CN102657788A - Traditional Chinese medical composition for prevention and control of avian influenza and preparation method thereof - Google Patents
Traditional Chinese medical composition for prevention and control of avian influenza and preparation method thereof Download PDFInfo
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- CN102657788A CN102657788A CN2012101496039A CN201210149603A CN102657788A CN 102657788 A CN102657788 A CN 102657788A CN 2012101496039 A CN2012101496039 A CN 2012101496039A CN 201210149603 A CN201210149603 A CN 201210149603A CN 102657788 A CN102657788 A CN 102657788A
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- 239000000203 mixture Substances 0.000 title claims abstract description 24
- 230000002265 prevention Effects 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 5
- 206010064097 avian influenza Diseases 0.000 title abstract description 6
- 208000002979 Influenza in Birds Diseases 0.000 title abstract description 4
- 239000003814 drug Substances 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- 239000000284 extract Substances 0.000 claims description 18
- 206010022000 influenza Diseases 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 14
- 239000009636 Huang Qi Substances 0.000 claims description 13
- 239000006071 cream Substances 0.000 claims description 12
- 239000006228 supernatant Substances 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 238000000746 purification Methods 0.000 claims description 9
- 230000001105 regulatory effect Effects 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 238000009833 condensation Methods 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims description 3
- 230000008021 deposition Effects 0.000 claims description 3
- 230000002879 macerating effect Effects 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 241000283690 Bos taurus Species 0.000 claims description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 2
- 241001494479 Pecora Species 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 241001465754 Metazoa Species 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 4
- 241000508725 Elymus repens Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 description 7
- 235000013330 chicken meat Nutrition 0.000 description 7
- 210000000952 spleen Anatomy 0.000 description 7
- 210000001669 bursa of fabricius Anatomy 0.000 description 6
- 230000037396 body weight Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 241000271566 Aves Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a traditional Chinese medical composition for prevention and control of avian influenza and a preparation method thereof. The traditional Chinese medical composition is prepared with astragali, couch grass roots and licorice according to a ratio, and can be applied to improve the immunity. Moreover, the traditional Chinese medical composition has significant effects on prevention and control of the avian influenza and can be widely applied in animals.
Description
Technical field
The present invention relates to field of medicinal compositions, be specifically related to a kind of Chinese medicine composition that is used for prevention and control of fowl influenza and preparation method thereof.
Background technology
If be used for the drug main antiviral class Western medicine of prevention and control of fowl influenza at present, after such medicine animal was taken, toxic and side effects was big; And cause that easily bird flu virus produces mutation; Medicine is produced drug resistance, have little effect, the Ministry of Agriculture has forbidden that at present this type of Western medicine uses in animal.
Summary of the invention
The objective of the invention is to according to the above-mentioned deficiency that exists in the prior art, providing a kind of is the Chinese medicine composition of the prevention and control of fowl influenza of raw material with the Chinese herbal medicine.
Another purpose of the present invention is to provide the method for preparing of above-mentioned Chinese medicine composition.
A further object of the invention is to provide the instructions of taking of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through following technical scheme:
A kind of Chinese medicine composition that is used for prevention and control of fowl influenza is combined by Radix Astragali, Rhizoma Imperatae and Radix Glycyrrhizae, and three's mass ratio is 2:2:1.
The method for preparing that is used for the Chinese medicine composition of prevention and control of fowl influenza according to the invention comprises the steps:
(1) Radix Astragali, Rhizoma Imperatae were added the purified water warm macerating 0.5 hour, decocte with water three times, 6 times of water yields for the first time; Decocted 2 hours, 4 times of water yields decocted 1.5 hours for the second time; 3 times of water yields decocted 1 hour for the third time, and extraction pot boils the water vapour that produces in the process of carrying and after condensation, gets in the extraction pot again.Temperature in the concentration tank is controlled at 80 ± 2 ℃; The steam pressure of regulating concentration tank is 0.03 ~ 0.04Mpa; Vacuum is-0.03 ~-0.04Mpa, carry out concentrating under reduced pressure to extracting medicinal liquid, be concentrated into relative density and be 1.10 ~ 1.15, temperature is 80 ℃ extracting solution; Spissated extract is transferred in the receipts cream jar of receiving between cream, and is subsequent use.
(2) Radix Glycyrrhizae is dropped in the extraction pot, added the purification water yield and be 6 times of decoction pieces amount, soaked 30 minutes earlier before decocting, open jacket steam and decoct; Steam regulation pressure 0.03 ~ 0.05Mpa, to boiling, steam regulation pressure 0.15 ~ 0.02Mpa, decocte with water 3 times; Add for the second time the purification water yield and be 4 times of decoction pieces amount, add the purification water yield for the third time and be 3 times of decoction pieces amount, keep boiling after 2 hours at every turn, open valve; 3 times decocting liquids are pumped into the medicine settling tank, and placement is spent the night, and makes deposition; Extract supernatant to supernatant basin; Again the supernatant that extracts in the supernatant basin is sent into to heat in the backflow concentration tank and be concentrated into the thick paste shape; Temperature in the concentration tank is controlled at 80 ± 2 ℃; The steam pressure of regulating concentration tank is 0.03 ~ 0.04Mpa, vacuum is-0.03 ~-0.04Mpa, be concentrated into relative density and be 1.10 ~ 1.15, temperature is 80 ℃ extracting solution; Spissated extract is transferred in the receipts cream jar of receiving between cream, and is subsequent use;
(3) Radix Glycyrrhizae extract that Radix Astragali, MAOGEN extract and the step (2) that step (1) is obtained obtains mixes, and carries out corresponding conventional steps and handles, and processes oral liquid, promptly gets through fill, sterilization.
Chinese medicine composition according to the invention can be prepared into various suitable dosage forms (particularly oral liquid) according to conventional methods, is prepared into the medicine of prevention and control of fowl influenza.
The instructions of taking of Chinese medicine composition according to the invention is:
When horse or cattle are taken, medicine is mixed 1 liter with water, wherein drug 15 ~ 60ml;
When sheep is taken, medicine is mixed 1 liter with water, wherein drug 6 ~ 12ml;
When rabbit or birds are taken, medicine is mixed 1 liter with water, wherein drug 1 ~ 2ml.
Compared with prior art, the present invention has following beneficial effect:
(1) Chinese medicine composition of the present invention is arranged in pairs or groups Rhizoma Imperatae, Radix Astragali, Radix Glycyrrhizae first, not only animal is had health-care effects such as the immunity of raising, also prevention and control of fowl influenza is had significant curative effect.Radix Astragali has effects such as invigorating the spleen and replenishing QI, inducing diuresis to remove edema.The QI invigorating effect of Radix Astragali is stronger, is the good merchantable brand of the benefiting vital QI and blood used always.Radix Astragali also has other function except having the QI invigorating effect, because of its widely purposes be described as " a medicine multipotency ".Rhizoma Imperatae has diuresis, heat clearing away, effect such as antibiotic.Radix Glycyrrhizae is as the king of ten thousand medicines, can tonification gas, and heat-clearing and toxic substances removing can be regulated effects such as taste again;
(2) Chinese medicine composition of the present invention is in human body immunity improving power, and there is significant curative effect the prevention and control of fowl influenza aspect, can be widely used in animal.Through evidence, when this Chinese medicine composition is processed medicine, can obviously improve the weight of chickling immune organ spleen and immune maincenter organ fabricius bursa, and can improve chickling index and spleen index and fabricius bursa index.Do not see as yet at present and adopt Radix Astragali and Rhizoma Imperatae, Radix Glycyrrhizae to process the relevant report of Chinese medicine composition.
(3) Chinese medicine composition of the present invention reaches the effect that prevention and control of fowl influenza has to promote animal body immunity, strengthens antibody titer, has no side effect, and is difficult for producing drug resistance.
The specific embodiment
Come further to explain the present invention below in conjunction with embodiment, but embodiment does not do any type of qualification to the present invention.
Embodiment 1
Radix Astragali 1200g, Rhizoma Imperatae 1200g were added the purified water warm macerating 0.5 hour, decocte with water three times, 6 times of water yields for the first time; Decocted 2 hours; 4 times of water yields decocted 1.5 hours, for the third time 3 times of water yields for the second time; Decocted 1 hour, extraction pot boils the water vapour that produces in the process of carrying and after condensation, gets in the extraction pot again.Temperature in the concentration tank is controlled at 80 ℃, and the steam pressure of regulating concentration tank is 0.04Mpa, and vacuum is-0.04Mpa to carry out concentrating under reduced pressure to extracting medicinal liquid.Be concentrated into relative density and be 1.13, temperature is 80 ℃ extracting solution.Spissated extract is transferred in the receipts cream jar of receiving between cream, and is subsequent use.
Radix Glycyrrhizae 600g is dropped in the extraction pot, add the purification water yield and be 6 times of decoction pieces amount, soaked 30 minutes earlier before decocting, open jacket steam and decoct; Steam regulation pressure 0.04Mpa, to boiling, steam regulation pressure 0.20Mpa, decocte with water 3 times; Add for the second time the purification water yield and be 4 times of decoction pieces amount, add the purification water yield for the third time and be 3 times of decoction pieces amount, keep boiling after 2 hours at every turn, open valve; 3 times decocting liquids are pumped into the medicine settling tank, and placement is spent the night, and makes deposition; Extract supernatant to supernatant basin; Again the supernatant that extracts in the supernatant basin is sent into to heat in the backflow concentration tank and be concentrated into the thick paste shape, temperature in the concentration tank is controlled at 80 ℃, the steam pressure of regulating concentration tank is 0.04Mpa, and vacuum is-0.04Mpa.Be concentrated into relative density and be 1.13, temperature is 80 ℃ extracting solution.Spissated extract is transferred in the receipts cream jar of receiving between cream, and is subsequent use.
Radix Astragali extract, Rhizoma Imperatae, Radix Glycyrrhizae extract are mixed, be settled to 3000mL, fill, sterilization make the Chinese medicine composition oral liquid.
Embodiment 2
Experimental group 1:
Extracting 100 chickens of not taking the oral liquid that embodiment 1 makes in the bird flu infected area respectively and be the chicken that matched group and 100 take the oral liquid that embodiment 1 makes is test group.The result is following:
Avian influenza infects test
| The matched group experimental group |
| Mortality rate (%) 60% 20% |
Experimental group 2: extracting 10 chickens of not taking oral liquid 28 ages in days that embodiment 1 makes, 35 ages in days, 42 ages in days and be 28 ages in days, 35 ages in days, the 42 age in days chickens that matched group and 10 take the oral liquid that embodiment 1 makes is that experimental group is catched and killed; Test weight, spleen spleen weight and the chicken body weight of its fabricius bursa respectively, fabricius bursa index=(fabricius bursa weight/chicken body weight) * 1000.* 1000 results are following for index and spleen index=(spleen weight/chicken body weight):
Fabricius bursa exponential experiment
The index and spleen index experiment
Claims (6)
1. a Chinese medicine composition that is used for prevention and control of fowl influenza is characterized in that being combined by Radix Astragali, Rhizoma Imperatae and Radix Glycyrrhizae, and three's mass ratio is 2:2:1.
2. the said method for preparing that is used for the Chinese medicine composition of prevention and control of fowl influenza of claim 1 is characterized in that comprising the steps:
(1) Radix Astragali, Rhizoma Imperatae were added the purified water warm macerating 0.5 hour, decocte with water three times, 6 times of water yields for the first time; Decocted 2 hours, 4 times of water yields decocted 1.5 hours for the second time; 3 times of water yields decocted 1 hour for the third time, and extraction pot boils the water vapour that produces in the process of carrying and after condensation, gets in the extraction pot again.
3. temperature in the concentration tank is controlled at 80 ± 2 ℃; The steam pressure of regulating concentration tank is 0.03 ~ 0.04Mpa; Vacuum is-0.03 ~-0.04Mpa, carry out concentrating under reduced pressure to extracting medicinal liquid, be concentrated into relative density and be 1.10 ~ 1.15, temperature is 80 ℃ extracting solution; Spissated extract is transferred in the receipts cream jar of receiving between cream, and is subsequent use.
4. drop into Radix Glycyrrhizae in the extraction pot (2), adds the purification water yield and be 6 times of decoction pieces amount, soaked 30 minutes earlier before decocting, and opens jacket steam and decoct; Steam regulation pressure 0.03 ~ 0.05Mpa, to boiling, steam regulation pressure 0.15 ~ 0.02Mpa, decocte with water 3 times; Add for the second time the purification water yield and be 4 times of decoction pieces amount, add the purification water yield for the third time and be 3 times of decoction pieces amount, keep boiling after 2 hours at every turn, open valve; 3 times decocting liquids are pumped into the medicine settling tank, and placement is spent the night, and makes deposition; Extract supernatant to supernatant basin; Again the supernatant that extracts in the supernatant basin is sent into to heat in the backflow concentration tank and be concentrated into the thick paste shape; Temperature in the concentration tank is controlled at 80 ± 2 ℃; The steam pressure of regulating concentration tank is 0.03 ~ 0.04Mpa, vacuum is-0.03 ~-0.04Mpa, be concentrated into relative density and be 1.10 ~ 1.15, temperature is 80 ℃ extracting solution; Spissated extract is transferred in the receipts cream jar of receiving between cream, and is subsequent use;
(3) Radix Glycyrrhizae extract that Radix Astragali, MAOGEN extract and the step (2) that step (1) is obtained obtains mixes, and carries out corresponding conventional steps and handles, and processes oral liquid, promptly gets through fill, sterilization.
5. the said application that is used for the Chinese medicine composition of prevention and control of fowl influenza at preparation prevention and control of fowl influenza medicine of claim 1.
6. after the said Chinese medicine composition that is used for prevention and control of fowl influenza of claim 1 was prepared into the prevention and control of fowl influenza medicine, its instructions of taking was:
When horse or cattle are taken, medicine is mixed 1 liter with water, wherein drug 15 ~ 60ml;
When sheep is taken, medicine is mixed 1 liter with water, wherein drug 6 ~ 12ml;
When rabbit or birds are taken, medicine is mixed 1 liter with water, wherein drug 1 ~ 2ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210149603.9A CN102657788B (en) | 2012-05-15 | 2012-05-15 | Traditional Chinese medical composition for prevention and control of avian influenza and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210149603.9A CN102657788B (en) | 2012-05-15 | 2012-05-15 | Traditional Chinese medical composition for prevention and control of avian influenza and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102657788A true CN102657788A (en) | 2012-09-12 |
| CN102657788B CN102657788B (en) | 2014-02-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210149603.9A Expired - Fee Related CN102657788B (en) | 2012-05-15 | 2012-05-15 | Traditional Chinese medical composition for prevention and control of avian influenza and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106310001A (en) * | 2016-11-17 | 2017-01-11 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine compound preparation used for relieving cough and asthma for livestock and poultry and preparation method thereof |
| CN111388613A (en) * | 2020-05-19 | 2020-07-10 | 山西中医药大学 | Traditional Chinese veterinary medicine astragalus root compound particles for promoting growth and enhancing immunity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6841176B2 (en) * | 2001-04-27 | 2005-01-11 | Goen Technologies, Inc. | Immunity enhancing supplements for lung support |
| CN1562273A (en) * | 2004-04-05 | 2005-01-12 | 王永清 | Method for producing compound Geqing capsule or granule |
| CN1650751A (en) * | 2004-04-30 | 2005-08-10 | 南阳市海达生物技术有限公司 | Food for relaxing bowel and reducing body weight and its preparation method |
| CN1879815A (en) * | 2006-05-16 | 2006-12-20 | 天津生机集团有限公司 | Compound decoction with astragalus root for birds and method for preparing same |
| CN101108203A (en) * | 2006-03-27 | 2008-01-23 | 姜宝库 | Radix astragali particle for preventing cold |
-
2012
- 2012-05-15 CN CN201210149603.9A patent/CN102657788B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6841176B2 (en) * | 2001-04-27 | 2005-01-11 | Goen Technologies, Inc. | Immunity enhancing supplements for lung support |
| CN1562273A (en) * | 2004-04-05 | 2005-01-12 | 王永清 | Method for producing compound Geqing capsule or granule |
| CN1650751A (en) * | 2004-04-30 | 2005-08-10 | 南阳市海达生物技术有限公司 | Food for relaxing bowel and reducing body weight and its preparation method |
| CN101108203A (en) * | 2006-03-27 | 2008-01-23 | 姜宝库 | Radix astragali particle for preventing cold |
| CN1879815A (en) * | 2006-05-16 | 2006-12-20 | 天津生机集团有限公司 | Compound decoction with astragalus root for birds and method for preparing same |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106310001A (en) * | 2016-11-17 | 2017-01-11 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine compound preparation used for relieving cough and asthma for livestock and poultry and preparation method thereof |
| CN111388613A (en) * | 2020-05-19 | 2020-07-10 | 山西中医药大学 | Traditional Chinese veterinary medicine astragalus root compound particles for promoting growth and enhancing immunity |
| CN111388613B (en) * | 2020-05-19 | 2021-11-23 | 山西中医药大学 | Traditional Chinese veterinary medicine astragalus root compound particles for promoting growth and enhancing immunity |
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| CN102657788B (en) | 2014-02-05 |
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