CN102128903A - High-resolution high-pressure prepacked column - Google Patents
High-resolution high-pressure prepacked column Download PDFInfo
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- CN102128903A CN102128903A CN2010105464396A CN201010546439A CN102128903A CN 102128903 A CN102128903 A CN 102128903A CN 2010105464396 A CN2010105464396 A CN 2010105464396A CN 201010546439 A CN201010546439 A CN 201010546439A CN 102128903 A CN102128903 A CN 102128903A
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- China
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- end cover
- column
- sieve plate
- column jecket
- prepacked
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention relates to a high-resolution high-pressure prepacked column which can be rapidly prepared and is suitable for the preparation requirement of column separating purification of most of medium-pressure fillers. The high-resolution high-pressure prepacked column is provided with an upper end cover, an upper sieve plate and a lower sieve plate. The high-resolution high-pressure prepacked column is characterized in that the upper end cover is arranged on an upper port of a column pipe which is provided with open type openings at the upper part and the lower part; a lower port of the column pipe is provided with a lower end cover which is provided with a discharging opening at the middle part; and the upper sieve plate and the lower sieve plate are respectively arranged at inner sides of both ends of the column pipe. The invention has the advantages that: compared with the traditional thread seal, the rotary welding process has high pressure resistance and can be suitable for higher flow rate and thinner filler; compared with the injection molding process column pipe, the extrusion process column pipe has less investment; the cost is low; and the die investment is reduced.
Description
Technical field:
The present invention relates to a kind of high resolving power high pressure prepacked column, can prepare fast, be suitable for pressing among the overwhelming majority column separating purification of filler to prepare requirement.
Background technology:
Chromatogram is a kind of compartment analysis means, and separation is a core, and the chromatographic column of therefore undertaking centrifugation is the heart of chromatographic system.Requirement to chromatographic column is that post is imitated height, selectivity is good, and analysis speed is fast etc.
Mostly the chromatographic column of Shi Yonging is by upper end cover in the market, and cylinder and sieve plate three parts are formed (as Fig. 1), the above two injection mold moulding, and during the column jecket moulding because to take out heart mould dark excessively, Gu manufacturing cost is higher.Because moulding process limits, its ratio of height to diameter (ratio of bed height degree and internal diameter in the post) is less, is about about 5: 1, influences separation efficiency simultaneously.Its upper end cover and shaft are thread seals, Gu withstand voltage limited, be about 100psi, influence velocity of separation.
Summary of the invention:
In order to solve the problems of the technologies described above, the invention provides a kind of high resolving power high pressure prepacked column.
The technical solution adopted for the present invention to solve the technical problems is: a kind of high resolving power high pressure prepacked column, be provided with upper end cover, upper sieve plate and following sieve plate, it is characterized in that: described upper end cover is arranged on one and is up and down on the upper port of column jecket of open opening, the lower port of described column jecket is provided with the bottom end cover that a middle part offers discharge port, and described upper sieve plate and following sieve plate place inboard, column jecket two ends respectively.
Further:
The internal diameter of described column jecket is less than 30mm, and described upper end cover, bottom end cover adopt the outer cover type, adopts inwall to be welded to connect between described upper end cover, bottom end cover and the column jecket.
The internal diameter of described column jecket is greater than 30mm, and described upper end cover, bottom end cover are plunger piston type, adopts inwall to be welded to connect between described upper end cover, bottom end cover and the column jecket.
The external diameter of described column jecket is 10mm-200mm, highly is 150mm-500mm.
Described column jecket is a standard series tubing.
Described upper end cover, bottom end cover adopt common mode technology.
Advantage of the present invention is as follows:
1. rotating welding technology is compared with traditional thread seal, and withstand voltage height can be fit to higher flow velocity and thinner filler;
2. expressing technique is compared with the Shooting Technique column jecket, invests little;
3. cost is low;
4. reduce the mould investment.
Description of drawings:
As 1 structural representation for existing chromatographic column.
Fig. 2 is a kind of structural representation of the present invention.
Fig. 3 is an another kind of structural representation of the present invention.
Among the figure: 1, upper end cover; 2, upper sieve plate; 3, following sieve plate; 4, column jecket; 5, discharge port; 6, bottom end cover.
Embodiment:
The present invention is further described below in conjunction with drawings and Examples.
As Fig. 2, a kind of high resolving power high pressure prepacked column shown in 3, be provided with upper end cover 1, upper sieve plate 2 and following sieve plate 3, described upper end cover 1 is arranged on one and is up and down on the upper port 4-1 of column jecket 4 of open opening, described column jecket 4 external diameters are 10mm-200mm, highly be 150mm-500mm, the lower port 4-2 of described column jecket 4 is provided with the bottom end cover 6 that a middle part offers discharge port 5, described upper sieve plate 2 and following sieve plate 3 place inboard, column jecket 4 two ends respectively, described upper end cover 1, bottom end cover 6 for column jecket 4 between can adopt rotating welding to be connected, and according to the internal diameter size of different column jecket 4, can adopt following two kinds of upper end covers 1, the shape of bottom end cover 6, be respectively: when column jecket during less than 30mm, upper end cover 1, bottom end cover 6 is the outer cover type, upper end cover 1, adopt outer wall to be welded to connect (as Fig. 2) between bottom end cover 6 and the column jecket 4, because this internal diameter is less, have certain degree of difficulty during installation, adopt this kind shape then can well solve installation question, when welding, can clamp the outer wall of column jecket 4 by its shade; When column jecket 4 during greater than 30mm, upper end cover 1, bottom end cover 6 are plunger piston type, adopt inwall to be welded to connect (as Fig. 3) between upper end cover 1, bottom end cover 6 and the column jecket 4.Rotating welding connects, and with respect to thread seal, selects welding can improve reliability greatly, and prepacked column is withstand voltage to reach 300psi, means that solvent can use higher flow velocity, improves applied sample amount and velocity of separation.With respect to original technology, the present invention makes former column jecket into column jecket 4 and bottom end cover 6 moulding respectively by an integral body, and column jecket 4 uses the standard series tubing, bottom end cover 2 can with upper end cover 6 common modes, save cost.And increase its ratio of height to diameter (ratio of bed height degree and internal diameter in the post) simultaneously, increase its separation efficiency.The present invention can adopt column jecket inner and outer wall welded structure according to different dimension serieses, adapts to wide.
It is emphasized that: above only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, every foundation technical spirit of the present invention all still belongs in the scope of technical solution of the present invention any simple modification, equivalent variations and modification that above embodiment did.
Claims (6)
1. high resolving power high pressure prepacked column, be provided with upper end cover (1), upper sieve plate (2) and following sieve plate (3), it is characterized in that: described upper end cover (1) is arranged on one and is up and down on the upper port (4-1) of column jecket (4) of open opening, the lower port (4-2) of described column jecket (4) is provided with the bottom end cover (6) that a middle part offers discharge port (5), and described upper sieve plate (2) and following sieve plate (3) place column jecket (4) inboard, two ends respectively.
2. high resolving power high pressure prepacked column according to claim 1, it is characterized in that: the internal diameter of described column jecket (4) is less than 30mm, described upper end cover (1), bottom end cover (6) adopt the outer cover type, adopt inwall to be welded to connect between described upper end cover (1), bottom end cover (6) and the column jecket (4).
3. high resolving power high pressure prepacked column according to claim 1, it is characterized in that: the internal diameter of described column jecket (4) is greater than 30mm, described upper end cover (1), bottom end cover (6) are plunger piston type, adopt inwall to be welded to connect between described upper end cover (1), bottom end cover (6) and the column jecket (4).
4. high resolving power high pressure prepacked column according to claim 1 is characterized in that: the external diameter of described column jecket (4) is 10mm-200mm, highly is 150mm-500mm.
5. high resolving power high pressure prepacked column according to claim 1 is characterized in that: described column jecket (4) is a standard series tubing.
6. according to claim 2 or 3 described high resolving power high pressure prepacked columns, it is characterized in that: described upper end cover (1), bottom end cover (6) adopt common mode technology.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105464396A CN102128903A (en) | 2010-11-17 | 2010-11-17 | High-resolution high-pressure prepacked column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105464396A CN102128903A (en) | 2010-11-17 | 2010-11-17 | High-resolution high-pressure prepacked column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102128903A true CN102128903A (en) | 2011-07-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105464396A Pending CN102128903A (en) | 2010-11-17 | 2010-11-17 | High-resolution high-pressure prepacked column |
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| Country | Link |
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| CN (1) | CN102128903A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105929095A (en) * | 2016-07-15 | 2016-09-07 | 烟台大学 | Chromatographic column used for liquid chromatography |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4280905A (en) * | 1979-07-31 | 1981-07-28 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chromatography column |
| US5601708A (en) * | 1994-04-07 | 1997-02-11 | Dyax Corp. | Apparatus for pressurizing a removable chromatography cartridge |
| EP2239029A1 (en) * | 2009-04-08 | 2010-10-13 | Biotage AB | Chromatography column |
| CN201892675U (en) * | 2010-11-17 | 2011-07-06 | 利穗科技(苏州)有限公司 | High-resolution and high-pressure pre-packed column |
-
2010
- 2010-11-17 CN CN2010105464396A patent/CN102128903A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4280905A (en) * | 1979-07-31 | 1981-07-28 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chromatography column |
| US5601708A (en) * | 1994-04-07 | 1997-02-11 | Dyax Corp. | Apparatus for pressurizing a removable chromatography cartridge |
| EP2239029A1 (en) * | 2009-04-08 | 2010-10-13 | Biotage AB | Chromatography column |
| CN201892675U (en) * | 2010-11-17 | 2011-07-06 | 利穗科技(苏州)有限公司 | High-resolution and high-pressure pre-packed column |
Non-Patent Citations (1)
| Title |
|---|
| 王宇成主编: "《最新色谱分析检测方法及应用技术实用手册 第4卷》", 31 December 2004, 银声音像出版社, article "色谱柱技术", pages: 1878 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105929095A (en) * | 2016-07-15 | 2016-09-07 | 烟台大学 | Chromatographic column used for liquid chromatography |
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Application publication date: 20110720 |