CN102551195B - 一种石油醚提取款冬花浸膏及其应用 - Google Patents
一种石油醚提取款冬花浸膏及其应用 Download PDFInfo
- Publication number
- CN102551195B CN102551195B CN201210038385.1A CN201210038385A CN102551195B CN 102551195 B CN102551195 B CN 102551195B CN 201210038385 A CN201210038385 A CN 201210038385A CN 102551195 B CN102551195 B CN 102551195B
- Authority
- CN
- China
- Prior art keywords
- extract
- benzinum
- tussilago
- cigarette
- medicinal extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- 239000000284 extract Substances 0.000 title claims abstract description 66
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title abstract description 8
- 235000004869 Tussilago farfara Nutrition 0.000 title abstract description 7
- 239000003208 petroleum Substances 0.000 title abstract description 4
- 238000002360 preparation method Methods 0.000 title abstract description 4
- 240000000377 Tussilago farfara Species 0.000 title description 3
- 241000249864 Tussilago Species 0.000 claims abstract description 55
- 235000019504 cigarettes Nutrition 0.000 claims abstract description 39
- 241000208125 Nicotiana Species 0.000 claims abstract description 30
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 238000000605 extraction Methods 0.000 claims abstract description 13
- 238000000926 separation method Methods 0.000 claims abstract description 7
- 238000004821 distillation Methods 0.000 claims abstract description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 42
- 238000009835 boiling Methods 0.000 claims description 8
- 238000010790 dilution Methods 0.000 claims description 8
- 239000012895 dilution Substances 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 7
- 235000012054 meals Nutrition 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 206010011224 Cough Diseases 0.000 abstract description 18
- 230000000391 smoking effect Effects 0.000 abstract description 9
- 208000006673 asthma Diseases 0.000 abstract description 8
- 210000004072 lung Anatomy 0.000 abstract description 4
- 239000003205 fragrance Substances 0.000 abstract description 2
- 238000007865 diluting Methods 0.000 abstract 2
- 206010013911 Dysgeusia Diseases 0.000 abstract 1
- 206010036790 Productive cough Diseases 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 208000024794 sputum Diseases 0.000 abstract 1
- 210000003802 sputum Anatomy 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 16
- 238000000034 method Methods 0.000 description 13
- 206010062717 Increased upper airway secretion Diseases 0.000 description 11
- 208000026435 phlegm Diseases 0.000 description 11
- CFUPNMDNSQIWBB-FYDLUACKSA-N Tussilagone Natural products CCC(=C/C(=O)O[C@@H]1C[C@@H](C(C)C)[C@H]2[C@@H](CC(=O)[C@@H]2[C@@H](C)OC(=O)C)C1=C)C CFUPNMDNSQIWBB-FYDLUACKSA-N 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- CFUPNMDNSQIWBB-MTLBRCJSSA-N [(1s,3as,5s,7r,7ar)-1-(1-acetyloxyethyl)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1h-inden-5-yl] (e)-3-methylpent-2-enoate Chemical compound C=C1[C@@H](OC(=O)/C=C(C)/CC)C[C@H](C(C)C)[C@H]2[C@@H](C(C)OC(C)=O)C(=O)C[C@@H]21 CFUPNMDNSQIWBB-MTLBRCJSSA-N 0.000 description 4
- 239000000779 smoke Substances 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 2
- BNHIQKVOPNHQKO-ZPWDLUOLSA-N (3s,4ar,6ar,6ar,6br,8s,8as,12s,12as,14ar,14br)-4,4,6a,6b,8a,11,12,14b-octamethyl-2,3,4a,5,6,6a,7,8,9,12,12a,13,14,14a-tetradecahydro-1h-picene-3,8-diol Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@H]3[C@H](C)C(C)=CC[C@]3(C)[C@@H](O)C[C@]21C BNHIQKVOPNHQKO-ZPWDLUOLSA-N 0.000 description 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- CNKHWTIOFSWRHP-UHFFFAOYSA-N Faradiol Natural products CC1C2C3CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CC(O)C2(C)C(=C)C=C1C CNKHWTIOFSWRHP-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- OVSQVDMCBVZWGM-SJWGPRHPSA-N Hyperin Natural products O[C@H]1[C@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-SJWGPRHPSA-N 0.000 description 2
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- LADVYSUMGRTFSZ-QXFUBDJGSA-N Tussilagine Chemical compound C1CCN2C[C@](O)(C)[C@@H](C(=O)OC)[C@@H]21 LADVYSUMGRTFSZ-QXFUBDJGSA-N 0.000 description 2
- -1 acyloxy farfaratin Chemical compound 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 230000001088 anti-asthma Effects 0.000 description 2
- 229940117173 croton oil Drugs 0.000 description 2
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229960002715 nicotine Drugs 0.000 description 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- OVSQVDMCBVZWGM-DTGCRPNFSA-N quercetin 3-O-beta-D-galactopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-DTGCRPNFSA-N 0.000 description 2
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 2
- BBFYUPYFXSSMNV-UHFFFAOYSA-N quercetin-7-o-galactoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 BBFYUPYFXSSMNV-UHFFFAOYSA-N 0.000 description 2
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 2
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 2
- 235000005493 rutin Nutrition 0.000 description 2
- 229960004555 rutoside Drugs 0.000 description 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- DYUUPIKEWLHQGQ-KYHIUUMWSA-N (3S, 5R, 6S, 3'R, 6'R)-5,6-epoxy-5,6-dihydro- beta,epsilon-carotene-3,3'-diol Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C12OC1(C)CC(O)CC2(C)C)C=CC=C(/C)C=CC3C(=CC(O)CC3(C)C)C DYUUPIKEWLHQGQ-KYHIUUMWSA-N 0.000 description 1
- IOPDFSGGBHSXSV-ZPWDLUOLSA-N (3s,4ar,6ar,6ar,6br,8s,8as,12s,12as,14ar,14br)-4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,6a,7,8,9,10,12,12a,13,14,14a-hexadecahydropicene-3,8-diol Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@H]3[C@H](C)C(=C)CC[C@]3(C)[C@@H](O)C[C@]21C IOPDFSGGBHSXSV-ZPWDLUOLSA-N 0.000 description 1
- XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 1
- HPDHKHMHQGCNPE-GFIWHYBVSA-N (4z,11z)-4-ethylidene-7-hydroxy-6,7,14-trimethyl-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione Chemical compound O1C(=O)C(=C/C)\CC(C)C(C)(O)C(=O)OC\C2=C\CN(C)CCC1C2=O HPDHKHMHQGCNPE-GFIWHYBVSA-N 0.000 description 1
- XTQQLVJPORCMAK-UHFFFAOYSA-N (ent-2beta,4E,9alpha)-9-(3-Methyl-2E-pentenoyl),2-(2-methylbutanoyl): 2,9-Dihydroxy-4,10(14)-oplopadien-3-one Natural products CC=C1C(=O)C(OC(=O)C(C)CC)C2C1C(C(C)C)CC(OC(=O)C=C(C)CC)C2=C XTQQLVJPORCMAK-UHFFFAOYSA-N 0.000 description 1
- YTOWGNDHXAGFBR-UHFFFAOYSA-N (ent-2beta,4S,9alpha)-9-(3-Methyl-2E-pentenoyl),2-(2-methylbutanoyl):2,4,9-Trihydroxy-10-oplopen-3-one Natural products CCC(C)C(=O)OC1C2C(C(CC(OC(=O)C=C(/C)CC)C2=C)C(C)C)C(C(C)O)C1=O YTOWGNDHXAGFBR-UHFFFAOYSA-N 0.000 description 1
- ZYTJBCOGBFUTOP-UHFFFAOYSA-N 14-acetoxy-7beta-angeloyloxy-notonipetranone Natural products C=C1C(OC(=O)C(C)=CC)CC(C(C)C)C2C(C(C)OC(C)=O)C(=O)CC21 ZYTJBCOGBFUTOP-UHFFFAOYSA-N 0.000 description 1
- VUQPPZBQPRNJCH-UHFFFAOYSA-N 14-acetoxy-7beta-senecioyloxy-notonipetranone Natural products CC(C)C1CC(OC(=O)C=C(C)C)C(=C)C2CC(=O)C(C(C)OC(C)=O)C12 VUQPPZBQPRNJCH-UHFFFAOYSA-N 0.000 description 1
- 241000086254 Arnica montana Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- LADVYSUMGRTFSZ-UHFFFAOYSA-N Isotussilagine Natural products C1CCN2CC(O)(C)C(C(=O)OC)C21 LADVYSUMGRTFSZ-UHFFFAOYSA-N 0.000 description 1
- DYUUPIKEWLHQGQ-UWYDEOQVSA-N Lutein 5,6-epoxide Natural products O[C@H]1C=C(C)[C@H](/C=C/C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/[C@]23C(C)(C)C[C@H](O)C[C@@]2(C)O3)\C)/C)\C)/C)C(C)(C)C1 DYUUPIKEWLHQGQ-UWYDEOQVSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 240000003705 Senecio vulgaris Species 0.000 description 1
- HPDHKHMHQGCNPE-QLJRNOHWSA-N Senkirkine Chemical compound O1C(=O)C(=C/C)\C[C@@H](C)[C@@](C)(O)C(=O)OC\C2=C\CN(C)CC[C@@H]1C2=O HPDHKHMHQGCNPE-QLJRNOHWSA-N 0.000 description 1
- HPDHKHMHQGCNPE-FQWLTQODSA-N Senkirkine Natural products O=C1/C(=C/C)/C[C@H](C)[C@](O)(C)C(=O)OCC=2C(=O)[C@H](O1)CCN(C)CC=2 HPDHKHMHQGCNPE-FQWLTQODSA-N 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- CFUPNMDNSQIWBB-UUVDBSHOSA-N [(1S,3aR,5R,7S,7aS)-1-[(1R)-1-acetyloxyethyl]-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl] (E)-3-methylpent-2-enoate Chemical compound CC\C(C)=C\C(=O)O[C@@H]1C[C@@H](C(C)C)[C@H]2[C@@H](CC(=O)[C@@H]2[C@@H](C)OC(C)=O)C1=C CFUPNMDNSQIWBB-UUVDBSHOSA-N 0.000 description 1
- XTQQLVJPORCMAK-NMNXYZJCSA-N [(1Z,3S,3aR,5R,7S,7aS)-1-ethylidene-3-(2-methylbutanoyloxy)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydroinden-5-yl] (E)-3-methylpent-2-enoate Chemical compound CCC(C)C(=O)O[C@H]1[C@@H]2[C@H]([C@@H](C[C@@H](OC(=O)\C=C(/C)CC)C2=C)C(C)C)\C(=C\C)C1=O XTQQLVJPORCMAK-NMNXYZJCSA-N 0.000 description 1
- ORVROQPLYIDWBD-QWCDRRILSA-N [(1Z,3aR,5R,7S,7aS)-1-ethylidene-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydroinden-5-yl] (E)-3-methylpent-2-enoate Chemical compound CC\C(C)=C\C(=O)O[C@@H]1C[C@@H](C(C)C)[C@H]2[C@@H](CC(=O)\C2=C/C)C1=C ORVROQPLYIDWBD-QWCDRRILSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- IOPDFSGGBHSXSV-UHFFFAOYSA-N arnidiol Natural products CC12CCC(O)C(C)(C)C1CCC1(C)C2CCC2C3C(C)C(=C)CCC3(C)C(O)CC21C IOPDFSGGBHSXSV-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940076810 beta sitosterol Drugs 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- HPDHKHMHQGCNPE-UHFFFAOYSA-N crotaverrine Natural products O1C(=O)C(=CC)CC(C)C(C)(O)C(=O)OCC2=CCN(C)CCC1C2=O HPDHKHMHQGCNPE-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000003546 flue gas Substances 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- DYUUPIKEWLHQGQ-FJOIUHRLSA-N lutein 5,6-epoxide Chemical compound C(/[C@]12[C@@](O1)(C)C[C@@H](O)CC2(C)C)=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C DYUUPIKEWLHQGQ-FJOIUHRLSA-N 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 230000005586 smoking cessation Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- BIVIKXQHDMPIQD-MRXMRZKZSA-N taraxanthin Natural products C[C@H]1CC(C)(C)[C@@]2(O[C@]2(C)C1)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=C[C@H]3C(=C[C@H](O)CC3(C)C)C)C)C BIVIKXQHDMPIQD-MRXMRZKZSA-N 0.000 description 1
- UAXOELSVPTZZQG-UHFFFAOYSA-N tiglic acid Natural products CC(C)=C(C)C(O)=O UAXOELSVPTZZQG-UHFFFAOYSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- BYLJOPYWVHDOGY-UHFFFAOYSA-N tussilagolactone Natural products CC(C)C1CC(OC(=O)C=C(C)CC)C(=C)C2C(OC(=O)C(C)CC)OC(=O)C(C(C)OC(C)=O)C21 BYLJOPYWVHDOGY-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种石油醚提取款冬花浸膏及其制备方法和在卷烟中的应用。将款冬花与石油醚混合均匀，经萃取、固液分离、蒸馏后得到所需的浸膏产品，将款冬花浸膏用浓度为95％的乙醇稀释至1-5％，然后按烟丝重量的0.015％～0.05％的乙醇稀释至1-5％，然后按烟丝重量的0.015％～0.05％添加到烟丝中制成卷烟，以提高卷烟的品质，降低吸烟对人体的危害，特别是针对有咳嗽、气喘、多痰的烟民，起到润肺、止咳、平喘的作用，卷烟香味醇和，余味颇佳，有很好的实用价值。
Description
技术领域
本发明属于烟用添加剂制备技术领域，具体涉及一种石油醚提取款冬花浸膏。同时还涉及一种所述的石油醚提取款冬花浸膏的制备方法及其在卷烟中的应用。
背景技术
烟草是我国的重要经济作物之一，卷烟在全球盛行了200多年，可直到20世纪，人类才开始认识到烟草对人类的危害。吸烟是心脑血管疾病、癌症和肺气肿等非传染性疾病的重要诱因，吸烟者更易感染结核病和肺炎等传染性疾病。据《2011年中国控制吸烟报告》指出，我国以3亿吸烟者成为全球最大的烟草生产国和最大的烟草消费国，我国每年有100多万人死于与烟草相关的疾病。但由于吸烟者的嗜好和尼古丁的依赖性，使众多的烟民又难以戒烟，能够在卷烟中添加一些既能解除咳喘和降低毒害的有益物质，以减少烟草对吸烟者的毒害，是烟工业选择的发展方向。
有益的中草药成分被应用到卷烟生产当中，起到了有益的显著效果，如ZL96117493.5“一种中草药保健型卷烟”能够降低烟雾中的有害物质的含量，具有补肾壮阳、化痰、止咳、平喘、增强调节人体免疫机能等作用。ZL200610054656.7是采用多种中草药的有效成分为中沸程馏分用95％乙醇稀释后加入到卷烟滤嘴中，具有明显的止咳、祛痰、平喘、消炎等缓解烟气对呼吸系统不良影响的作用。
款冬花被中医药列为治疗喘嗽的要药，其作用与效果是公认的。在卷烟中的应用其止咳喘功效是明显的，如上述两项专利中都采用款冬花药材。专利ZL200710017853.6则采用将款冬花挥发油与香精混合加入烟丝中卷制成一种中式降焦减毒香烟，可以预防或减轻香烟烟雾对呼吸道粘膜的刺激作用，同时能够降低香烟烟雾中的焦油及尼古丁含量，起到降焦减毒作用，起到润肺、化痰、止咳的作用。
款冬花为菊科植物款冬Tussilago farfara L.的干燥花蕾。其药用部位是其花蕾部分，其药材的有效性不仅仅是其含有的挥发油部分，其中很多有效成分体现款冬花的较佳功效是不可忽视的，将款冬花中的有效成分充分提取应用，才能更有效地起到镇咳、祛痰和平喘作用。款冬花的花中含有生物碱：款冬花碱(tussilagine)，克氏千里光碱(senkirkine)；倍半萜成分：款冬花酮(tussilagone)又称款冬花素〔tussilagin，14-acetoxy-7β -(3-ethylcrotonoyloxy)notonipetranone〕，甲基丁酸款冬花素脂〔14-acetoxy-7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)notonipetranone〕，去乙酰基款冬花素〔7β-(3-ethyl-cis-crotonoyloxy)-14-hydroxy-notonipetranone〕、7β-去(3-乙基巴豆油酰氧基)-7β-当归酰氧基款冬花素(14-acetoxy-7β-angeloyloxynotonipetranone)、7β-去(3-乙基巴豆油酰氧基)-7β-千里光酰氧基款冬花素(14-ace-toxy-7β-senecioyloxy-notonipetranone)、14-去乙酰基-1α-甲基丁酸款冬花素酯〔7β-(3-ethyl-cis-crotonoy-loxy)-14-hydroxy-1α-(2-methylbutyryloxy)notonipetra-none〕、款冬花内酯(tussilagolactone)，14-去乙酰氧基-3，14-去氢-Z-甲基丁酸款冬花素酯〔7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methyl butyryloxy)-3，14-dehydro-Z-notonipetranone〕；三萜成分：款冬二醇(faradiol)、山金车二醇(arnidiol)；黄酮甙成分：芸香甙(rutin)、金丝桃甙(hyperin)。还含β-谷甾醇(β-sitosterol)，薄公英黄质(taraxanthin)等。花另含挥发油，还含有氨基酸，主要成分是：γ-氨基丁酸(γ-aminobutyric acid)、丙氨酸(alanine)、丝氨酸(serine)和甘氨酸(glycine)；又含无机元素：锌、铜、铁、锰、钴等。古人早有用款冬花燃烟止咳之法，早在宋代以前就已发明，据宋代药学家苏颂的《本草图经》记载：“疗久咳熏法，每日取款冬花如鸡子许，稍用蜂蜜拌润，纳茶壶中，以面固其盖，勿令漏气，壶下着炭火，待烟从壶中出，以口含吸，数日必效。”可以看出款冬花燃烟吸食治疗喘嗽具有悠久的历史渊源，既有很好的防治效果也具有吸食的安全性。
利用现代科技条件，将其款冬花的有效成分加以充分萃取，与卷烟结合，将会对提高卷烟的品质，防治咳、喘、痰的作用会发挥更好的作用，但现有技术中尚未见有关的报道。
发明内容
本发明的目的在于针对现有技术的不足，提供一种石油醚提取款冬花浸膏，将其用于卷烟中，以降低吸烟对人体的危害，特别是针对有咳嗽、气喘、多痰的烟民，起到润肺、止咳、化痰的作用，减轻吸烟者的病痛，丰富卷烟品种，提高卷烟品质。
本发明的另一目的在于提供一种制备所述石油醚提取款冬花浸膏的方法。
本发明的目的还在于提供一种所述石油醚提取款冬花浸膏在卷烟中的应用。
除非另有说明，本发明所采用的百分数均为重量百分数。
本发明的目的是通过以下技术方案予以实现的。
一种石油醚提取款冬花浸膏，由下述方法制备获得：将款冬花与石油醚混合均匀，经萃取、固液分离、蒸馏后得到所需的款冬花浸膏。
本发明提供了一种制备石油醚提取款冬花浸膏的方法，该方法包括下述顺序的步骤：
(1)将款冬花干燥花蕾粉碎为20-30目粗粉，与石油醚混合均匀，混合重量比为1∶5-10；
(2)在室温条件下萃取12h-24h；
(3)固液分离，收集澄清液体；
(4)在真空度0.01-0.05Mpa、蒸馏温度25℃-30℃条件下减压蒸馏0.5-2.0h，除去溶剂后得到所需浸膏。
所述的石油醚优选医用级石油醚。
所述的医用级石油醚沸点为30℃-60℃时，萃取时间优选12h。
所述的医用级石油醚沸点为60℃-90℃时，萃取时间优选24h。
本发明提供了一种石油醚提取款冬花浸膏在卷烟中的应用，具体为：将本发明的石油醚提取款冬花浸膏用浓度为95％的乙醇稀释至浓度为1-5％，然后按烟丝重量的0.015％-0.05％添加到烟丝中。优选按烟丝重量的0.025％，将稀释后的石油醚提取款冬花浸膏添加到烟丝中。
优选以喷洒方式将稀释后的石油醚提取款冬花浸膏添加到烟丝中。
本发明具有如下有益效果：
(1)款冬花经石油醚萃取可以在室温条件下进行，不需加热，工艺简单，操作简便，既能保证其花蕾中的有效成分得到提取，同时对具有挥发性脂溶性油类成分物质得到保留，更能保证其有效成分作用的发挥；
(2)款冬花中含有游离氨基酸；氨基酸在烟草醇化、燃烧过程中能够很好的参与梅拉德反应产生致香物质，从而丰富烟香，减少刺激和杂气，有利于改善卷烟的口感余味；
(3)石油醚提取款冬花浸膏制备的卷烟，能够使有喘嗽而又不能戒除吸烟的病人，在吸烟中起到润肺、化痰、止咳、平喘的作用。
(4)石油醚款冬花浸膏在卷烟中的应用，不需因加入香精等调味物质而导致烟质的变化，其卷烟香味醇和，余味彼佳。
(5)石油醚能将款冬花中有效成分充分提取，且可以回收循环利用，产品生产过程不存在溶剂污染。
具体实施方式
下面结合实施例和应用实施例对本发明作进一步的详细说明，但它们并不是对本发明的限定。
实施例1
称取经粗粉碎过20目筛的款冬花粗粉1000克，装入三角烧瓶，加入浓度5000ml沸点为30℃-60℃的医用级石油醚，在20℃条件下浸泡12h，用布氏漏斗进行固液分离，收集澄清液体，得到的液体在真空度为0.025Mpa、蒸馏温度为28℃条件下蒸馏1.0h，除去溶剂得到浸膏2.85克。
实施例2
称取经粗粉碎过25目筛的款冬花粗粉1000克，装入三角烧瓶，加入7500ml沸点为60℃-90℃的医用级石油醚，在25℃条件下浸泡24h，用布氏漏斗进行固液分离，收集澄清液体，得到的液体在真空度为0.01Mpa、蒸馏温度为30℃条件下蒸馏0.5h，除去溶剂得到浸膏2.80克。
实施例3
称取经粗碎过30目筛的款冬花粗粉1000克，装入三角烧瓶，加入10000ml沸点为30℃-60℃的医用级石油醚，在15℃条件下浸泡12h，用布氏漏斗进行固液分离，收集澄清液体，得到的液体在真空度为0.05Mpa、蒸馏温度为25℃条件下蒸馏2.0h，除去溶剂得到浸膏2.90克。
应用实施例1
将实施例1所得石油醚提取款冬花浸膏用浓度为95％的乙醇溶解稀释为1％浓度后备用。分别按烟丝重量的0.015％、0.025％和0.05％喷洒到烟丝中，按常规工艺制成香烟，采用评吸法进行评吸，认为添加0.025％石油醚提取款冬花浸膏在烟丝中口感适中，与对照卷烟比较，具有明显的化痰、止咳、平喘作用。评吸结果见下表：
应用实施例2
将实施例2所得石油醚提取款冬花浸膏用浓度为95％的乙醇溶解稀释为2.5％浓度后备用。分别按烟丝重量的0.015％、0.025％和0.05％喷洒到烟丝中，按常规 工艺制成烟，采用评吸法进行评吸，认为添加0.025％石油醚提取款冬花浸膏在烟丝中口感适中，与对照卷烟比较，具有明显的化痰、止咳、平喘的作用。评吸结果见下表：
应用实施例3
将实施例3所得石油醚提取款冬花浸膏用浓度为95％的乙醇溶解稀释为5％浓度后备用。分别按烟丝重量的0.015％、0.025％和0.05％喷洒到烟丝中，按常规工艺制成烟，采用评吸法进行评吸，认为添加0.025％石油醚提取款冬花浸膏在烟丝中口感适中，与对照卷烟比较，具有明显的化痰、止咳、平喘的作用。评吸结果见下表：
Claims (8)
1.一种石油醚提取款冬花浸膏，其特征在于：(1)将款冬花干燥花蕾粉碎为20～30目粗粉，与石油醚混合均匀，混合重量比为1：5～10；(2)在室温条件下萃取12h～24h；(3)固液分离，收集澄清液体；(4)在真空度0.01～0.05MPa、蒸馏温度25℃～30℃条件下减压蒸馏0.5～2.0h，除去溶剂后得到所需浸膏。
2.根据权利要求1所述的石油醚提取款冬花浸膏，其特征在于：所述的石油醚为医用级石油醚。
3.根据权利要求2所述的石油醚提取款冬花浸膏，其特征在于：所述的医用级石油醚沸点为30℃～60℃时，萃取时间为12h。
4.根据权利要求2所述的石油醚提取款冬花浸膏，其特征在于：所述的医用级石油醚沸点为60℃～90℃时，萃取时间为24h。
5.权利要求1所述的石油醚提取款冬花浸膏在卷烟中的应用。
6.根据权利要求5所述的石油醚提取款冬花浸膏在卷烟中的应用，其特征在于：所述的石油醚提取款冬花浸膏用浓度为95％的乙醇稀释至浓度为1-5％，然后按烟丝重量的0.015％～0.05％添加到烟丝中。
7.根据权利要求6所述的应用，其特征在于：按烟丝重量的0.025％，将稀释后的石油醚提取款冬花浸膏添加到烟丝中。
8.根据权利要求6所述的应用，其特征在于：以喷洒方式将稀释后的石油醚提取款冬花浸膏添加到烟丝中。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210038385.1A CN102551195B (zh) | 2012-02-17 | 2012-02-17 | 一种石油醚提取款冬花浸膏及其应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210038385.1A CN102551195B (zh) | 2012-02-17 | 2012-02-17 | 一种石油醚提取款冬花浸膏及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102551195A CN102551195A (zh) | 2012-07-11 |
| CN102551195B true CN102551195B (zh) | 2014-04-02 |
Family
ID=46398841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210038385.1A Withdrawn - After Issue CN102551195B (zh) | 2012-02-17 | 2012-02-17 | 一种石油醚提取款冬花浸膏及其应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102551195B (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103704700A (zh) * | 2013-12-30 | 2014-04-09 | 徐州绿之野生物食品有限公司 | 一种石油醚提取枸杞浸膏及其制备方法和应用 |
| CN103734741B (zh) * | 2013-12-30 | 2015-11-04 | 徐州绿之野生物食品有限公司 | 一种枸杞提取物的制备方法和应用 |
| CN106491683B (zh) * | 2017-01-10 | 2019-09-24 | 山西大学 | 一种用于治疗哮喘的款冬花提取物及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101317690A (zh) * | 2008-07-03 | 2008-12-10 | 广西中烟工业公司 | 一种桂花香型烟用添加剂及其制备方法和应用 |
| CN101342010A (zh) * | 2008-07-29 | 2009-01-14 | 红云烟草(集团)有限责任公司 | 一种石油醚提取白茶浸膏及其制备方法和应用 |
| CN102754911A (zh) * | 2012-07-02 | 2012-10-31 | 广西中烟工业有限责任公司 | 一种天然植物烟用减害添加剂及其制备方法和应用 |
-
2012
- 2012-02-17 CN CN201210038385.1A patent/CN102551195B/zh not_active Withdrawn - After Issue
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101317690A (zh) * | 2008-07-03 | 2008-12-10 | 广西中烟工业公司 | 一种桂花香型烟用添加剂及其制备方法和应用 |
| CN101342010A (zh) * | 2008-07-29 | 2009-01-14 | 红云烟草(集团)有限责任公司 | 一种石油醚提取白茶浸膏及其制备方法和应用 |
| CN102754911A (zh) * | 2012-07-02 | 2012-10-31 | 广西中烟工业有限责任公司 | 一种天然植物烟用减害添加剂及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102551195A (zh) | 2012-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101444331B (zh) | 金银花、野菊花、桑叶的超高压提取法及其提取液的应用 | |
| CN102423124B (zh) | 一种烟草薄片及其制备方法 | |
| WO2013097164A1 (zh) | 替代烟丝的组合物及其制备方法 | |
| CN104397871A (zh) | 一种含茶叶提取物的电子烟烟油及其制备方法 | |
| CN101156711A (zh) | 一种茶香型烟用添加剂及其制备方法 | |
| CN101161801A (zh) | 菊花挥发油提取方法及利用该菊花挥发油对香烟加香方法 | |
| CN101623126B (zh) | 烟用中药降毒戒烟加香添加液的制备工艺 | |
| CN104544543A (zh) | 一种利用红茶茶叶提取物制备的电子烟烟液 | |
| CN102304430B (zh) | 一种具有甜润香气的烟草加料香精 | |
| CN102551195B (zh) | 一种石油醚提取款冬花浸膏及其应用 | |
| CN109156895A (zh) | 一种降低卷烟抽吸干燥感和刺激性的滤棒添加剂、其制备方法及用途 | |
| CN108998241B (zh) | 用于加热不燃烧卷烟中的熟化烤烟香味香精及其制备方法和应用 | |
| CN101926508B (zh) | 射干在卷烟中的应用 | |
| CN103393214B (zh) | 香料烟、酒精和丙二醇混合溶液提取物及其制备方法和应用 | |
| CN102578703B (zh) | 一种款冬花醇提浸膏及其制备方法和应用 | |
| CN108113049A (zh) | 一种凉茶风味液体香精、微胶囊香精及其在卷烟中的应用 | |
| CN107057856A (zh) | 一种嘴棒用甘草增甜增润香精制备方法 | |
| CN101342010B (zh) | 一种石油醚提取白茶浸膏及其制备方法和应用 | |
| CN101176570A (zh) | 一种天然烟用香料添加剂及其制备方法 | |
| CN101322581B (zh) | 一种石油醚提取普洱熟茶浸膏及其制备方法和应用 | |
| CN101323817A (zh) | 一种普洱熟茶精油及其制备方法和应用 | |
| CN109105941A (zh) | 一种含有岩兰草精油的烟草增香剂 | |
| CN104862077B (zh) | 烟用苏合香浸膏及其制备方法 | |
| CN114431509A (zh) | 具有止咳功效的电子烟烟液 | |
| CN101322583B (zh) | 一种石油醚提取普洱生茶浸膏及其制备方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Tingting Inventor after: Shen Xin Inventor before: Zhang Tingting Inventor before: Zhang Kuichang |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG TINGTING ZHANG KUICHANG TO: ZHANG TINGTING SHEN XIN |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20140402 Effective date of abandoning: 20200716 |
|
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20140402 Effective date of abandoning: 20200716 |