CN102397532B - Compound propolis composition for treating muscovy duck parvovirus disease and preparation method thereof - Google Patents
Compound propolis composition for treating muscovy duck parvovirus disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound propolis composition for treating the muscovy duck parvovirus disease and a preparation method thereof, relating to the field of animal medicaments. The preparation method of the composition comprises the following steps of: (1) performing ultrafine smashing on various components (except interferon) in a formula respectively, and sieving with a 700-mesh sieve; (2) weighing 15-35 parts by weight of propolis, 5-20 parts by weight of interferon for duck, 10-30 parts by weight of common andrographis herb and 15-30 parts by weight of coptis root, and mixing for 5-10 minutes to uniform state; (3) weighing 10-40 parts by weight of Chinese pulsatilla root, 10-35 parts by weight of garden burnet root, 15-45 parts by weight of indigowoad leaf and 10-40 parts by weight of hairyvein agrimonia herb and bud, and mixing for 5-10 minutes to uniform state; and (4) combining the compositions obtained in the steps (2) and (3), and continually mixing for 10-15 minutes to uniform state to obtain the compound propolis composition. The preparation method has the beneficial effects of reasonable formula and easiness for preparing; the compound propolis composition has the advantages of no toxic or side effect, environmental friendliness, no medicament residue, no medicament tolerance, ultrafine smashing, high bioavailability and very remarkable effect; and as proved by clinical application, the compound propolis composition has a special treatment effect on the muscovy duck parvovirus disease.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment muscovy duckling parvovirosis and preparation method thereof.
Background technology
Muscovy duckling parvovirosis is a kind of acute, the septic infectious disease that is caused by muscovy duckling parvovirosis virus, and main manifestations is that the serious inflammation of intestinal, intestinal mucosa necrosis come off, the swollen pus of intestinal tube is hemorrhage.This disease has infectiousness and the mortality rate of height, mainly betides for 3 ages in week with interior young Muscovy duck, and case fatality rate has a strong impact on the growth of Muscovy duck between 22%-43%.This disease all can occur throughout the year, is one of principal disease of the foster duck industry of harm.
The pathogen of primary disease is muscovy duckling parvovirosis virus, and virus resistance to external world is very strong.It is national that this disease almost spreads all over all poultry of the world, is widely distributed.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is unreasonable or simple pulverizing the just due to its prescription, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.
Therefore researching and developing a kind of drug residue free of muscovy duckling parvovirosis, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness for the treatment of is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment muscovy duckling parvovirosis of drug residue and preparation method thereof.
For achieving the above object, implementation of the present invention is as follows: a kind of compound bee-glue composition for the treatment of muscovy duckling parvovirosis, by following component by weight mixed preparing form: propolis 15-35 part, duck are with interferon 5-20 part, Herba Andrographis 10-30 part, Rhizoma Coptidis 15-36 part, Radix Pulsatillae 10-40 part, Radix Sanguisorbae 10-35 part, Folium Isatidis 15-45 part, Herba Agrimoniae 10-40 part.
Described various component optimum ratio amount is: 25 parts of propolis, 10 parts of interferon of duck, 20 parts of Herba Andrographis, 20 parts of Rhizoma Coptidis, 25 parts of the Radix Pulsatillaes, 25 parts of Radix Sanguisorbaes, 35 parts of Folium Isatidiss, 30 parts of Herba Agrimoniaes.
A kind of preparation method for the treatment of the compound bee-glue composition of muscovy duckling parvovirosis, carry out as follows:
(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, duck with interferon 5-20 part, Herba Andrographis 10-30 part, Rhizoma Coptidis 15-30 part, mix 5-10 minute to even;
(3) take by weight Radix Pulsatillae 10-40 part, Radix Sanguisorbae 10-35 part, Folium Isatidis 15-45 part, Herba Agrimoniae 10-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had inhibition or killing action; Can inducing apoptosis of tumour cell, thus killing off tumor cells; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.
Herba Andrographis: bitter, cold, GUIXIN, lung, bladder, large intestine channel have the function of heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Cure mainly cold, fever, damp-heat diarrhea, carbuncle sore furunculosis etc.
Rhizoma Coptidis: bitter, cold, return liver, the heart, spleen, stomach, gallbladder, large intestine channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder, conjunctival congestion and swelling pain, fire-toxin carbuncle sore etc.
The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot removing heat from blood etc.
Radix Sanguisorbae: sour, bitter, puckery, be slightly cold, return liver, large intestine channel, have the function of removing pathogenic heat from blood and toxic substance from the body, arresting bleeding and healing up ulcer; Cure mainly dysentery, epistaxis, metrorrhagia, the yellow furunculosis of skin ulcer etc.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Herba Agrimoniae: bitter, puckery, flat, GUIXIN, Liver Channel have the function of astringing to arrest bleeding, dysentery relieving, detoxifcation; Cure mainly have blood in stool, hematuria, haematemesis, epistaxis, dysentery, carbuncle sore tumefacting virus etc.
Above all flavor Chinese medicine for pathogenic microorganism and clinical symptoms and the pathological change of muscovy duckling parvovirosis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease according to the Chinese medical theory compatible combination.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, the treatment muscovy duckling parvovirosis there is specially good effect, and make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition for the treatment of muscovy duckling parvovirosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, duck with 50 parts of interferon, 100 parts of Herba Andrographis, 150 parts of Rhizoma Coptidis, mix 5-10 minute to even;
(3) take by weight 100 parts of the Radix Pulsatillaes, 100 parts of Radix Sanguisorbaes, 150 parts of Folium Isatidiss, 100 parts of Herba Agrimoniaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of muscovy duckling parvovirosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, duck with 100 parts of interferon, 200 parts of Herba Andrographis, 200 parts of Rhizoma Coptidis, mix 5-10 minute to even;
(3) take by weight 250 parts of the Radix Pulsatillaes, 200 parts of Radix Sanguisorbaes, 300 parts of Folium Isatidiss, 250 parts of Herba Agrimoniaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of muscovy duckling parvovirosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, duck with 00 part of interferon alpha-2,300 parts of Herba Andrographis, 300 parts of Rhizoma Coptidis, mix 5-10 minute to even;
(3) take by weight 400 parts of the Radix Pulsatillaes, 350 parts of Radix Sanguisorbaes, 450 parts of Folium Isatidiss, 400 parts of Herba Agrimoniaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
With the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 120kg feeds, and drinking-water 220kg, is used in conjunction 3-5 day at every day 2-3 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.
Table is the field applicable cases contrast of the present invention and other medicines treatment muscovy duckling parvovirosis:
| Numbering | Group | Case fatality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 29.2 | 32.9 | 37.9 |
| II | The loose group of muscovy duckling parvovirosis | 12.4 | 70.0 | 17.6 |
| III | Present composition group | 8.6 | 81.8 | 9.6 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the loose group of muscovy duckling parvovirosis aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment muscovy duckling parvovirosis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (2)
1. compound bee-glue composition for the treatment of muscovy duckling parvovirosis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, duck are with interferon 5-20 part, Herba Andrographis 10-30 part, Rhizoma Coptidis 15-30 part, Radix Pulsatillae 10-40 part, Radix Sanguisorbae 10-35 part, Folium Isatidis 15-45 part, Herba Agrimoniae 10-40 part, and the preparation method of described compositions is carried out as follows:
(1) the various compositions except interferon in prescription are crossed 700 mesh sieves after micronizing respectively;
(2) take by weight and get propolis 15-35 part, duck with interferon 5-20 part, Herba Andrographis 10-30 part, Rhizoma Coptidis 15-30 part, mixes 5-10 minute to even;
(3) take by weight Radix Pulsatillae 10-40 part, Radix Sanguisorbae 10-35 part, Folium Isatidis 15-45 part, Herba Agrimoniae 10-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
2. the compound bee-glue composition for the treatment of muscovy duckling parvovirosis according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of propolis, 10 parts of interferon of duck, 20 parts of Herba Andrographis, 20 parts of Rhizoma Coptidis, 25 parts of the Radix Pulsatillaes, 25 parts of Radix Sanguisorbaes, 35 parts of Folium Isatidiss, 30 parts of Herba Agrimoniaes.
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| CN102397532B true CN102397532B (en) | 2013-05-22 |
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| CN104758865A (en) * | 2015-03-10 | 2015-07-08 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine composition for treating parvovirus diseases of cairna moschata and preparation method thereof |
| ES2964618T3 (en) * | 2018-01-31 | 2024-04-08 | Sichuan Inlu Weite Pharmaceutical Tech Co Ltd | Saponin B4 from pulsatilla for the treatment of mastitis in dairy cows |
| CN110269880A (en) * | 2019-07-26 | 2019-09-24 | 烟台海研制药有限公司 | A kind of clear particle of wormwood artemisia indigo plant epidemic disease, preparation method and application |
| NL2032218B1 (en) * | 2022-06-20 | 2023-02-24 | Inst Of Animal Husbandry And Veterinary Medicine Jiangxi Academy Of Agricultural Sciences | A Chinese medicinal preparation for preventing and treating duck virus disease, and its preparation method |
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| CN1362059A (en) * | 2001-01-05 | 2002-08-07 | 唐山王清任制药有限公司 | Nano Chinese medicine piece and its prepn |
| CN101411762A (en) * | 2007-10-19 | 2009-04-22 | 天津生机集团有限公司 | Chinese medicinal composition for treating Canine parvovirus disease and preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362059A (en) * | 2001-01-05 | 2002-08-07 | 唐山王清任制药有限公司 | Nano Chinese medicine piece and its prepn |
| CN101411762A (en) * | 2007-10-19 | 2009-04-22 | 天津生机集团有限公司 | Chinese medicinal composition for treating Canine parvovirus disease and preparation thereof |
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