CN102813801B - Traditional Tibetan medicine for treating cough and preparation method thereof - Google Patents
Traditional Tibetan medicine for treating cough and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Tibetan medicine for treating cough and a preparation method thereof. The traditional Tibetan medicine for treating the cough is composed of active ingredients or is composed of the active ingredients and pharmaceutically acceptable auxiliary materials, wherein the active ingredients are prepared from liquorice, phyllanthus emblica, common vladimiria root, sea buckthorn paste, cordyceps sinensis and bulbus fritillariae cirrhosae in certain weight proportion. The traditional Tibetan medicine for treating the cough disclosed by the invention can be preparedinto any common oral administration dosage form. The traditional Tibetan medicine for treating the cough disclosed by the invention has the effects of relieving cough and reducing sputum, clearing throat and relieving sore throat, invigorating blood circulation and removing blood stasis, moistening lung and diminishing inflammation. The traditional Tibetan medicine for treating the cough disclosed by the invention is used for treating cough, vomiturition, thick and excessive phlegm, bronchitis, lung infection and throat fatigue, hoarseness, chronic pharyngitis and asthma which are caused by cold.
Description
Technical field
The present invention relates to a kind of Tibetan medicine for the treatment of cough and preparation method thereof.
Background technology
The respiratory system disease cardinal symptom for cough, expectorant, breathe heavily, inflammation, for one of high morbidity in the world today, account for 1/4 of internal disease, its mortality rate accounts for the 3rd in the city, rank first in the rural area.Along with the development of aged tendency of population and the mouth of atmospheric pollution become serious, respiratory system disease takes place in rising trend.
Cough is disease the most common in the internal medicine disease, sickness rate height, and the exogenous cough is because the diseases caused by exogenous pathogenic factor six climate exopathogens, it is unclear to cause lung qi, lose in a surname respectful due to, with cough, to cough up phlegm be the disease of main performance.
Though the medicine for the treatment of cough at present is a lot, curative effect still can not be satisfactory.Therefore, there is tight demand in people's Tibetan medicinal preparation that curative effect is better treated cough.Up to now, also do not find the report of any relevant Tibetan medicine compositions of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has found the Tibetan medicine oral drugs of the treatment cough that better curative effect is arranged finally, thereby has finished the present invention.
Summary of the invention
The object of the invention just provides a kind of Tibetan medicine of more effective treatment cough.
Another object of the present invention has provided the preparation method of this Tibetan medicine.
The present invention is a kind of Tibetan medicine, formed or be made up of active component and acceptable accessories by active component, wherein said active component is to be made by following bulk drugs: Radix Glycyrrhizae, Fructus Phyllanthi, Radix Vladimiriae, Fructus Hippophae extractum, Cordyceps, Bulbus Fritillariae Cirrhosae.
It has selected Radix Glycyrrhizae, Fructus Phyllanthi, Radix Vladimiriae, Fructus Hippophae extractum, Cordyceps, Bulbus Fritillariae Cirrhosae to make up as raw material, and wherein (1) Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhizainflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Nature and flavor are sweet, and are flat; GUIXIN, lung, spleen, stomach warp.Has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Have arrhythmia, antiulcer, gastric acid inhibitory secretion, alleviate gastrointestinal smooth muscular spasm and analgesia, promotion pancreatic secretion, antitussive, eliminate the phlegm, relieving asthma, pharmacological actions such as antibiotic, antiviral, antiinflammatory, antiallergic; can protect throat and the tunica mucosa tracheae of inflammation; some poisonous substance there is the Detoxication of similar glucuronic acid; the effect of similar adrenocortical hormone sample is arranged, effect such as also have diuresis, blood fat reducing, protect the liver.(2) Fructus Phyllanthi is the fruit of Euphorbiaceae phyllanthus plant Fructus Phyllanthi Phyllanthus emblica L..Sweet in the mouth, acid, puckery, cool in nature; Has clearing away heat and cooling blood, promoting digestion and invigorating the stomach, the effect of promoting the production of body fluid to quench thirst; Cure mainly the heat in blood blood stasis, dyspepsia, abdominal distention, cough, laryngalgia, xerostomia and vitamin C deficiency disease; In Tibetan medicine, Fructus Phyllanthi cures mainly Baconic's disease, red bar disease, disorders of blood, hypertension etc.; In recent years result of study shows, Fructus Phyllanthi has antiinflammatory, antioxidation, and defying age such as protects the liver at effect.(3) Radix Vladimiriae is the dry root of feverfew river wood Vladimirasouliei (Franch.) Ling or gray wool Radix Vladimiriae Vladimirasouliei (Franch.) Lingvar.cinereaLing.Nature and flavor suffering, hardship, temperature; Return spleen, stomach, large intestine, gallbladder meridian.Function with promoting the circulation of QI to relieve pain.Be used for the breast side of body, abdominal distention, borborygmus diarrhoea, tenesmus.Have antibiotic, antitumor, to the inhibition of gastric ulcer and pharmacological action such as protect the liver.(4) Fructus Hippophae extractum is the herbal decoction of Elaeangnaceae plant Fructus Hippophae Hippophae rhamnoides L. mature fruit.Nature and flavor acid, flat.Has clearing and antitussive, blood circulation promoting and blood stasis dispelling, the more effect of ulcer.Be used for tracheitis, dyspepsia, diseases such as gastric ulcer and amenorrhea.Have and resist myocardial ischemia, anoxia, improve pharmacological actions such as myocardial cell function, arrhythmia, antitumor, the liver protecting and ALT lowering, raise immunity, antioxidation and slow down aging.(5) Cordyceps is that section ergot fungus cordyceps sinensis bacterium Cordyceps sinensis (BerK.) Sacc. colonizes in Stroma and the larva cadaveric complex on the Vespertilio pretty young woman section insect larvae.Nature and flavor are sweet, and are flat; Return lung, kidney channel.Has invigorating the lung and the kidney, the effect of hemostasis and phlegm.Be used for the chronic cough dyspnea due to deficiency, chronic cough spitting of blood, impotence and seminal emission, soreness of waist and knee joint.Have resisting fatigue, brace up energy and delay senility, slow down aging, enhancing normal pressure hypoxia-bearing capability, anti-injury of kidney, resisting pathogenic microbes, calmness, detoxifcation, antibiotic, immunomodulating, relieving asthma, eliminate the phlegm, pharmacological action such as anticancer, antitumor.(6) Bulbus Fritillariae Cirrhosae is liliaceous plant Bulbus Fritillariae Cirrhosae FritillariacirrhosaD.Don, dark violet Bulbus Fritillariae Uninbracteatae FritillariaunibracteataHsiaoetK.C.Hsia, Gansu Bulbus Fritillariae Uninbracteatae FritillariaprzewalskiiMaxim., Bulbus Fritillariae cirrhosae FritillardelavayiFranch., Bulbus Fritillariae taipaiensis FritillariataipaiensisP.Y.Li or Fritillaria wabuensis FritillariaunibracteataHsiaoetK.C.HsiaVar.wabuensis (S.Y.TangetS.C.Yue) Z.D.Liu, the dry bulb of S.WangetS.C.chen.Nature and flavor hardship, sweet is slightly cold; Return lung, heart channel.Have clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, the effect of eliminating stagnation eliminating carbuncle.Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum mixed with blood, scrofula, acute mastitis, lung abscess etc.The effect of have antitussive, eliminating the phlegm, and for blood pressure and blood glucose certain opsonic action is arranged also.Make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat cough.
The consumption of Tibetan medicine component of the present invention is also groped to sum up to draw through the inventor in a large number, and each crude drug consumption is for all to have better curative effect in the following weight parts scope: Radix Glycyrrhizae 15～70g, Fructus Phyllanthi 10～50g, Radix Vladimiriae 10～40g, Fructus Hippophae extractum 4～16g, Cordyceps 0.5～3g, Bulbus Fritillariae Cirrhosae 5～20g.
Be preferably: Radix Glycyrrhizae 35g, Fructus Phyllanthi 25g, Radix Vladimiriae 20g, Fructus Hippophae extractum 8g, Cordyceps 1.5g, Bulbus Fritillariae Cirrhosae 10.5g.
The preparation of Tibetan medicine active component of the present invention can be the crude drug convection drying of above-mentioned consumption to be pulverized make; Also the crude drug of above-mentioned consumption can be adopted the conventional method of Chinese medicine preparation such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation (referring to Cao Chunlin chief editor's " pharmaceutics of Chinese drugs " the 73rd～74 page, Science and Technology of Shanghai publishing house publishes in November, 1986) to make.
The active component of Tibetan medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine (referring to Cao Chunlin chief editor's " pharmaceutics of Chinese drugs ", Science and Technology of Shanghai publishing house publishes in November, 1986) be prepared into any peroral dosage form commonly used, as decoction pulvis, medicinal tea, powder, pill, capsule, granule, tablet etc.
Tibetan medicine of the present invention has the effect of relieving cough and resolving phlegm, throat-benefiting, promoting blood circulation to remove blood stasis, lung moistening antiinflammatory.The thick abundant expectoration of cough, retch, expectorant, bronchitis, pulmonary infection and the laryngopharynx fatigue that causes for catching a cold, hoarseness, chronic pharyngitis, asthma etc.
[specific embodiment]
Come further to set forth the preparation method of Tibetan medicine of the present invention by the following examples.
The decoction pulvis preparation of [embodiment 1] Tibetan medicine of the present invention:
Take by weighing Radix Glycyrrhizae 35g, Fructus Phyllanthi 25g, Radix Vladimiriae 20g, Fructus Hippophae extractum 8g, Cordyceps 1.5g, Bulbus Fritillariae Cirrhosae 10.5g, be ground into coarse powder after the mixing jointly, mixing, packing namely gets decoction pulvis.
Usage and dosage is: put in the 150ml water and decoct, during decocting to 1/3, taking liquid is drunk; A 3g, 2～3 times on the one.
The medicinal tea preparation of [embodiment 2] Tibetan medicine of the present invention:
Take by weighing Radix Glycyrrhizae 20g, Fructus Phyllanthi 30g, Radix Vladimiriae 30g, Fructus Hippophae extractum 10g, Cordyceps 2.5g, Bulbus Fritillariae Cirrhosae 7.5g, be ground into coarse powder after the mixing jointly, mixing, packing namely gets medicinal tea.
Usage and dosage is: boiled water brews to be drunk; A 3g, 2～3 times on the one.
The powder preparation of [embodiment 3] Tibetan medicine of the present invention:
Take by weighing Radix Glycyrrhizae 50g, Fructus Phyllanthi 15g, Radix Vladimiriae 15g, Fructus Hippophae extractum 6g, Cordyceps 0.5g, Bulbus Fritillariae Cirrhosae 14.5g, be ground into fine powder after the mixing jointly, mixing, packing namely gets powder.
Usage and dosage is: oral; A 1.2～2g, 2～3 times on the one.
The pill preparation of [embodiment 4] Tibetan medicine of the present invention:
Take by weighing Radix Glycyrrhizae 70g, Fructus Phyllanthi 10g, Radix Vladimiriae 10g, Fructus Hippophae extractum 4g, Cordyceps 0.5g, Bulbus Fritillariae Cirrhosae 15g, be ground into fine powder after the mixing jointly, mixing is used water pill, dry below 60 ℃, and polishing, packing namely gets pill.
Usage and dosage is: oral; A 1.2～2g, 2～3 times on the one.
The granule preparation of [embodiment 5] Tibetan medicine of the present invention:
Take by weighing Radix Glycyrrhizae 15g, Fructus Phyllanthi 50g, Radix Vladimiriae 40g, Fructus Hippophae extractum 16g, Cordyceps 2g, Bulbus Fritillariae Cirrhosae 10g, be ground into fine powder after the mixing jointly, mixing adds adjuvant and makes granule, dry below 60 ℃, and granulate, packing namely gets granule.
Usage and dosage is: oral; A 1.2～2g, 2～3 times on the one.
The capsule preparation of [embodiment 6] Tibetan medicine of the present invention:
Take by weighing Radix Glycyrrhizae 20g, Fructus Phyllanthi 40g, Radix Vladimiriae 30g, Fructus Hippophae extractum 12g, Cordyceps 1.2g, Bulbus Fritillariae Cirrhosae 18.8g, be ground into fine powder after the mixing jointly, mixing, the gelatine capsule of packing into namely gets capsule.
Usage and dosage is: oral; A 1.2～2g, 2～3 times on the one.
The preparation tablets of [embodiment 7] Tibetan medicine of the present invention:
Take by weighing Radix Glycyrrhizae 45g, Fructus Phyllanthi 15g, Radix Vladimiriae 25g, Fructus Hippophae extractum 6g, Cordyceps 0.8g, Bulbus Fritillariae Cirrhosae 11.2g, be ground into fine powder after the mixing jointly, mixing adds adjuvant and makes granule, dry below 60 ℃, and granulate, tabletting namely gets tablet.
Usage and dosage is: oral; A 1.2～2g, 2～3 times on the one.
Below further sets forth the beneficial effect of Tibetan medicine of the present invention by testing example, these are tested the routine pharmacodynamics test of Tibetan medicine embodiment 4 of the present invention and the clinical observation on the therapeutic effect of having comprised and test.
The antitussive of [test example 1] Tibetan medicine embodiment 4 of the present invention, eliminate the phlegm, relieving asthma, test such as antiinflammatory action:
Test material: anthology invention Tibetan medicine embodiment 4; Prednisone acetate tablets 5mg/ sheet (Zhejiang Province XianJu Pharmacy stock Co., Ltd), lot number: 20100311; Pinellia tuber for relieving cough syrup (Guizhou Yibai Pharmaceutical Co., Ltd), lot number: 20101008; Histamine phosphate (Shanghai three outstanding Bioisystech Co., Ltd), lot number: 090101; 25% ammonia (the Jiangxi flood is the biological chemical reagent company limited all), lot number: 080102; Chloral hydrate (going up seamount Pu chemical industry company limited); Ammonium chloride (chemical plant, the Taishan, Guangdong); Dimethylbenzene (Shantou City's brilliance laboratory), lot number: 20070709; Kunming mouse, SD rat, Cavia porcellus are provided by Qinghai Province's Experimental Animal Center.
Experimental technique: 1, the antitussive of Tibetan medicine embodiment 4 of the present invention test: get 50 of mices, male and female half and half are divided into 5 groups at random, 10 every group.Be the blank group, give the isometric(al) distilled water; Positive controls is given pinellia tuber for relieving cough syrup 15ml/kg.d
-lTibetan medicine embodiment 4 high, medium and low dosage groups of the present invention are given Tibetan medicine embodiment 4 10g of the present invention, 5g, 2.5g crude drug/kg.d respectively
-lEach organizes equal gastric infusion, and 1 time/d, continuous 7 days.Behind the last administration 60min, mice is accepted 25% strong aqua ammonia spraying 10s, observes time and number of times that the cough reaction occurs, cough number of times in the cough latent period of record mice and the 2min.The results are shown in Table 1.
2, the expectorant test of Tibetan medicine embodiment 4 of the present invention: get 50 of SD rats, male and female half and half are divided into 5 groups at random, and 10 every group, namely the blank group is given the isometric(al) distilled water; Positive controls is given ammonium chloride lg/kg.d
-lTibetan medicine embodiment 4 high, medium and low dosage groups of the present invention are given Tibetan medicine embodiment 4 6g of the present invention, 3g, 1.5g crude drug/kg.d respectively
-lAfter water 8～12h is can't help in fasting before the experiment, 10% chloral hydrate 0.35g/kg, behind the intraperitoneal injection of anesthesia, the rat dorsal position is fixed on the operation plate, and cervical region is sterilized with 75% cotton ball soaked in alcohol, the long otch of the about 1cm of medisection, find trachea, prick an aperture in trachea thyroid cartilage lower edge with sharp needle, the capillary tube with 0.5mm inserts trachea subsequently, to just contacting till the trachea.Draw sputum length as the expectorant effect of estimating medicine with capillary tube, when putting sputum in the capillary tube and be full of, change one immediately in addition.After the normal secretory volume of 2h, behind duodenal administration, continue to observe again 2h sputum secretory volume before the record administration.Compare the sputum secretory volume of on average per hour secreting before and after the administration, and take statistics is analysed.The results are shown in Table 2.
3, the test of relievining asthma of Tibetan medicine embodiment 4 of the present invention: Cavia porcellus is placed in the 4000mL clear glass bell jar, 0.2% histamine phosphate solution ultrasonic atomizatio gives 15s, drawing of observed and recorded Cavia porcellus breathed heavily incubation period and (begun to asthma attack from spraying, dyspnea appears, until the time that tic is fallen), if surpass the 150s nonresponder, will not select for use.Get 50 of the qualified Cavia porcelluss of screening, male and female half and half are divided into 5 groups at random, 10 every group.Be the blank group, give the isometric(al) distilled water; Positive controls is given pinellia tuber for relieving cough syrup 5.5ml/kg.d
-lTibetan medicine embodiment 4 high, medium and low dosage groups of the present invention are given Tibetan medicine embodiment 4 6g of the present invention, 3g, 1.5g crude drug/kg.d respectively
-lEach organizes equal gastric infusion, and 1 time/d, continuous 7d.Behind the last administration 1h, Cavia porcellus is put in the people 4000mL clear glass bell jar, measure drawing of Cavia porcellus by preselected conditions and method and breathe heavily incubation period.If surpass the 6min person of still asthma reaction not thing take place, press 360s calculating its incubation period.The results are shown in Table 3.
4, the antiinflammatory of Tibetan medicine embodiment 4 of the present invention test: get 50 of mices, male and female half and half are divided into 5 groups at random, 10 every group.Be negative control group, give the isometric(al) distilled water; Positive controls is given prednisone acetate tablets 12mg/kg.d
-lTibetan medicine embodiment 4 high, medium and low dosage groups of the present invention are given Tibetan medicine embodiment 4 10g of the present invention, 5g, 2.5g crude drug/kg.d respectively
-lEach organizes all gastric infusions, and 1 time/d, continuous 7d.Behind the last administration 60min, every Mus auris dextra is coated with dimethylbenzene 20 μ l and causes inflammation, puts to death mice after causing scorching 30min, takes off bilateral auricle (getting symmetric position) with the card punch of diameter 6mm, divides another name its quality, as the swelling degree, calculates suppression ratio with the difference of two auricle quality.The results are shown in Table 4.
Experimental result: 1, the antitussive action of 4 pairs of mices of Tibetan medicine embodiment of the present invention sees Table 1.
The antitussive action of 4 pairs of mices of table 1 Tibetan medicine embodiment of the present invention (x ± s, n=10)
Group number of animals dosage cough latent period cough number of times
(only) be (s) (inferior) (g/kg)
Blank group 10 29.5 ± 12.27 53.1 ± 9.65
Positive controls 10 15ml/Kg 48.6 ± 5.77
*30.3 ± 6.20
*
Low dose group 10 2.5 45.3 ± 19.62
*32.6 ± 7.25
*
Middle dosage group 10 5 57.6 ± 9.54
*25.5 ± 4.68
*
High dose group 10 10 56.9 ± 7.89
*28.6 ± 5.40
*
Illustrate: with the blank group relatively:
*P＜0.05;
*P＜O.0l.
As seen from Table 1: Tibetan medicine embodiment 4 of the present invention can effectively suppress the mouse cough that strong aqua ammonia is induced, when the cough number of times of mice is obviously reduced obviously prolonged the incubation period of mouse cough, compare with the blank group, little, in, heavy dose of group has significant difference (P＜O.01), illustrates that the mouse cough that 4 pairs of strong aqua ammonia of Tibetan medicine embodiment of the present invention bring out has antitussive action.
2, the phlegm-dispelling functions of 4 pairs of rats of Tibetan medicine embodiment of the present invention sees Table 2.
The phlegm-dispelling functions of 4 pairs of rats of table 2 Tibetan medicine embodiment of the present invention (x ± s, n=10)
(cm/h) difference (cm/h) after (cm/h) administration before group number of animals dosage (g/kg) administration
Blank group 10 isometric(al)s 3.65 ± 0.54 4.15 ± 1.32 0.50 ± 0.88
Positive controls 10 1.0 3.73 ± 0.48 9.69 ± 2.54 5.96 ± 2.33
*
Low dose group 10 1.5 3.72 ± 0.76 5.26 ± 1.37 1.54 ± 1.44
*
Middle dosage group 10 3 3.66 ± 0.83
7.56 ± 1.82 3.90 ± 1.66
*
High dose group 10 6 3.57 ± 0.69 8.86 ± 2.33
5.29 ± 2.47
*
Illustrate: with the blank group relatively:
*P＜0.05;
*P＜O.0l.
As seen from Table 2: Tibetan medicine embodiment 4 of the present invention can effectively increase rat trachea sputum secretory volume, with the blank group relatively, high, middle dosage can significantly increase the expectoration amount (P＜O.O1) of rat.
3, the antiasthmatic effect of 4 pairs of Cavia porcelluss of Tibetan medicine embodiment of the present invention sees Table 3.
The antiasthmatic effect of 4 pairs of Cavia porcelluss of table 3 Tibetan medicine embodiment of the present invention (x ± s, n=10)
Group number of animals dosage (g/kg) asthma hide (s)
Blank group 10 65.6 ± 38.07
Positive controls 10 5.5ml/Kg 117.2 ± 53.86
Low dose group 10 1.5 155.7 ± 119.44
Middle dosage group 10 3 187.8 ± 105.33
*
High dose group 10 6 220.4 ± 111.46
*
Illustrate: with the model matched group relatively:
*P＜0.05.
As seen from Table 3: Tibetan medicine embodiment 4 of the present invention can suppress the Cavia porcellus asthma due to the histamine phosphate.Compare with the blank group, prolongation of latency is breathed heavily in drawing of high, middle dosage group Cavia porcellus, has significant difference (P＜0.05).
4, the Tibetan medicine embodiment 4 xylol of the present invention influence that causes mice ear sees Table 4.
Table 4 Tibetan medicine embodiment 4 xylol of the present invention cause mice ear influence (x ± s, n=10)
Group number of animals dosage (g/kg) swelling degree (mg)
Blank group 10 13.58 ± 2.28
Positive controls 10 12mg/Kg 5.53 ± 2.84
*
Low dose group 10 2.5 10.53 ± 3.67
Middle dosage group 10 5 12.33 ± 2.76
High dose group 10 10 8.98 ± 3.25
*
Illustrate: with the model matched group relatively:
*P＜0.05;
*P＜O.0l.
As seen from Table 4: Tibetan medicine embodiment 4 of the present invention can suppress the mice ear due to the dimethylbenzene, compares with the blank group, and low dosage has significant difference (P＜0.05), illustrates that the acute inflammation of 4 pairs of mices of Tibetan medicine embodiment of the present invention has certain inhibitory action.
[test example 2] Tibetan medicine embodiment 4 treatment exogenous coughs' of the present invention clinical observation on the therapeutic effect:
Physical data: totally 160 examples are observed patients, from February, 2009～2011 year November this gate emergency case, male 86 examples, women 74 examples, the oldest 84 years old, minimum 6 years old, 52 years old mean age, onset was in the majority in 4 days, average 2 days, morbidity season was many with the Winter-Spring.Be divided into two groups at random by digital method, 80 examples are organized in treatment, male 42 examples, women 38 examples, 52.4 years old mean age; Matched group 80 examples, male 44 examples, women 36 examples, 52 years old mean age.The age of two groups of cases, sex and physical data difference not statistically significant.
Diagnostic criteria: with reference to the cough clinical judgment standard of in August, 1999 version " Chinese Internal Medicine " teaching material formulation.1. be cardinal symptom to cough, to cough up phlegm.Onset is anxious, can be with the fever with aversion to cold symptom.2. two pulmonary respiration sounds are coarse, or audible does moist rale, and 3. total white blood cells or neutrophilic granulocyte increase, and the normal or texture of conducting lung X-ray examination increases slightly.
Therapeutic Method: 1, matched group: conventional western medical treatment: bromhexine hydrochloride, mucosolvan, antibiotic, the Supporting Therapy of suiting the medicine to the illness, 3 is a course for the treatment of.
2, treatment group: on the basis for the treatment of of control group, adopt 4,1.2～2g of Tibetan medicine embodiment of the present invention, 2～3 times on the one.
Clinical efficacy evaluation criteria: formulate with reference to State Administration of Traditional Chinese Medicine's " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " cough disease criterion of therapeutical effect.Cure: cough and clinical sign disappear.Take a turn for the better: cough alleviates, and the amount of coughing up phlegm is few.Do not heal: symptom does not have obvious change.
Healing adding improvement and adding up to total effective rate.
Clinical observation result sees Table 5.
Table 5 liang group clinical efficacy comparison (example, %)
Group example number is cured the more total effective rate that takes a turn for the better not
Treatment organizes 80 49 28 3 96.3
*
Matched group 80 33 38 9 88.7
Annotate: compare with matched group
*P＜0.05.
Clinical observation result shows: Tibetan medicine embodiment 4 treatment exogenous cough determined curative effects of the present invention, and be worth clinical expansion to use, have certain application prospect.
Claims (8)
1. Tibetan medicine for the treatment of cough, it is characterized in that it is made up of active component or is made up of active component and acceptable accessories, wherein said active component is to be made by the crude drug of following concrete weight: Radix Glycyrrhizae 15～70g, Fructus Phyllanthi 10～50g, Radix Vladimiriae 10～40g, Fructus Hippophae extractum 4～16g, Cordyceps 0.5～3g, Bulbus Fritillariae Cirrhosae 5～20g.
2. Tibetan medicine according to claim 1, wherein said active component is to be made by the crude drug of following concrete weight: Radix Glycyrrhizae 35g, Fructus Phyllanthi 25g, Radix Vladimiriae 20g, Fructus Hippophae extractum 8g, Cordyceps 1.5g, Bulbus Fritillariae Cirrhosae 10.5g.
3. Tibetan medicine according to claim 1 and 2, it is peroral dosage form.
4. Tibetan medicine according to claim 3, it is medicinal tea, powder, pill, granule, capsule or tablet.
5. the preparation method of the described Tibetan medicine of claim 1, it comprises the following steps: to take by weighing the crude drug of following concrete weight: Radix Glycyrrhizae 15～70g, Fructus Phyllanthi 10～50g, Radix Vladimiriae 10～40g, Fructus Hippophae extractum 4～16g, Cordyceps 0.5～3g, Bulbus Fritillariae Cirrhosae 5～20g; Mix, be ground into fine powder then jointly, mixing is made active component.
6. the preparation method of the described Tibetan medicine of claim 1, it comprises the following steps: to take by weighing the crude drug of following concrete weight: Radix Glycyrrhizae 15～70g, Fructus Phyllanthi 10～50g, Radix Vladimiriae 10～40g, Fructus Hippophae extractum 4～16g, Cordyceps 0.5～3g, Bulbus Fritillariae Cirrhosae 5～20g; Mix, adopt decoction and alcohol sedimentation technique or ethanol extract from water precipitation to make active component.
7. according to claim 5 or 6 described preparation methoies, wherein take by weighing the crude drug of following concrete weight: Radix Glycyrrhizae 35g, Fructus Phyllanthi 25g, Radix Vladimiriae 20g, Fructus Hippophae extractum 8g, Cordyceps 1.5g, Bulbus Fritillariae Cirrhosae 10.5g.
8. according to claim 5 or 6 described preparation methoies, it also comprises the following steps: active component and acceptable accessories are made medicinal tea, powder, pill, granule, capsule or tablet.
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| CN103340932B (en) * | 2013-07-19 | 2014-06-11 | 宋永心 | Tibetan medicine for treating chronic bronchitis and preparation method thereof |
| CN103463421B (en) * | 2013-08-27 | 2015-05-27 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine oral liquid for relieving cough and asthma for livestock |
| CN105288107B (en) * | 2015-10-28 | 2018-12-18 | 西藏海容唐果健康产业有限公司 | Compound hippophae rhamnoides clearing composition and preparation method thereof |
| CN106389589A (en) * | 2016-11-22 | 2017-02-15 | 西宁志培知识产权咨询有限公司 | Medicine with effect of relieving cough and reducing sputum |
| CN106387233A (en) * | 2016-11-23 | 2017-02-15 | 西宁志培知识产权咨询有限公司 | Preparation method of cough-relieving and sputum-reducing substitute tea from edible plants as components |
| CN106421365A (en) * | 2016-11-23 | 2017-02-22 | 西宁志培知识产权咨询有限公司 | Cough-relieving and sputum-reducing substitutive tea prepared from food plants serving as ingredients |
| CN108210657A (en) * | 2016-12-19 | 2018-06-29 | 浏阳市利美免疫力修复中心有限公司 | A traditional Chinese medicine composition for preventing and treating lung cancer |
| CN108813608A (en) * | 2018-05-25 | 2018-11-16 | 陕西黄龙国寿堂生物工程有限公司 | A kind of production method of sea-buckthorn wilsonii cream |
| CN111249388A (en) * | 2020-03-26 | 2020-06-09 | 王芬 | A Chinese medicinal composition for treating chronic cough, and its preparation method |
| CN113876844B (en) * | 2021-10-11 | 2022-07-15 | 山南市藏医医院 | Pure traditional Chinese medicine Tibetan medicine for treating chronic tracheitis and preparation method and application thereof |
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| CN1410109A (en) * | 2002-10-17 | 2003-04-16 | 王勇智 | Cordyceps and sichuan fritillaria cough suppressing paste and its preparation method |
| CN1569066A (en) * | 2003-07-18 | 2005-01-26 | 西南民族大学 | Seabuckthorn fruit contained preparation and its preparing process |
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