CN102552520B - Blood circulation-promoting and pain-stopping medicament and preparation process and application thereof - Google Patents
Blood circulation-promoting and pain-stopping medicament and preparation process and application thereof Download PDFInfo
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Abstract
The invention relates to a blood circulation-promoting and pain-stopping capsule, a preparation method and an application thereof. The medicament consists of the following bulk pharmaceuticals in parts by weight: 12-18 parts of Chinese angelica, 12-18 parts of rehmannia root, 6-10 parts of officinal magnolia bark, 6-10 parts of cassia twig, 8-12 parts of szechuan lovage rhizome, 12-18 parts of tree peony root-bark, 8-12 parts of sargentg loryvine stem, 8-12 parts of corydalis tuber, 8-12 parts of safflower, 6-10 parts of immature bitter orange, 8-12 parts of red paeony root, 8-12 parts of fortune's drynaria rhizome and 3-5 parts of borneol. A preparation process of the medicament comprises the following steps of: smashing 3-5 parts by weight of borneol into fine powder of 120-150 meshes; smashing other medicinal materials except borneol into fine powder of 20-40 meshes, and performing ethanol extraction to obtain ethanol extract fine powder; and uniformly mixing the products. After the medicinal materials are used together, the effects of promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain are achieved; and the form of the medicine is capsule. The medicament is used for treating symptoms such as chest stuffiness and pains and the like caused by blood stasis in chest and obstruction of the blood circulation. The total effective rate is 90.3 percent.
Description
Technical field
The present invention relates to a kind of promoting blood circulation and stopping pain medicine and preparation technology and application for the treatment of obstruction of qi in the chest and cardialgia, be particularly related to a kind for the treatment of obstruction of qi in the chest and cardialgia due to blood stasis, hematogenous blockage in the heart, there is Chinese medicine composition and preparation technology and the application of promoting blood circulation and stopping pain effect, belong to technical field of Chinese medicines.
Background technology
Obstruction of qi in the chest and cardialgia refers to suffocating pain over the chest a kind of disease that very chest pain radiating to the back is losed heart, failing to sleep due to dyspnea is primary symptom.The lighter only feels uncomfortable in chest as stops up, and breathes and owes smooth; Severe one has chest pain; Severe patient chest pain radiating to the back, backache radiating to the heart.Along with the change of modern society's life style and dietary structure, morbidity has the trend increasing gradually, thereby primary disease more and more causes people's attention.Because obstruction of qi in the chest and cardialgia shows as deficiency in origin and excess in superficiality, have complicated clinical manifestation and pathological change, and Chinese medicine is from integral body, has the advantage of comprehensive function, thereby is paid close attention to widely.As: name is called < < Chinese medicine preparation for the treatment of obstruction of qi in the chest and cardialgia and preparation method thereof > > CN200610138675.8, by the extract of the Benexate Hydrochloride of Chinese medicine Flos Caryophylli volatile oil, Lactiflora, Fructus Choerospondiatis, Herba Erigerontis, Semen Persicae, Flos Caryophylli and Borneolum Syntheticum, being active component etc. forms, there is good blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain function, coronary heart disease is belonged to venation block pattern of syndrome person good therapeutical effect.However, in prior art, to treating the obstruction of qi in the chest and cardialgia due to blood stasis, hematogenous blockage in the heart, the curative effect with the Chinese medicine composition of promoting blood circulation and stopping pain effect needs further to be improved.
Summary of the invention
Therefore, people are for the obstruction of qi in the chest and cardialgia for the treatment of due to blood stasis, hematogenous blockage in the heart, and the Chinese medicine composition with the promoting blood circulation and stopping pain effect of better curative effect still exists demand.Up to the present, not yet find to destroy the data of novelty of the present invention, present inventor people is by clinical practice, a large amount of clinical datas have been collected, obtained treating the obstruction of qi in the chest and cardialgia due to blood stasis, hematogenous blockage in the heart, there is the Chinese medicine composition of the better curative effect of promoting blood circulation and stopping pain effect, thereby completed the present invention.
Object of the present invention is exactly that a kind for the treatment of with better curative effect obstruction of qi in the chest and cardialgia due to blood stasis, hematogenous blockage in the heart will be provided, and has Chinese medicine composition and preparation technology and the application of promoting blood circulation and stopping pain effect.
Technical solution of the present invention one: it is comprised of the crude drug of following weight portion: 12-18 parts of Radix Angelicae Sinensis, 12-18 parts, the Radix Rehmanniae, 6-10 parts of Cortex Magnoliae Officinalis, 6-10 parts of Ramulus Cinnamomi, 8-12 parts of Rhizoma Chuanxiongs, 12-18 parts of Cortex Moutans, 8-12 parts of DAHUOXUE, 8-12 parts of Rhizoma Corydalis, 8-12 parts, Flos Carthami, 6-10 parts of Fructus Aurantii Immaturuss, 8-12 parts of Radix Paeoniae Rubra, 8-12 parts of Rhizoma Drynariae, 3-5 parts of Borneolum Syntheticums.
Preferred: it is comprised of the crude drug of following weight portion: 15 parts of Radix Angelicae Sinensis, 15 parts, the Radix Rehmanniae, 8 parts of Cortex Magnoliae Officinalis, 8 parts of Ramulus Cinnamomi, 10 parts of Rhizoma Chuanxiongs, 15 parts of Cortex Moutans, 10 parts of DAHUOXUE, 10 parts of Rhizoma Corydalis, 10 parts, Flos Carthami, 8 parts of Fructus Aurantii Immaturuss, 10 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
Technical solution of the present invention two: this preparation technology comprises the steps:
A. proportioning weighting raw materials by weight;
B. the Borneolum Syntheticum powder of getting described weight portion is broken into 120-150 object fine powders; Standby;
C. get the medical material outside described Borneolum Syntheticum, be ground into 20-40 object fine powders, the alcohol reflux that the concentration that adds 6-10 times of amounts of its weight is 50-70% 1-3 times, each 1-2 hours, standing 12-48 hours, filter, filtrate decompression is concentrated into the clear paste that 40 ℃ of relative densities are 1.10-1.30, and vacuum drying is ground into 120-150 object fine powders, obtain ethanol extract fine powder, standby;
D. 120-150 object fine powders that Borneolum Syntheticum powder are broken into, and ethanol extract fine powder mix homogeneously, obtain.
Technical solution of the present invention three: this promoting blood circulation and stopping pain medicine has following dosage form: pill, capsule, granule, tablet, oral liquid.
Technical solution of the present invention four: the application of described a kind of promoting blood circulation and stopping pain medicine for the treatment of obstruction of qi in the chest and cardialgia in preparation promoting blood circulation and stopping pain medicine.
Described a kind of promoting blood circulation and stopping pain medicine for the treatment of obstruction of qi in the chest and cardialgia is in the application for the preparation for the treatment of in the medicine of the obstruction of qi in the chest and cardialgia due to blood stasis, hematogenous blockage in the heart.
Preparation technology is in the situation that meet the specification requirement > > of < < new Chinese medicine Study on Preparation, the effective constituent that mainly contains that uses modern new agent technology to extract Chinese medicine composition is used as medicine, add some accessory substances, as water, sugar, starch etc., also exist other method to make pill, capsule, granule, tablet, oral liquid.
In the present invention: Rhizoma Chuanxiong, Flos Carthami, DAHUOXUE, Cortex Moutan, Rhizoma Drynariae, Rhizoma Corydalis blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain; Radix Angelicae Sinensis, Radix Paeoniae Rubra nourshing blood and promoting blood circulation; Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Ramulus Cinnamomi circulation of qi promoting warming middle-JIAO, dispersing cold for relieving pain; Radix Rehmanniae is joined Chinese Angelica blood replonishing and blood, makes blood stasis dispelling and non-impairment of YIN blood; Borneolum Syntheticum clearing away heat to alleviate pain.All medicines share, and play altogether synthetic blood circulation promoting and blood stasis dispelling, the merit of promoting the circulation of QI to relieve pain.Be used for the treatment of the diseases such as obstruction of qi in the chest and cardialgia due to blood stasis, hematogenous blockage in the heart.
The specific embodiment
The present invention can specifically implement by the technical scheme illustrating in summary of the invention, test and embodiment is described further, yet scope of the present invention is not limited to following embodiment by following clinical observation.
Clinical observation on the therapeutic effect data
1, clinical data:
1.1 physical data: this group amounts to 294 routine coronary atherosclerotic heart disease patients and is my Out-patient Department and inpatient, male 166 examples wherein, female's 128 examples; 31-50 years old 49 examples, 51-65 years old 133 example, over-65s 112 examples; The oldest 86 years old, minimum 32 years old of age.With reference to demonstrate,proving the diagnosis basis that marquis's type is type of obstruction of heart-blood in < < disease of tcm Standardization of diagnosis and curative effect > > obstruction of qi in the chest and cardialgia.At random all cases are divided into two groups, treatment group 167 examples, male 94 examples, female's 73 examples; Matched group 127 examples, male 72 examples, female's 55 examples; Two groups of patients learn processing by statistics at aspects such as sex, age, the course of disease, the state of an illness, and difference nonsignificance, has comparability.When being admitted to hospital, all record the situations such as its electrocardiogram, blood pressure, heart rate, blood fat, hepatic and renal function.
1.2 Therapeutic Method: matched group gives isosorbide mononitrate; Treatment group is with blood circulation promoting and blood stasis dispelling, and promoting the circulation of QI to relieve pain are method for the treatment of.Prescription adjusts accordingly in following scope endogenous cause of ill symptom:
It is comprised of the crude drug of following weight portion: 12-18 parts of Radix Angelicae Sinensis, 12-18 parts, the Radix Rehmanniae, 6-10 parts of Cortex Magnoliae Officinalis, 6-10 parts of Ramulus Cinnamomi, 8-12 parts of Rhizoma Chuanxiongs, 12-18 parts of Cortex Moutans, 8-12 parts of DAHUOXUE, 8-12 parts of Rhizoma Corydalis, 8-12 parts, Flos Carthami, 6-10 parts of Fructus Aurantii Immaturuss, 8-12 parts of Radix Paeoniae Rubra, 8-12 parts of Rhizoma Drynariae, 3-5 parts of Borneolum Syntheticums.Preparation technology adopts the technique in technical solution of the present invention two.
During treating, two groups of patients all stop using, and other resist myocardial ischemia and anticoagulant, but sublingual administration nitroglycerine tablets temporarily during angina pectoris attacks, and the person that has other diseases concurrently continues to apply related drugs and treats.Capsule, every fills 0.5 gram with warm water delivery service.One time 3,2 times on the one.Continuous use 1 month, checks the situations such as patient's electrocardiogram, blood pressure, heart rate, blood fat, hepatic and renal function again.
1.3 curative effect determinate standards are according to the efficacy assessment standard evaluation of obstruction of qi in the chest and cardialgia in the < < of State Administration of Traditional Chinese Medicine disease of tcm Standardization of diagnosis and curative effect > >.
1. cure: transference cure, it is normal that electrocardiogram and relevant lab testing recover;
2. take a turn for the better: symptom alleviates, attack times reduces, and the intermission extends, and lab testing is improved;
3. do not heal: cardinal symptom and electrocardiogram are without change.
1.4 statistical methods adopt
tcheck and
x 2check.
2, result
The comparison of two groups of patient clinical curative effects, effective 48 examples in treatment group 167 examples, effective 103 examples, invalid 16 examples, total effective rate is 90.3%; Effective 75 examples in matched group 127 examples, effective 39 examples, invalid 13 examples, total effective rate 89.8%.Epidemiological Analysis by statistics, treatment group and matched group on clinical efficacy relatively there was no significant difference (
p > 0.05).But by check result, shown, treatment group patient is after treatment in 1 month, and the clinical effectiveness that its blood viscosity and blood lipid level improve is obviously better than matched group.
Embodiment 1: it is comprised of the crude drug of following weight portion: 15 parts of Radix Angelicae Sinensis, 15 parts, the Radix Rehmanniae, 8 parts of Cortex Magnoliae Officinalis, 8 parts of Ramulus Cinnamomi, 10 parts of Rhizoma Chuanxiongs, 15 parts of Cortex Moutans, 10 parts of DAHUOXUE, 10 parts of Rhizoma Corydalis, 10 parts, Flos Carthami, 8 parts of Fructus Aurantii Immaturuss, 10 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
This preparation technology comprises the steps:
A. proportioning weighting raw materials by weight;
B. the Borneolum Syntheticum powder of getting described weight portion is broken into 120-150 object fine powders; Standby;
C. get the medical material outside described Borneolum Syntheticum, be ground into 20-40 object fine powders, the alcohol reflux that the concentration that adds 6-10 times of amounts of its weight is 50-70% 1-3 times, each 1-2 hours, standing 12-48 hours, filter, filtrate decompression is concentrated into the clear paste that 40 ℃ of relative densities are 1.10-1.30, and vacuum drying is ground into 120-150 object fine powders, obtain ethanol extract fine powder, standby;
D. 120-150 object fine powders that Borneolum Syntheticum powder are broken into, and ethanol extract fine powder mix homogeneously, obtain.
Embodiment 2: it is comprised of the crude drug of following weight portion: 12 parts of Radix Angelicae Sinensis, 18 parts, the Radix Rehmanniae, 6 parts of Cortex Magnoliae Officinalis, 10 parts of Ramulus Cinnamomi, 8 parts of Rhizoma Chuanxiongs, 18 parts of Cortex Moutans, 8 parts of DAHUOXUE, 12 parts of Rhizoma Corydalis, 8 parts, Flos Carthami, 10 parts of Fructus Aurantii Immaturuss, 8 parts of Radix Paeoniae Rubra, 12 parts of Rhizoma Drynariae, 3 parts of Borneolum Syntheticums.
Preparation technology adopts the technique of embodiment 1.
Embodiment 3: it is comprised of the crude drug of following weight portion: 18 parts of Radix Angelicae Sinensis, 12 parts, the Radix Rehmanniae, 10 parts of Cortex Magnoliae Officinalis, 6 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs, 12 parts of Cortex Moutans, 12 parts of DAHUOXUE, 8 parts of Rhizoma Corydalis, 12 parts, Flos Carthami, 6 parts of Fructus Aurantii Immaturuss, 12 parts of Radix Paeoniae Rubra, 8 parts of Rhizoma Drynariae, 5 parts of Borneolum Syntheticums.
Preparation technology adopts the technique of embodiment 1.
Embodiment 4: it is comprised of the crude drug of following weight portion: 12 parts of Radix Angelicae Sinensis, 12 parts, the Radix Rehmanniae, 6 parts of Cortex Magnoliae Officinalis, 6 parts of Ramulus Cinnamomi, 8 parts of Rhizoma Chuanxiongs, 12 parts of Cortex Moutans, 8 parts of DAHUOXUE, 8 parts of Rhizoma Corydalis, 8 parts, Flos Carthami, 6 parts of Fructus Aurantii Immaturuss, 8 parts of Radix Paeoniae Rubra, 8 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
Preparation technology adopts the technique of embodiment 1.
Embodiment 5: it is comprised of the crude drug of following weight portion: 18 parts of Radix Angelicae Sinensis, 18 parts, the Radix Rehmanniae, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs, 18 parts of Cortex Moutans, 12 parts of DAHUOXUE, 12 parts of Rhizoma Corydalis, 12 parts, Flos Carthami, 10 parts of Fructus Aurantii Immaturuss, 12 parts of Radix Paeoniae Rubra, 12 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
Preparation technology adopts the technique of embodiment 1.
Claims (2)
1. a preparation technology for HUOXUE ZHIRONG JIAONANG, is characterized in that this preparation technology comprises the steps:
A. proportioning weighting raw materials by weight: 12-18 parts of Radix Angelicae Sinensis, 12-18 parts, the Radix Rehmanniae, 6-10 parts of Cortex Magnoliae Officinalis, 6-10 parts of Ramulus Cinnamomi, 8-12 parts of Rhizoma Chuanxiongs, 12-18 parts of Cortex Moutans, 8-12 parts of DAHUOXUE, 8-12 parts of Rhizoma Corydalis, 8-12 parts, Flos Carthami, 6-10 parts of Fructus Aurantii Immaturuss, 8-12 parts of Radix Paeoniae Rubra, 8-12 parts of Rhizoma Drynariae, 3-5 parts of Borneolum Syntheticums;
B. the Borneolum Syntheticum powder of getting described weight portion is broken into 120-150 object fine powders; Standby;
C. get the medical material outside described Borneolum Syntheticum, be ground into 20-40 object fine powders, the alcohol reflux that the concentration that adds 6-10 times of amounts of its weight is 50-70% 1-3 times, each 1-2 hours, standing 12-48 hours, filter, filtrate decompression is concentrated into the clear paste that 40 ℃ of relative densities are 1.10-1.30, and vacuum drying is ground into 120-150 object fine powders, obtain ethanol extract fine powder, standby;
D. 120-150 object fine powders that Borneolum Syntheticum powder are broken into, and ethanol extract fine powder mix homogeneously, obtain, and dosage form is capsule.
2. the promoting blood circulation and stopping pain medicine that prepared by the preparation technology of a kind of HUOXUE ZHIRONG JIAONANG according to claim 1 is in the application for the preparation for the treatment of in the medicine of the obstruction of qi in the chest and cardialgia due to blood stasis, hematogenous blockage in the heart.
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| CN104547875A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Traditional Chinese medicine for treating arteries and veins stasis type chest stuffiness and pain |
| CN104547972A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Chinese medicinal composition for treating heart and qi deficiency type chest stuffiness and pain |
| CN104547844A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Traditional Chinese medicine for treating chest stuffiness and pains with syndrome of yang deficiency and cold congelation and preparation method thereof |
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| CN1452997A (en) * | 2002-04-28 | 2003-11-05 | 咸阳步长医药科技发展有限公司 | Chinese patent medicine for treating coronary heart disease and angina pectoris |
| CN1296075C (en) * | 2003-09-12 | 2007-01-24 | 北京国仁堂医药科技发展有限公司 | Xuefu Zhuyu soft capsule and its preparation method |
| CN1943649A (en) * | 2006-11-10 | 2007-04-11 | 吴梅春 | A Chinese traditional medicine preparation for treating chest numb cardiodynia and its preparing method |
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| US20050037094A1 (en) * | 2003-07-31 | 2005-02-17 | Xijun Yan | Composition for heart disease, its active ingredients, method to prepare same and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1124153C (en) * | 2001-08-31 | 2003-10-15 | 石家庄以岭药业股份有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1452997A (en) * | 2002-04-28 | 2003-11-05 | 咸阳步长医药科技发展有限公司 | Chinese patent medicine for treating coronary heart disease and angina pectoris |
| CN1296075C (en) * | 2003-09-12 | 2007-01-24 | 北京国仁堂医药科技发展有限公司 | Xuefu Zhuyu soft capsule and its preparation method |
| CN1943649A (en) * | 2006-11-10 | 2007-04-11 | 吴梅春 | A Chinese traditional medicine preparation for treating chest numb cardiodynia and its preparing method |
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