CN102551674B - Needle with biological detecting function and application of needle - Google Patents
Needle with biological detecting function and application of needle Download PDFInfo
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- CN102551674B CN102551674B CN201210020697.XA CN201210020697A CN102551674B CN 102551674 B CN102551674 B CN 102551674B CN 201210020697 A CN201210020697 A CN 201210020697A CN 102551674 B CN102551674 B CN 102551674B
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- needle
- syringe needle
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- detecting function
- detection site
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Abstract
The invention discloses a needle with a biological detecting function and application of the needle. The needle comprises a needle body (1), and is characterized in that a biological detecting point (2) is arranged on the outer wall of the needle body (1). In the technical scheme, the biological detecting point is creatively arranged on the outer wall of the needle, biological indexes in blood and tissue fluid can be detected by means of analyzing the needle inserted into a human body, sufferings to patients in processes of blood drawing, fluid drawing and the like are avoided, and the needle brings convenience for medical staffs.
Description
Technical field
The invention belongs to medical device studying technological domain, be specifically related to a kind of syringe needle with biological detecting function.
Background technology
In the development course of the mankind, various disease emerges in an endless stream, and some disease even jeopardizes the health of the whole mankind.In order to defeat these difficulties, the Treatment and diagnosis of disease is most important.Along with the progressively enforcement of the Human Genome Project and human proteomics project, and the fast development of the related discipline such as molecular biology, the relation of a lot of biomolecule and human health status is illustrated.Some disease of human body just can be disclosed by analyzing corresponding biomarker molecule.
When using current biotechnology to carry out medical diagnosis on disease, mainly based on the concentration information of the biomarker molecule in blood, tear, saliva, urine and tissue fluid.In order to obtain these information, common way utilizes infusion needle, injection needle or piercing needle in the body of patient, directly extract corresponding liquid to carry out analyzed in vitro.This process, particularly extracts the process of blood, brings great misery to patient.In addition, because the impact of vitro and target are detected molecule low concentration in extracting liquid, final biomolecule detection often program is complicated, and accuracy is poor, and price is also extremely expensive.
Consider as patient palliates the agonizing sufferings, reduce expense, and simplify testing process, facilitate medical personnel, therefore, need to develop a kind of new Measurement for Biotechnique.The present invention therefore.
Summary of the invention
The object of the invention is to provide a kind of syringe needle with biological detecting function, makes patient in the process of transfusion, injectable drug, puncture or acupuncture, just can realize antibacterial in body, virus or biomolecule detection.Solve existing biotechnology in use to need extract blood and tissue fluid and bring misery to patient, bring the problem of work load to medical personnel.
In order to solve these problems of the prior art, technical scheme provided by the invention is:
There is a syringe needle for biological detecting function, comprise spike body, it is characterized in that the outer wall of described spike body is provided with biological detection site.
Preferably, described spike body is selected from common infusion needle body, retained transfusion spike body, injection needle body, piercing needle body or middle Medical acupuncture needle head body.
Preferably, described biological detection site is positioned at the local or whole of syringe needle outer wall, and described biological detection site is single or multiple.
Preferably, the spike body outer wall place of described biological detection site location is concave inward structure or flat structures.
Preferably, the biological detection site location of described syringe needle is fixed, and be fixed be selected from first, second, third, fourth, antibody to hepatitis E antigen, tumor marker, heart disease label, inflammatory factor, Treponema pallidum antigen antibody, acquired immune deficiency syndrome (AIDS) antigen-antibody, antibacterial play one or more combination in any of the probe molecule of specific reaction.
Another object of the present invention is to provide a kind of described application of the syringe needle with biological detecting function in biological disease detection.
Preferably, described method is when detecting, and described syringe needle inserts vein, tremulous pulse, abdominal cavity, muscle, subcutaneous, urethra, lachrymal gland, bone marrow, canalis spinalis or oral cavity and detects.
Preferably, described method when detecting, detection target be first, second, third, fourth, hepatitis E, tumor, heart disease, inflammation, syphilis, acquired immune deficiency syndrome (AIDS), one or more combination in any in septicemia.
Preferably, detect in described method and carry out in syringe needle insertosome internal procedure or carry out after syringe needle is extracted.
Preferably, in described method in syringe needle insertosome internal procedure, by detect the Raman spectrum of syringe needle, infrared spectrum, electrical impedance signal obtain biological detection information in body; Or after syringe needle is extracted, obtain biological detection information in body by one or more the combination during direct fluorescent marker method, euzymelinked immunosorbent assay (ELISA), nano gold mark method, immune turbidimetry, Raman spectrum detection, infrared spectrum detection, electrical impedance detect.
The spike body adopted in the present invention can be the acupuncture syringe needle of common infusion needle, retained transfusion syringe needle, injection needle, piercing needle or the traditional Chinese medical science.
Relative to scheme of the prior art, advantage of the present invention is:
The present invention by designing biological detection site on medical needle, makes the target substance detection that patient just can realize in the processes such as acupuncture and moxibustion therapy in organism in transfusion, administration or accept.Therefore, this syringe needle with biological detecting function avoids patient and to draw blood the misery of the processes such as drawing liquid, brings conveniently to medical personnel.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described:
Fig. 1 is the structural representation that the embodiment of the present invention has the syringe needle of biological detecting function;
Wherein: 1 is spike body; 2 make a living thing detection site.
Detailed description of the invention
Below in conjunction with specific embodiment, such scheme is described further.Should be understood that these embodiments are not limited to for illustration of the present invention limit the scope of the invention.The implementation condition adopted in embodiment can do further adjustment according to the condition of concrete producer, and not marked implementation condition is generally the condition in normal experiment.
Embodiment 1 has the infusion needle of acquired immune deficiency syndrome (AIDS) measuring ability
As shown in Figure 1, this has the syringe needle of biological detecting function, comprises spike body 1, and the outer wall of described spike body is provided with biological detection site 2.Spike body 1 selects common infusion needle, after utilizing oxygen plasma treatment, modifies carboxyl, then the probe molecule of anti-AIDS antibody is fixed to the outer wall surface of syringe needle in its outer wall surface.
When patient infusion, the tube for transfusion containing this syringe needle is selected medicine to be inputted the venous blood of patient.Normal infusion speed is kept in infusion process.Syringe needle is taken out after transfusion completes, after normal saline flushing syringe needle, syringe needle is placed in containing fluorescence molecule labelling can with the antibody-solutions of aids antibody specific binding, react after 30 minutes, the method selecting fluorescence signal to read is to judge the positive or negative of aids antibody.As being shown as the positive, then patient obtains the possible high of acquired immune deficiency syndrome (AIDS), and anti regular gets rid of HIV (human immunodeficiency virus) infection.
Embodiment 2 has the infusion needle of hepatitis B measuring ability
As shown in Figure 1, this has the syringe needle of biological detecting function, comprises spike body 1, and the outer wall of described spike body is provided with biological detection site 2.Spike body 1 selects common infusion needle, after utilizing oxygen plasma treatment, carboxyl is modified in its outer wall surface, then utilize biochip point sample instrument the probe molecule of the probe molecule of the probe molecule of anti-hepatitis B virus surface antigen, anti-hepatitis virus surface antibody, anti-hepatitis virus e antigen, the probe molecule of anti-hepatitis virus e antibody, the probe molecule of anti-hepatitis virus core antibody to be respectively fixed to the different loci of syringe needle outer wall surface, 20 dot matrix repeated are prepared in often kind of site.
When patient infusion, the tube for transfusion containing this syringe needle is selected medicine to be inputted the venous blood of patient.Normal infusion speed is kept in infusion process.Syringe needle is taken out after transfusion completes, after normal saline flushing syringe needle, syringe needle is placed in containing peroxidase labelling can with the antibody-solutions of target detection thing specific binding, react after 30 minutes, select the method for enzyme linked immunosorbent detection to judge the positive or negative of hepatitis B, and then instruct prevention or medication.
Embodiment 3 has the infusion needle of tumor marker measuring ability
As shown in Figure 1, this has the syringe needle of biological detecting function, comprises spike body 1, and the outer wall of described spike body is provided with biological detection site 2.Spike body 1 selects common infusion needle, after utilizing oxygen plasma treatment, aldehyde radical is modified in its outer wall surface, then utilize biochip point sample instrument by the probe molecule of anti-alpha-fetoprotein, the probe molecule of anti-carcinoembryonic antigen, the probe molecule of anti-carbohydrate antigen 199, the probe molecule of anti-CA125, the probe molecule of anti-neuron specific enolase, the probe molecule of anti-carbohydrate antigen242, the probe molecule of anti-Carbohydrate antigen 153, the probe molecule of anti-hCG, the probe molecule of anti-total-PSA, the probe molecule of anti-free prostate gland specificity antigen is respectively fixed to the different loci of syringe needle outer wall surface, 10 dot matrix repeated are prepared in often kind of site.
When patient infusion, the tube for transfusion containing this syringe needle is selected medicine to be inputted the venous blood of patient.Normal infusion speed is kept in infusion process.Syringe needle is taken out after transfusion completes, after normal saline flushing syringe needle, syringe needle is placed in containing peroxidase labelling can with the antibody-solutions of target detection thing specific binding, react after 30 minutes, select the method for enzyme linked immunosorbent detection to judge the positive or negative of often kind of tumor marker, and then direction of medication usage.
Embodiment 4 has the infusion needle of blood bacteria detection function
As shown in Figure 1, this has the syringe needle of biological detecting function, comprises spike body 1, and the outer wall of described spike body is provided with biological detection site 2.Spike body 1 selects common acupuncture syringe needle, after utilizing oxygen plasma treatment, at the gold grain of its outer wall surface 2-5 nanometer, and with vancomycin trapping gold particle modification position.
Above-mentioned acupuncture syringe needle is thrust in venous patient gently, selects Raman spectrum detecting instrument to modify position to golden nanometer particle on syringe needle and carry out Real-Time Monitoring, and collect detection signal continuously.Along with syringe needle is in the prolongation of intravenous indwelling time, if there is antibacterial in blood, it grows on the vancomycin of needle surface, and then changes the raman spectral signal of syringe needle.Therefore, just can antibacterial situation in Real-Time Monitoring blood by the change of analyzing raman spectral signal, even if only contain the antibacterial of micro-concentrations in blood, because syringe needle is in intravenous enrichment effect, it also can be detected accurately.
Above-mentioned example, only for technical conceive of the present invention and feature are described, its object is to person skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.All equivalent transformations of doing according to spirit of the present invention or modification, all should be encompassed within protection scope of the present invention.
Claims (4)
1. one kind has the syringe needle of biological detecting function, comprise spike body (1), the outer wall of described spike body (1) is provided with biological detection site (2), it is characterized in that: described spike body is selected from common infusion needle body, retained transfusion spike body, injection needle body, piercing needle body or middle Medical acupuncture needle head body.
2. the syringe needle with biological detecting function according to claim 1, is characterized in that described biological detection site is positioned at the local of syringe needle outer wall or all, described biological detection site is single or multiple.
3. the syringe needle with biological detecting function according to claim 1, is characterized in that the spike body outer wall place of described biological detection site location is concave inward structure or flat structures.
4. the syringe needle with biological detecting function according to claim 1, it is characterized in that the biological detection site location of described syringe needle is fixed, and be fixed be selected from first, second, third, fourth, antibody to hepatitis E antigen, tumor marker, heart disease label, inflammatory factor, Treponema pallidum antigen antibody, acquired immune deficiency syndrome (AIDS) antigen-antibody, antibacterial play one or more combination in any of the probe molecule of specific reaction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210020697.XA CN102551674B (en) | 2012-01-30 | 2012-01-30 | Needle with biological detecting function and application of needle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210020697.XA CN102551674B (en) | 2012-01-30 | 2012-01-30 | Needle with biological detecting function and application of needle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102551674A CN102551674A (en) | 2012-07-11 |
| CN102551674B true CN102551674B (en) | 2015-04-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210020697.XA Expired - Fee Related CN102551674B (en) | 2012-01-30 | 2012-01-30 | Needle with biological detecting function and application of needle |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014120129A1 (en) | 2013-01-29 | 2014-08-07 | Hewlett-Packard Development Company, L.P. | Apparatus having surface-enhanced spectroscopy elements on an exterior surface |
| CN104807760B (en) * | 2015-04-29 | 2017-04-19 | 鲁东大学 | Universal type multi-signal output biosensor, as well as preparation method and application thereof |
| CN106580399A (en) * | 2016-12-21 | 2017-04-26 | 侯信明 | Surgical clamp type tweezers |
| CN109060764B (en) * | 2018-08-23 | 2020-12-29 | 安徽中科赛飞尔科技有限公司 | Preparation method of functionalized SERS platform and application of functionalized SERS platform in ATP detection |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223124A (en) * | 1988-02-05 | 1993-06-29 | Novo Nordisk A/S | Method for immobilizing a polypeptide in a polymer and a membrane produced thereby |
| CN1846130B (en) * | 2003-08-06 | 2012-01-18 | 布里杰技术有限公司 | Bridged element for detection of a target substance |
| CN202568207U (en) * | 2012-01-30 | 2012-12-05 | 东南大学 | Needle head with biological detection function |
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2012
- 2012-01-30 CN CN201210020697.XA patent/CN102551674B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223124A (en) * | 1988-02-05 | 1993-06-29 | Novo Nordisk A/S | Method for immobilizing a polypeptide in a polymer and a membrane produced thereby |
| CN1846130B (en) * | 2003-08-06 | 2012-01-18 | 布里杰技术有限公司 | Bridged element for detection of a target substance |
| CN202568207U (en) * | 2012-01-30 | 2012-12-05 | 东南大学 | Needle head with biological detection function |
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| CN102551674A (en) | 2012-07-11 |
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