CN102885300A - Health-care food with blood sugar reducing effect and preparation method thereof - Google Patents
Health-care food with blood sugar reducing effect and preparation method thereof Download PDFInfo
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- CN102885300A CN102885300A CN2012103492719A CN201210349271A CN102885300A CN 102885300 A CN102885300 A CN 102885300A CN 2012103492719 A CN2012103492719 A CN 2012103492719A CN 201210349271 A CN201210349271 A CN 201210349271A CN 102885300 A CN102885300 A CN 102885300A
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Abstract
The invention discloses health-care food with a blood sugar reducing effect. The health-care food comprises the following components in percentage by weight: 40 to 55 percent of schisandra oil, 40 to 55 percent of evening primrose oil, 1 to 3 percent of astaxanthin and 0.5 to 2 percent of yeast chromium. The health-care food consists of natural Chinese medicaments and medicinal and edible raw materials, is scientific and easy to prepare, does not have any side effect, is suitable for crowds of all ages, has the functions of conditioning the body and reducing blood sugar, and has a good blood fat reducing effect at the same time.
Description
Technical field
The present invention relates to a kind of health food and preparation method thereof, particularly relate to a kind of health food with hypoglycemic activity and preparation method thereof.
Background technology
Hyperglycaemia refers to that people's blood sugar is higher than normal level, and is if this situation exists lastingly, all harmful to the each several part of human body.The reason that causes hyperglycaemia is a lot, may be genetic cause, also or caused by other diseases.But along with improving constantly of modern life level, most of factors often are bad life habits and environment, and present young man mostly is delithted with the fast foods such as KFC, does not like vegetables and fruit, and permanent eating habit may cause blood sugar higher; In addition, along with the pollution of environment, cause that negative oxygen ion content reduces sharply in the air, human intake's negative oxygen ion is not enough, and this also is a major reason that causes hyperglycaemia.
At present, be flooded with all kinds of antihypelipidemic products on the market, but can play real effect but seldom, therefore provide a kind of health products that can really play blood sugar reducing function very important.
Summary of the invention
Goal of the invention: the object of the invention is to for the deficiencies in the prior art, a kind of health food with hypoglycemic activity is provided.
Another object of the present invention is to, the preparation method of above-mentioned health food is provided.
Technical scheme: in order to achieve the above object, the present invention specifically is achieved like this: a kind of health food with hypoglycemic activity comprises the component of following percentage by weight: 40 ~ 55% magnolia vine fruit oil, 40 ~ 55% evening primrose oil, 1 ~ 3% astaxanthin and 0.5 ~ 2% yeast chromium.
On the basis of said components, the invention provides one group of more excellent component, comprise the component of following percentage by weight: 40 ~ 55% magnolia vine fruit oil, 40 ~ 55% evening primrose oil, 2 ~ 6% lycopene, 1 ~ 3% astaxanthin and 0.5 ~ 2% yeast chromium.
Wherein, described magnolia vine fruit oil is that schisandra fruit is through supercritical CO
2Extraction process extracts; Evening primrose oil is that evening primrose is through supercritical CO
2Extraction process extracts.
Prepare above-mentioned method with health food of hypoglycemic activity, may further comprise the steps:
(1) measures magnolia vine fruit oil, evening primrose oil heat fused by prescription, stir and evenly mix;
(2) get all the other each raw materials and pulverize, cross 80 mesh sieves;
(3) with step (1) and (2) mixing of materials, the rear grinding that stirs is left standstill and is evacuated to without Bubble formation, and the pressurization discharging is also sieved, after incapsulate.
Wherein, the static vacuum that vacuumizes of step (3) is at 0.06 ~ 0.08Mpa.
The speed of wherein, grinding in the step (3) is 2400 ~ 2600r/min.
Beneficial effect: the present invention is comprised of natural traditional Chinese medicine and integration of drinking and medicinal herbs raw material, and preparation method's science is simple, and is without any side effects, is fit to all age group crowd, falls the hypoglycemic while at conditioning engine body, has good effect for reducing blood fat.
The specific embodiment
Embodiment 1:
Getting percetage by weight is that 40% magnolia vine fruit oil, 55% evening primrose oil are heated to fusing, stir, get percetage by weight and be 3% astaxanthin and 2% yeast chromium and pulverized 80 mesh sieves, add in the magnolia vine fruit oil and evening primrose oil of fusing, stir, leave standstill and be evacuated to without Bubble formation, the pressurization discharging is also sieved, after incapsulate.
Embodiment 2:
Getting percetage by weight is that 45% magnolia vine fruit oil, 52% evening primrose oil are heated to fusing, stir, get percetage by weight and be 2.5% astaxanthin and 0.5% yeast chromium and pulverized 80 mesh sieves, add in the magnolia vine fruit oil and evening primrose oil of fusing, stir, leave standstill and be evacuated to without Bubble formation, the pressurization discharging is also sieved, after incapsulate.
Embodiment 3:
Getting percetage by weight is that 53% magnolia vine fruit oil, 45% evening primrose oil are heated to fusing, stir, get percetage by weight and be 1% astaxanthin and 1% yeast chromium and pulverized 80 mesh sieves, add in the magnolia vine fruit oil and evening primrose oil of fusing, stir, leave standstill and be evacuated to without Bubble formation, the pressurization discharging is also sieved, after incapsulate.
Embodiment 4:
Getting percetage by weight is that 55% magnolia vine fruit oil, 40% evening primrose oil are heated to fusing, stir, get percetage by weight and be 2% lycopene, 1% astaxanthin and 2% yeast chromium and pulverized 80 mesh sieves, add in the magnolia vine fruit oil and evening primrose oil of fusing, stir, leave standstill and be evacuated to without Bubble formation, the pressurization discharging is also sieved, after incapsulate.
Embodiment 5:
Getting percetage by weight is that 45% magnolia vine fruit oil, 45% evening primrose oil are heated to fusing, stir, get percetage by weight and be 6% lycopene, 3% astaxanthin and 1% yeast chromium and pulverized 80 mesh sieves, add in the magnolia vine fruit oil and evening primrose oil of fusing, stir, leave standstill and be evacuated to without Bubble formation, the pressurization discharging is also sieved, after incapsulate.
Embodiment 6:
The zoopery of hypoglycemic activity of the present invention
1. material
1.1 sample: provided by the Wuxi City health bio tech ltd of being bestowed by heaven.The oral recommended amounts of human body is every day 2 times, each 2, and become body weight for humans press 60kg calculating, amount to dosage 0.0333g/kg.bw.
1.2 animal used as test
40 of SPF level male SD rats.
1.3 high lipid food
78.8% basal feed, 1% cholesterol, 10% yolk powder, 10% lard, 0.2% cholate.
2. experiment
2.1 dosage design
If being respectively 0.167g/kg.bw, 0.333g/kg.bw, 1.000g/kg.bw(, basic, normal, high dosage is equivalent to respectively 5,10,30 times of human body recommended amounts), the tested material preparation time is got respectively content 3.34g of the present invention, 6.66g, 20.00g add vegetable oil and be assigned to 100ml, give respectively the animal subject gavage, once a day, the gavage volume is 0.5ml/100g.bw, continuous 30 days, control group gave the equal-volume vegetable oil.
2.2 experimental technique
With basal feed feed raise rat and observe a week after, fasting 16 hours, get tail blood, measure serum total cholesterol (TC), triglycerides (TG), HDL-C (HDL-C) with OLYMPUS AU400 automatic clinical chemistry analyzer, take into account TG according to the TC level animal is divided into 4 groups at random: high fat control group and basic, normal, high three tested material groups.From formal test, each treated animal is used high lipid food instead, designs to each group animal subject gavage by 2.1 dosage simultaneously.Weigh weekly once, finish fasting 16 hours in experiment, pull out the eyeball blood sampling and measure serum TC, TG, HDL-C.
3. data are processed
Data are carried out statistical analysis with Excel2003, Spss11.0 software.First data are carried out homogeneity test of variance, if variance is neat, adopt one-way analysis of variance totally to compare, find differences again and to carry out comparing in twos between a plurality of dosage groups and control group mean with the Dunnett method.If heterogeneity of variance then carries out the conversion of suitable variable to initial data, satisfy homogeneity test of variance after, add up with the data after changing; If do not reach yet the neat purpose of variance after the variable conversion, use rank test instead and add up, find totally more variantly, then adopt the Tamhane ' sT2 that does not require homogeneity of variance to check and compare.
4. the result judges
4.1 the auxiliary lipid-lowering function result judges
In serum total cholesterol, triglycerides, HDL-C detected, serum total cholesterol, the triglycerides binomial index positive can judge that this given the test agent auxiliary lipid-lowering function results of animal is positive.
4.2 the auxiliary triglycerides result that reduces judges
1. two dosage groups of triglycerides result is positive; 2. a dosage group of triglycerides result is positive, and HDL-C is significantly higher than control group simultaneously, can judge the auxiliary triglycerides results of animal positive that reduces of this given the test agent.
4.3 the auxiliary serum total cholesterol result that reduces judges
1. two dosage groups of serum total cholesterol result is positive; 2. a dosage group of serum total cholesterol result is positive, and HDL-C is significantly higher than control group simultaneously, can judge the auxiliary serum total cholesterol results of animal positive that reduces of this given the test agent.
5. result
5.1 the present invention is on the impact of rat body weight
Table 1 the present invention on the impact of rat body weight (
)
By as seen from Table 1, tested material treated animal body weight and experimental session body weight gain and the comparison of high fat control group before and after the experiment, no significant difference (P〉0.05), illustrate the present invention on rat body weight without impact.
5.2 the present invention is on the impact of Serum TC, TG, HDL-C
Respectively organize before and after table 2 experiment Serum TC level (
)
Respectively organize before and after table 3 experiment rat blood serum TG level (
)
Respectively organize before and after table 4 experiment rat blood serum DHL-C level (
)
By table 2 ~ 4 as seen, after the experiment, high fat control group serum TC, TG all obviously raise, and relatively front with experiment, difference has conspicuousness (P＜0.05), surperficial modeling success.Compare with high fat control group, middle and high dosage group can significantly reduce the rat blood serum triglyceride levels, and high dose group can significantly reduce rat total cholesterol level (P＜0.05).
6. sum up
Under this experiment condition, with the content of the present invention of 0.167g/kg.bw, 0.333g/kg.bw, 1.000g/kg.bw dosage to SD level rat oral gavage 30 days, compare with high fat control group, 0.333g/kg.bw, 1.000g/kg.bw dosage can significantly reduce and raise high lipid food rat blood serum triglyceride levels, 1.000g/kg.bw dosage can significantly reduce raises high lipid food rat blood serum total cholesterol level (P＜0.05).Judge according to " health food check and assessment technique standard " (version in 2003), the present invention has hypoglycemic activity to animal.
Embodiment 7:
The human experiment experiment of hypoglycemic activity of the present invention
1. material
1.1 sample: provided by the Wuxi City health bio tech ltd of being bestowed by heaven, be divided into capsule No. 1, No. 2, wherein No. 1 capsule is placebo, and No. 2 capsules are content of the present invention.The oral RD of human body is every day 2 times, each 2.
1.2 the experimenter selects
1.2.1 inclusive criteria
Experimenter's male or female, 18 ~ 65 years old age.Blood sampling is 2 times in half a year, 2 serum total cholesterols all 〉=5.2mmol/L or serum triglyceride 〉=1.65mmol/L, simple dyslipidemia, without obviously brain, the heart, liver, lung, kidney, Hematological Diseases, without the Long-term taking medicine history, voluntary tested assurance cooperates.
1.2.2 experimenter's exclusion standard
Gestation or women breast-feeding their children are to the health food allergy sufferers; Merge to have the inclination, the serious disease patients such as liver, kidney and hemopoietic system; Take in a short time the article relevant with tested function, have influence on judgement person as a result; Do not meet inclusive criteria, practical given the test agent in accordance with regulations not, can't judge effect or data not umbra ring effect or security judgement person.
2. experiment
2.1 design and grouping
Adopt two kinds of control design between self and group.Be divided at random capsule test-meal group of the present invention and placebo group by experimenter's blood lipid level, consider as far as possible affect result's principal element such as age, sex, diet etc., carry out harmony to check, with the comparativity between the assurance group.Carry out the test-meal test by double-blind study.
2.2 experimental technique
The experimenter takes sample by RD every day, takes continuously 45 days.Duration of test does not change original eating habit, normal diet.
3. observation index
Each measures once every observation index when test-meal on-test and end.
3.1 safety indexes
3.1.1 general physical examination: the situations such as the detailed spirit of inquiring and understanding the experimenter, sleep, diet, stool and urine before the test, measure test front and back body weight, blood pressure, changes in heart rate.
3.1.2 routine blood test: red blood cell count(RBC), white blood cell count(WBC) and classification, content of hemoglobin mensuration etc.
3.1.3 routine urinalysis: pH value, leucocyte, glucose in urine etc.
3.1.4 stool routine examination.
3.1.5 Abdominal B type ultrasonography, electrocardiogram, x-ray fluoroscopy of chest check (measuring once before on-test).
3.1.6 blood biochemistry index inspection: the mensuration such as total serum protein (TP), albumin (ALB), glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), uric acid (UA), urea nitrogen (BUN), creatinine (Cr), blood sugar (GLU).
3.1.7 bad reaction is observed.
3.2 effect index
Serum total cholesterol (CHOL), triglycerides (TG), HDL-C (HDL-C).
4. the result judges
4.1CHOL reduce〉10%; TG reduces〉15%; HDL-C rises〉0.104mmol/L; Between group statistical significance is arranged more all after each functional observation index Test front and back self comparison and the test-meal, can judge that this index is positive.
4.2 serum total cholesterol, the triglycerides binomial index positive, HDL-C significantly is not lower than control group, can judge that tested material has the auxiliary lipid-lowering function effect: positive in serum total cholesterol, the triglycerides binomial index, HDL-C significantly is not lower than control group, can judge that tested material has auxiliary reduce serum total cholesterol or the effect of auxiliary reduction triglycerides.
5. statistical procedures
The result represents with mean ± standard deviation, and self paired data adopts paired t-test, between test group and the control group under the neat prerequisite of variance, mean relatively adopts in groups t check, transforms otherwise carry out variable, satisfies the neat rear t of the employing check of variance, if variance is still uneven, adopt rank test.
6. result
6.1 security is observed
6.1.1 ordinary circumstance: test-meal group 53 examples, control group 53 examples.Before and after the test-meal, examination trencherman spirit, sleep, diet, stool and urine situation no abnormality seen; Control group: male/female is 20/33, and the age is 46.74 ± 11.56 years old; The test-meal group: male/female is 20/33, and the age is 46.72 ± 11.55.
6.1.2 Abdominal B type ultrasonography, electrocardiogram, x-ray fluoroscopy of chest detect: all in normal range (NR).
6.1.3 body weight, blood pressure, heart rate, routine urinalysis, stool routine examination, routine blood test index situation of change
Body weight, blood pressure, heart rate, routine urinalysis, stool routine examination and routine blood test situation of change before and after table 5 test-meal (
)
By as seen from Table 5, the forward and backward test-meal group of test-meal tested material and control group body weight, blood pressure, heart rate, routine urinalysis, stool routine examination and routine blood test are showed no obvious abnormalities variation, illustrate that the present invention is without the harmful effect of above-mentioned aspect.
6.1.4 blood biochemistry index situation of change before and after the test-meal test
Blood biochemistry index situation of change before and after the table 6 test-meal test (
)
By as seen from Table 6, the forward and backward test-meal group of test-meal tested material and control group total serum protein (TP), albumin (ALB), glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), creatinine (Cr), blood sugar (GLU), uric acid (UA), urea nitrogen (BUN) are and see obvious ANOMALOUS VARIATIONS, illustrate that the present invention is without the harmful effect of above-mentioned aspect.
6.1.5 have no obvious adverse reaction during the test-meal.
6.2 functional observation
Change of serum C HOL, TG before and after the table 7 test-meal test, HDL-C level (
)
Change of serum C HOL, TG before and after the table 8 test-meal test, HDL-C level (
)
Annotate: compare P＜0.05 before * and the test-meal, # and control group be P＜0.05 relatively.
Change of serum C HOL, TG, HDL-C situation of change before and after table 9 test-meal
By table 7 ~ 9 as seen, blood sampling twice is respectively the front 2 blood fat data of test-meal front 1 and test-meal in half a year, divides into groups and statistical disposition with 2 blood lipid levels before the close test-meal of taking tested material of date.Control group and test-meal group change of serum C HOL, TG level compare before the test, and no significant difference (P〉0.05), point out between two groups to have comparativity.Compare before CHOL, TG and the test-meal and after the control group test-meal after the test-meal of test-meal group, difference all has conspicuousness (P＜0.05).The HDL-C level be obviously change (P〉0.05) before and after the test-meal.
7. conclusion
Adopt counter point between own control and group, the volunteer that selection meets experimental condition took tested material after 45 days, the result shows: take after the tested material test group of the present invention test-meal before CHOL, the TG and test-meal relatively, difference has conspicuousness (P＜0.05), and descends more respectively 10.21%, 20.99% before CHOL, TG and the test-meal after the test-meal; Compare before test-meal group CHOL, TG and the test-meal and after the control group test-meal after the test-meal, difference has conspicuousness (P＜0.05); Test-meal group HDL-C and control group comparing difference are without conspicuousness (P〉0.05) after the test-meal.Have no obvious adverse reaction during the test-meal.According to " health food check and assessment technique standard " (version in 2003) evaluation criterion, can judge that the present invention has hypoglycemic activity.
Claims (7)
1. the health food with hypoglycemic activity is characterized in that, comprises the component of following percentage by weight: 40 ~ 55% magnolia vine fruit oil, 40 ~ 55% evening primrose oil, 1 ~ 3% astaxanthin and 0.5 ~ 2% yeast chromium.
2. the health food with hypoglycemic activity according to claim 1 is characterized in that, also comprises 2 ~ 6% lycopene.
3. the health food with hypoglycemic activity according to claim 1 and 2 is characterized in that, described magnolia vine fruit oil is that schisandra fruit is through supercritical CO
2Extraction process extracts.
4. the health food with hypoglycemic activity according to claim 1 and 2 is characterized in that, described evening primrose oil is that evening primrose is through supercritical CO
2Extraction process extracts.
5. the described arbitrary method with health food of hypoglycemic activity of preparation claim 1 ~ 4 is characterized in that, may further comprise the steps:
(1) measures magnolia vine fruit oil, evening primrose oil heat fused by prescription, stir and evenly mix;
(2) get all the other each raw materials and pulverize, cross 80 mesh sieves;
(3) with step (1) and (2) mixing of materials, the rear grinding that stirs is left standstill and is evacuated to without Bubble formation, and the pressurization discharging is also sieved, after incapsulate.
6. preparation according to claim 5 has the method for the health food of hypoglycemic activity, it is characterized in that, the static vacuum that vacuumizes of step (3) is at 0.06 ~ 0.08Mpa.
7. preparation according to claim 5 has the method for the health food of hypoglycemic activity, it is characterized in that, the speed of grinding in the step (3) is 2400 ~ 2600r/min.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103829234A (en) * | 2013-12-25 | 2014-06-04 | 无锡市天赐康生物科技有限公司 | Health food capable of improving immunity and reducing blood fat and preparation method thereof |
| CN104621258A (en) * | 2015-01-15 | 2015-05-20 | 山东省农业科学院畜牧兽医研究所 | Health milk with effect of reducing blood sugar and preparation method of health milk |
| CN104905271A (en) * | 2015-06-19 | 2015-09-16 | 青岛浩大海洋保健食品有限公司 | Health-care astaxanthin capsule with blood lipid regulating effect |
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| US20100021533A1 (en) * | 2008-04-07 | 2010-01-28 | Mazed Mohammad A | Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance |
| CN101940620A (en) * | 2010-09-14 | 2011-01-12 | 广州市和藤医药研究开发有限公司 | Medicinal composition for treating diabetes mellitus and application thereof |
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| CN1475254A (en) * | 2003-07-16 | 2004-02-18 | 西安千禾药业有限责任公司 | Medicine for treating coronary disease and stenocardia and its preparation method |
| US20100021533A1 (en) * | 2008-04-07 | 2010-01-28 | Mazed Mohammad A | Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance |
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| CN103829234A (en) * | 2013-12-25 | 2014-06-04 | 无锡市天赐康生物科技有限公司 | Health food capable of improving immunity and reducing blood fat and preparation method thereof |
| CN104621258A (en) * | 2015-01-15 | 2015-05-20 | 山东省农业科学院畜牧兽医研究所 | Health milk with effect of reducing blood sugar and preparation method of health milk |
| CN104905271A (en) * | 2015-06-19 | 2015-09-16 | 青岛浩大海洋保健食品有限公司 | Health-care astaxanthin capsule with blood lipid regulating effect |
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