CN103014629A - Application of PVD (physical vapor deposition) nano coating in manufacture of medical appliance or pharmaceutical tabletting mold - Google Patents
Application of PVD (physical vapor deposition) nano coating in manufacture of medical appliance or pharmaceutical tabletting mold Download PDFInfo
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- CN103014629A CN103014629A CN201210536514XA CN201210536514A CN103014629A CN 103014629 A CN103014629 A CN 103014629A CN 201210536514X A CN201210536514X A CN 201210536514XA CN 201210536514 A CN201210536514 A CN 201210536514A CN 103014629 A CN103014629 A CN 103014629A
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- cleaning
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Abstract
The invention discloses a medical appliance or pharmaceutical tabletting mold which comprises a workpiece body of the metal medical appliance or pharmaceutical tabletting mold, wherein a PVD (physical vapor deposition) nano coating is coated on the workpiece body of the metal medical appliance or pharmaceutical tabletting mold. The production technique of the medical appliance or pharmaceutical tabletting mold comprises the following steps: ultrasonic cleaning; secondary in-furnace ion beam discharge cleaning; tertiary ion beam electric arc cleaning; and application of an electric field and magnetic field in a vacuum furnace to form a metallic ion compact film. The invention has the following advantages: 1. the provided pharmaceutical equipment is easy to clean and disinfect, has better corrosion resistance, does not produce chemical change with medicines or adsorb the medicines, and can effectively control the insoluble granules; 2. the provided manufacturing technique is simple and easy to operate and popularize; and 3. the PVD nano coating is popularized and applied in the fields of pharmacy and medical appliances, and brings in a more wear-resistant and corrosion-resistant material to the fields of medical appliances and pharmacy.
Description
Technical field
The present invention relates to PVD nano coating technical field, relate in particular to the application of PVD nano coating in medicine equipment, pharmacy compression mold are made.
Background technology
Metal medical appliance, pharmacy compression mold workpiece are used very extensive, but some metal medical appliance, pharmacy compression mold workpiece are applied in some special environment, be subject to for a long time friction and the serious corrosion of Working environment of work particular interface, tested greatly wear resistance and the erosion resistance of workpiece.
1 the 32nd of GMP (98 editions) thinks: " equipment surface that directly contacts with medicine should be bright and clean, smooth, easy cleaning or sterilization, corrosion-resistant, not with medicine generation chemical transformation or absorption medicine." see again 211.65 (a) moneys among the U.S. cGMP3; it is thought: " answer Fails To Respond when equipment surface contacts with component, intermediate material or medicine, without sorption, adsorption, with security, diagnostic characteristics, the content of unlikely change medicine or tire, quality or purity and make it to exceed legal or other both provisioning request." 2, pharmaceutical technology is to the material requirements of pharmaceutical equipment: people pay close attention to the pharmaceutical equipment material should " easy cleaning or sterilization, corrosion-resistant, not with medicine generation chemical transformation or absorption medicine " time; more do not forget another selection principle, this is effective control of particulate matter.
The major cause that particulate matter produces comprises because the relative value of polishing between the hardness between medicine machinery and the medicine that acts on is basically identical, the pulverizing particulate that brings.How avoiding these particulate matters, is the problem that this area usually runs into.
Summary of the invention
The purpose of this invention is to provide a kind of medicine equipment, pharmacy compression mold and production technique thereof.
Another purpose of the present invention is to provide the application of PVD nano coating in medicine equipment, pharmacy compression mold field.
According to an aspect of the present invention, the invention provides a kind of medicine equipment, pharmacy compression mold, comprise the workpiece body of metal medical appliance, pharmacy compression mold, plating PVD nano coating on the workpiece body of described metal medical appliance, pharmacy compression mold.
Described medicine equipment, pharmacy compression mold, its production technique may further comprise the steps:
1) ultrasonic cleaning;
2) ionic fluid Discharge Cleaning in the secondary stove;
3) ionic fluid electric arc cleans for the third time;
4) in vacuum oven internal electric field and the magnetic field with the fine and close film forming of metal ion.
Particularly, described ultrasonic cleaning is specially: die workpiece is put into after cleaning in the ultrasonic wave of neutral detergent, cleans by pure water, dry up or drying and processing after, the qualified rear clamping of testing.
Particularly, ionic fluid Discharge Cleaning in the described secondary stove is specially: die workpiece is put into the PVD vacuum plating unit close the door and vacuumize; In the PVD vacuum plating unit, carry out heat treatment, heat to the 100-450 degree, carry out ionic fluid Discharge Cleaning in the secondary stove.
Particularly, described for the third time ionic fluid electric arc cleans, and is specially, and under the vacuum background, adds rare gas element in the stove, adds the 100-1000V negative bias to die workpiece, opens electric arc target, carries out for the third time ionic fluid electric arc cleaning in the stove.
Particularly, in described vacuum oven internal electric field and the magnetic field with the fine and close film forming of metal ion, be specially: after ionic fluid electric arc cleans for the third time in the stove, reduce bias voltage, the electric current of regulating target, the flow of rare gas element, pass through under the effect of Electric and magnetic fields in the vacuum oven, make the metal on monometallic target or the alloys target become film coating with ionic means densification on die workpiece, cooling is come out of the stove.
Particularly, described rare gas element can be nitrogen or argon gas.
Particularly, described medicine equipment, pharmacy compression mold can be: slip thimble, slide block, the slide unit of medical plastic consumptive material mould; Can also be the jumper bar of tabletting machine and punch die, the metering screw mould of portioning machine, medicinal material pulverizer mould.
Further, described medical plastic consumptive material mould can be syringe mould or drip bag mould.
Further, the kind of described PVD nano coating comprises: TiN, CrN, AlTiCrCN.
The application of PVD nano coating in medicine equipment, pharmacy compression mold are made.Described medicine equipment, pharmacy compression mold can be: slip thimble, slide block, the slide unit of medical plastic consumptive material mould; Can also be the jumper bar of tabletting machine and punch die, the metering screw mould of portioning machine, medicinal material pulverizer mould.
The present invention has following beneficial effect:
One, the pharmaceutical equipment easy cleaning that provides, sterilization, better corrosion-resistant, with medicine generation chemical transformation or absorption medicine, its particulate matter is not effectively controlled yet.
The manufacture craft that two, provides, simple, easy handling and popularization.
Three, make the PVD nano coating, obtained promoting and using at pharmacy field and medical instruments field, bring more wear-resisting and corrosion-resistant material for medicine equipment and pharmacy field.
Embodiment
Below in conjunction with embodiment technical scheme of the present invention is further specified.
Embodiment one
A kind of medicine equipment, pharmacy compression mold comprise the workpiece body of metal medical appliance, pharmacy compression mold, plating PVD nano coating on the workpiece body of described metal medical appliance, pharmacy compression mold.
Described medicine equipment, pharmacy compression mold, its production technique may further comprise the steps:
1) ultrasonic cleaning;
2) ionic fluid Discharge Cleaning in the secondary stove;
3) ionic fluid electric arc cleans for the third time;
4) in vacuum oven internal electric field and the magnetic field with the fine and close film forming of metal ion.
Particularly, described ultrasonic cleaning is specially: die workpiece is put into after cleaning in the ultrasonic wave of neutral detergent, cleans by pure water, dry up or drying and processing after, the qualified rear clamping of testing.
Particularly, ionic fluid Discharge Cleaning in the described secondary stove is specially: die workpiece is put into the PVD vacuum plating unit close the door and vacuumize; In the PVD vacuum plating unit, carry out heat treatment, heat to the 100-450 degree, carry out ionic fluid Discharge Cleaning in the secondary stove.
Particularly, described for the third time ionic fluid electric arc cleans, and is specially, and under the vacuum background, adds rare gas element in the stove, adds the 100-1000V negative bias to die workpiece, opens electric arc target, carries out for the third time ionic fluid electric arc cleaning in the stove.
Particularly, in described vacuum oven internal electric field and the magnetic field with the fine and close film forming of metal ion, be specially: after ionic fluid electric arc cleans for the third time in the stove, reduce bias voltage, the electric current of regulating target, the flow of rare gas element, pass through under the effect of Electric and magnetic fields in the vacuum oven, make the metal on monometallic target or the alloys target become film coating with ionic means densification on die workpiece, cooling is come out of the stove.
Particularly, described rare gas element can be nitrogen or argon gas.
Embodiment two
According to the applied environment of medicine equipment, pharmacy compression mold, on applicable material, can select different PVD nano coatings, the kind of coating comprises: TiN, CrN, AlTiCrCN.TiN is the coating of universal standard: high-wearing feature and erosion resistance, suitable medical apparatus easy-abrasion part and pharmacy compression mold; CrN high corrosion resistance, high temperature resistant and wear-resistant, suitable medical plastics consumptive material mould is such as syringe mould, drip bag mould etc.; AlTiCrCN low frictional factor and good abrasion resistance are applicable to slip thimble, slide block, slide unit on the plastic mould, improve sticking to mould.
The present invention is not limited to above-mentioned embodiment; the according to the above description announcement of book and guidance; those skilled in the art in the invention also can carry out suitable change and modification to above-mentioned embodiment, and its change also should fall into the protection domain of claim of the present invention.In addition, although used some specific terms in this specification sheets, these terms do not consist of any restriction to the present invention just for convenience of description.
Claims (10)
1. medicine equipment, pharmacy compression mold is characterized in that: comprise the workpiece body of metal medical appliance, pharmacy compression mold, plating PVD nano coating on the workpiece body of described metal medical appliance, pharmacy compression mold.
2. according to claim 1 described medicine equipment, pharmacy compression mold, it is characterized in that: its production technique may further comprise the steps:
1) ultrasonic cleaning;
2) ionic fluid Discharge Cleaning in the secondary stove;
3) ionic fluid electric arc cleans for the third time;
4) in vacuum oven internal electric field and the magnetic field with the fine and close film forming of metal ion.
3. according to claim 2 described medicine equipment, pharmacy compression mold, it is characterized in that: described ultrasonic cleaning is specially: die workpiece is put into after cleaning in the ultrasonic wave of neutral detergent, cleans by pure water, dry up or drying and processing after, the qualified rear clamping of testing.
4. according to claim 2 described medicine equipment, pharmacy compression mold, it is characterized in that: ionic fluid Discharge Cleaning in the described secondary stove is specially: die workpiece is put into the PVD vacuum plating unit close the door and vacuumize; In the PVD vacuum plating unit, carry out heat treatment, heat to the 100-450 degree, carry out ionic fluid Discharge Cleaning in the secondary stove.
5. according to claim 2 described medicine equipment, pharmacy compression mold, it is characterized in that: described for the third time ionic fluid electric arc cleans, be specially, under the vacuum background, add rare gas element in the stove, add the 100-1000V negative bias to die workpiece, open electric arc target, carry out for the third time ionic fluid electric arc cleaning in the stove.
6. according to claim 2 described medicine equipment, pharmacy compression mold, it is characterized in that: in described vacuum oven internal electric field and the magnetic field with the fine and close film forming of metal ion, be specially: after ionic fluid electric arc cleans for the third time in the stove, reduce bias voltage, the electric current of regulating target, the flow of rare gas element, pass through under the effect of Electric and magnetic fields in the vacuum oven, make the metal on monometallic target or the alloys target become film coating with ionic means densification on die workpiece, cooling is come out of the stove.
7. according to claim 1 described medicine equipment, pharmacy compression mold, it is characterized in that: described medicine equipment, pharmacy compression mold can be: slip thimble, slide block, the slide unit of medical plastic consumptive material mould; Can also be the jumper bar of tabletting machine and punch die, the metering screw mould of portioning machine, medicinal material pulverizer mould.
8. according to claim 1 described medicine equipment, pharmacy compression mold, it is characterized in that: the kind of described PVD nano coating comprises: TiN, CrN, AlTiCrCN.
9.PVD the application of nano coating in medicine equipment, pharmacy compression mold are made.
10. the according to claim 9 application of described PVD nano coating in medicine equipment, pharmacy compression mold are made, it is characterized in that: described medicine equipment, pharmacy compression mold can be: slip thimble, slide block, the slide unit of medical plastic consumptive material mould; Can also be the jumper bar of tabletting machine and punch die, the metering screw mould of portioning machine, medicinal material pulverizer mould.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210536514XA CN103014629A (en) | 2012-12-12 | 2012-12-12 | Application of PVD (physical vapor deposition) nano coating in manufacture of medical appliance or pharmaceutical tabletting mold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210536514XA CN103014629A (en) | 2012-12-12 | 2012-12-12 | Application of PVD (physical vapor deposition) nano coating in manufacture of medical appliance or pharmaceutical tabletting mold |
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| Publication Number | Publication Date |
|---|---|
| CN103014629A true CN103014629A (en) | 2013-04-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210536514XA Pending CN103014629A (en) | 2012-12-12 | 2012-12-12 | Application of PVD (physical vapor deposition) nano coating in manufacture of medical appliance or pharmaceutical tabletting mold |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003070998A1 (en) * | 2002-02-20 | 2003-08-28 | University Of Washington | Method and apparatus for ion beam coating |
| CN101437978A (en) * | 2006-11-27 | 2009-05-20 | 先健科技(深圳)有限公司 | Method for preparing nickle titanium alloy medical instrument surface coating |
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2012
- 2012-12-12 CN CN201210536514XA patent/CN103014629A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003070998A1 (en) * | 2002-02-20 | 2003-08-28 | University Of Washington | Method and apparatus for ion beam coating |
| CN101437978A (en) * | 2006-11-27 | 2009-05-20 | 先健科技(深圳)有限公司 | Method for preparing nickle titanium alloy medical instrument surface coating |
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Application publication date: 20130403 |