CN102973498A - Florfenicol injection and preparation method thereof - Google Patents
Florfenicol injection and preparation method thereof Download PDFInfo
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- CN102973498A CN102973498A CN2012105390762A CN201210539076A CN102973498A CN 102973498 A CN102973498 A CN 102973498A CN 2012105390762 A CN2012105390762 A CN 2012105390762A CN 201210539076 A CN201210539076 A CN 201210539076A CN 102973498 A CN102973498 A CN 102973498A
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- florfenicol
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention aims at disclosing a florfenicol injection and a preparation method thereof; every 1000mL of florfenicol injection comprises the components by weight: 50-300g of florfenicol, 150-800g of organic solvent, 5-90g of complexing agent and 0.2-1g of antioxidant. Compared with the prior art, the florfenicol injection is good in antibacterial effect and low in toxic and side effects, thus being widely applied to controlling diseases of livestock and poultry and mainly being used for controlling gastrointestinal infection of livestock and poultry caused by colibacillosis, salmonellosis, pasteurellosis and the like. Therefore, the aim of the invention can be realized.
Description
Technical field
The present invention relates to a kind of injection and preparation method thereof, particularly a kind of florfenicol injection for animals and preparation method thereof.
Background technology
Florfenicol (Florfenicol) Chinese: fluprofen, florfenicol or Florfenicol are the broad spectrum antibiotics of the special-purpose chloromycetin of a kind of new veterinary successfully developed in the late nineteen eighties.
Nineteen ninety, go on the market in Japan first; 1993, Norway ratified the furunculosis of this medicine treatment salmon; Nineteen ninety-five, France, Britain, Austria, Mexico and Spain's approval are used for the treatment of cattle respiratory system bacterial disease.Also ratify to be used as feed additive, prevention and the bacterial disease for the treatment of pig of pig in Japanese and Mexico.
Florfenicol is the semi-synthetic antimicrobial drug of chloropharin amine element class of latest generation, has become one of a kind of special-purpose antimicrobial drug for animals of global sales maximum at present.
Therefore, need especially a kind of florfenicol injection and preparation method thereof, solved the problem of above-mentioned existing existence.
Summary of the invention
The object of the present invention is to provide a kind of florfenicol injection and preparation method thereof, for the deficiencies in the prior art, good anti-bacterial effect, toxic and side effects is little and be widely used for the control of livestock and poultry, is mainly used in preventing and treating the gastrointestinal infection that poultry colibacillosis, salmonellosis and Bacillus pasteurii disease etc. cause.
Technical problem solved by the invention can realize by the following technical solutions:
On the one hand, the invention provides a kind of florfenicol injection, it is characterized in that, it comprises the following components by weight percent of every 1000ml: florfenicol 50-300g, organic solvent 150-800g, chelating agent 5-90g and antioxidant 0.2-1g.
In one embodiment of the invention, described organic solvent comprises one or more the combination in 2-Pyrrolidone, propylene glycol, dimethyl acetylamide, dimethyl formamide, ethanol, glycerin methylal or the glycerol.
In one embodiment of the invention, described chelating agent comprises one or more the combination in magnesium chloride, magnesium sulfate, magnesium oxide, magnesium hydroxide or the magnesium carbonate.
In one embodiment of the invention, described antioxidant comprises one or more the combination in sodium formaldehyde sulphoxylate, sodium pyrosulfite, thiourea, sodium sulfite, L-half light amine hydrochlorate, vitamin C or the ethylenediamine.
On the other hand, the invention provides a kind of preparation method of florfenicol injection, it is characterized in that, get suitable quantity of water, add chelating agent and make dissolving, be heated to 70-90 ℃, add florfenicol and make mix homogeneously, add organic solvent, heating makes the florfenicol dissolve complete, add pre-solvent antioxidant, transferring pH value with ethanolamine is 6.0-9.5, adds water to full dose again; Detect doxycycline hydrochloride and florfenicol content and answer requirement up to specification, otherwise regulate with raw material or organic solvent; Filter, by loading amount requirement embedding; 100 ℃, sterilization 30 minutes and get final product.
Florfenicol injection of the present invention and preparation method thereof, compared with prior art, good anti-bacterial effect, toxic and side effects is little and be widely used for the control of livestock and poultry, be mainly used in preventing and treating the gastrointestinal infection that poultry colibacillosis, salmonellosis and Bacillus pasteurii disease etc. cause, realize purpose of the present invention.
Characteristics of the present invention can be consulted the detailed description of the better embodiment of this case and be obtained to be well understood to.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, further set forth the present invention below in conjunction with concrete.
Florfenicol injection of the present invention, it comprises the following components by weight percent of every 1000ml: florfenicol 50-300g, organic solvent 150-800g, chelating agent 5-90g and antioxidant 0.2-1g.
In the present invention, described organic solvent comprises one or more the combination in 2-Pyrrolidone, propylene glycol, dimethyl acetylamide, dimethyl formamide, ethanol, glycerin methylal or the glycerol.Described chelating agent comprises one or more the combination in magnesium chloride, magnesium sulfate, magnesium oxide, magnesium hydroxide or the magnesium carbonate.Described antioxidant comprises one or more the combination in sodium formaldehyde sulphoxylate, sodium pyrosulfite, thiourea, sodium sulfite, L-half light amine hydrochlorate, vitamin C or the ethylenediamine.
The preparation method of florfenicol injection of the present invention, it is characterized in that, get suitable quantity of water, add chelating agent and make dissolving, be heated to 70-90 ℃, add florfenicol and make mix homogeneously, add organic solvent, heating makes the florfenicol dissolve complete, adds pre-solvent antioxidant again, transferring pH value with ethanolamine is 6.0-9.5, adds water to full dose; Detect doxycycline hydrochloride and florfenicol content and answer requirement up to specification, otherwise regulate with raw material or organic solvent; Filter, by loading amount requirement embedding; 100 ℃, sterilization 30 minutes and get final product.
Embodiment 1:
Water intaking 130ml adds magnesium chloride 5g, makes dissolving, is heated to 70-90 ℃, adds florfenicol 50g, makes mix homogeneously, and is for subsequent use; Add 2-Pyrrolidone 100ml, propylene glycol 100ml in reserve liquid, heating makes the florfenicol dissolving, adds with what the pre-solvent formaldehyde of 20ml water closed time sodium sulfite and sodium pyrosulfite composition again and mixes antioxidant 2g, adds water to full dose 1000ml; Be up to the standards, filter, fill the nitrogen embedding; Sterilized 30 minutes and get final product for 100 ℃.
Embodiment 2:
Water intaking 130ml adds magnesium chloride 20g, makes dissolving, is heated to 70-90 ℃, adds florfenicol 75g, makes mix homogeneously, and is for subsequent use; In reserve liquid, add ethanol 300ml, propylene glycol 100ml, heating makes florfenicol dissolving, adds with what the pre-solvent formaldehyde of 20ml water closed time sodium sulfite and sodium pyrosulfite composition again and mixes antioxidant 3g, regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml; Be up to the standards, filter, fill the nitrogen embedding; Sterilized 30 minutes and get final product for 100 ℃.
Embodiment 3:
Water intaking 130ml adds magnesium sulfate 10g, magnesium oxide 5g, makes dissolving, heats 70-90 ℃, adds florfenicol 100g, makes mix homogeneously, and is for subsequent use; Add dimethyl acetylamide 200ml, ethanol 100ml in reserve liquid, heating makes the florfenicol dissolving, add again the mixing antioxidant 4g that forms with the pre-solvent thiourea of 20ml water, sodium sulfite, regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; Sterilized 30 minutes and get final product for 100 ℃.
Embodiment 4:
Water intaking 130ml adds magnesium sulfate 10g, magnesium oxide 10g, makes dissolving, is heated to 70-90 ℃, adds florfenicol 300g again, makes mix homogeneously, and is for subsequent use; Add dimethyl acetylamide 300ml, ethanol 100ml in reserve liquid, heating makes the florfenicol dissolving, add again the mixing antioxidant 5g that forms with the pre-solvent thiourea of 20ml water, sodium sulfite, regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; Sterilized 30 minutes and get final product for 100 ℃.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in above-described embodiment and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications; these changes and improvements all fall in the claimed scope of the invention, and the claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (5)
1. a florfenicol injection is characterized in that, it comprises the following components by weight percent of every 1000mL: florfenicol 50-300g, organic solvent 150-800g, chelating agent 5-90g and antioxidant 0.2-1g.
2. florfenicol injection as claimed in claim 1 is characterized in that, described organic solvent comprises one or more the combination in 2-Pyrrolidone, propylene glycol, dimethyl acetylamide, dimethyl formamide, ethanol, glycerin methylal or the glycerol.
3. florfenicol injection as claimed in claim 1 is characterized in that, described chelating agent comprises one or more the combination in magnesium chloride, magnesium sulfate, magnesium oxide, magnesium hydroxide or the magnesium carbonate.
4. florfenicol injection as claimed in claim 1, it is characterized in that described antioxidant comprises one or more the combination in sodium formaldehyde sulphoxylate, sodium pyrosulfite, thiourea, sodium sulfite, L-half light amine hydrochlorate, vitamin C or the ethylenediamine.
5. the preparation method of a florfenicol injection, it is characterized in that, get suitable quantity of water, add chelating agent and make dissolving, be heated to 70-90 ℃, add florfenicol and make mix homogeneously, add organic solvent, heating makes the florfenicol dissolve complete, adds pre-solvent antioxidant again, be 6.0-9.5 with the ethanolamine adjust pH, add water to full dose; Detect doxycycline hydrochloride and florfenicol content and answer requirement up to specification, otherwise regulate with raw material or organic solvent; Filter, by loading amount requirement embedding; 100 ℃, sterilization 30 minutes and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105390762A CN102973498A (en) | 2012-12-13 | 2012-12-13 | Florfenicol injection and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012105390762A CN102973498A (en) | 2012-12-13 | 2012-12-13 | Florfenicol injection and preparation method thereof |
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| CN102973498A true CN102973498A (en) | 2013-03-20 |
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| CN2012105390762A Pending CN102973498A (en) | 2012-12-13 | 2012-12-13 | Florfenicol injection and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520211A (en) * | 2013-10-23 | 2014-01-22 | 挑战（天津）动物药业有限公司 | Compound florfenicol injection as well as preparation method and application thereof |
| CN104306421A (en) * | 2014-11-07 | 2015-01-28 | 广西大学 | Balsamiferou Blumea herb and florfenicol containing compound medicine for livestock and poultry |
| CN106236705A (en) * | 2016-08-30 | 2016-12-21 | 瑞普（天津）生物药业有限公司 | A kind of florfenicol solution agent that can be used for drinking water administration and preparation method thereof |
| CN108904442A (en) * | 2018-08-09 | 2018-11-30 | 山西瑞象生物药业有限公司 | A kind of florfenicol solution agent and preparation method thereof |
| CN109602697A (en) * | 2018-12-07 | 2019-04-12 | 佛山市正典生物技术有限公司 | A kind of florfenicol solution and preparation method thereof |
| CN111494312A (en) * | 2020-05-20 | 2020-08-07 | 山东省健牧生物药业有限公司 | Oral liquid for preventing and treating chicken colibacillosis and preparation method thereof |
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| EP0546018B1 (en) * | 1990-08-29 | 1994-10-19 | Schering Corporation | Pharmaceutical composition of florfenicol |
| KR20050102310A (en) * | 2004-04-21 | 2005-10-26 | 대한뉴팜(주) | Injectible composition comprising flofenicol |
| US20090275662A1 (en) * | 2004-12-21 | 2009-11-05 | Intervet International B.V. | Injectable veterinary composition |
| RU2397753C1 (en) * | 2009-05-12 | 2010-08-27 | Общество с ограниченной ответственностью "Алвис" | Composition for treating bacterial infections in animals |
| CN102008490A (en) * | 2010-12-07 | 2011-04-13 | 江西新天地药业有限公司 | Compound florfenicol injection for animal |
| CN102133213A (en) * | 2011-03-25 | 2011-07-27 | 湖北武当动物药业有限责任公司 | Veterinary compound florfenicol injection and preparation method thereof |
| CN102488709A (en) * | 2011-12-28 | 2012-06-13 | 广州市和生堂动物药业有限公司 | Florfenicol-zinc chelate injection and preparation method thereof |
| CN102784145A (en) * | 2012-08-06 | 2012-11-21 | 四川德润通生物科技有限公司 | Veterinary compound florfenicol injection |
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2012
- 2012-12-13 CN CN2012105390762A patent/CN102973498A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0546018B1 (en) * | 1990-08-29 | 1994-10-19 | Schering Corporation | Pharmaceutical composition of florfenicol |
| KR20050102310A (en) * | 2004-04-21 | 2005-10-26 | 대한뉴팜(주) | Injectible composition comprising flofenicol |
| US20090275662A1 (en) * | 2004-12-21 | 2009-11-05 | Intervet International B.V. | Injectable veterinary composition |
| RU2397753C1 (en) * | 2009-05-12 | 2010-08-27 | Общество с ограниченной ответственностью "Алвис" | Composition for treating bacterial infections in animals |
| CN102008490A (en) * | 2010-12-07 | 2011-04-13 | 江西新天地药业有限公司 | Compound florfenicol injection for animal |
| CN102133213A (en) * | 2011-03-25 | 2011-07-27 | 湖北武当动物药业有限责任公司 | Veterinary compound florfenicol injection and preparation method thereof |
| CN102488709A (en) * | 2011-12-28 | 2012-06-13 | 广州市和生堂动物药业有限公司 | Florfenicol-zinc chelate injection and preparation method thereof |
| CN102784145A (en) * | 2012-08-06 | 2012-11-21 | 四川德润通生物科技有限公司 | Veterinary compound florfenicol injection |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520211A (en) * | 2013-10-23 | 2014-01-22 | 挑战（天津）动物药业有限公司 | Compound florfenicol injection as well as preparation method and application thereof |
| CN103520211B (en) * | 2013-10-23 | 2015-10-07 | 天津市中升挑战生物科技有限公司 | A kind of compound florfenicol injection and preparation method thereof and application |
| CN104306421A (en) * | 2014-11-07 | 2015-01-28 | 广西大学 | Balsamiferou Blumea herb and florfenicol containing compound medicine for livestock and poultry |
| CN106236705A (en) * | 2016-08-30 | 2016-12-21 | 瑞普（天津）生物药业有限公司 | A kind of florfenicol solution agent that can be used for drinking water administration and preparation method thereof |
| CN108904442A (en) * | 2018-08-09 | 2018-11-30 | 山西瑞象生物药业有限公司 | A kind of florfenicol solution agent and preparation method thereof |
| CN108904442B (en) * | 2018-08-09 | 2021-04-06 | 山西瑞象生物药业有限公司 | Florfenicol solution and preparation method thereof |
| CN109602697A (en) * | 2018-12-07 | 2019-04-12 | 佛山市正典生物技术有限公司 | A kind of florfenicol solution and preparation method thereof |
| CN111494312A (en) * | 2020-05-20 | 2020-08-07 | 山东省健牧生物药业有限公司 | Oral liquid for preventing and treating chicken colibacillosis and preparation method thereof |
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Application publication date: 20130320 |