by second step respectively;
3rd step, first medicine coarse powder is placed in percolation vat ethanol obtains first medicated powder ethanol percolate by the contained percolation diafiltration of Chinese Pharmacopoeia annex, recovered alcohol becomes thick paste;
4th step, second medicine coarse powder is by volume added the pure water of ten times amount, boil and keep boiling to filter for 30 minutes, then in medicinal residues, add the pure water of 5 times amount, boil and keep boiling 15 minutes to filter, merge twice filtrate and add the thick paste that under reduced pressure control temperature is condensed into;
5th step, adds the thick paste that first medicine group recovered alcohol becomes, makes into 1 gram of Chinese medicine/milliliter and get final product by second medicine thick paste.For making oral liquid, granulated quickly dissolving.
Claims (8)
1. treat a Chinese medicine preparation for gastrointestinal motility disorders, be prepared from by following raw material of Chinese medicine medicine:
Cortex Magnoliae Officinalis 9-20 grams, Fructus Aurantii Immaturus 9-20 grams, Pericarpium Citri Reticulatae 9-25 grams, the raw Radix Aucklandiae 3-10 grams,
The Radix Linderae 5-15 grams, Pericarpium Arecae 9-25 grams, Radix Codonopsis 9-30 grams, Rhizoma Atractylodis Macrocephalae 9-20 grams,
Endothelium Corneum Gigeriae Galli 9-30 grams.
2. Chinese medicine preparation according to claim 1, is prepared from by following raw material of Chinese medicine medicine:
Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the raw Radix Aucklandiae 5 grams, the Radix Linderae 10 grams,
Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams.
3. Chinese medicine preparation according to claim 1, be any can the dosage form of oral medicine.
4. Chinese medicine preparation according to claim 1, dosage form is selected from: tablet, capsule, granule, pill, powder, unguentum, sublimed preparation.
5. the preparation method of the Chinese medicine preparation of claim 1 is by being processed through extraction or other modes by raw material of Chinese medicine medicine, making pharmaceutically active substance, subsequently, with this material for raw material, then add medicine acceptable carrier, make according to the routine techniques of galenic pharmacy.
6. preparation method according to claim 5, described pharmaceutically active substance obtains by extracting raw material of Chinese medicine medicine respectively, or is obtained by the common raw material of Chinese medicine medicine that extracts.
7. preparation method according to claim 5, step is as follows: all raw material of Chinese medicine medicine decocts with water, and obtains decoction liquor, is condensed into extractum, obtain pharmaceutically active substance, add medicine acceptable carrier and make pharmaceutical preparation according to galenic pharmacy routine techniques.
8. preparation method according to claim 5, step is as follows: all raw material of Chinese medicine medicine adds soak by water 1-3 time of 2-10 times amount, each 1-3h, merge decoction liquor, when 60 DEG C, be concentrated into the extractum of relative density 1-1.5, add medicine acceptable carrier and make pharmaceutical preparation according to galenic pharmacy routine techniques.
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| CN1473590A (en) * | 2003-04-01 | 2004-02-11 | 贵州太和制药有限公司 | Chinese medicinal preparation for treating stomach swelling pain caused by splenic-gastric Qi stagnation and its preparing method |
| CN102018845A (en) * | 2010-11-24 | 2011-04-20 | 荣成市新技术应用研究所 | Chinese medicinal composition for treating abdominal pain |
| CN102600281A (en) * | 2012-03-31 | 2012-07-25 | 江西省中医药研究院 | Traditional Chinese medicine composition for promoting digestion as well as preparation method and use |
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| KR101444698B1 (en) * | 2010-12-30 | 2014-10-07 | 주식회사 엘지생명과학 | Composition for improvement, treatment and prevention of gastrointestinal motility disorders |
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| CN1473590A (en) * | 2003-04-01 | 2004-02-11 | 贵州太和制药有限公司 | Chinese medicinal preparation for treating stomach swelling pain caused by splenic-gastric Qi stagnation and its preparing method |
| CN102018845A (en) * | 2010-11-24 | 2011-04-20 | 荣成市新技术应用研究所 | Chinese medicinal composition for treating abdominal pain |
| CN102600281A (en) * | 2012-03-31 | 2012-07-25 | 江西省中医药研究院 | Traditional Chinese medicine composition for promoting digestion as well as preparation method and use |
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| 宽肠行气汤治疗肝脾曲综合征175例;刘书芝等;《辽宁中医杂志》;19960930;第23卷(第9期);第411页，尤其是第411页左栏第1、2节 * |
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