CN102283720A

CN102283720A - Artificial cornea

Info

Publication number: CN102283720A
Application number: CN2011102182373A
Authority: CN
Inventors: 于莉; 姚晓明; 林宝涛; 罗仲宽; 陈建苏; 周莉; 肖爱民
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-08-01
Filing date: 2011-08-01
Publication date: 2011-12-21
Also published as: WO2013016907A1

Abstract

The invention discloses an artificial cornea, and relates to the technical field of artificial corneas, in particular to a connecting structure and the function improvement of the artificial cornea. The invention overcomes the technical defects that the conventional artificial cornea has low adaptability and low stability during connection. The artificial cornea comprises an optical zone, wherein the periphery of the optical zone is provided with a skirt. The artificial cornea is characterized in that: the inner surface and the outer surface of the skirt are provided with biological material coatings which are compatible with human eye tissues; the edge of the skirt is saw-toothed; and more than four through holes are formed on the skirt. The edge of the skirt is gear-shaped, so that the skirt can adapt to different cornea radians more easily, and the irregular jointing caused by the heaving of the skirt is avoided; and more than four through holes are formed on the skirt, so that the fixation of sutures is facilitated, the fusion of anterior and posterior lamellar corneas and the artificial cornea, fiber growth, nutrition communication and the like is strengthened, and the biocompatibility of the artificial cornea is strengthened.

Description

A kind of artificial cornea

Technical field

The present invention relates to artificial cornea's technical field, the syndeton and the function that refer more particularly to the artificial cornea are improved.

Background technology

At present, because the cornea radian of different people is different, the artificial cornea occurs radian easily and mismatches implanting between people's corneal lamellar, and the operation that has influence between the two is connected.In addition, because when the artificial cornea implants, preceding lamellar cornea contacts with artificial cornea shirt rim outer surface, the metaplax layer cornea contacts with artificial cornea shirt rim inner surface, if the artificial cornea's curvature after implanting and the curvature of forward and backward corneal lamellar are inconsistent, just cause the attaching of the two not tight, have influence on artificial cornea's stability.Also have, be connected to same plane between the transparent body of existing artificial eye's cornea and shirt rim, or seamlessly transit, postoperative, the paraplasm ocular tissue optical zone of may dividing a word with a hyphen at the end of a line from the shirt rim is blocked sight line, is difficult to remove with medicine or operation.

Summary of the invention

In sum, main purpose of the present invention is to solve above-mentioned existing artificial cornea and has bad adaptability, the technological deficiency of poor stability during connection, and a kind of Multifunction artificial cornea's conception is proposed.

For solving technical problem proposed by the invention, the technical scheme that adopts is: a kind of artificial cornea, include an optical zone, periphery in optical zone is provided with the shirt rim, it is characterized in that: the described biomaterial coating that on shirt rim inner surface and outer surface, is equipped with the human eye tissue compatible, the edge of described shirt rim is a zigzag, at the through hole that is provided with on the shirt rim more than four.

As the technical scheme that the present invention is further improved be: the inner surface edge of described optical zone is protruded the shirt rim, and is the ledge structure of 90 degree between the shirt rim.

The outer surface of described optical zone is provided with the fluorine heparin surface decoration layer.

Described optical zone be yellow.

Described optical zone is a how burnt optical zone of central authorities.

The zone of described optical zone central diameter 3.5mm is the diffraction ring district.

Number of openings on the described shirt rim is 6～20, and through-hole diameter is 0.5～1.0mm, apart from the nearest through hole of optical zone and optical interval every at 1.0～2.0mm.

The protruding 0.2～0.5mm in back, zone in the 4mm scope of described optical zone center.

Biomaterial coating on the described shirt rim is a hydroxyapatite coating layer.

Described shirt rim is provided with the material layer that promotes nerve and angiogenic growth.

Beneficial effect of the present invention is: the edge of shirt rim is a gear-like, makes it to be easier to adapt to different cornea radians, avoids the shirt rim protuberance, causes the out-of-flatness of fitting; The shirt rim is provided with the through hole more than 4, not only helps suture and fixes, and more can strengthen forward and backward lamellar cornea and artificial cornea's fusion, fiber growth and nutrition communication etc., strengthens artificial cornea's biocompatibility.

Description of drawings

Fig. 1 is a main TV structure sketch map of the present invention;

Fig. 2 is an A-A cross section structure sketch map among Fig. 1.

The specific embodiment

Below in conjunction with accompanying drawing and preferred a kind of specific embodiment structure of the present invention is further described:

Shown in seeing figures.1.and.2, the present invention mainly is made up of 2 two parts of optical zone 1 and shirt rim.

Described shirt rim 2 is located at the periphery of optical zone 1, is used for fixed support optical zone 1, and the shirt rim is and the biomaterial of human eye tissue compatible, and this biomaterial is hydroxyapatite preferably, but does not get rid of or comprise that other have the biomaterial of histocompatibility.Hydroxyapatite is a kind of biomaterial of nanometer, mixes to have the porous crack in the other materials, and people's cornea tissue can be grown in it, and biocompatibility is good.

In order to promote nerve and angiogenic growth, be provided with the material that promotes nerve and angiogenic growth material in the hydroxyapatite hole on shirt rim 2, such as neuropeptide or fibroblast growth factor or its slow-releasing microcapsule, with better promotion cornea and artificial cornea's healing in opposite directions, prevent that postoperative from deviating from.

In recent years the research that hinders is sent out in the back and affirmed that the artificial intraocular lenses of square rim design can suppress lens epithelial cells and be grown to central visual axis by peripheral cyst membrane, thereby suppress the back and send out barrier, the crystalline square sharp-edged of old friend worker has barrier action, thereby protrude shirt rim 2 in the inner surface edge of described optical zone 1, and 2 of shirt rims are the ledge structure of 90 degree, artificial cornea's central 4mm optical zone is carried out the protruding 0.2-0.5mm in back, thereby reduce the transplanting back comea fibrous propagation of optical zone periphery metaplax layer and promptly suppress caudacoria formation, stop effectively and ooze out in the human eye and fibroplasia is divided a word with a hyphen at the end of a line to optical zone 1 inner surface, block vision reduces the effect of recovering lost eyesight.

The edge of described shirt rim 2 is a gear-like, is easy to adapt to different cornea radians, shirt rim 2 marginal swells can not occur in the operation implantation process, avoids because of the applying out-of-flatness, and causes people's cornea tissue and shirt rim 2 can't realize the generation of the compatible phenomenon that is connected.

On shirt rim 2, be provided with a plurality of through hole 23, can select manual punching and laser drill, best 6～20 of the quantity of through hole 23, the diameter of through hole 23 is 0.5～1.0mm, apart from the nearest through hole of optical zone 1 and optical interval every at 1.0～2.0mm.Suture via through holes 23 in the implantation process with forward and backward lamellar cornea and shirt rim 2 sutured, not only helps suture and fixes, and more can strengthen forward and backward lamellar cornea via through holes 23 back fusions, fiber growth and nutrition communication etc., strengthens artificial cornea's stability.

Described optical zone 1 outer surface is provided with fluorine heparin (do not get rid of other and help preventing that pathologic cell and tissue are adsorbed in the material of optical zone) finishing coat.With the heparin is example, artificial cornea's optical zone of heparin finishing, and its hydrophilic strengthens, and reduces cell adhesion, reduces the growth of granulocyte reaction and foreign body maxicell deposition and fibroblast, increases biocompatibility; Surface hydrophobic after the fluorine surface treatment increases, and can reduce inflammatory cell equally and stick, and reduces cell-stimulating.The general Electrostatic Absorption that adopts is connected the outer surface of fluorine heparin surface decoration layer with optical zone 1 with the fixed two kinds of methods of covalent bond.Electrostatic Absorption is to utilize the characteristic on heparin molecule base elecrtonegativity surface, is attached to material surface by electrical coupling, physical absorption.Covalent bond fixedly is the functional group that utilizes heparin and polymer surfaces, obtains through methods such as chemical bondings.

Described optical zone 1 be yellow.Studies show that blue light is relevant with the generation of degeneration of macula, the sodium yellow school district can stop and absorb blue light, reduces the photic damage to macula lutea.Patient's macula lutea that the design of yellow artificial cornea's optical zone will make the artificial cornea transplant is protected.

Described optical zone 1 is a how burnt optical zone of central authorities, can suitably enlarge or dwindle at central diameter 3.5mm() the zone be the diffraction ring district, many focuses artificial cornea optical zone can be divided into refractive and diffraction type, all reaches by the light that disperses to enter ophthalmic and looks far away and look near purpose.Diffractive multifocal artificial cornea wherein has under bright and clear microcoria condition and mainly looks far away the and auxiliary ability of looking near, and at night during platycoria, more rays enters pupil and is used for looking closely.Other, the thin peripheral thick design of the central authorities of central optical zone also can be assisted the patient to regulate and be looked far and look closely.Have exotic matter absorption also to remove easily even many burnt designs mainly are positioned at anterior surface of cornea, it is smooth that the rear surface still keeps, and prevents exotic matter absorption.For meeting individual requirements, central optical zone mirror post is carried out different refractive power designs, to adapt to aphakia or ametropia patient's selection.

Annotate: " cornea " refers to eye cornea when using separately herein.

Claims

1. an artificial cornea includes an optical zone, is provided with the shirt rim at the periphery of optical zone, and it is characterized in that: described shirt rim is the human eye histocompatibility biomaterial that contains the space, and its edge is a gear-like, which is provided with the through hole more than 4.

2. a kind of artificial cornea according to claim 1 is characterized in that: the inner surface edge of described optical zone protrudes from the shirt rim, and is the ledge structure of 90 degree between the shirt rim.

3. a kind of artificial cornea according to claim 1 is characterized in that: the surfaces externally and internally of described optical zone is provided with the finishing coat that helps preventing pathologic cell and organize adsorbing material.

4. a kind of artificial cornea according to claim 1 is characterized in that: the yellow of described optical zone for absorbing or stop ultraviolet to see through.

5. a kind of artificial cornea according to claim 1 is characterized in that: described optical zone is a how burnt optical zone of central authorities.

6. a kind of artificial cornea according to claim 5 is characterized in that: the zone of described optical zone central diameter 3.5mm is the diffraction ring district.

7. a kind of artificial cornea according to claim 1 is characterized in that: 6～20 of the number of openings on the described shirt rim, through-hole diameter are 0.5～1.0mm, apart from the nearest through hole of optical zone and optical interval every at 1.0～2.0mm.

8. a kind of artificial cornea according to claim 1 is characterized in that: the protruding 0.2～0.5mm in back, zone in the 4mm scope of described optical zone center.

9. a kind of artificial cornea according to claim 1 is characterized in that: described shirt rim is the material of hydroxyapatite.

10. a kind of artificial cornea according to claim 9 is characterized in that: composition or the material that promotes nerve and angiogenic growth contained in described shirt rim.