CN102441096B

CN102441096B - Disperse blood stasis and dredge collateral compound recipe pill and preparation method thereof

Info

Publication number: CN102441096B
Application number: CN201110394710.3A
Authority: CN
Inventors: 孙殿良; 孙华荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-12-02
Filing date: 2011-12-02
Publication date: 2016-07-27
Anticipated expiration: 2031-12-02
Also published as: CN102441096A

Abstract

A kind of herbal mixture pill, its raw material composition is, Radix Salviae Miltiorrhizae 8～12g, Radix Puerariae 6～8g, Fructus Crataegi 6～8g, Rhizoma Chuanxiong 6～8g, the Radix Astragali 6～8g, Folium Ginkgo 8～12g, GUANG Radix Notoginseng 2～4g, Sargassum 2～4g, the Radix Paeoniae Alba 2～4g, Radix Et Rhizoma Rhei 2～4g, Flos Carthami 2～4g, Bulbus Allii Macrostemonis 2～4g, Pheretima 2～4g, Auricularia 2～4g, Flos Echinopsis latifolii 5～7g.Medicine of the present invention is for disperse blood stasis and dredge collateral preventing and treating cardiovascular and cerebrovascular disease.

Description

Disperse blood stasis and dredge collateral compound recipe pill and preparation method thereof

Technical field

Chinese medicine compound pill that the present invention relates to a kind of acupuncture-stimulating blood stasis dispersing and preparation method thereof, this pill is intended to for preventing and treating cardiovascular and cerebrovascular disease.

Background technology

Cardio-cerebral diseases is the general designation of cardiovascular disease and cerebrovascular disease, and along with the raising of living standards of the people and the continuous of medical science detection means are improved, people have increasing understanding for cardiovascular and cerebrovascular disease.Cardiovascular and cerebrovascular disease has " sickness rate is high, disability rate is high, mortality rate is high, relapse rate is high, and complication is many " the i.e. feature of " four is high by more than ", and at present, China's Patients with Cardiovascular/Cerebrovascular Diseases alreadys more than 2.7 hundred million people！China dies from nearly 3,000,000 people of cardiovascular and cerebrovascular disease every year, accounts for the 51% of China's total Death causes every year.And patient 75% disability in various degree survived.

Existing medicine, majority is the treatment for incidence, and owing to the site of action of cardiovascular and cerebrovascular disease is special, prison bed rescue time is of short duration, so, many cardiovascular and cerebrovascular diseases cause due to relief worsening rapidly even death not in time.Namely being able to timely treatment, most chemical synthetic drugs all have stronger toxic and side effects, and clinical therapeutic efficacy is unsatisfactory.Therefore, for cardiovascular and cerebrovascular disease, preventing and treating combines, and reduces incidence probability, reduces the sick order of severity sent out and is easy to treatment.And prevention emphasis strengthens anticoagulant platelet activating factor in blood exactly, improve plasmin activity, promote fibrinolysis, to dissolve thrombosis, avoid hemostatic composition in blood to form thromboembolism at Ink vessel transfusing, thus disperse blood stasis and dredge collateral, reduce the incidence probability of cardiovascular and cerebrovascular disease.

China's crude drug is very abundant, and many Chinese medicine materials all have effect of disperse blood stasis and dredge collateral.Namely the present invention is that the Chinese crude drug filtering out specific drug effect carries out studying, processing, and prepares into the preparation of applicable clinical practice according to Chinese materia medica principle, it is possible to effectively prevent the generation of cardiovascular and cerebrovascular disease.

Technology contents

It is an object of the invention to develop a kind of medicine pill, this pill has the function of disperse blood stasis and dredge collateral, can effectively prevent the disease of cardiovascular and cerebrovascular disease to send out.

The technical scheme is that, the medicine pill of described disperse blood stasis and dredge collateral is made up of following raw material: Radix Salviae Miltiorrhizae, Radix Puerariae, Fructus Crataegi, Rhizoma Chuanxiong, the Radix Astragali are each, Folium Ginkgo, GUANG Radix Notoginseng, Sargassum, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, Flos Carthami, Bulbus Allii Macrostemonis, Pheretima, Auricularia, Flos Echinopsis latifolii.

Above-mentioned Chinese medicine, functionally, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, can improve the activity of fibrinolysin, promote fibrinous dissolving, hemorheology in patients index can be made to improve；Containing puerarin, Pueraria lobota flavone antioxidation in Radix Puerariae, it is possible to increase human immunocyte's function, defence, from steady, coronary artery, cerebral arteries can be made expands, vascular resistance reduction, blood sugar lowering, blood pressure lowering；Fructus Crataegi have help digestion long-pending, the function of dissipating blood stasis blood；Rhizoma Chuanxiong effective ingredient alkaloid, ligustrazine etc., can alleviate atherosclerosis, expands blood vessel, reduces blood pressure, and increases arteria coronaria and cerebral blood flow；The stasis of blood is not stayed in GUANG Radix Notoginseng hemostasis, and dissipating blood stasis is not acted recklessly, containing saponins, it is possible to suppresses platelet aggregation, has thrombolytic, blood pressure lowering, study of anti-atherogenic effect；Sargassum is apt to walk and is apt to break, the meridian dredging, and broken heavily fortified point knot, expectorant is turbid, with controlling blood thickness；The Radix Paeoniae Alba can nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant, short blood sugar lowering；Radix Et Rhizoma Rhei has heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation effect；Flos Carthami includes saffloside, it is possible to latus rectum of invigorating blood circulation, eliminating stasis to stop pain, moreover it is possible to improve heart and brain hypoxia-bearing capability；Bulbus Allii Macrostemonis can be regulated the flow of vital energy, and the chest stuffiness relieving activates yang, eliminating stagnation；Pheretima contains several amino acids, lumbricin, adjusts, vitamin, has blood pressure lowering, blood coagulation resisting function；Folium Ginkgo has astringes the lung, and relievings asthma, the pharmacological function of blood circulation promoting and blood stasis dispelling；.Auricularia have QI invigorating keep fit, the function such as invigorate blood circulation, it can anticoagulant, antithrombotic, blood fat reducing, reduce blood and glue, vessel softening, make blood flowing dynamic smooth, reduce cardiovascular diseases and occur；Flos Echinopsis latifolii can promoting flow of QI and blood, dredging collateral is invigorated blood circulation and is reduced blood pressure, and often controls traumatic injury, numb hand and foot, hemiplegia of limb；The Radix Astragali contains the various trace elements such as saponins, amino acids and ferrum, copper, zinc, manganese, there is enhancing body immune function.The Fang Zhongyong Radix Astragali with QI invigorating, take its power obligate walk, move the power of all medicines with boosting.

Prescription used by the present invention is not for all kinds of simple combination with disperse blood stasis and dredge collateral medical material, but considering the basis of the character of various kinds of drug, taste, the property of medicine, drug interaction screens, and the prescription formed according to a certain ratio, Each performs its own functions in each side, both organic cooperation, mutually promoted again.

The preparation method of pill of the present invention is according to certain mass ratio selection by said medicine, dries, sterilizing, co-grinding, sieves, and granulates with ethanol wet, and grain weighs about 0.4g.

The made pill of the present invention, the mode of taking is every day three times, half an hour ante cibum, warm water delivery service 15～20.

Specific embodiment

1, material prepares, and takes Radix Salviae Miltiorrhizae 10g, Radix Puerariae, Fructus Crataegi, Rhizoma Chuanxiong, each 6g of the Radix Astragali, Folium Ginkgo 10g, GUANG Radix Notoginseng, Sargassum, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, Flos Carthami, Bulbus Allii Macrostemonis, Pheretima, each 3g of Auricularia, Flos Echinopsis latifolii 7g.Cleaning, be placed in baking oven, baking oven is transferred to 45 DEG C, dries 16 hours at this temperature, re-uses ultraviolet disinfection tank and carry out disinfection, and ultraviolet disinfection tank is transferred to 25 DEG C and is sterilized 3 hours, takes out stand-by.

2, being placed on by ready material in pulverizer and pulverize 30 minutes, cross 100 mesh sieves, obtain canescence planar powder, add ethanol in proper amount, stirring makes it have adhesion sense to be advisable, and puts into granulator and granulates, and the ball obtaining pill weighs about as 0.4g.

3, putting in an oven by obtained pill, baking oven is transferred to 35 DEG C dries this pill, and envelope stores.

Clinical efficacy

1. clinical data

33 example cardio-cerebralvascular diseases patients, wherein male 21 examples, female 12 example, the oldest person patient 72 years old, age minimum patient 26 years old, patient applies Chinese and western drugs treatment unsatisfactory curative effect, uses we's treatment instead.

2. clinical observation

Application " disperse blood stasis and dredge collateral ball ", take to patient by doctor's advice, every day three times, each 15～20 balls, half an hour ante cibum warm water delivery service, and by doctor's advice to patient avoid, within 30 days, be a course for the treatment of.

3. treatment situation

Treat notable patient 18 example and account for 54.6%；Therapeutically effective patient 10 example accounts for 30.3%；Patient 5 example of failing to respond to any medical treatment accounts for 15.1%.

4. model case

1), patient Zhao, man, 59 years old, in February, 2009 went to a doctor, and main suit has palpitation, precordialgia uncomfortable in chest, momentary, often because of anxious state of mind or tired and increase the weight of.Once taking multiple Chinese medicine and western medicine poor effect, body is had a blood test and is pressed 172/90mmHg, 98 times/min of heart rate, hyperlipemia, T-CHOL 7.8mmol/L, triglyceride 3.2mmol/L, low density lipoprotein, LDL 5.84g/L, electrocardiogram prompting coronary heart disease.Give disperse blood stasis and dredge collateral ball immediately and enjoin bfore meals, every day three times.Taking one week, effect substantially takes a turn for the better, and checks to institute after January, and blood fat T-CHOL drops to 5.52mmol/L, and triglyceride drops to 2.25mmol/L, and low density lipoprotein, LDL drops to 3.36g/L, the bimester of continuing to take, then looks into, and indices is normal, nervous transference cure uncomfortable in chest.

2), patient's thunder, man, 65 years old.In March, 2010 goes to a doctor, and for many years, aphasis before two weeks, extremity are aching and limp unable and hold down, and in hospital are diagnosed as cerebral thrombosis for patient's dizziness.The traditional Chinese medical science discerns facial hemiparalysis, dysphasia, hemiplegia, pale complexion, shortness of breath and fatigue, and chromaticness secretly has petechia, white and thin fur, deep and hesitant pulse, distinguishes and belongs to the hemiplegia of blood stasis due to qi deficiency apoplexy, controls suitable benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral, and with Modified Buyang Huangwu Decoction 5 doses to the greatest extent, curative effect does not show.Using disperse blood stasis and dredge collateral ball instead, after January of taking medicine, jewelry are wriggled, and half body can be movable, no more side effects, and the bimester of defence, the hand-held waddy of patient can be left the bed walking, and after March, language is clear, goes battle walking, and trick manipulation tends to flexible, visits so far, does not recur, such as ordinary person.

Claims

1. a herbal mixture pill with disperse blood stasis and dredge collateral function, it is characterised in that: described herbal mixture pill is to be configured to by different quality proportionings by following raw material: Radix Salviae Miltiorrhizae 8～12g, Radix Puerariae 6～8g, Fructus Crataegi 6～8g, Rhizoma Chuanxiong 6～8g, the Radix Astragali 6～8g, Folium Ginkgo 8～12g, GUANG Radix Notoginseng 2～4g, Sargassum 2～4g, the Radix Paeoniae Alba 2～4g, Radix Et Rhizoma Rhei 2～4g, Flos Carthami 2～4g, Bulbus Allii Macrostemonis 2～4g, Pheretima 2～4g, Auricularia 2～4g, Flos Echinopsis latifolii 5～7g.

2. herbal mixture pill according to claim 1; it is characterized in that: the compound method of described herbal mixture pill is as follows: after weighing up material; cleaned; it is placed in baking oven; baking oven is transferred to 45 DEG C; dry 16h at this temperature; re-using ultraviolet disinfection tank to carry out disinfection, ultraviolet disinfection tank is transferred to 25 DEG C and is sterilized 3 hours, places it in pulverizer and pulverize 30 minutes after taking-up; cross 100 mesh sieves; obtaining canescence planar powder, add ethanol in proper amount, stirring makes it have adhesion sense to be advisable; put into granulator to granulate, obtain the ball of pill heavily for 0.4g.

3. the method for preparation herbal mixture pill described in claim 1 or 2; it is characterized in that: after comprising the steps: to weigh up material; cleaned; it is placed in baking oven; baking oven is transferred to 45 DEG C; dry 16h at this temperature; re-using ultraviolet disinfection tank to carry out disinfection, ultraviolet disinfection tank is transferred to 25 DEG C and is sterilized 3 hours, places it in pulverizer and pulverize 30 minutes after taking-up; cross 100 mesh sieves; obtaining canescence planar powder, add ethanol in proper amount, stirring makes it have adhesion sense to be advisable; put into granulator to granulate, obtain the ball of pill heavily for 0.4g.

4. method according to claim 3, it is characterised in that: putting in an oven by obtained pill, baking oven is transferred to 35 DEG C dries this pill, and then envelope stores.

5. the herbal mixture pill that herbal mixture pill described in claim 1 or 2 or method described in claim 3 or 4 prepare application in preparation preventing and treating cardiovascular and cerebrovascular diseases medicament.