CN102349522B - Synergy sterilizing composition containing tetraconazole and tricyclazole - Google Patents
Synergy sterilizing composition containing tetraconazole and tricyclazole Download PDFInfo
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- CN102349522B CN102349522B CN 201110273418 CN201110273418A CN102349522B CN 102349522 B CN102349522 B CN 102349522B CN 201110273418 CN201110273418 CN 201110273418 CN 201110273418 A CN201110273418 A CN 201110273418A CN 102349522 B CN102349522 B CN 102349522B
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- tricyclazole
- tetraconazole
- bactericidal composition
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Abstract
The invention relates to a synergy sterilizing composition containing tetraconazole and tricyclazole. The weight ratio of tetraconazole to tricyclazole is (1-30): (1-70). The composition is mainly used for preventing and controlling rice diseases, especially rice blast and also has a good effect on preventing and controlling the diseases of other crops. The composition has he advantages of wide applicable range, good effect, low cost, low residue and obvious crop production increase effect within the recommended dose range and is safe to people, livestock, environment and the like.
Description
Technical field
The present invention relates to a kind of Synergistic bactericidal composition containing tetraconazole and tricyclazole, belong to Pesticidal products field.
Background technology
Rice blast is also known as rice blast, is worldwide disease, the widely distributed each paddy fields in the world, is the disease of harm most serious in Rice Production.In the popular time, the paddy rice underproduction 10~20% can be typically caused, it is serious up to more than 40~50%.Chemical prevention is the Main Means for preventing and treating rice blast; conventional medicament has rice blast, different rice blast net, kitazine etc. at present; but due to use for many years, these medicaments all seriously produce resistance, and tricyclazole is widelyd popularize and applied in recent years; but have there is resistance in many areas; prevention effect is decreased obviously, and tricyclazole action site is single, is protective fungicide warp; do not have therapeutic action, the lasting period is shorter.
Tetraconazole is the triazole bactericidal agent developed in recent years, and the mechanism of action is sterol demethylation inhibitors, due to good absorbability, therefore can be promptly absorbed by plants, and is internally conducted；With good protection and therapeutic activity.Lasting period is longer, typically at 6 weeks or so.Medicament disinfecting spectrum is wide, the preventing and treating available for diseases such as paddy rice, cereal crop, water fruits and vegetables, garden crops.And plant growth can be promoted under recommended dose, well developed root system is allowed to, strengthens photosynthesis, increases plant effective tillering, enhancing 'Gulibao ' plant growth regulator solidity and mass of 1000 kernel, so as to provide yield.But because the product cost is higher, using extremely limited.
The content of the invention
An object of the present invention is to overcome above-mentioned deficiency there is provided a kind of applied widely, excellent effect, low cost, remain the Synergistic bactericidal composition low, with synergistic effect containing tetraconazole and tricyclazole.
The second object of the present invention is to provide a kind of purposes of the bactericidal composition containing tetraconazole and tricyclazole.
The object of the present invention is achieved like this：
A kind of Synergistic bactericidal composition containing tetraconazole and tricyclazole, the composition contains tetraconazole and tricyclazole, and the weight ratio of the tetraconazole and tricyclazole is 1 ~ 30：1~70.
The optimization weight ratio of the tetraconazole and tricyclazole is 1 ~ 25：5~50.
The weight ratio of the tetraconazole and tricyclazole is 1: 1,1: 5,1: 10,1: 15,1: 20,1: 30,5: 1,10: 1 or 20: 1.
The combination dosage form is any one formulation allowed on agricultural chemicals.
The combination dosage form is wettable powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil.
The tetraconazole is 1 ~ 90% with the mass percent of tricyclazole in the composition.
A kind of purposes of the bactericidal composition containing tetraconazole and tricyclazole, for the medicine as cereal crop, melon and fruit or vegetable crop disease.
It is mainly used in the preventing and treating of the preventing and treating of rice blast, especially rice blast.
Compared with prior art, the beneficial effects of the invention are as follows：
（1）The synergistic effect that the present composition is done well in certain ratio range, the bactericidal effect of composition is obviously improved than single dose；
（2）The mechanism of action of two kinds of active components is different in the present composition, and the application of composition can delay or overcome the resistance of pathogen, extends the service life of product；
（3）The present composition expands fungicidal spectrum, disease available for crops such as preventing and treating cereal crop, various melon fruits and vegetables, the particularly disease such as paddy rice, watermelon, tomato, potato, apple, pears, pear tree, such as rice blast, wheat powdery mildew, early blight of tomato, alternaria leaf spot of apple, pear scab；
（4）The present composition not only reduces use cost, and the harm to crop, environment etc. is alleviated again.
Embodiment
In order to which the objects, technical solutions and advantages of the present invention are more clearly understood, the present invention is illustrated with following instantiation, but the present invention is not limited to these examples.
The present composition is tested through indoor bioassay and found using tetraconazole and tricyclazole as active ingredient, and antagonistic drug venereal disease evil has obvious synergistic function after both compound, and is specifically illustrated with following biologicall test example.
Material object determines example：Tetraconazole and tricyclazole compound the toxicity test to rice blast
1st, subjects：Rice Pyricularia grisea
2nd, test method：Reference《Pesticide bioassay test rule NY/T 1156.8-2007》, using containing pot-culture method.
3rd, data statistic analysis：Analyzed with SAS6.12 statistical softwares.Mycelial growth inhibition rate is calculated according to test data（%）, obtain virulence regression equation, coefficient correlation（r）、EC50And co-toxicity coefficient.
4th, evaluation method：Reference《Pesticide bioassay test rule NY/T 1156.8-2007》, according to the co-toxicity coefficient method of Sun＆Johnson (1960)（CTC）To evaluate the synergistic effect of pharmacy mix, i.e. CTC≤80 for antagonism, 80<CTC<120 be summation action, and CTC >=120 are synergistic effect.
5th, result and analysis
It is " tetraconazole that the mixture combination of tetraconazole, tricyclazole and its two different proportion the results are shown in Table in 1, table 1 " fluorine: azoles " to the toxicity test of rice Pyricularia grisea：Tricyclazole " is write a Chinese character in simplified form.
The tetraconazole of table 1 and toxicity test result of the tricyclazole mixture to rice Pyricularia grisea
Indoor biometricses result of the test shows：Tetraconazole and tricyclazole carry out mixture with 1: 1,1: 5,1: 10,1: 15,1: 20,1: 30,5: 1,10: 1,15: 1 and 20: 1 ratios and rice Pyricularia grisea are shown to be added or synergistic effect, and wherein the two is the most obvious with 1: 5,1: 15 and 1: 20 ratio mixed synergies.Therefore, only compare from synergy virulence, 1: 5,1: 15 and 1: 20 can be regarded as tetraconazole and the optimum proportioning of tricyclazole mixture.As for which kind of ratio carrying out mixture in produce reality with, still needing and carrying out considering decision with reference to synergy virulence, financial cost, processing technology and toxicity etc..
The present composition can be prepared into any one formulation for being adapted to agriculturally use with known method, wherein relatively good formulation has missible oil, wettable powder, aqueous emulsion, suspending agent and water dispersible granules, be illustrated below with instantiation.
Embodiment 1：
Tetraconazole 5g, tricyclazole 25g, cyclohexanone 15g, phenethyl phenol polyethenoxy ether 5g, diesel oil are added into 100g, mixed to homogeneous liquid phase, the missible oil of the present composition 30% is made.
Embodiment 2：
Tetraconazole 7g, tricyclazole 35g, neopelex 6g, naphthalenesulfonic acid-formaldehyde condensate 5g, kaolin are added into 100g, the water dispersible granules of the present composition 40% are made in blended, air-flow crushing, granulation.
Embodiment 3：
By tetraconazole 15g, tricyclazole 30g, dodecyl sodium sulfate 5g, NPE 6g, xanthans 0.2g, propane diols 5g, suitable quantity of water, the suspending agent of the present composition 45% is made through wet grinding, homogenizing in mixing.
Embodiment 4：
Tetraconazole 5g, tricyclazole 20g, aliphatic alcohol sulfate 5g, sodium lignin sulfonate 3g, white carbon 5g, polyethylene glycol 2g, xanthans 0.5g, kaolin are added into 100g, the water dispersible granules of the present composition 25% are made through air-flow crushing, granulation in mixing.
Embodiment 5：
By tetraconazole 8g, tricyclazole 2g, dimethylbenzene 6g, alkylaryl formaldehyde resin APEO 10g, APES phosphate 1g, ethylene glycol 4g and suitable quantity of water, prepare oil phase, prepare aqueous phase, under high shear, it will be added in oil phase aqueous phase or by aqueous phase in oil phase, the aqueous emulsion of the present composition 10% is made in shearing.
Embodiment 6：
By tetraconazole 5g, tricyclazole 10g, 1-METHYLPYRROLIDONE 10g, alkylaryl formaldehyde resin APEO 10g, APES phosphate 1g, propane diols 4g and suitable quantity of water, prepare oil phase, prepare aqueous phase, under high shear, it will be added in oil phase aqueous phase or by aqueous phase in oil phase, the aqueous emulsion of the present composition 15% is made in shearing.
Application Example：
Utilize preparation preventing and treating rice blast experiment made from above-described embodiment.
1st, test process：This test medicine consumption sets three concentration for the treatment of respectively according to the difference of each composition, and comparison medicament is commercially available 40% rice blast missible oil, 75% tricyclazole wettable powder and clear water blank control respectively.
2nd, test method：Experiment selection is carried out in rice blast over the years than more serious rice terrace, is tested each cell and is no less than 40m2, it is repeated 4 times.Investigation method and evaluating drug effect are carried out by GB/T 17980.19-2000.
3rd, result of the test such as following table：
Note：A represented in the level of α=0.05 significantly, and b represents variant in the level of α=0.05, and c represents there is not notable in the level of α=0.05.
4. growth and effect of increasing production
| Processing | Every mu of effective fringe | Defined daily doses | Mass of 1000 kernel (g) | Theoretical yield (kg/667 ㎡) | Rate of growth（%） |
| The 15g a.i. of embodiment 1/mu | 215014.41 | 105.73 | 29.8 | 677.45 | 5.85 |
| The 15g a.i. of embodiment 2/mu | 216641.08 | 106.63 | 30.18 | 697.17 | 8.93 |
| The 15g a.i. of embodiment 5/mu | 215601.08 | 104.42 | 29.93 | 673.81 | 5.28 |
| The g a.i./ha of 75% tricyclazole WP 30 | 215107.74 | 101.78 | 29.4 | 643.67 | 0.57% |
| Clear water is compareed | 215067.74 | 101.57 | 29.3 | 640.04 | / |
Field control effectiveness test shows that tetraconazole has good preventive effect to rice blast with tricyclazole bactericidal composition, and prevention effect is better than conventional dose tricyclazole and Isoprothiolane etc., and effect of increasing production is fairly obvious.
Claims (7)
1. a kind of Synergistic bactericidal composition containing tetraconazole and tricyclazole, it is characterised in that：The composition contains tetraconazole and tricyclazole, and the weight ratio of the tetraconazole and tricyclazole is 1: 1,1: 5,1: 10,1: 15,1: 20,1: 30,5: 1,10: 1 or 20: 1.
2. the Synergistic bactericidal composition containing tetraconazole and tricyclazole according to claim 1, it is characterised in that the combination dosage form is any one formulation allowed on agricultural chemicals.
3. the Synergistic bactericidal composition according to claim 2 containing tetraconazole and tricyclazole, it is characterised in that the combination dosage form is wettable powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil.
4. the Synergistic bactericidal composition according to claim 1 containing tetraconazole and tricyclazole, it is characterised in that the tetraconazole is 1 ~ 90% with the mass percent of tricyclazole in the composition.
5. a kind of purposes of the Synergistic bactericidal composition containing tetraconazole and tricyclazole described in claim 1, it is characterised in that：For the medicine as cereal crop, melon and fruit or vegetable crop disease.
6. the purposes of the Synergistic bactericidal composition according to claim 5 containing tetraconazole and tricyclazole, it is characterised in that：Application in the preventing and treating of rice disease.
7. the purposes of the Synergistic bactericidal composition according to claim 6 containing tetraconazole and tricyclazole, it is characterised in that：It is used as the protective agents of rice blast.
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| CN 201110273418 CN102349522B (en) | 2011-09-15 | 2011-09-15 | Synergy sterilizing composition containing tetraconazole and tricyclazole |
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| CN 201110273418 CN102349522B (en) | 2011-09-15 | 2011-09-15 | Synergy sterilizing composition containing tetraconazole and tricyclazole |
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| CN102349522B true CN102349522B (en) | 2013-06-05 |
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| CN108064869A (en) * | 2018-01-03 | 2018-05-25 | 佛山市盈辉作物科学有限公司 | A kind of composition pesticide containing ferimzone and tricyclazole |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0234242A2 (en) * | 1986-01-23 | 1987-09-02 | MONTEDIPE S.r.l. | Fungicidal azolyl-derivatives |
| CN101790986A (en) * | 2010-04-16 | 2010-08-04 | 陕西美邦农药有限公司 | Fungicide composite containing tricyclazole and hexaconazole |
| CN102037980A (en) * | 2010-12-31 | 2011-05-04 | 利尔化学股份有限公司 | Bactericidal pesticide composition |
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- 2011-09-15 CN CN 201110273418 patent/CN102349522B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0234242A2 (en) * | 1986-01-23 | 1987-09-02 | MONTEDIPE S.r.l. | Fungicidal azolyl-derivatives |
| CN101790986A (en) * | 2010-04-16 | 2010-08-04 | 陕西美邦农药有限公司 | Fungicide composite containing tricyclazole and hexaconazole |
| CN102037980A (en) * | 2010-12-31 | 2011-05-04 | 利尔化学股份有限公司 | Bactericidal pesticide composition |
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Address after: 214444 Jiangsu city of Wuxi province Jiangyin City Yun Li Gang Zhen Hua Road 7 Patentee after: JIANGYIN SULI CHEMICAL CO., LTD. Address before: 214444 Jiangsu city of Wuxi province Jiangyin City Yun Li Gang Zhen Hua Road 7 Patentee before: Jingyin Suli Chemical Co., Ltd. |