CN102532901A - Method for preparing simethicone - Google Patents
Method for preparing simethicone Download PDFInfo
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- CN102532901A CN102532901A CN2010106036352A CN201010603635A CN102532901A CN 102532901 A CN102532901 A CN 102532901A CN 2010106036352 A CN2010106036352 A CN 2010106036352A CN 201010603635 A CN201010603635 A CN 201010603635A CN 102532901 A CN102532901 A CN 102532901A
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- simethicone
- dimethicone
- silicon dioxide
- heating
- preparation
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Abstract
The invention relates to the technical field of medicines and discloses a method for preparing simethicone. The method comprises the following steps of: (1) mixing, namely uniformly mixing a proper amount of dimethicone and silicon dioxide in a stirring mode; and (2) heating, namely heating the uniformly mixed dimethicone and silicon dioxide to the temperature of between 150+/-5DEG C, and reacting for 4 to 5 hours with stirring. The dimethicone is heated by a simple heating method skillfully, the solubility of the dimethicone is increased by a heat expansion principle, and fine silicon dioxide particles are fully fused into the dimethicone. After the reaction is completed, the reaction product is cooled to normal temperature, and a whitish semi-transparent sticky liquid is formed. By the preparation method, the dimethicone and the silicon dioxide contained in the simethicone can be fully fused; and the preparation method is simple, easy to control and suitable for industrial production.
Description
One, technical field
The present invention relates to medical technical field, be specifically related to a kind of preparation method of Simethicone.
Two, background technology
Simethicone (Simethicone) is a kind of skimmer commonly used, and its chemical structural formula is following:
Can find out that by above structural formula Simethicone is the mixture of Simethicone and silicon-dioxide.
We find in test, through stirring, mediate or physical method such as roller bundle, though can Simethicone and silicon-dioxide be mixed the sort of mode no matter, adularescent silicon-dioxide in the equal content visible thing.This phenomenon shows that silicon-dioxide is not melted in the Simethicone, equals in oil, to add solids; Respectively be each, though can layering, there is not flowability; Proterties is semi-solid, does not have the characteristic of liquid, does not meet the description down of British Pharmacopoeia version Simethicone [proterties] in 2009: a kind of heavy-gravity; Greyish white, milky white liquid.
The inventor is through TE, and if beat all discovery with Simethicone and silicon-dioxide mixing post-heating, is stirred, and just can overcome silicon-dioxide and can not merge the defective in Simethicone.
Three, summary of the invention
The invention discloses a kind of preparation method of Simethicone, may further comprise the steps:
(1) mixes.With an amount of Simethicone and silicon-dioxide, the mode through stirring mixes;
(2) heating.With the Simethicone and the silicon-dioxide of mixing, be heated to 150 ℃ ± 5 ℃, stirring reaction 4～5 hours promptly gets.
The present invention uses the simple heating method cleverly, with Simethicone heating, utilizes the principle of heat expansion, and its solubleness is strengthened, and expands, and can the silicon-dioxide fine particle fully be dissolved in the Simethicone after it is expanded.Reaction is cooled to normal temperature after accomplishing, and just becomes the translucent thick liquid of off-white color.
Preparing method of the present invention can guarantee that Simethicone contained in the Simethicone and silicon-dioxide are merged fully, and technology is simple, is easy to control, is suitable for suitability for industrialized production.
Following Test Example has further proved beneficial effect of the present invention:
Test name: grind Simethicone and USP Simethicone standard substance froth breaking ability certainly relatively
Trial-product: grind Simethicone certainly
Source: Chongqing Beibei Modem Application Pharmaceutical Institute
Lot number: 090601
Reference substance: USP Simethicone standard substance
Lot number: JOH301
The source: the USP council provides
Foam solution: the TX 405 aqueous solution with 1%.
Need testing solution: take from respectively and grind Simethicone and each 200mg of USP Simethicone puts in the 100mL measuring bottle, add the 50mL trimethyl carbinol, close plug, powerful jolting (heating in case of necessity) makes dispersion.
Assay method: with reference to froth breaking power measuring method under the 32nd edition Simethicone item of USP, get two parts of foamless 1% TX 405 aqueous solution 100mL, carefully inject in the 250mL tool plug Erlenmeyer flask of two cleanings; Measure need testing solution 0.5mL respectively, put in one of them flask; Add a cover, vibrate up and down 5 times, its height V that bubbles of observed and recorded
1, measure the bubble ability that presses down; Again in 300 times/minute, radian is jolting under the condition of 10 degree, and accurately timing, and jolting to foam disappears fully, writes down the used time, measures the froth breaking ability.Not add the foam height V of trial-product
0Be blank, with foam reduction and lather collapse Time Calculation froth breaking power.Its MV is got in each experiment repetition 3 times.Experimental result is seen table 1.
Table 1 concussion fask oscillating method is measured from grinding Simethicone and USP Simethicone froth breaking power contrast experiment
Test-results shows: adopt the concussion fask oscillating method to measure from the froth breaking power of grinding Simethicone and USP Simethicone, i.e. foam completely dissolve time basically identical.
Four, embodiment
Further specify technical scheme of the present invention through specific embodiment below.
In the 250ml there-necked flask, add 95 gram dimethyl silicone oils, 5g silicon-dioxide stirs, and with 150 ℃ ± 5 ℃ of oil bath heating, reacts after 4 hours, and 80 order stainless steel sifts are crossed in cooling, promptly get.
Claims (2)
1. the preparation method of a Simethicone is characterized in that: with Simethicone and silicon-dioxide mixing post-heating, stirring reaction 4～5 hours.
2. the temperature that heats during the said preparation Simethicone of claim 1 should be controlled at 120 ℃～170 ℃, preferred 150 ℃ ± 5 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106036352A CN102532901A (en) | 2010-12-21 | 2010-12-21 | Method for preparing simethicone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106036352A CN102532901A (en) | 2010-12-21 | 2010-12-21 | Method for preparing simethicone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102532901A true CN102532901A (en) | 2012-07-04 |
Family
ID=46341004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010106036352A Pending CN102532901A (en) | 2010-12-21 | 2010-12-21 | Method for preparing simethicone |
Country Status (1)
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| CN (1) | CN102532901A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446594A (en) * | 2013-07-25 | 2013-12-18 | 西安医学院 | Method for preparing medical defoaming agent from simethicone and differential silicone |
| CN104610745A (en) * | 2015-01-13 | 2015-05-13 | 山东大学 | Preparation method for simethicone |
| CN105287625A (en) * | 2015-12-04 | 2016-02-03 | 重庆希尔安药业有限公司 | Hydrotalcite combined medicine tablet as well as preparation method and application thereof |
| CN107573689A (en) * | 2017-08-03 | 2018-01-12 | 江苏汉斯通药业有限公司 | The preparation method of Simethicone |
| CN110652504A (en) * | 2018-06-28 | 2020-01-07 | 三捷生物科技（北京）有限公司 | Drug-loaded microsphere and preparation method and application thereof |
| CN112263851A (en) * | 2020-09-30 | 2021-01-26 | 四川健能制药有限公司 | Preparation method of simethicone defoaming composition |
| CN113425848A (en) * | 2020-03-20 | 2021-09-24 | 山东威高药业股份有限公司 | Composition for inhibiting gastrointestinal motility and gastrointestinal motility inhibitor |
| US11433051B2 (en) | 2016-02-16 | 2022-09-06 | Siga Technologies, Inc. | ST-246 (tecovirimat monohydrate) suspension formulations |
-
2010
- 2010-12-21 CN CN2010106036352A patent/CN102532901A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446594A (en) * | 2013-07-25 | 2013-12-18 | 西安医学院 | Method for preparing medical defoaming agent from simethicone and differential silicone |
| CN104610745A (en) * | 2015-01-13 | 2015-05-13 | 山东大学 | Preparation method for simethicone |
| CN105287625A (en) * | 2015-12-04 | 2016-02-03 | 重庆希尔安药业有限公司 | Hydrotalcite combined medicine tablet as well as preparation method and application thereof |
| CN105287625B (en) * | 2015-12-04 | 2019-03-22 | 重庆希尔安药业有限公司 | A kind of Hydrotalcite composition of medicine tablet, preparation method and applications |
| US11433051B2 (en) | 2016-02-16 | 2022-09-06 | Siga Technologies, Inc. | ST-246 (tecovirimat monohydrate) suspension formulations |
| US11779566B2 (en) | 2016-02-16 | 2023-10-10 | Siga Technologies, Inc. | ST-246 (tecovirimat monohydrate) suspension formulations |
| CN107573689A (en) * | 2017-08-03 | 2018-01-12 | 江苏汉斯通药业有限公司 | The preparation method of Simethicone |
| CN110652504A (en) * | 2018-06-28 | 2020-01-07 | 三捷生物科技（北京）有限公司 | Drug-loaded microsphere and preparation method and application thereof |
| CN113425848A (en) * | 2020-03-20 | 2021-09-24 | 山东威高药业股份有限公司 | Composition for inhibiting gastrointestinal motility and gastrointestinal motility inhibitor |
| CN113425848B (en) * | 2020-03-20 | 2022-10-21 | 山东威高宏瑞医学科技有限公司 | Composition for inhibiting gastrointestinal motility and gastrointestinal motility inhibitor |
| CN112263851A (en) * | 2020-09-30 | 2021-01-26 | 四川健能制药有限公司 | Preparation method of simethicone defoaming composition |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Chongqing Beibei Research Institute of Modern Applied Medicines Document name: Notification that Application Deemed to be Withdrawn |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120704 |