CN102614404B - Health product with auxiliary effect on reducing blood glucose and preparation method thereof - Google Patents
Health product with auxiliary effect on reducing blood glucose and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health product with an auxiliary effect on reducing the blood glucose and preparation method thereof. The health product mainly comprises: mulberry leaf, bitter gourd, henom bamboo leaf and astragalus root. The above raw materials are decocted in water, extracted, filtered and concentrated to form an extractum, the extractum is subjected to spray drying to obtain an extractum powder, and the extractum powder is processed into granulated powder, tablets, capsules, oral liquid or the like. The composition compatibility of the health product is reasonable and scientific, and the health product not only can clear away the lung-heat and moisturize the dryness, but also can purge the fire of the gastric heat to quench thirst, thus the health product can timely reduce the blood glucose of the user to treat the symptoms of the disease and moreover can condition the human yin-yang qi-blood balance, increase the human immunity, improve the health, and keep the blood glucose be stable for a long time, so as to treat the cause of the disease and promote the health. The raw materials of the health product are all edible and medical foods, thus the health product is safe and non-toxic and can be taken for a long time.
Description
Technical field
the present invention relates to health product technology field, particularly a kind of health product for auxiliary hyperglycemic and preparation method thereof.
Background technology
diabetes (diabetes) are by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, the various virulence factors of Nervous and Mental Factors etc. act on body and cause insulin function to go down, the anti-grade of Yi Dao Su Arrived and the sugar that causes, protein, fat, a series of metabolism disturbance syndromes such as power and water Xie Zhi, clinically taking hyperglycemia as main Te Dian, can there is polyuria in model case, polydipsia, polyphagia, the performance such as become thin, i.e. " three-many-one-little " symptom, diabetes (blood glucose) cause complication once control bad meeting, cause kidney, eye, the exhaustion pathological changes at the positions such as foot, and cannot Zhi More.
along with the raising of people's living standard, the change of dietary structure, the factors such as rhythm of life and few moving life style methods of sitting that day is becoming tight more, whole world glycosuria sickness rate rapid development, diabetes have become the chronic disease of the third-largest serious threat human health after tumor, cardiovascular pathological changes, human body health in serious threat, has become the public health problem of global concern.At present, global diabetics number has exceeded 200,000,000 people.Announce according to health ministry, China suffers from I, II phase diabetic population and reaches 6,000 ten thousand left and right, and prevalence is occupied second place of the world, and pathoglycemia or unstable crowd reach 1.2 hundred million more than, and with every days at least 3000 people speed increase, annual increasing exceedes 1,200,000.Therefore, people are not only concerned about that medical and health industry can develop the medicine of remarkable effectively treatment diabetes, also expect to develop the green health product that the existing certain auxiliary therapeutic action of hyperglycemia had again to health care preventive effect.
at present, the blood sugar reducing health product of selling on international market have at least more than hundreds of, are wherein followed successively by 4 kinds of best blood sugar reducing health product of western countries' sales situations such as the U.S.: Fructus Momordicae charantiae; India's Largeleaf Gymnema; Calabash Fructus Crotonis; Cortex Cinnamomi powder.The blood sugar reducing health product that other sales volumes are larger have: the wild Rhizoma Dioscoreae of Mexico (to China Rhizoma Dioscoreae have similar, but not exclusively the same), Chroma-Pak class (as " skin Courlene-chromium " etc.), saccharomyces cerevisiae class (its main component is vitamin B group and chromium), America Radix Ginseng, India Rhizoma Curcumae Longae, Flos Caryophylli purple common vetch extract, Passion flower P.E, citrus peel extract, Citrus aurantium Linn. extract, auxiliary sour Q10(C0Q10), Carlina acaulis extract, Europe Pericarpium Citri tangerinae extract, Semen Vitis viniferae extract, microelement kind (as vfanadium compound and so on) etc.Therefore above-mentioned blood sugar reducing health product are simple vegetable food or its extract substantially, have no side effect, and take safety, therefore, favored by people.
but, if with some plants with hypoglycemic activity with tcm theory prescription, science compatibility, makes the hypoglycemic activity tonification each other of each prescription plant the usefulness that superposes, made health-caring product capable of reducing blood sugar can reach better more stable effect.
Summary of the invention
object of the present invention is exactly according to the theory of " conditioning human body yang blood and qi, the tonifying for deficiency syndrome; reducing for the excess syndrome " of the traditional Chinese medical science, with some medicines, food dual purpose plant prescription, make a kind of health product with auxiliary hyperglycemic function, the preparation method of these health product is provided simultaneously.
technical scheme of the present invention is: a kind of preparation method of the health product with auxiliary hyperglycemic function, its health product with auxiliary hyperglycemic function are primary raw material by Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri and the Radix Astragali, and its proportioning is counted by weight: 40 parts, Folium Mori, 40 parts, Fructus Momordicae charantiae, 18 parts of Herba Lophatheris, 24 parts of the Radixs Astragali;
concrete steps are as follows:
(1) take through cleaning the Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri, the Radix Astragali that dry and be placed in container in component ratio, add the clear water of 10~16 times of inventories, be heated to 95~105 DEG C, be incubated and decoct for 2~3 hours, filter out decoction liquor, filtering residue adds water and decocts equally, so repeats to decoct, filter decoction liquor 2~3 times;
(2) merging filtrate heating is condensed into extractum;
(3) by the dry extractum spraying extract powder of making;
(4) extract powder is processed into the product of granule or tablet, capsule, oral liquid formulation.
above-mentioned composition principle is:
folium Mori: be moraceae plants, Mulberry (Morus alba L.).Chinese medicine thinks, Folium Mori are cold in nature, and sweet-bitter flavor enters lung meridian, has dispelling wind and heat pathogens, clear abundant moisturizing and effect of liver heat removing and eyesight improving.Modern pharmacological research shows in Folium Mori that total polysaccharides and total flavones isoreactivity composition have hypoglycemic activity.
fructus Momordicae charantiae: be cucurbitaceous plant, Fructus Momordicae charantiae (Momordica charantia L.).Chinese medicine thinks, Fructus Momordicae charantiae is cold in nature, enters the heart, lung, stomach warp, has the clearing away summer-heat effect of quenching one's thirst." Quanzhou book on Chinese herbal medicine " recorded, and Fructus Momordicae charantiae " cures mainly the scorching taking fluids profusely of quenching one's thirst."; " the southern regions of the Yunnan Province book on Chinese herbal medicine " recorded, and Fructus Momordicae charantiae " rush down three through excess-fire, clearing away summer-heat, QI invigorating, quenches the thirst." modern pharmacological research proves, balsam pear hypoglycemic effect is obvious.
herba Lophatheri: be grass, Herba Lophatheri (Lophatherum gracile Brongn.), Chinese medicine thinks, and Herba Lophatheri hardship is light, cold, enters the heart, kidney channel, and function is the sweet light profit of rushing down, and cold in naturely falls clearly, only quenches one's thirst." holding spirit book on Chinese herbal medicine " recorded, and Herba Lophatheri " goes gastric heat."; " detailed outline " recorded, and Herba Lophatheri " quench the thirst by relieving restlessness."; " book on Chinese herbal medicine is new again " recorded, and Herba Lophatheri " quench the thirst for clearing away heart-fire, diuresis by relieving restlessness." modern pharmacological research shows, in Herba Lophatheri, the composition such as flavone compound and bioactive polysaccharide has the effect such as immunomodulating, blood sugar lowering.
the Radix Astragali: be leguminous plant, Radix Astagali (Astragalus membranaceus(Fisch.) Bge.var.mongholicus(Bge) or Radix Astragali (Astragalus membranaceus(Fisch.) Bge.) root, Chinese medicine is thought, Radix Astragali nature and flavor are sweet, tepor, enters lung, spleen, Liver and kidney warp, has benefiting QI for strengthening the superficies, arresting sweating admittedly de-, effect of inducing diuresis to remove edema, be used for the treatment of the deficiency of vital energy weak, mountain pass under middle gas, interior-heat is quenched one's thirst, nephritic proteinuria, diabetes etc.Modern pharmacological research shows, the Radix Astragali has that the glycogen synthetase of making is active increases and improve insulin sensitivity, thereby performance reduces blood glucose effect.
above-mentioned all medicine compatibilities share, existing clearing away lung-heat and moistening for dryness, and pathogenic fire purging is quenched the thirst, and has again QI invigorating effect of lowering blood sugar, therefore the disease of quenching one's thirst of the impairment of both QI and YIN to the dryness of the lung, gastric heat has good treatment and health-care effect.
as preferably, the relative density of described extractum at 60 DEG C is 0.8~1.0.
as preferably, the processing method of tablet is: get described extract powder and through pulverizing the microcrystalline Cellulose of 100 mesh sieves, the consumption of microcrystalline Cellulose is 0.4~0.5 times of extract powder amount, the method that two materials are progressively increased by equivalent adds mix homogeneously in blender, adds binding agent wet-method extrusion and granulates, and then dries, control pellet moisture < 5%, then the magnesium stearate bulk material that adds inventory 5 ‰, mixes rear tabletting, obtains tablet finished product.
as preferably, described microcrystalline Cellulose is that textile fiber is hydrolyzed the microcrystalline Cellulose making.
as preferably, the processing method of described granule is: get extract powder and through pulverizing the dextrin of 100 mesh sieves, the consumption of dextrin is 0.4~0.5 times of extract powder amount, the method of progressively increasing by equivalent is put mix homogeneously in blender, adding additives wet-method extrusion is granulated, and then dries granule water content < 5%, cross 14 mesh sieve granulate, pouch-packaged.
as preferably, the processing method of described capsule is: described extract powder is added to suitable amount of adhesive wet granulation, wet granular is in 55~60 DEG C of oven dry, make its moisture content be less than 5%, then cross 40 mesh sieve granulate, the granule after granulate is by capsule filling machine fill, capsule polishing in polishing machine that fill is good, reject damaged capsule, packaging into products.
as preferably, the processing method of described oral liquid is: get the pure water that described extract powder adds 6~15 times and fully stir, be dissolved into oral liquid, Packaging Bottle packaging.
in oral liquid, add appropriate vitamin C.
outstanding advantages of the present invention and beneficial effect are: prescription compatibility is scientific and reasonable, the both clearing away lung-heat and moistening for dryness of prescription product, rush down again the fire of gastric heat and quench the thirst, not only there is timely reduction blood sugar for human body and control the certain effect of table, more be that it has nursed one's health yin-Yang QI and blood balance, improve body immunity, strong health, make blood glucose remain steadily long-term, and reach the effect of the health care that effects a permanent cure; This products material is all medicine-food two-purpose food, and safety non-toxic, can long-term taking.The preparation method of this prescription product is simple, specification, safe and reliable.
health product product of the present invention has been done respectively " acute toxicity test " and " auxiliary hyperglycemic function zoopery ", " experiment of auxiliary hyperglycemic function human experiment " through Zhejiang Academy of Medical Sciences and disease prevention and control center of Hunan Province, proved health promoting product safety non-toxic, all has auxiliary hyperglycemic function to animal and human's body.Concrete survey report is as follows:
one, acute toxicity test, No. B-BJ-110054 " survey report " of Zhejiang medical courses in general inspection
inspection, judgment basis are " health food inspection and assessment technique specification " (2003 editions)
check conclusion:
(1) acute toxicity: MTD is all greater than 20.0g/ ㎏ body weight to the large and small Mus per os of male and female, belongs to nontoxic level.
(2) micronucleus test: negative to PCEMNR micronucleus test testing result.
(3) Salmonella reversion test: testing result is negative.
(4) mouse sperm deformity test: testing result is negative.
(5) 30 days feeding trials: laboratory animal growing state is good, hematological examination, biochemical analysis, when histological examination result of main dirty body, compared with matched group, is showed no extremely, proves safety non-toxic of the present invention.
two, auxiliary hyperglycemic function zoopery, No. J20100370, disease prevention and control center of Hunan Province " survey report "
inspection, judgment basis are " health food inspection and assessment technique specification " (2003 editions)
experimental result shows, high dose group hyperglycemia model mouse blood sugar decline percentage rate and matched group relatively have and increase, and difference has significance (P < 0.05); Hyperglycemia model mice fasting glucose measured value, Area under the curve of blood glucose are had no significant effect to (P > 0.05); Normal mouse fasting glucose is had no significant effect to (P > 0.05).Point out this sample to there is auxiliary hyperglycemic function to animal.
three, auxiliary hyperglycemic function human experiment experiment, No. J20100370, disease prevention and control center of Hunan Province " survey report "
inspection, judgment basis are " health food inspection and assessment technique specification " (2003 editions)
experimental result shows, product of the present invention is improved effect to diabetes main clinic symptoms, and total effective rate is that 80.39%(matched group is 17.65%); Test-meal group fasting glucose fall and matched group test-meal comparison, difference all has significance (P < 0.05), and after the test-meal of fasting glucose test-meal group compared with declining 10.22% before test-meal; Before and after the test-meal of test-meal group post-prandial glycemia self relatively and with matched group test-meal after relatively, difference has significance (P < 0.05), after the test-meal of test-meal group post-prandial glycemia compared with declining 7.28% before test-meal; Point out product of the present invention to there is auxiliary hyperglycemic function.After test-meal, body weight, blood pressure, heart rate are showed no obvious abnormalities change, and routine blood test, routine urinalysis (except glucose in urine), stool routine examination and biochemical indicator detection all, within normal range, are not found obvious adverse reaction during test-meal.
Detailed description of the invention
embodiment 1, makes tablet product, and its compositing formula is counted by weight: 40 parts, Folium Mori, 40 parts, Fructus Momordicae charantiae, 18 parts of Herba Lophatheris, 24 parts of the Radixs Astragali.
preparation method, concrete steps are as follows:
(1) take through cleaning the Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri, the Radix Astragali that dry and be placed in container in component ratio, add the clear water of 14 times of inventories, with being steam heated to 95~105 DEG C, be incubated and decoct for 2 hours, be press-filtered out decoction liquor with filter press, filtering residue adds water and decocts equally, so repeats to decoct, filter decoction liquor 3 times;
(2) merging filtrate heating is condensed into extractum, and controlling the relative density of extractum at 60 DEG C is 0.8~1.0;
(3) make extract powder by dry extractum spraying, extract powder is crossed 80 mesh sieves, water content < 5%;
(4) get extract powder and be hydrolyzed through the textile fiber of pulverizing 100 mesh sieves the microcrystalline Cellulose making, the consumption of microcrystalline Cellulose is 0.4~0.5 times of extract powder amount, the method of progressively increasing by equivalent is put mix homogeneously in blender, adding 75% ethanol wet-method extrusion granulates, then dry, granule water content < 5%, crosses 20 mesh sieve granulate;
(5) magnesium stearate is crossed to 100 mesh sieves, then taken the magnesium stearate after sieving in the ratio of above-mentioned inventory 5 ‰, fully mix homogeneously with the prepared particulate material of step (4), deliver to tablet machine and be pressed into tablet;
(6) by molding tablet spray coating solution oven dry, obtain tablet product.
0.8 gram/piece, the present embodiment tablet, dose is every day three times, 2 pieces/times.
embodiment 2, granulation agent product, its compositing formula is counted by weight: 20 parts, Folium Mori, 60 parts, Fructus Momordicae charantiae, 25 parts of Herba Lophatheris, 15 parts of the Radixs Astragali.
preparation method, concrete steps are as follows:
(1) take through cleaning the Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri, the Radix Astragali that dry and be placed in container in component ratio, add the clear water of 10 times of inventories, with being steam heated to 95~105 DEG C, be incubated and decoct for 2 hours, be press-filtered out decoction liquor with filter press, filtering residue adds water and decocts equally, so repeats to decoct, filter decoction liquor 3 times;
(2) merging filtrate heating is condensed into extractum, and controlling the relative density of extractum at 60 DEG C is 0.8~1.0;
(3) make extract powder by dry extractum spraying, extract powder is crossed 80 mesh sieves, water content < 5%;
(4) get extract powder and through pulverizing the dextrin of 100 mesh sieves, the consumption of dextrin is 0.4~0.5 times of extract powder amount, the method of progressively increasing by equivalent is put mix homogeneously in blender, adding 75% ethanol wet-method extrusion granulates, then dry, granule water content < 5%, crosses 14 mesh sieve granulate, pouch-packaged.
embodiment 3, makes capsule product, and its compositing formula is counted by weight: 30 parts, Folium Mori, 45 parts, Fructus Momordicae charantiae, 5 parts of Herba Lophatheris, 40 parts of the Radixs Astragali.
preparation method, concrete steps are as follows:
(1) take through cleaning the Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri, the Radix Astragali that dry and be placed in container in component ratio, add the clear water of 12 times of inventories, with being steam heated to 95~105 DEG C, be incubated and decoct for 3 hours, be press-filtered out decoction liquor with filter press, filtering residue adds water and decocts equally, so repeats to decoct, filter decoction liquor 3 times;
(2) merging filtrate heating is condensed into extractum, and controlling the relative density of extractum at 60 DEG C is 0.8~1.0;
(3) make extract powder by dry extractum spraying, extract powder is crossed 80 mesh sieves, water content < 5%;
(4) get extract powder and add 75% ethanol wet-method extrusion granulation, then at 55~60 DEG C, dry, granule water content < 5%, crosses 40 mesh sieve granulate;
(5) granule after granulate is passed through to capsule filling machine fill, capsule polishing in polishing machine that fill is good, rejects damaged capsule, packaging into products.
embodiment 4, makes oral liquid product, and its compositing formula is counted by weight: 50 parts, Folium Mori, 20 parts, Fructus Momordicae charantiae, 45 parts of Herba Lophatheris, 5 parts of the Radixs Astragali.
preparation method, concrete steps are as follows:
(1) take through cleaning the Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri, the Radix Astragali that dry and be placed in container in component ratio, add the clear water of 16 times of inventories, with being steam heated to 95~105 DEG C, be incubated and decoct for 2.5 hours, be press-filtered out decoction liquor with filter press, filtering residue adds water and decocts equally, so repeats to decoct, filter decoction liquor 3 times;
(2) merging filtrate heating is condensed into extractum, and controlling the relative density of extractum at 60 DEG C is 0.8~1.0;
(3) make extract powder by dry extractum spraying, extract powder is crossed 80 mesh sieves, water content < 5%;
(4) get the pure water that extract powder adds 6~15 times and fully stir, be dissolved into oral liquid, be filled in the Packaging Bottle of certain specification amount, oral liquid product.In oral liquid, also can add appropriate vitamin C.
embodiment 5, makes tablet product, and its compositing formula is counted by weight: 65 parts, Folium Mori, 10 parts, Fructus Momordicae charantiae, 10 parts of Herba Lophatheris, 35 parts of the Radixs Astragali.
preparation method, concrete steps are as follows:
(1) take through cleaning the Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri, the Radix Astragali that dry and be placed in container in component ratio, add the clear water of 13 times of inventories, with being steam heated to 95~105 DEG C, be incubated and decoct for 2 hours, be press-filtered out decoction liquor with filter press, filtering residue adds water and decocts equally, so repeats to decoct, filter decoction liquor 3 times;
(2) merging filtrate heating is condensed into extractum, and controlling the relative density of extractum at 60 DEG C is 0.8~1.0;
(3) make extract powder by dry extractum spraying, extract powder is crossed 80 mesh sieves, water content < 5%;
(4) get extract powder and be hydrolyzed through the textile fiber of pulverizing 100 mesh sieves the microcrystalline Cellulose making, the method of progressively increasing by equivalent is put mix homogeneously in blender, adds 75% ethanol wet-method extrusion and granulates, and then dries, granule water content < 5%, crosses 20 mesh sieve granulate;
(5) magnesium stearate is crossed to 100 mesh sieves, then taken the magnesium stearate after sieving in the ratio of above-mentioned inventory 5 ‰, fully mix homogeneously with the prepared particulate material of step (4), deliver to tablet machine and be pressed into tablet;
(6) by molding tablet spray coating solution oven dry, obtain product.
Claims (1)
1. one kind has the preparation method of the health product of auxiliary hyperglycemic function, it is characterized in that, the health product with auxiliary hyperglycemic function are primary raw material by Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri and the Radix Astragali, and its proportioning is counted by weight: 40 parts, Folium Mori, 40 parts, Fructus Momordicae charantiae, 18 parts of Herba Lophatheris, 24 parts of the Radixs Astragali;
Concrete steps are as follows:
(1) take through cleaning the Folium Mori, Fructus Momordicae charantiae, Herba Lophatheri, the Radix Astragali that dry and be placed in container in component ratio, add the clear water of 10~16 times of inventories, be heated to 95~105 DEG C, be incubated and decoct for 2~3 hours, filter out decoction liquor, filtering residue adds water and decocts equally, so repeats to decoct, filter decoction liquor 2~3 times;
(2) merging filtrate heating is condensed into extractum;
(3) by the dry extractum spraying extract powder of making;
(4) extract powder is processed into the product of granule or tablet, capsule, oral liquid formulation
.
2
.the preparation method of the health product with auxiliary hyperglycemic function according to claim 1, is characterized in that the relative density of described extractum at 60 DEG C is 0.8~1.0.
3. the preparation method of the health product with auxiliary hyperglycemic function according to claim 1, the processing method that it is characterized in that described tablet is: get described extract powder and through pulverizing the microcrystalline Cellulose of 100 mesh sieves, the consumption of microcrystalline Cellulose is 0.4~0.5 times of extract powder amount, the method that two materials are progressively increased by equivalent adds mix homogeneously in blender, adding binding agent wet-method extrusion granulates, then dry, control pellet moisture < 5%, then add the magnesium stearate bulk material of inventory 5 ‰, mix rear tabletting, obtain tablet finished product.
4. the preparation method of the health product with auxiliary hyperglycemic function according to claim 3, is characterized in that described microcrystalline Cellulose is that textile fiber is hydrolyzed the microcrystalline Cellulose making.
5
.the preparation method of the health product with auxiliary hyperglycemic function according to claim 1, the processing method that it is characterized in that described granule is: get extract powder and through pulverizing the dextrin of 100 mesh sieves, the consumption of dextrin is 0.4~0.5 times of extract powder amount, the method of progressively increasing by equivalent is put mix homogeneously in blender, adding additives wet-method extrusion is granulated, and then dries granule water content < 5%, cross 14 mesh sieve granulate, pouch-packaged.
6
.the preparation method of the health product with auxiliary hyperglycemic function according to claim 1, the processing method that it is characterized in that described capsule is: described extract powder is added to suitable amount of adhesive wet granulation, wet granular is in 55~60 DEG C of oven dry, make its moisture content be less than 5%, then cross 40 mesh sieve granulate, the granule after granulate is by capsule filling machine fill, capsule polishing in polishing machine that fill is good, reject damaged capsule, packaging into products.
7
.the preparation method of the health product with auxiliary hyperglycemic function according to claim 1, the processing method that it is characterized in that described oral liquid is: get the pure water that described extract powder adds 6~15 times and fully stir, be dissolved into oral liquid, Packaging Bottle packaging, adds appropriate vitamin C in oral liquid.
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CN106722918A (en) * | 2015-11-25 | 2017-05-31 | 北京华昱安然医药科技有限公司 | A kind of hypoglycemia healthcare food and preparation method thereof |
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