CN102552699A - Preparation method of dendrobium candidum ultrafine powder - Google Patents
Preparation method of dendrobium candidum ultrafine powder Download PDFInfo
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- CN102552699A CN102552699A CN2012100129901A CN201210012990A CN102552699A CN 102552699 A CN102552699 A CN 102552699A CN 2012100129901 A CN2012100129901 A CN 2012100129901A CN 201210012990 A CN201210012990 A CN 201210012990A CN 102552699 A CN102552699 A CN 102552699A
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- herba dendrobii
- dendrobium candidum
- superfine powder
- ultrafine powder
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Abstract
The invention discloses a preparation method of dendrobium candidum ultrafine powder. The method comprises the following specific steps of: (1) cleaning fresh dendrobium candidum stalks, and draining; (2) putting drained dendrobium candidum into freeze drying equipment, pre-freezing at the temperature of between 30 DEG C below zero+/-5 DEG C for 1-3 hours, and preserving heat for 2-4 hours when the temperature falls to 35 DEG C below zero; and (3) under the condition of low temperature, smashing the dried dendrobium candidum with a nanometer mechanical smasher to obtain nanoparticles, wherein 95 percent of particle sizes are distributed between 100 nanometers and 500 nanometers, and ultrafine powder is obtained till complete wall breaking is realized; and a nanometer smashing ultrafine powder technology is free from the defect of incomplete extraction, and is an optimal all-natural all-component preparation method. Due to the adoption of a modern nanometer solid dispersing technology, the solubility of a Chinese medicine is increased greatly, a quick acting characteristic is achieved, and the bioavailability is enhanced completely.
Description
Technical field
The present invention relates to a kind of method for preparing of superfine powder, a kind of specifically method for preparing of Herba Dendrobii superfine powder.
Background technology
Herba Dendrobii Dendrobium officinale Kimura et Migo is a orchid family Dendrobium plant, is China tradition rare Chinese medicine, and poor growth under the natural conditions, self-reproduction ability are extremely low, because long-term predatoriness is excavated, cause wild resource seriously exhausted.Herba Dendrobii is a orchid family Dendrobium herbaceos perennial, and the another name Herba hedyotis costatae is a kind of precious Chinese medicine plant that is distributed in karst area, the laudatory title that " help Herba mesonae chinensis ", " Chinese Herba mesonae chinensis " are arranged among the people.The Herba Dendrobii chemical constituent is various, mainly contains alkaloid, polysaccharide, aminoacid, luxuriant and rich with fragrance compounds chemical compound etc.Pharmacological research proof Herba Dendrobii has effects such as defying age, antitumor, blood sugar lowering, raising immunologic function, in diseases such as treatment malignant tumor, gastroenteropathy, diabetes, cataract, arthritis, thromboangiitis obliterans and chronic pharyngitiss better curative effect is arranged.
Because it is long-time that the bright article of Herba Dendrobii should not be preserved, existing Herba Dendrobii is edible not to be easily, the most effective active compositions that especially contain; Like Organic substances such as polysaccharide, aminoacid, vitamin, trace element; How water insoluble or only be slightly soluble in water, wherein a large amount of polysaccharide component viscosity ratios are bigger in addition, adopt the common breaking method can't micronization; Cause its a large amount of effective active composition fully not absorbed, waste bigger by human body.
Nanotechnology is that unprecedented chance has been created in the transformation of Chinese medicine industry; Nanometer Chinese medicine penetrates the characteristics such as quick-acting, efficient, long-acting and targeted therapy of dynamics with its original high-dissolvability, high trap, high absorption dynamics, high bioavailability, height, represents modernization of industry of Chinese materia medica radiance prospect.
Summary of the invention
The present invention aims to provide a kind of method for preparing of Herba Dendrobii superfine powder, makes the nutritional labeling of Herba Dendrobii more be prone to stripping, is beneficial to absorption of human body.
The object of the invention can be realized through following technical scheme.
A kind of method for preparing of Herba Dendrobii superfine powder, specifically adopt following steps:
1) the bright article stem of Herba Dendrobii section is cleaned, drained away the water;
2) Herba Dendrobii that drains away the water is placed freeze drying equipment, at-30 ± 5 ℃ of pre-freeze 1-3h, when temperature drops to-35 ℃, constant temperature 2-4h;
3) under cryogenic situation, the Herba Dendrobii that drying is crossed is pulverized with the nano-machine pulverizer, be prepared into nano-particle; Particle size 95% is distributed between the 100-500nm, reaches full breaking cellular wall, promptly gets superfine powder;
The superfine powder of gained is carried out cobalt 60 radiation sterilizations, can obtain the Herba Dendrobii superfine powder.Be convenient to preservation.
Research knows that all component contents of Herba Dendrobii are very unrealistic.This just requires, and it be unclear that under the situation of all chemical constituents, should keep the essence of its original All Pure Nature, whole part.And nano-pulverization superfine powder technology does not have the infull anxiety of extraction, is the best method for preparing of All Pure Nature, whole part.Adopt modern nano-solid dispersion technology, increased substantially the Chinese medicine dissolution and have quick-acting characteristics, fully improved bioavailability.
The specific embodiment
Further set forth technical characterstic of the present invention below in conjunction with specific embodiment.
Embodiment 1
1. the bright article stem of Herba Dendrobii section is cleaned, drained away the water;
2. the Herba Dendrobii that drains away the water is placed freeze drying equipment, at-28 ℃ of left and right sides pre-freeze 3h, when temperature drops to-35 ℃, constant temperature 4h.
3. under cryogenic situation, the Herba Dendrobii that drying is crossed is pulverized with the nano-machine pulverizer, be prepared into nano-particle; Particle size 95% is distributed between the 200-500nm, reaches full breaking cellular wall.
4. the superfine powder with gained carries out cobalt 60 radiation sterilizations, can obtain the Herba Dendrobii superfine powder.
Embodiment 2
1. the bright article stem of Herba Dendrobii section is cleaned, drained away the water.
2. the Herba Dendrobii that drains away the water is placed freeze drying equipment, at-30 ℃ of pre-freeze 2h, when temperature drops to-35 ℃, constant temperature 3h.
3. under cryogenic situation, the Herba Dendrobii that drying is crossed is pulverized with the nano-machine pulverizer, be prepared into nano-particle; Particle size 95% is distributed between the 200-400nm, reaches full breaking cellular wall.
4. the superfine powder with gained carries out cobalt 60 radiation sterilizations, can obtain being convenient to the Herba Dendrobii superfine powder of preservation.
Embodiment 3
1. the bright article stem of Herba Dendrobii section is cleaned, drained away the water;
2. the Herba Dendrobii that drains away the water is placed freeze drying equipment, at-33 ℃ of left and right sides pre-freeze 1h, when temperature drops to-35 ℃, constant temperature 2h.
3. under cryogenic situation, the Herba Dendrobii that drying is crossed is pulverized with the nano-machine pulverizer, be prepared into nano-particle; Particle size 95% is distributed between the 100-500nm, reaches full breaking cellular wall.
4. the superfine powder with gained carries out cobalt 60 radiation sterilizations, can obtain the Herba Dendrobii superfine powder.
Claims (2)
1. the method for preparing of a Herba Dendrobii superfine powder, it is characterized in that: concrete steps are following:
1) the bright article stem of Herba Dendrobii section is cleaned, drained away the water;
2) Herba Dendrobii that drains away the water is placed freeze drying equipment, at-30 ± 5 ℃ of pre-freeze 1-3h, when temperature drops to-35 ℃, constant temperature 2-4h;
3) under cryogenic situation, the Herba Dendrobii that drying is crossed is pulverized with the nano-machine pulverizer, be prepared into nano-particle; Particle size 95% is distributed between the 100-500nm, reaches full breaking cellular wall, promptly gets superfine powder.
2. the method for preparing of Herba Dendrobii superfine powder according to claim 1 is characterized in that: the superfine powder of gained is carried out cobalt 60 radiation sterilizations.
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| CN2012100129901A CN102552699A (en) | 2012-01-16 | 2012-01-16 | Preparation method of dendrobium candidum ultrafine powder |
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| CN2012100129901A CN102552699A (en) | 2012-01-16 | 2012-01-16 | Preparation method of dendrobium candidum ultrafine powder |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191311A (en) * | 2013-04-22 | 2013-07-10 | 丽水学院 | Preparation method of dendrobium officinale super-micropowder |
| CN103285242A (en) * | 2013-05-23 | 2013-09-11 | 重庆市中药研究院 | Dendrobium buccal tablets and preparation method for same |
| CN103301322A (en) * | 2013-06-01 | 2013-09-18 | 普洱淞茂制药股份有限公司 | Dendrobium ultramicro-pure powder, as well as preparation method and preparation thereof |
| CN103735857A (en) * | 2013-12-18 | 2014-04-23 | 广西健宝石斛有限责任公司 | Application of Dendrobium officinale fruit extract in preparing medicines for treating pharyngitis |
| CN103920013A (en) * | 2014-04-02 | 2014-07-16 | 浙江亚林生物科技股份有限公司 | Preparation method of dendrobium officinale ultramicro wall-broken powder |
| CN103920012A (en) * | 2014-04-01 | 2014-07-16 | 安徽源牌实业（集团）有限责任公司 | Dendrobe pure micro-powder buccal tablet and preparation method thereof |
| CN104432012A (en) * | 2013-09-16 | 2015-03-25 | 江苏天润本草生命科技有限公司 | Dendrobium compound superfine powder and preparation method thereof |
| CN104435743A (en) * | 2014-06-10 | 2015-03-25 | 武义寿仙谷中药饮片有限公司 | Method for preparing dendrobium officinale super micropowder |
| CN106138747A (en) * | 2015-03-09 | 2016-11-23 | 陈亚海 | Herba Dendrobii dispersible tablet and preparation technology thereof |
| CN108096086A (en) * | 2016-11-25 | 2018-06-01 | 深圳市弘创农业科技有限公司 | A kind of method that the ice plant extract without preservative is prepared using ice plant freeze-dried powder |
| CN109223982A (en) * | 2018-11-14 | 2019-01-18 | 湖南衡岳中药饮片有限公司 | A kind of processing method of bletilla powder |
| CN109876093A (en) * | 2019-04-08 | 2019-06-14 | 浙江中医药大学 | Dendrobium candidum is applied in the product of preparation prevention or treatment endotoxemia |
| CN113577202A (en) * | 2021-09-13 | 2021-11-02 | 浙江理工大学 | Dendrobium officinale composition for treating diabetes and preparation method and application thereof |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191311B (en) * | 2013-04-22 | 2015-08-12 | 丽水学院 | The preparation method of dendrobium candidum ultrafine powder |
| CN103191311A (en) * | 2013-04-22 | 2013-07-10 | 丽水学院 | Preparation method of dendrobium officinale super-micropowder |
| CN103285242A (en) * | 2013-05-23 | 2013-09-11 | 重庆市中药研究院 | Dendrobium buccal tablets and preparation method for same |
| CN103285242B (en) * | 2013-05-23 | 2016-01-27 | 重庆市中药研究院 | Herba Dendrobii buccal tablet and preparation method thereof |
| CN103301322A (en) * | 2013-06-01 | 2013-09-18 | 普洱淞茂制药股份有限公司 | Dendrobium ultramicro-pure powder, as well as preparation method and preparation thereof |
| CN104432012B (en) * | 2013-09-16 | 2016-06-01 | 江苏天润本草生命科技有限公司 | A kind of stem of noble dendrobium composite superfine powder and its preparation method |
| CN104432012A (en) * | 2013-09-16 | 2015-03-25 | 江苏天润本草生命科技有限公司 | Dendrobium compound superfine powder and preparation method thereof |
| CN103735857B (en) * | 2013-12-18 | 2017-01-04 | 广西健宝石斛有限责任公司 | The application in preparation treatment pharyngitis medicine of the Dendrobium officinale fruit extract |
| CN103735857A (en) * | 2013-12-18 | 2014-04-23 | 广西健宝石斛有限责任公司 | Application of Dendrobium officinale fruit extract in preparing medicines for treating pharyngitis |
| CN103920012A (en) * | 2014-04-01 | 2014-07-16 | 安徽源牌实业（集团）有限责任公司 | Dendrobe pure micro-powder buccal tablet and preparation method thereof |
| CN103920013A (en) * | 2014-04-02 | 2014-07-16 | 浙江亚林生物科技股份有限公司 | Preparation method of dendrobium officinale ultramicro wall-broken powder |
| CN104435743A (en) * | 2014-06-10 | 2015-03-25 | 武义寿仙谷中药饮片有限公司 | Method for preparing dendrobium officinale super micropowder |
| CN104435743B (en) * | 2014-06-10 | 2018-06-19 | 武义寿仙谷中药饮片有限公司 | A kind of preparation method of dendrobium candidum ultrafine powder |
| CN106138747A (en) * | 2015-03-09 | 2016-11-23 | 陈亚海 | Herba Dendrobii dispersible tablet and preparation technology thereof |
| CN108096086A (en) * | 2016-11-25 | 2018-06-01 | 深圳市弘创农业科技有限公司 | A kind of method that the ice plant extract without preservative is prepared using ice plant freeze-dried powder |
| CN109223982A (en) * | 2018-11-14 | 2019-01-18 | 湖南衡岳中药饮片有限公司 | A kind of processing method of bletilla powder |
| CN109876093A (en) * | 2019-04-08 | 2019-06-14 | 浙江中医药大学 | Dendrobium candidum is applied in the product of preparation prevention or treatment endotoxemia |
| CN113577202A (en) * | 2021-09-13 | 2021-11-02 | 浙江理工大学 | Dendrobium officinale composition for treating diabetes and preparation method and application thereof |
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Application publication date: 20120711 |