CN102793975A - Electromagnetic field generating instrument for promoting bone healing and application - Google Patents
Electromagnetic field generating instrument for promoting bone healing and application Download PDFInfo
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- CN102793975A CN102793975A CN2012101924794A CN201210192479A CN102793975A CN 102793975 A CN102793975 A CN 102793975A CN 2012101924794 A CN2012101924794 A CN 2012101924794A CN 201210192479 A CN201210192479 A CN 201210192479A CN 102793975 A CN102793975 A CN 102793975A
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Abstract
The invention discloses an electromagnetic field generating instrument for promoting bone healing and application. By generating electromagnetic fields with different waveforms for combined stimulation, the treatment effect of promoting fracture healing through the electromagnetic fields can be improved. The instrument can be applied to proliferation, differentiation and mineralization of bone promoting cells; at the proliferation stage of osteoblasts, the osteoblasts are irradiated for 4 to 5 days by using the pulse string electromagnetic field; at the differentiation stage of the osteoblasts, the osteoblasts are irradiated for 2 to 3 days by using the sine wave electromagnetic field; and the mineralization stage of the osteoblasts, the osteoblasts are irradiated for 10 to 11 days by using the triangular wave electromagnetic field.
Description
Technical field
The invention belongs to short knitting device technique field, relate to a kind of electromagnetic field generator and application of short knitting.
Background technology
Fracture is a commonly encountered diseases clinically, and the delayed union and the bone does not connect of fracture are difficult and complicated illness clinically, have seriously influenced patient's quality of life.Electromagnetic field is as a kind of naturopathy method, have noinvasive, painless, do not have and advantage such as infect, treatment is convenient, side effect is little, by clinical practice in promoting union of fracture, the treatment bone does not connect.
But still exist at present when electromagnetic field is used and how to select how to make up problems such as just can reaching the therapeutic effect optimization between concrete parameter and each parameter for use.Use low frequency, low intensive pulse electromagnetic field to be applied to the whole process of patient clinically more at present, do not select the electromagnetic stimulation parameter according to the characteristics in each stage in the osteogenetic process.
Summary of the invention
The problem that the present invention solves is to provide a kind of electromagnetic field generator and application of short knitting, through producing the electromagnetic field combined stimulation of different wave, can improve the therapeutic effect that electromagnetic field promotes union of fracture.
The present invention realizes through following technical scheme:
A kind of electromagnetic field generator of short knitting comprises signal generator and close around solenoid.
Signal generator, the developmental stage different according to osteoblast, select a kind of sending in the middle of triangular wave, sine wave and the pulse wave signal:
In osteoblastic propagation period, send pulse signal;
In osteoblastic differentiation period, send sine wave signal;
In osteoblastic mineralising period, send triangular signal;
Close around solenoid, receive the signal that generator sends, produce the electromagnetic field of corresponding waveform.
The frequency of the signal that described generator sends is that 0.1～150Hz, electric current are 0.1～10A.
The intensity of the described close electromagnetic field that produces around solenoid is 0.5～50mT.
The described time of sending pulse signal is fracture back the 1st～5 day, and the time of sending sine wave signal is fracture back the 6th～8 day, and the time of sending triangular signal is fracture back the 9th～20 day.
The electromagnetic field generator of described short knitting is applied to facilitate propagation, differentiation and the mineralising of osteocyte:
In osteoblastic propagation period, with train of pulse electromagnetic field irradiation 4～5 days;
In osteoblastic differentiation period, with sinusoidal wave electromagnetic field irradiation 2～3 days;
In osteoblastic mineralising period, with triangular wave electromagnetic field irradiation 10～11 days.
Osteoblastic propagation, differentiation and mineralising after the electromagnetic field generator of described short knitting is applied to fracture:
After fracture the 1st～5 day, with the irradiation of train of pulse electromagnetic field, signal frequency was 10～15Hz, and magnetic induction is 3～10mT;
After fracture the 6th～8 day, with sinusoidal wave electromagnetic field irradiation, signal frequency was 10～15Hz, and magnetic induction is 3～10mT;
After fracture the 9th～20 day, with the irradiation of triangular wave electromagnetic field, signal frequency was 10～15Hz, and magnetic induction is 3～10mT.
Compared with prior art, the present invention has following beneficial technical effects:
The electromagnetic field generator and the application of short knitting provided by the invention; Be to urge knitting as the osteoblastic growth of the major function cell of skeletonization through the electromagnetic stimulation promotion; And osteoblast is in the bone formation overall process; Synthetic, secretion like collagen reach in the mineralization process, all play critical effect.And select and the design of generator through signal; Just can select the electromagnetic stimulation of different wave according to the characteristics in each stage in the osteogenetic process: adopt pulse, sine wave, triangular wave electromagnetic field respectively in osteoblastic propagation, differentiation and mineralization stage, come stimulating osteoblast thereby form corresponding electromagnetic field.Compare with adopting single electromagnetic stimulation osteoblast, after having adopted different waveform electromagnetic stimulation osteoblast, the mineralising area is significantly greater than single electromagnetic field effect.
Description of drawings
Fig. 1 is that structure of the present invention connects sketch map.
Fig. 2 utilizes the quadracycline salt dyeing to be detected as the figure as a result of osteocyte mineralising.
The specific embodiment
Below in conjunction with concrete embodiment the present invention is done further detailed description, said is to explanation of the present invention rather than qualification.
A kind of electromagnetic field generator of short knitting comprises signal generator and close around solenoid.Signal generator, the developmental stage different according to osteocyte selected a kind of sending in the middle of triangular wave, sine wave and pulse wave signal; Close around solenoid, receive the signal that generator sends, produce the electromagnetic field of corresponding waveform.
Referring to Fig. 1; Signal generator can send 0～150Hz, triangular wave, sine wave and pulse wave signal that electric current 0～10A is adjustable; At least the triangular wave module, sine wave module and the impulse wave module that comprise signal generation unit, signal transition control that control unit calls in the signal generator; Begin after the initialization of signal generation unit to call a kind of in triangular wave module, sine wave module and the impulse wave module through the signal transition control unit; Send to D/A and integrated amplifier module after calling successfully successively, send signal at last and give close around solenoid.
Wherein signal generation unit, D/A and integrated amplifier module can adopt prior function unit or module; The signal transition control unit increases the transition module unit that is complementary with the osteocyte developmental stage on the basis of signaling control unit; The transition module unit comes from three kinds of modules to select wherein a kind of according to the osteocyte developmental stage information of being imported; Pass through this module output signal after activating selected module; Signal is amplified by integrated amplifier behind D/A again to be accomplished, and then outputs to close around solenoid.The transition module unit can gather together with signaling control unit, can certainly divide to be arranged.
Certainly the signal generator of also not getting rid of single generation triangular wave, sine wave and pulse wave signal respectively with close after solenoid is connected; According to the different times of osteoblastic growth, artificial or automanual to the scheme of signal generator switch to realize that the signal variation is exported.
On the basis of said apparatus, face osteoblastic effect of different wave electromagnetic stimulation and single electromagnetic stimulation down and compare explanation:
The setting of electromagnetic field parameter: sinusoidal wave (SEMF), train of pulse (PEMF), triangular wave (TEMF); Frequency is 15Hz; The magnetic induction amplitude is 5mT.
Specifically be divided into six groups of illumination scheme, as shown in table 1.Every group of 6 parallel sampless.Processed group places the solenoid center to select the electromagnetic field of relevant parameter to shine once each 30min every day respectively.
Group 1: the postvaccinal 1-3d of osteoblast uses the SEMF irradiation, and 4-8d uses the PEMF irradiation, and 9-20d uses the TEMF irradiation;
Group 2: osteoblast inoculation back 1-5d uses the PEMF irradiation, and 6-8d uses the SEMF irradiation, and 9-20d uses the TEMF irradiation;
When processed group is shone, place identical close of another specification in solenoid, to carry out the vacation irradiation in Control skeletonization group cell.
Table 1 electromagnetic field illumination scheme is divided into groups
| SEMF | PEMF | TEMF | |
| Control | - | - | - |
| Group?1 | 1-3d | 4-8d | 9-20d |
| Group?2 | 6-8d | 1-5d | 9-20d |
| Group?3 | 1-20d | - | - |
| Group?4 | - | 1-20d | - |
| Group?5 | - | - | 1-20d |
Osteoblastic detection
The mineralising tuberosity is used to estimate osteoblastic mineralization ability usually; Choose the mineralising tuberosity and estimate the action effect of electromagnetic field; Fig. 2 utilizes the quadracycline salt dyeing to be detected as the figure as a result of osteocyte mineralising, and table 2 is concrete result of calculation, in conjunction with Fig. 2 and table 2; Can see at the mineralising area of the symphyogenetic Group 1 of three kinds of waveform electromagnetic fields and Group 2 significantly greater than the Group3-5 of single electromagnetic field effect, and wherein the 2nd group result is best.So, the developmental stage different according to osteoblast, the scheme optimization of the various signals of sending is:
In osteoblastic propagation period, send pulse signal;
In osteoblastic differentiation period, send sine wave signal;
In osteoblastic mineralising period, send triangular signal.
The different mineralising knuckle area ratios of forming osteocyte of table 2
| Control | Group?1 | Group?2 | Group?3 | Group?4 | Group?5 | |
| Area?ratio | 4.77±2.04 | 13.0±2.91 | 11.4±2.72 | 7.12±1.40 | 9.66±1.63 | 10.1±2.17 |
And the growth of osteoblast after inoculation beginning just with fracture after osteoblastic growth course suitable, seeing that above-mentioned preferred scheme, so urge propagation, differentiation and the mineralising that the electromagnetic field generator of knitting just can be applied to facilitate osteocyte:
In osteoblastic propagation period, with train of pulse electromagnetic field irradiation 4～5 days;
In osteoblastic differentiation period, with sinusoidal wave electromagnetic field irradiation 2～3 days;
In osteoblastic mineralising period, with triangular wave electromagnetic field irradiation 10～11 days.
And can from following scheme, choose suitable parameters according to osteoblastic developmental state after the different fracture, thereby promote the growth of osteocyte and the healing of fracture:
After fracture the 1st～5 day, with the irradiation of train of pulse electromagnetic field, signal frequency was 10～15Hz, and magnetic induction is 3～10mT;
After fracture the 6th～8 day, with sinusoidal wave electromagnetic field irradiation, signal frequency was 10～15Hz, and magnetic induction is 3～10mT;
After fracture the 9th～20 day, with the irradiation of triangular wave electromagnetic field, signal frequency was 10～15Hz, and magnetic induction is 3～10mT.
Claims (6)
1. the electromagnetic field generator of a short knitting is characterized in that, comprises signal generator and close around solenoid;
Signal generator, the developmental stage different according to osteoblast, select a kind of sending in the middle of triangular wave, sine wave and the pulse wave signal:
In osteoblastic propagation period, send pulse signal;
In osteoblastic differentiation period, send sine wave signal;
In osteoblastic mineralising period, send triangular signal;
Close around solenoid, receive the signal that generator sends, produce the electromagnetic field of corresponding waveform.
2. the electromagnetic field generator of short knitting as claimed in claim 1 is characterized in that, the frequency of the signal that described generator sends is that 0.1～150Hz, electric current are 0.1～10A.
3. the electromagnetic field generator of short knitting as claimed in claim 1 is characterized in that, the intensity of the described close electromagnetic field that produces around solenoid is 0.5～50mT.
4. the electromagnetic field generator of short knitting as claimed in claim 1; It is characterized in that; The described time of sending pulse signal is fracture back the 1st～5 day, and the time of sending sine wave signal is fracture back the 6th～8 day, and the time of sending triangular signal is fracture back the 9th～20 day.
5. the electromagnetic field generator of the described short knitting of claim 1 is applied to facilitate propagation, differentiation and the mineralising of osteocyte:
In osteoblastic propagation period, with train of pulse electromagnetic field irradiation 4～5 days;
In osteoblastic differentiation period, with sinusoidal wave electromagnetic field irradiation 2～3 days;
In osteoblastic mineralising period, with triangular wave electromagnetic field irradiation 10～11 days.
6. osteoblastic propagation, differentiation and mineralising after the electromagnetic field generator of the described short knitting of claim 1 is applied to fracture:
After fracture the 1st～5 day, with the irradiation of train of pulse electromagnetic field, signal frequency was 10～15Hz, and magnetic induction is 3～10mT;
After fracture the 6th～8 day, with sinusoidal wave electromagnetic field irradiation, signal frequency was 10～15Hz, and magnetic induction is 3～10mT;
After fracture the 9th～20 day, with the irradiation of triangular wave electromagnetic field, signal frequency was 10～15Hz, and magnetic induction is 3～10mT.
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| CN2012101924794A CN102793975A (en) | 2012-06-12 | 2012-06-12 | Electromagnetic field generating instrument for promoting bone healing and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108937905A (en) * | 2018-08-06 | 2018-12-07 | 合肥工业大学 | A kind of contactless heart rate detection method based on signal fitting |
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| CN201094810Y (en) * | 2007-05-18 | 2008-08-06 | 才秀君 | Electromagnetic field and ultrasound wave composite device for curing osteoporosis |
| CN101306228A (en) * | 2007-05-18 | 2008-11-19 | 才秀君 | Electromagnetic field and ultrasonic wave composite therapy device for osteoporosis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201094810Y (en) * | 2007-05-18 | 2008-08-06 | 才秀君 | Electromagnetic field and ultrasound wave composite device for curing osteoporosis |
| CN101306228A (en) * | 2007-05-18 | 2008-11-19 | 才秀君 | Electromagnetic field and ultrasonic wave composite therapy device for osteoporosis |
Non-Patent Citations (1)
| Title |
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| 张晓军: "极低频电磁场对新生大鼠成骨细胞的影响", 《中国优秀硕士论文电子期刊网》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108937905A (en) * | 2018-08-06 | 2018-12-07 | 合肥工业大学 | A kind of contactless heart rate detection method based on signal fitting |
| CN108937905B (en) * | 2018-08-06 | 2021-05-28 | 合肥工业大学 | Non-contact heart rate detection method based on signal fitting |
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Application publication date: 20121128 |