CN102499902A - Oral cavity care composition - Google Patents
Oral cavity care composition Download PDFInfo
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- CN102499902A CN102499902A CN2012100029871A CN201210002987A CN102499902A CN 102499902 A CN102499902 A CN 102499902A CN 2012100029871 A CN2012100029871 A CN 2012100029871A CN 201210002987 A CN201210002987 A CN 201210002987A CN 102499902 A CN102499902 A CN 102499902A
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Abstract
The invention provides an oral cavity care composition which contains vitamin C and pearl hydrolysate which is prepared from sea pearl by a biochemical method. The oral cavity care composition can be applied to toothpaste, gel, mouth wash, powder, candy, lozenge and other oral cavity care products. The vitamin C and the pearl hydrolysate can be used together for improving the stability of the composition in a product shelf life, and can act synergistically to promote absorption, and have the effects of nourishing teeth and gum, caring oral cavity, strengthening gum and firming teeth, which are superior to those of a single active matter.
Description
Technical field
The present invention relates to a kind of oral care composition, more specifically the present invention relates to a kind of oral care composition that contains vitamin C and Margarita hydrolyzed solution.
Background technology
Vitamin C is ascorbic acid again, is a kind of water soluble vitamins, and its structure is as follows:
Vitamin C is a kind of water miscible vitamin, can prevent gingival atrophy and hemorrhage.It is the essential material of collagen protein synthesis.Collagen protein is the key component of intercellular substance, and intercellular substance connects cell, constitutes tissue.Equally, collagen protein has also determined microvascular intensity, elasticity in the blood vessel, has guaranteed blood vessel intensity, makes blood vessel be not easy to break.Healthy dental bed tightly encases each tooth.Gingiva is a soft tissue, and vitamin C can prevent gingival atrophy and hemorrhage.In addition, vitamin C has very strong antioxygenic property, prevents the destruction of radical pair oral cavity tissue, helps to prevent various oral diseases.Also there is patent that vitamin C is made an addition in the oral care product at present,, can reduces the generation of oral disease as disclosing more full needed by human body trace element and the vitamin of adding in toothpaste in the patent 92108108.1.
But, in aqueous solution, very easily receive the destruction of heat, light and oxygen, thereby its activity is weakened because vitamin C has stronger reproducibility.Therefore contain ascorbic oral care implement, often because the unstability of vitamin causes the activity of vitamin in the shelf-life to reduce.In addition, because the occupation mode of oral care implement, model of action and food, medicine are different, lack the action time of oral care product, uses ascorbic oral cavity residual quantity low, thereby caused vitamin C absorbtivity in the oral cavity low, and bioavailability is low.
Margarita hydrolyzed solution is through biochemical reaction, decomposition, extraction, and calcium carbonate a large amount of in the Margarita powder is removed, and extracts its effective ingredient-several amino acids and other nutritional labelings.These aminoacid comprise 8 kinds of essential amino acids, serine wherein, scalable human endocrines such as a word used in person's names propylhomoserin, enhancing immunity and remove free radical, antidotal effect.Also there is patent Margarita hydrolyzed solution to be applied in the oral care products such as toothpaste; In patent CN1148486A; Announced a kind of toothpaste and collutory liquid that contains water solutable component of pearl; This invention adds Margarita hydrolyzed solution in toothpaste and collutory, make it have good cleaning and nutrition health-care functions to tooth and oral cavity, can prevent and treat various tooth diseases and oral disease.But because Margarita hydrolyzed solution has stronger reproducibility, very easily receive the destruction of heat, light and oxygen, contain the oral care implement of Margarita hydrolyzed solution, have unstability equally, action time is short, the shortcoming that bioavailability is low.
In addition, aspect the free radical of removing oral cavity, vitamin C mainly is to remove peroxy radical, alkoxy free group and hydroxyl radical free radical.Margarita hydrolyzed solution can significantly improve the superoxide dismutase (SOD) in the tissue, mainly is to remove alkoxy free group and nitric oxide free radical.And common free radical comprises peroxy radical in the oral cavity, alkoxy free group, hydroxyl radical free radical, alkoxy free group and nitric oxide free radical.The product that contains single vitamin C or Margarita hydrolyzed solution, it is removed in oral cavity, and the free radical ability is not enough, and the kind of removing free radical in the oral cavity is not comprehensive, thereby has caused the effect of product not strong yet, to characteristics such as the preventive effect of tooth or oral disease are not high.Single vitamin C, Margarita hydrolyzed solution all can't be removed free radical several frequently seen in the oral cavity, thereby cause the scarce capacity of its prophylaxis of teeth and oral disease.
Summary of the invention
The purpose of this invention is to provide a kind of oral care composition that contains vitamin C and Margarita hydrolyzed solution; The invention solves the oral care product that contains single vitamin C or Margarita hydrolyzed solution and can't remove free radical several frequently seen in the oral cavity, thereby cause the problem of the scarce capacity of its prophylaxis of teeth and oral disease.
A kind of oral care composition, said compositions contains vitamin C and Margarita hydrolyzed solution, and wherein the weight ratio of vitamin C and Margarita hydrolyzed solution is 0.001 ~ 1:1.It is 0.01 ~ 1:1 that the weight ratio of described vitamin C and Margarita hydrolyzed solution is preferably.The weight ratio of described vitamin C and Margarita hydrolyzed solution is 0.1 ~ 0.5:1 more preferably.
Margarita hydrolyzed solution in the said oral care composition is from sea water pearls, particularly the Hepu Margarita.Through biochemical method, through reaction, decomposition, extraction, calcium carbonate a large amount of in the Margarita powder remove, and extract its effective ingredient-several amino acids and other nutritional labelings.Contain 8 kinds of necessary aminoacid of human body in this Margarita hydrolyzed solution, and kind more than ten and the closely-related aminoacid of human life metabolism.Scalable human endocrine, enhancing immunity and defying age such as serine, a word used in person's names propylhomoserin wherein.
Also contain a large amount of trace element in the described Margarita hydrolyzed solution, calcium, taurine and small molecule active peptide.
The percentage by weight of calcium ion is 5%-8% in the described Margarita hydrolyzed solution, and the percentage by weight of micromolecule polypeptide is 1%-2%.
The method for preparing of said oral care composition may further comprise the steps: (a) in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion, make it act on 1-2 hour at normal temperatures; (b) be incorporated as the carase of Margarita weight 0.01%, 60-70 ℃ of effect 4-6 hour; (c) supernatant of getting mixture obtains required Margarita hydrolyzed solution; (d) take by weighing vitamin C and under stirring condition, join in the Margarita hydrolyzed solution of corresponding weight ratio; (e) mixture in the step (d) is mixed, can obtain described oral care composition.
The used Margarita hydrolyzed solution of described oral care composition also can be produced like the CN1051394A disclosed method by the prior art method.
Said oral care composition can be added in the oral care product, and said oral care product comprises dosage form usually such as toothpaste, dentifrice, prophylaxis pastes, mouthwass, lozenge, chewing gum.
In different embodiments of the present invention, the oral care product of selected interpolation preferably is applied to the product of actinal surface regularly; The oral care product that use preferred every day continues many days at least once a day; Most preferably, said oral cavity composition every day be applied to actinal surface 1-3 time, continued at least 2 thoughtful 8 weeks or longer, like toothpaste, dentifrice etc.
In different embodiments, according to the concentration of said oral care composition and the form of said oral care product, the addition of said oral care composition is 0.0001% ~ 10% of an oral care product weight; The addition of said oral care composition is preferably 0.001% ~ 5% of oral care product weight; The addition of said oral care composition more preferably oral care product weight 0.01% ~ 3%.
Can add various other optional oral care actives in the said oral care composition; For example antibacterial, ascoxal, antitack agent (the prevention bacterial plaque sticks to enamel surface), polyphenoils (like coenzyme Q10), caries preventive agent, desensitizer (like potassium nitrate, Soluble tartar., potassium citrate and strontium chloride), brightening agent, tartar controlling agent, periodontal actives, chlorophyll compound, abrasive material, breath freshening controlling agent are (like zinc salt; For example zinc gluconate, zinc citrate, zinc chloride) and saliva stimulant (for example citric acid, lactic acid, malic acid), and well known by persons skilled in the art any other is applicable to the composition of MC.
Said oral care composition can add a kind of or its combination in viscosity modifier, diluent, surfactant, emulsifying agent, foam modifier, pH regulator agent, abrasive material, wetting agent, softening agent, mouthfeel regulator, sweeting agent, flavoring agent, coloring agent, the antiseptic.Though the general aspects of each type of above-mentioned substance classification can be different, also can have some common properties, and any given material can belong in these material classifications two types or multiclass more.Preferably, according to the material compatible with Margarita hydrolyzed solution with vitamin C of the present invention, as: sodium carboxymethyl cellulose, sodium lauryl sulphate, sorbitol, glycerol, saccharin sodium, sodium fluoride, silicon dioxide, sodium lauryl sulfate etc.
Beneficial effect of the present invention: the first, vitamin C and Margarita hydrolyzed solution stability in oral care product significantly improves, thereby has guaranteed the stability of two kinds of active matters in shelf life of products; The second, two active component-vitamin Cs and Margarita hydrolyzed solution in this oral care composition can be brought into play synergism in product, and Margarita hydrolyzed solution can promote the absorption of vitamin C and several amino acids, increases ascorbic bioavailability.Vitamin C and Margarita hydrolyzed solution can be removed free radical common in the human oral cavity in this oral care composition, and both bring into play synergism, promote to absorb.Added oral care product of the present invention, be employed in reusable science method for using in period of many days, can help to replenish the tooth required nutrition of growing up,, given the gingiva prescribing adequate nutrition, healthy mouth, strong gingiva, firm tooth to the oral problem origin.
With respect to prior art; The present invention has following characteristics: vitamin C and Margarita hydrolyzed solution have appropriate blend proportion; Ascorbic amount is not more than the amount of Margarita hydrolyzed solution, owing in the Margarita hydrolyzed solution a certain amount of calcium ion and micromolecule polypeptide are arranged, thus guarantee ascorbic stability; Vitamin C and Margarita hydrolyzed solution combined effect can be removed free radical common in the oral cavity, and the kind of removing free radical is superior to single active component or other antioxidant.
The specific embodiment
One, the preparation embodiment of oral care composition of the present invention:
Embodiment one:
1. preparation Margarita hydrolyzed solution: in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion; Act on 1-2 hour at normal temperatures; Add 0.01% carase again,, get the supernatant and obtain required Margarita hydrolyzed solution 60 ~ 70 ℃ of effects 4 ~ 6 hours;
2. take by weighing the 0.1g vitamin C, under stirring condition, join in the Margarita hydrolyzed solution of 0.9g gained in step 1, stirred 10 minutes, room temperature preservation get final product this oral care composition.
Embodiment two:
1. preparation Margarita hydrolyzed solution: in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion; Act on 1-2 hour at normal temperatures; Add 0.01% carase again,, get the supernatant and obtain required Margarita hydrolyzed solution 60 ~ 70 ℃ of effects 4 ~ 6 hours;
2. take by weighing the 0.25g vitamin C, under stirring condition, join in the Margarita hydrolyzed solution of 1.0g, stirred 15 minutes, room temperature preservation get final product this oral care composition.
Embodiment three:
1. preparation Margarita hydrolyzed solution: in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion; Act on 1-2 hour at normal temperatures; Add 0.01% carase again,, get the supernatant and obtain required Margarita hydrolyzed solution 60 ~ 70 ℃ of effects 4 ~ 6 hours;
2. take by weighing the 0.5g vitamin C, under stirring condition, join in the Margarita hydrolyzed solution of 1.0g, stirred 15 minutes, room temperature preservation get final product this oral care composition.
The oral care composition of different embodiment preparation put in 40 ℃ the baking oven, investigate the stability of vitamin C and Margarita hydrolyzed solution.Experimental result is as shown in table 1:
The Detection of Stability of table 1 vitamin C and Margarita hydrolyzed solution different proportion
Table 1 result shows that embodiment one is with the vitamin C among the embodiment two, and aminoacid has all shown stability preferably in 40 ℃ of high temperature investigation processes, and wherein aminoacid and ascorbic stability are best among the embodiment two.Can find out that from experimental result there are an optimal proportion value in vitamin C and Margarita hydrolyzed solution.
Two, the embodiment that in oral care product, uses of this oral care composition:
Described interpolation oral care product of the present invention can assign to prepare through the said one-tenth of suitable mixing.
Embodiment one: this oral care composition is used in toothpaste
Table 2 contains the formulation of tooth-paste of oral care composition
Preparation technology is following:
The oral care composition that (1) will comprise vitamin C and Margarita hydrolyzed solution dissolves in water by a certain amount of prescription;
(2) various salt (comprising fluoride) and sweeting agent (for example saccharin sodium) are added in the container 1, add entry and stirring;
(3) whole wetting agents and rubber powder are joined in the container 2, the aqueous mixtures in the step 2 is added in the container 2;
(4) with said mixture with after abrasive material mixes, mixed at high speed is 15 to 20 minutes under vacuum;
(5) adding flavoring agent, active component and surfactant at last fully mixes, disperses under vacuum.
By the toothpaste of above-mentioned prepared, accelerated ageing detected vitamin C and content of amino acids in the toothpaste after 3 months under 40 ℃ temperature.Testing result such as table 3:
Table 3 vitamin C and the aminoacid Detection of Stability in toothpaste
The testing result of table 3 shows, vitamin C and amino acid whose having good stability in this toothpaste.This explanation, vitamin C and Margarita hydrolyzed solution reasonably combined can promote both stability.Release its mechanism, maybe since in the Margarita hydrolyzed solution calcium ion or micromolecule polypeptide and vitamin C complex reaction has taken place, thereby played the effect of stable vitamin C.Simultaneously, ascorbic reproducibility has guaranteed that again the several amino acids in the Margarita hydrolyzed solution is not oxidized.Both connect each other, react to each other, and have promoted both stability.
Vitamin C and Margarita hydrolyzed solution use simultaneously not only can improve the two stability in shelf life of products, more can synergism, and promote to absorb, and nutrition tooth, the gingiva that is superior to the single-activity thing, healthy mouth, strong gingiva, the effect of firm tooth are provided.Add the oral care product of this oral care composition, be employed in reusable science method for using in period of many days, can help to replenish the tooth required nutrition of growing up; To the oral problem origin, give the gingiva prescribing adequate nutrition, healthy mouth; Strong gingiva, firm tooth.
Use contains the toothpaste of said composition after 1 week, gingiva tissue, and the ascorbic content in the oral mucosa only contains ascorbic toothpaste apparently higher than using; The 3rd, said composition can effectively be removed the peroxy radical in the oral cavity, alkoxy free group, and hydroxyl radical free radical, alkoxy free group and nitric oxide free radical, kind and ability that it removes free radical all obviously are superior to single active matter.
Embodiment two: the application of this oral care composition in collutory
Table 4 contains the collutory prescription of oral care composition
Choose 12 child experimenters, use and contain one week of oral care composition of the present invention, every day 2 times.Get experimenter's saliva and level in gingival sulcus fluid, adopt HPLC (HPLC) to detect ascorbic content wherein.Testing result is as shown in table 5:
The Clinical detection test of table 5 oral care composition
The result shows in the table 5, uses the toothpaste that contains oral care composition of the present invention after one week, the vitamin C of residual 0.02mg of difference and 0.004mg in saliva and the level in gingival sulcus fluid.The vitamin C of this concentration can be removed 20% of free radical in the oral cavity.Simultaneously, because Margarita hydrolyzed solution can significantly improve the superoxide dismutase (SOD) in the tissue, remove alkoxy free group and nitric oxide free radical; Both interact, and can effectively remove free radical unnecessary in the oral cavity, the nutrition gingiva; Healthy mouth helps to prevent various oral diseases.
According to the announcement and the instruction of above-mentioned description, those skilled in the art in the invention can also change and revise above-mentioned embodiment.Therefore, the specific embodiment that discloses and describe above the present invention is not limited to also should fall in the protection domain of claim of the present invention modifications more of the present invention and change.In addition, although used some specific terms in this description, these terms are explanation for ease just, the present invention is not constituted any restriction.
Claims (10)
1. oral care composition, it is characterized in that: said compositions contains vitamin C and Margarita hydrolyzed solution, and wherein the weight ratio of vitamin C and Margarita hydrolyzed solution is 0.001 ~ 1:1.
2. according to the oral care composition of claim 1, it is characterized in that: the weight ratio of described vitamin C and Margarita hydrolyzed solution is 0.01 ~ 1:1.
3. according to the oral care composition of claim 2, it is characterized in that: the weight ratio of described vitamin C and Margarita hydrolyzed solution is 0.1 ~ 0.5:1.
4. according to the arbitrary described oral care composition of claim 1 to 3, it is characterized in that: contain trace element in the described Margarita hydrolyzed solution, calcium, taurine and small molecule active peptide.
5. according to the arbitrary described oral care composition of claim 1 to 3, it is characterized in that: the percentage by weight of calcium ion is 5%-8% in the described Margarita hydrolyzed solution, and the percentage by weight of micromolecule polypeptide is 1%-2%.
6. the method for preparing of oral care composition is characterized in that, may further comprise the steps:
(a) in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion, make it act on 1-2 hour at normal temperatures;
(b) be incorporated as the carase of Margarita weight 0.01%, 60-70 ℃ of effect 4-6 hour;
(c) supernatant of getting mixture obtains required Margarita hydrolyzed solution;
(d) take by weighing vitamin C and under stirring condition, joining in the Margarita hydrolyzed solution of corresponding weight ratio, can obtain described oral care composition.
7. the method for using of oral care composition, it is characterized in that: described compositions can be added in the oral care product, and said oral care product comprises toothpaste, dentifrice, prophylaxis pastes, mouthwass, lozenge, chewing gum.
8. according to the method for using of the oral care composition of claim 7, it is characterized in that: the compositions addition is 0.0001% ~ 10% of an oral care product weight ratio.
9. according to Claim 8 the method for using of oral care composition, it is characterized in that: the compositions addition is 0.001% ~ 5% of an oral care product weight ratio.
10. according to the method for using of the oral care composition of claim 9, it is characterized in that: the compositions addition is 0.01% ~ 3% of an oral care product weight ratio.
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| CN201210002987.1A CN102499902B (en) | 2012-01-06 | 2012-01-06 | Oral cavity care composition |
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| CN201210002987.1A CN102499902B (en) | 2012-01-06 | 2012-01-06 | Oral cavity care composition |
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| CN102499902A true CN102499902A (en) | 2012-06-20 |
| CN102499902B CN102499902B (en) | 2014-05-14 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105534749A (en) * | 2015-12-25 | 2016-05-04 | 名臣健康用品股份有限公司 | Child intelligence benefiting toothpaste |
| CN105994922A (en) * | 2016-07-06 | 2016-10-12 | 安徽米乐食品有限公司 | Refreshing and antifatigue nutritive healthcare chewing gum and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889969A (en) * | 2009-05-20 | 2010-11-24 | 广州薇美姿个人护理用品有限公司 | Natural fluorine-free edible transparent child nutrition toothpaste |
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2012
- 2012-01-06 CN CN201210002987.1A patent/CN102499902B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889969A (en) * | 2009-05-20 | 2010-11-24 | 广州薇美姿个人护理用品有限公司 | Natural fluorine-free edible transparent child nutrition toothpaste |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105534749A (en) * | 2015-12-25 | 2016-05-04 | 名臣健康用品股份有限公司 | Child intelligence benefiting toothpaste |
| CN105994922A (en) * | 2016-07-06 | 2016-10-12 | 安徽米乐食品有限公司 | Refreshing and antifatigue nutritive healthcare chewing gum and preparation method thereof |
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| Publication number | Publication date |
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| CN102499902B (en) | 2014-05-14 |
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