CN102526394A - External use medicine for preventing and treating infantile asthma as well as acupoint application and preparation method thereof - Google Patents
External use medicine for preventing and treating infantile asthma as well as acupoint application and preparation method thereof Download PDFInfo
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Abstract
The invention discloses external use medicine for preventing and treating infantile asthma as well as an acupoint application and a preparation method of the external use medicine and belongs to the field of traditional Chinese medicine. The external use medicine disclosed by the invention comprises semen brassicae, baked ephedra, baked astragalus root, euphorbia kansui, asarum, aconite, dried pinellia tuber and cinnamon. The invention also discloses the acupoint application and external patch of the external use medicine, and the application to the preparation of infantile asthma preventing and treatment medicine. By aiming at the characteristic that the infantile asthma belongs to lung and spleen deficiency in traditional Chinese medicine syndrome differentiation, the spleen strengthening and the lung tonifying are main measures; the azone is matched to be used, the skin permeability is enhanced, and the medicine absorption is promoted; and through the mixing of far infrared micro powder, natural heating bodies and magnetic powder, the medicine effect is combined with the far infrared rays and the magnetic therapy, and the curative effect is more obvious. The medicine disclosed by the invention has the effects of strengthening the spleen to tonify the lung and digesting the watery phlegm to eliminate the phlegm, the viscera function is conditioned through cold dispelling to eliminate the phlegm, meridian warming and body resistance strengthening to consolidate the constitution, and the modern pharmacological research shows that the external use medicine has a certain anti-inflammatory effect and is particularly applicable to the infantile asthma.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of plaster medicine and point application and method for making of preventing and treating infantile asthma.
Background technology
The child is a colony with special physiological characteristics, is in the stage of growth promoter.The function of each system of body and each organ is immaturity, particularly infant still, and the unify growth of hormonal system of liver, renal function, central nervous system is still unsound, and poor to metabolism, drainage and the toleration of many medicines, medication must be careful.There is statistics to show that the medicine of domestic market 90.0% does not all have child's dosage form.Child's sickness rate is higher than the adult, and the ill child of China accounts for more than 20.0% of total ill population, but the special-purpose medicaments that is used for child's common disease seldom, can not satisfy the needs of child health care cause.
Adult's asthma and infantile asthma have important difference; The childhood period that first symptom of adult's asthma appearing at mostly (about 3 years old); And adult's asthma is the disease (the GINA scheme of world health organisation recommendations) of " can not cure "; And infantile asthma can be cured through correct treatment mostly, be converted into the adult asthma less than 10%.Therefore, the treatment of infantile asthma is even more important.
Traditional traditional Chinese medical science point application is adopted to add medicine to and is ground back adding vaseline furnishing pasty state, does the patent medicine cake, and on the acupuncture point, this method is used inconvenience with immobilization with adhesive tape, and effect is also stable inadequately.
Summary of the invention
Goal of the invention: the purpose of this invention is to provide a kind of external used medicine of preventing and treating infantile asthma; A further object of the invention provides the point application that said external used medicine is processed; A further object of the invention provides the external use plaster that said external used medicine is processed, and a further object of the invention provides the application of said point application on preparation control infantile asthma medicine.
Technical scheme: for realizing above-mentioned purpose, a kind of external used medicine of preventing and treating infantile asthma of the present invention comprises the following materials based on weight medicine: 7～12 parts of Semen Sinapis Albaes; 5～12 parts of Herba Ephedrae (processed), 4～11 parts of Radix Astragali Preparatas, 4～8 parts of Radix Kansuis; 4～8 parts of Herba Asaris; 4～8 parts of Aconitum carmichjaelii Debx.s, 4～7 parts of Rhizoma Pinelliae, 2～4 parts of Cortex Cinnamomis.
In the prescription of the present invention, the Semen Sinapis Albae acrid in the mouth, warm in nature.Return lung stomach warp.The effect warming the lung for resolving phlegm, promoting the circulation of QI, mass dissipating and swelling eliminating.Say in " medicineization justice ": " Semen Sinapis Albae ... walk crosswise very victory ... current very sharp, special relieving accumulation of pathogens expectorant, expectorant belongs to hot person can be separated, and belonging to cold person can separate.Expectorant is outside the flesh side film, and non-this does not reach, and at extremity two side of body, non-this is obstructed." modern pharmacological research thinks: Semen Sinapis Albae promoting the circulation of QI eliminating phlegm, the uncommon propyl ester of its main component Hydrogen thiocyanate has pungent acid and stimulation, can make skin rubefaction, warm, even cause blister, and research confirms to have antitussive, eliminate the phlegm and antiasthmatic effect.For treating the key medicine that asthma is applied ointment or plaster.
The property that the hot diffusing and little double hardship of Herba Ephedrae (processed) is fallen, but the closing of external-open fur are so that lung qi a surname is smooth; In the gas of superinverse falls, with multiple lung department respectful fall normal, so be apt to relieving asthma, for curing mainly the key medicine of breathing with cough due to the sluggishness of lung-QI.Semen Sinapis Albae and Herba Ephedrae (processed) are we's monarch drug altogether.
The Radix Astragali, arresting sweating is defended in the tonifying the lung spleen invigorating in fact, and the medicine of wind dispelling fortune poison is also.Be the principal agent of treatment asthenia of pulmonosplenic qi, asthma children's belongs to asthenia of pulmonosplenic qi more, and treatment is often with Radix Astragali QI invigorating, spleen invigorating.
Radix Kansui, bitter in the mouth, cold in nature, poisonous.Return lung kidney large intestine channel.The effect removing fluid-retention by purgation, dispersing swelling and dissipating binds.Talk about in " pearl sac ": " bitter in the mouth gas is cold, and bitterness is let out, cold prevailing over heat, and through part that aqueous vapor is tied is the panacea of sluicing.In the accumulation of fluid in the chest, non-this can not remove, so the Zhong Jing Daxianxiong Tang is used it, but poisonous, can not gently use." Radix Kansui bitter cold opening lung-energy, promote sputum to discharge.
Herba Asari, acrid in the mouth, warm in nature.Slightly poisonous.Return lung kidney heart channel.The effect cold expelling that induces sweat, sensible, warming the lung to resolve fluid-retention.Research shows that Herba Asari has antiallergic, anti-allergy action, can eliminate the bronchospasm that neostigmine causes.
The Rhizoma Pinelliae, acrid in the mouth, warm in nature.Poisonous.Return the taste lung meridian.The effect drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.
The Radix Astragali, Radix Kansui, Herba Asari, the Rhizoma Pinelliae are ministerial drug altogether.
Aconitum carmichjaelii Debx. has the effect of expelling wind and removing dampness, antalgic, and external ability chafe can be used as analgesic.Be adjuvant drug.
Cortex Cinnamomi, acrid in the mouth, sweet, extremely hot in nature.Return kidney spleen conscience warp.It is supporing yang that effect is mended fire, dispersing cold for relieving pain, warming the meridian and promoting blood circulation, conducting fire back to its origin.Shennong's Herbal is said: " Your Majesty's gas cough with dyspnea stagnation of QI, sore throat is told suction, sharp joint, invigorating the spleen and replenishing QI." be messenger drug.
As preferred version of the present invention, said external used medicine comprises the following materials based on weight medicine: 9 parts of Semen Sinapis Albaes, 6 parts of Herba Ephedrae (processed), 9 parts of Radix Astragali Preparatas, 6 parts of Radix Kansuis, 6 parts of Herba Asaris, 6 parts of Aconitum carmichjaelii Debx.s, 6 parts of Rhizoma Pinelliae, 3 parts of Cortex Cinnamomis.
External used medicine according to the invention can be processed point application; Method for preparing comprises: crude drug is processed the prepared slices of Chinese crude drugs according to concocting rule; Add vaseline after the micronizing and process moist granule, add spontaneous hot body, nano-far-infrared micropowder, magnetic powder again and process the medicine cake, place the acupuncture point to paste.
When preparation point application, the acupuncture point that the present invention adopted is pasted to common on the market acupuncture point and is pasted, and is provided with the annulus that is used to fill plaster medicine in it.
Said point application cooperates paraffin in use: azone uses by the liquid of 10: 1 volume ratio mixed preparing.Cleaning skin before using is thrown off the viscose release paper, with the liquid for preparing, drips 1～2 and to the medicine cake, the plaster centre is affixed on the acupuncture point, and the viscose glue flap is affixed on that the skin surface applying light is fixing to get final product.Whenever applied ointment or plaster 1 time at a distance from 2 days, each 2～4 hours, when sticking or apply the back local skin and scorching hot, pain, redness, foaming etc. occur and can reduce the time of applying ointment or plaster.Applying ointment or plaster 10 times is 1 course of treatment.Acupoint selection when said point application is used is: FEIYU acupoint, SHANZHONG acupoint, DINGCHUAN acupoint.
Fei shu: the back shu points for lung cures mainly: cough, asthma, spitting of blood; The deficiency of YIN such as osteopyrexia and fever, night sweat disease.
Danzhong: be the pericardium the Mu-front acupoints, the air pocket of the Eight Strategic Nerve Points cures mainly: cough, asthma, uncomfortable in chest, singultus etc. be the disease of functional activity of QI being not smooth in the heart.
Dingchuan: be the back air pocket, cure mainly: asthma, cough; Pain in the shoulder and back, diseases such as stiff neck.
Because the basic cause of disease of infantile asthma is a volt in the phlegm retention, lung spleen kidney deficiency.Get the back shu points of lung, eliminate the phlegm with lung qi dispersing.Danzhong is the crossing point of gas, but the chest stuffiness relieving regulate the flow of vital energy, unfold mechanism of qi.The effect cave of Dingchuan for relievining asthma.Therefore for infantile asthma, spread on the characteristics of pointed strong, the good drug efficacy in above-mentioned acupuncture point with applying ointment or plaster.
Said moist granule, spontaneous hot body, nano-far-infrared micropowder, magnetic powder are successively by 5: 2: 1: 1 volume ratio is mixed.
External used medicine of the present invention can also be processed external use plaster, comprises common patch, ointment, cataplasma.The method for preparing of said external use plaster comprises: Semen Sinapis Albae, Cortex Cinnamomi are concocted into decoction pieces; Flooding obtains volatile oil and filtrating I; Last medicinal residues and Herba Ephedrae (processed), Radix Astragali Preparata, Herba Asari, Rhizoma Pinelliae, Aconitum carmichjaelii Debx., Radix Kansui heating flooding obtain filtrate II, and I and the filtrate II of will filtrating adds said volatile oil after merging, concentrating; And spontaneous hot body, nano-far-infrared micropowder, magnetic powder, process external use plaster.
Beneficial effect: because infantile asthma and adult have important difference, the catabasis, the adult was main with deficiency of spleen-YANG and kidneyYANG, and children's is main with the asthenia of pulmonosplenic qi deficiency, and therefore to the characteristics of infantile asthma, it is main with strengthening the spleen and tonifying the lung all that the present invention selects medicine, medication; The present invention has increased the absorption of medicine through being used the holding time of azone prolongation medicine cake; Through mixing far infrared micropowder, spontaneous hot body and magnetic powder, make drug effect combine far infrared, magnetic therapy, make curative effect more obvious; Medicine of the present invention has strengthening the spleen and tonifying the lung, the effect of dissipating fluid-retention expectorant, through cold expelling eliminate the phlegm, temperature three-way meridian, strengthening the body resistance, and conditioning viscera function, modern pharmacological research the present invention has certain antiinflammatory action, is specially adapted to infantile asthma.
The specific embodiment
Embodiment 1
A kind of external used medicine of treating infantile asthma, 9 parts of Semen Sinapis Albaes, 6 parts of Herba Ephedrae (processed), 9 parts of Radix Astragali Preparatas, 6 parts of Radix Kansuis, 6 parts of Herba Asaris, 6 parts of Aconitum carmichjaelii Debx.s, 6 parts of Rhizoma Pinelliae, 3 parts of Cortex Cinnamomis.
Embodiment 2
A kind of external used medicine of treating infantile asthma, 9 parts of Semen Sinapis Albaes, 9 parts of Herba Ephedrae (processed), 9 parts of Radix Astragali Preparatas, 7 parts of Radix Kansuis, 7 parts of Herba Asaris, 7 parts of Aconitum carmichjaelii Debx.s, 5 parts of Rhizoma Pinelliae, 3 parts of Cortex Cinnamomis.
Embodiment 3
A kind of external used medicine of treating infantile asthma, 7 parts of Semen Sinapis Albaes, 5 parts of Herba Ephedrae (processed), 4 parts of Radix Astragali Preparatas, 4 parts of Radix Kansuis, 4 parts of Herba Asaris, 4 parts of Aconitum carmichjaelii Debx.s, 4 parts of Rhizoma Pinelliae, 2 parts of Cortex Cinnamomis.
Embodiment 4
A kind of external used medicine of treating infantile asthma, 12 parts of Semen Sinapis Albaes, 12 parts of Herba Ephedrae (processed), 12 parts of Radix Astragali Preparatas, 8 parts of Radix Kansuis, 8 parts of Herba Asaris, 8 parts of Aconitum carmichjaelii Debx.s, 7 parts of Rhizoma Pinelliae, 4 parts of Cortex Cinnamomis.
Embodiment 5
The point application of processing like the external used medicine of above-mentioned embodiment 1～4; Its preparation method comprises: crude drug is processed the prepared slices of Chinese crude drugs according to concocting rule; Add vaseline after the micronizing and process moist granule; Add spontaneous hot body, nano-far-infrared micropowder, magnetic powder again and process the medicine cake, place the acupuncture point to paste.Wherein, moist granule, spontaneous hot body, nano-far-infrared micropowder, magnetic powder are successively by 5: 2: 1: 1 volume ratio is mixed.
Point application cooperates paraffin in use: azone uses by the liquid of 10: 1 volume ratio mixed preparing.Cleaning skin before using is thrown off the viscose release paper, with the liquid for preparing, drips 1～2 and to the medicine cake, the plaster centre is affixed on the acupuncture point, and the viscose glue flap is affixed on that the skin surface applying light is fixing to get final product.Whenever applied ointment or plaster 1 time at a distance from 2 days, each 2～4 hours, when sticking or apply the back local skin and scorching hot, pain, redness, foaming etc. occur and can reduce the time of applying ointment or plaster.Applying ointment or plaster 10 times is 1 course of treatment.Acupoint selection when said point application is used is: FEIYU acupoint, SHANZHONG acupoint, DINGCHUAN acupoint.
Embodiment 6
Like the external use plaster that the external used medicine of above-mentioned embodiment 1～4 is processed, its preparation method comprises: Semen Sinapis Albae, Cortex Cinnamomi are concocted into decoction pieces, add 6～10 times of floodings; Obtain volatile oil and filtrating I, last medicinal residues and Herba Ephedrae (processed), Radix Astragali Preparata, Herba Asari, Rhizoma Pinelliae, Aconitum carmichjaelii Debx., Radix Kansui add 8～12 times of water heating extraction 1～1.5 hour after merging, and filter; Add 6～10 times of water extraction again 1～1.5 hour, and filtered, obtain filtrate II; I merges with filtrating, (the medical material: medicinal liquid) that is concentrated into 2: 1.
Add 95% ethanol in the medicinal liquid after concentrating to containing alcohol amount 70%, cold preservation was left standstill 24～48 hours, filtered; Filtrate recycling ethanol is to there not being the alcohol flavor; Be concentrated into relative density 1～1.2, in concentrated solution, add the required conventional adjuvant of preparation different dosage form, add above-mentioned volatile oil; Add heater, nano-far-infrared micropowder, magnetic powder, process external use plaster.
External use plaster comprises common patch, ointment, cataplasma.
Test Example 1
The effect that this Test Example is prevented and treated infantile asthma through tcm clinical practice evidence external used medicine of the present invention and point application.
Adopt the kidney and spleen invigorating method to cooperate the paracmastic asthenia of both the spleen and kidney card of Chinese medicine point application treatment infantile asthma, clinical case 60 examples of collecting altogether meet research approach 57 examples, and 28 examples are organized in treatment, matched group 29 examples.The treatment group is given embodiment 1 described external prescription, and matched group gives the suction Pulmicort Turbuhaler.Treat and carry out follow-up observation after 3 months, follow up a case by regular visits to the comparison before and after treating after 3 months.The result sees shown in the table 1.
The judgement of table 1 liang group curative effect of disease
Can find out from table 1: (1) two group aspect the improving of cardinal symptom such as respiratory tract number of times, asthma attack time, the treatment group is superior to matched group (P＜0.05); And aspect asthma attack number of times, asthma attack degree, two groups are all obviously improved, but curative effect is similar, difference not statistically significant (P＞0.05); Inferior disease integration improves the aspect, and the treatment group obviously is superior to matched group, and two groups of differences have statistical significance (P＜0.05).(2) aspect the curative effect of disease evaluation; Treatment group and matched group control, produce effects, effective, invalid routine number are respectively 5,16,7,0 and 3,9,15,2; Treatment group control obvious effective rate is 75%; Matched group control obvious effective rate is 41.1%, shows that the Chinese traditional treatment group totally is superior to matched group (P＜0.05) aspect the improving of primary symptom.Tcm syndrome therapeutic evaluation aspect, treatment group and matched group clinical recovery, produce effects, effective, invalid routine number are respectively 3,18,7,0 and 2,12,14,1, and treatment group clinical recovery rate is 10.7%; The recovery from illness obvious effective rate is 75.0%; Matched group clinical recovery rate is 6.9%, and the recovery from illness obvious effective rate is that 48.3%, two group of curative effect compares; Statistical significance (P＜0.05) is arranged, and treatment group effective percentage is superior to matched group.Two groups of infants side effect all do not occur in therapeutic process.
Test Example 2
This Test Example is through the clinical trial proof antiinflammatory action of applying ointment or plaster according to the invention to rat.
Get 60 of KM mices, male and female half and half, body weight 19～21g.Be divided into 4 groups at random by body weight: be respectively 1. blank group: NS 10ml/kg; 2. Dexamethasone group: 2mg/kg; 3. test group.Matched group press the volume gastric infusion 1 time of 20ml/kg every day by above-mentioned dosage, and the test group employing is affixed on abdominal part like embodiment 5 described medicament plasters, for three days on end.Behind the last administration 30min, tail vein injection 0.5% azovan blue 0.1ml/10g, lumbar injection 0.6% glacial acetic acid 0.2ml/ is only simultaneously.Take off cervical vertebra behind the 20min and put to death mice,, extract the about 4.5ml of abdominal cavity washing liquid out with syringe with 5ml normal saline flushing abdominal cavity.The centrifugal 5min of 2000rpm measures ultraviolet absorptivity value (A) in the 590nm place.The result sees shown in the table 2.
Table 2 medicament plaster is to the influence
of mouse peritoneal capillary permeability
*P＜0.05,
*P＜0.01 and blank group
Can find out that from table 2 compare with the blank group, the medicament plaster group can significantly suppress glacial acetic acid and cause mice capillary permeability increase (p＜0.05).Show that this patent has significantly antiinflammatory action.
Test Example 3
Get 60 of male ICR mouses, body weight 26～29g is divided into 4 groups at random by body weight: be respectively 1. blank group: NS 20ml/kg; 2. Dexamethasone group: 2mg/kg; 3. test group.Matched group press the volume gastric infusion 1 time of 20ml/kg every day by above-mentioned dosage, and test group adopts thing drug application subsides abdominal part, for three days on end.Be applied to ear both sides, a mice left side with xylene 0.1ml behind the last administration 30min.After causing scorching 1h, put to death mice, two ears about cutting, (diameter 9mm) takes off round auricle at same position respectively with card punch, and scales/electronic balance weighing calculates auricle weight, and respectively organizes mice auricle swelling degree (left auricle weight-auris dextra is wide heavy).Mice auricle swelling degree * 100% of the mice auricle swelling degree/blank control group of inhibitory rate of intumesce=administration group.The result is as shown in table 3.
The influence
of table 3 medicament plaster xylol induced mice ear swelling
*P＜0.05,
*Compare with the blank group p＜0.01
Can find out that from table 3 medicament plaster of test group can obviously alleviate mice auricle swelling degree and swelling rate,, show that the present invention can resist the inflammatory reaction due to the xylene, has antiinflammatory action with blank group comparing difference significantly (p＜0.05,0.01).
The above only is a preferred implementation of the present invention; Be noted that for those skilled in the art; Under the prerequisite that does not break away from the principle of the invention, can also make some improvement and retouching, these improvement and retouching also should be regarded as protection scope of the present invention.
Claims (7)
1. external used medicine of preventing and treating infantile asthma is characterized in that comprising the following materials based on weight medicine:
7～12 parts of Semen Sinapis Albaes,
5～12 parts of Herba Ephedrae (processed),
4～11 parts of Radix Astragali Preparatas,
4～8 parts of Radix Kansuis,
4～8 parts of Herba Asaris,
4～8 parts of Aconitum carmichjaelii Debx.s,
4～7 parts of Rhizoma Pinelliae,
2～4 parts of Cortex Cinnamomis.
2. a kind of external used medicine of preventing and treating infantile asthma according to claim 1 is characterized in that, said external used medicine comprises the fractional crude drug of following weight:
9 parts of Semen Sinapis Albaes,
6 parts of Herba Ephedrae (processed),
9 parts of Radix Astragali Preparatas,
6 parts of Radix Kansuis,
6 parts of Herba Asaris,
6 parts of Aconitum carmichjaelii Debx.s,
6 parts of Rhizoma Pinelliae,
3 parts of Cortex Cinnamomis.
3. the external used medicine point application of processing according to claim 1; It is characterized in that; This method for preparing of applying ointment or plaster comprises: crude drug is processed the prepared slices of Chinese crude drugs according to concocting rule; Add vaseline after the micronizing and process moist granule, add spontaneous hot body, nano-far-infrared micropowder, magnetic powder again and process the medicine cake, place the acupuncture point to paste.
4. a kind of point application according to claim 3 is characterized in that: said moist granule, spontaneous hot body, nano-far-infrared micropowder, magnetic powder are successively by 5: 2: 1: 1 volume ratio is mixed.
5. the external use plaster that external used medicine as claimed in claim 1 is processed is characterized in that: Semen Sinapis Albae, Cortex Cinnamomi are concocted into decoction pieces, and water logging is extracted and is obtained volatile oil and filtrating I; Last medicinal residues and Herba Ephedrae (processed), Radix Astragali Preparata, Herba Asari, Rhizoma Pinelliae, Aconitum carmichjaelii Debx., Radix Kansui; Extracting in water obtains filtrate II, and I and the filtrate II of will filtrating adds said volatile oil after merging, concentrating; And spontaneous hot body, nano-far-infrared micropowder, magnetic powder, process external use plaster.
6. external use plaster according to claim 5 is characterized in that: said external use plaster comprises common patch, ointment, cataplasma.
7. like the application of the said point application of claim 3 on preparation control infantile asthma medicine.
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| CN107213300A (en) * | 2017-06-14 | 2017-09-29 | 广西壮族自治区疾病预防控制中心 | A kind of externally-applied medicinal composition for treating san bronchial asthma disease |
| CN108653694A (en) * | 2018-06-21 | 2018-10-16 | 王涛 | A kind of spontaneous heating acupoint plaster for treating children's dyspneic cough |
| CN109464646A (en) * | 2019-01-04 | 2019-03-15 | 河南尚工药业有限公司 | Ointment formula, preparation method and application are massaged in cough-relieving paediatrics external application |
| CN113181335A (en) * | 2021-06-09 | 2021-07-30 | 山东中医药大学 | Acupoint application for treating bronchial asthma cold drink accumulation in lung and preparation method thereof |
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| 陈寿永: "乌头汤在内妇科运用举例", 《四川中医》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107213300A (en) * | 2017-06-14 | 2017-09-29 | 广西壮族自治区疾病预防控制中心 | A kind of externally-applied medicinal composition for treating san bronchial asthma disease |
| CN108653694A (en) * | 2018-06-21 | 2018-10-16 | 王涛 | A kind of spontaneous heating acupoint plaster for treating children's dyspneic cough |
| CN109464646A (en) * | 2019-01-04 | 2019-03-15 | 河南尚工药业有限公司 | Ointment formula, preparation method and application are massaged in cough-relieving paediatrics external application |
| CN113181335A (en) * | 2021-06-09 | 2021-07-30 | 山东中医药大学 | Acupoint application for treating bronchial asthma cold drink accumulation in lung and preparation method thereof |
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Application publication date: 20120704 |