CN102119693B - Synergetic antibacterial composition containing fluazinam and tebuconazole and use thereof - Google Patents
Synergetic antibacterial composition containing fluazinam and tebuconazole and use thereof Download PDFInfo
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- CN102119693B CN102119693B CN 201010017620 CN201010017620A CN102119693B CN 102119693 B CN102119693 B CN 102119693B CN 201010017620 CN201010017620 CN 201010017620 CN 201010017620 A CN201010017620 A CN 201010017620A CN 102119693 B CN102119693 B CN 102119693B
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Abstract
The invention discloses a synergetic antibacterial composition containing fluazinam and tebuconazole and use thereof. The main active ingredients of the antibacterial composition are fluazinam and tebuconazole, wherein the weight ratio of the fluazinam to the tebuconazole is 30:1 to 1:20. The composition is suitable to be used for preparing antibacterial for preventing and controlling diseases in crops. The composition can enlarge a prevention and control spectrum, has a synergetic effect, produces good effect, lowers the total amount of applied active ingredients and is low in cost.
Description
Technical field
The present invention relates to a kind of bactericidal composition and uses thereof, especially a kind of bactericidal composition and application thereof take fluazinam and Tebuconazole as main active.
Background technology
Fluazinam (kresoxim-methyl) is a kind of efficient, wide spectrum, new pyridine series bactericidal agent.Be applicable to prevent and treat phytophthora root rot, rotten stalk break, black spot, scab and other the pathogene diseases such as Cereal, various melon and fruit, vegetables, grape, apple, pears, oranges and tangerines, soybean, potato, tomato, cucumber, tea, lawn good control efficiency is arranged.Concrete disease such as gray mold of cucumber, citrus scab, gray mold, potato late blight, lawn spot disease.Except bactericidal activity, fluazinam also demonstrates the acaricidal activity to two spotted spider mite etc.These characteristics so that the commodity of fluazinam be used widely in the whole world.But the former medicine production of fluazinam is less in China, and its price is high, is difficult to prevent and treat in the farmland promote the use of aspect the disease.
Tebuconazole is absorption triazole bactericidal agent in the high-efficiency broad-spectrum of new generation, the tool protection, and treatment and eradicant action are applicable to the crops such as Cereal, peanut, banana, grape, tea, fruit tree.Be used for control Erysiphe, Puccinia, Rhynchosporium spp．, nuclear cavity Pseudomonas and the microbial disease of Septoria, wheat powdery mildew, wheat scab, take-all, soybean rust, sclerotinia rot of colza, sigatoka, tea gall, alternaria leaf spot of apple, pear scab and grape grey mould etc.
But these two kinds of prescriptions solely use, and consumption is large, and bactericidal effect is unstable.
Summary of the invention
The objective of the invention is for above-mentioned weak point provide a kind of applied widely, cost is low, the plant bactericidal composition of effective containing fluazinam and Tebuconazole.
Another object of the present invention provides the application of this bactericidal composition in the bactericide of preparation control corps diseases.
The objective of the invention is to realize by following measures:
The Synergistic bactericidal composition of a kind of containing fluazinam and Tebuconazole, it is characterized in that this bactericidal composition take fluazinam and Tebuconazole as main active, wherein, the mass ratio of fluazinam and Tebuconazole is 30: 1～1: 20, be preferably 25: 1～1: 15, more preferably 20: 1～1: 10.
Fluazinam and Tebuconazole and known auxiliary agent and excipient are re-dubbed any one formulation that allows on the agricultural chemicals among the present invention.Can be processed into pulvis, wetting powder, suspension emulsion, missible oil or granule after the combination of two active components.These known auxiliary agents have dispersant, diffusant, defoamer, wetting agent, disintegrant etc.The gross mass percentage composition of active ingredient is 5%～80% in the preparation, is preferably 10%～60%.
Bactericidal composition of the present invention can be prevented and treated the multiple kinds of crops disease, be mainly used in preventing and treating the disease of Cereal, melon and fruit or vegetable crop, especially to fungus-caused wheat powdery mildew, banded sclerotial blight, full rot, sigatoka, grape grey mould has obvious effect.
Beneficial effect of the present invention compared with the prior art:
1, the used fluazinam pyridine bactericide of the present invention, Tebuconazole is triazole bactericidal agent, but the Synergistic that mutually is mixed reduces dosage, reduces cost.
2, the present composition scope of application increases, be applicable to prevent and treat the crop pest of Cereal, various melon and fruit, vegetables, particularly prevent and treat fruit tree, vegetables, rape, peanut, grape, tea tree, lawn, the crop pest such as ornamental plants in garden and various cereal crops, it is effective especially to prevent and treat the diseases such as wheat smut, powdery mildew of cucumber, pear scab, rice sheath blight disease, alternaria leaf spot of apple.
Embodiment
The invention will be further described below in conjunction with embodiment.The preparation method of formulation is conventional method among the embodiment.
Embodiment 1:
Fluazinam 30g, Tebuconazole 10g, agricultural newborn 500#4g, agricultural newborn 600#3g, Nongru-700 #2g, dimethylbenzene are added to 100g, and mixture fully mixes the missible oil that namely makes active ingredient 40% for all resembling transparency liquid.
Embodiment 2:
Fluazinam 40g, Tebuconazole 10g, naphthalene sulfonate 6g, polysiloxane defoamers 0.2g, xanthans 0.3g, water are added to 100g to be mixed, stir by the one-level sand mill, the secondary sand mill grinds, in modulation kettle, allocate, carry out the suspending agent that the dosage packing makes effective content 50% after inspection by sampling is qualified.
Embodiment 3:
With fluazinam 50g, Tebuconazole 30g, naphthalene sulfonate 6g, ammonium sulfate 4g, kaolin adds to 100g; Add naphthalene sulfonate and ammonium sulfate after the dissolving of active ingredient fluazinam and Tebuconazole, the rear interpolation filler kaolin that stirs grinds the pressure granulation after the mixing, and it is 80% water-dispersible granules that oven dry can make active constituent content.
Embodiment 4:
With fluazinam 8g, Tebuconazole 2g, pull open powder 3g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 2g, white carbon 5g, kaolin adds to 100g, mixture carries out air-flow crushing, makes active constituent content and be 10% wetting powder.
Embodiment 5:
With fluazinam 4g, Tebuconazole 1g, alkyl naphthalene formaldehyde condensate sulfonates 3g, alkylphenol-polyethenoxy base phosphate 2g, bentonite 2g, xanthans 0.3g, ethylene glycol 5g, polyvinyl alcohol blending modification film forming agent 0.2g, red pigments 0.2g, water adds to 100g, with active component fluazinam and Tebuconazole, bentonite, husky mill behind emulsifier and the abundant mix and blend of part water, then in modulation kettle, add successively polyvinyl alcohol blending modification film forming agent, the thickener xanthans, antifreeze glycol can make active constituent content and be 5% suspension seed-coating agent after red pigments and excess water fully mix.
Embodiment 6:
With fluazinam 30g, Tebuconazole 1g, naphthalene sulfonate 6g, ammonium sulfate 4g, kaolin adds to 100g, add naphthalene sulfonate and ammonium sulfate after active ingredient fluazinam and the Tebuconazole dissolving, rear interpolation filler kaolin stirs, grind the pressure granulation after the mixing, it is 31% water-dispersible granules that oven dry can make active constituent content.
Embodiment 7:
With fluazinam 2g, Tebuconazole 40g, pull open powder 3g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 2g, white carbon 5g, kaolin adds to 100g, mixture carries out air-flow crushing, makes active constituent content and be 42% wetting powder.
Embodiment 8:
With fluazinam 40g, Tebuconazole 2g, naphthalene sulfonate 6g, ammonium sulfate 4g, white carbon adds to 100g, add naphthalene sulfonate and ammonium sulfate after active ingredient fluazinam and the Tebuconazole dissolving, rear interpolation filler white carbon stirs, grind the pressure granulation after the mixing, it is 42% water-dispersible granules that oven dry can make active constituent content.
Embodiment 9:
With fluazinam 2g, Tebuconazole 20g, pull open powder 3g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 2g, white carbon 5g, kaolin adds to 100g, mixture carries out air-flow crushing, makes active constituent content and be 22% wetting powder.
Application Example 1: prevent and treat the experiment of powdery mildew of cucumber
1. be indoor conventional screening cucumber sense powdery mildew kind for studying thing
2. test is processed: this test medicine consumption arranges 5 concentration gradients according to the difference of composition, and the contrast medicament is 50% fluazinam suspending agent and 20% Tebuconazole missible oil and the contrast of blank clear water.
3. test method: from the cucumber cotyledons phase, on the cucumber leaves that 2 true leaves are arranged, the spray medicine is processed after 24 hours with cucurbits powdery mildew bacterium spore suspension spray inoculation.Calculate EC
50, calculate co-toxicity coefficient.
4. result of the test sees the following form
| Medicament | Regression equation | ?EC 50(95% confidence interval) (mg/L) | Co-toxicity coefficient (CTC) |
| 50% fluazinam suspending agent | Y＝1.9841+2.1104x | ?54.751(43.371～74.724) | / |
| 20% Tebuconazole missible oil | Y＝2.4231+1.5451x | ?98.345(83.371～127.76) | / |
| Embodiment 1 | Y＝0.9493+1.7583x | ?37.76(26.763～47.456) | 173.86 |
| Embodiment 2 | Y＝0.8265+2.1254x | ?29.875(18.743～41.453) | 212.45 |
| Embodiment 3 | Y＝1.2774+1.4972x | ?33.107(21.435～45.561) | 187.32 |
From Toxicity Determination, two kinds of group of effective components are combined it and spend coefficient together greater than 100, have obvious synergistic effect.
Application Example 2: prevent and treat the powdery mildew of cucumber test
1, test is processed: the difference of each composition of this experimental evidence is established respectively three concentration for the treatment of, and the contrast medicament is respectively commercially available agricultural chemicals 500g/l fluazinam suspending agent and 40% Tebuconazole missible oil and the test of blank clear water.
2, each residential quarter of test method is the duplicate rows cucumber seedling, and isolation strip is established in the centre, repeats 3 times; Investigation disease index before the dispenser, the inspection drug effect method after the control is: random sampling 5 points in the test treatment region, every 10 strains check the powdery mildew of cucumber occurrence degree.(test refers to effective ingredient consumption in each preparation with dosage.)
3, result of the test sees the following form:
Annotate: a is illustrated on α=0.05 level remarkable, and b is illustrated on α=0.05 level variant, and c is illustrated on α=0.05 level not remarkable.
Field efficacy is the result show, fluazinam and Tebuconazole composition have good control efficiency to powdery mildew of cucumber, and control efficiency all is better than the single dose kind.
Application Example 3: the field control effectiveness test of control wheat sharp eyespot
1, test is processed: this test medicine consumption is the consumption of active ingredient, and different preparations are established respectively three concentration for the treatment of, and the contrast medicament is respectively commercially available agricultural chemicals 50% fluazinam suspending agent (SC) and 20% Tebuconazole missible oil (EC) and the test of blank clear water.
2, test method: each residential quarter area is 100m
2, repeat 3 times; Inspection drug effect method before the dispenser behind the Investigation and Prevention is: random sampling 5 points in the test treatment region, every 50 fringes check the banded sclerotial blight occurrence degree.
3, result of the test sees the following form:
Annotate: a is illustrated on α=0.05 level remarkable, and b is illustrated on α=0.05 level variant, and c is illustrated on α=0.05 level not remarkable.
Field control effectiveness test shows that the composition of fluazinam and Tebuconazole has significant control efficiency to wheat sharp eyespot, has the preventive effect than certain medicine excellence of single use.
Application Example 4: the field control effectiveness test of preventing and treating sigatoka
1, test is processed: this test medicine consumption is the consumption of active ingredient, and different preparations are established respectively three concentration for the treatment of, and the contrast medicament is respectively commercially available agricultural chemicals 50% fluazinam suspending agent (SC) and 40% Tebuconazole missible oil (EC) and the test of blank clear water.
2, test method: each residential quarter area is 100m
2, repeat 3 times; Inspection drug effect method before the dispenser behind the Investigation and Prevention is: random sampling 5 points in the test treatment region check the banded sclerotial blight occurrence degree.
3, result of the test sees the following form:
Annotate: a is illustrated on α=0.05 level remarkable, and b is illustrated on α=0.05 level variant, and c is illustrated on α=0.05 level not remarkable.
Field control effectiveness test shows that the composition of fluazinam and Tebuconazole has significant control efficiency to sigatoka, has the preventive effect than certain medicine excellence of single use.
Claims (8)
1. the Synergistic bactericidal composition of a containing fluazinam and Tebuconazole is characterized in that this bactericidal composition take fluazinam and Tebuconazole as active component, and wherein, the mass ratio of fluazinam and Tebuconazole is 20:1 ~ 1:10.
2. bactericidal composition according to claim 1 is characterized in that fluazinam and the Tebuconazole gross mass percentage composition in bactericidal composition is 5% ~ 80%.
3. bactericidal composition according to claim 2 is characterized in that the two gross mass percentage composition in composition of fluazinam and Tebuconazole is 10～60%.
4. bactericidal composition according to claim 1 is characterized in that fluazinam and Tebuconazole and known auxiliary agent are mixed with any one formulation that allows on the agricultural chemicals.
5. bactericidal composition according to claim 4 is characterized in that described formulation is pulvis, suspending agent, missible oil or granule.
6. the application of bactericidal composition claimed in claim 1 in the bactericide of preparation control corps diseases.
7. the application of bactericidal composition claimed in claim 1 in the bactericide of preparation control wheat, corn, peanut, vegetables or fruit tree crop disease.
8. bactericidal composition claimed in claim 1 is in preparation control wheat powdery mildew, banded sclerotial blight, full rot, maize head smut, sclerotinia rot of colza, the application in the bactericide of sigatoka, grape grey mould.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010017620 CN102119693B (en) | 2010-01-08 | 2010-01-08 | Synergetic antibacterial composition containing fluazinam and tebuconazole and use thereof |
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| CN 201010017620 CN102119693B (en) | 2010-01-08 | 2010-01-08 | Synergetic antibacterial composition containing fluazinam and tebuconazole and use thereof |
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| CN102119693A CN102119693A (en) | 2011-07-13 |
| CN102119693B true CN102119693B (en) | 2013-03-20 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101984821B (en) * | 2010-07-15 | 2013-06-05 | 江阴苏利化学股份有限公司 | Bactericidal composition containing fluazinam and tebuconazole and application thereof |
| CN101984822B (en) * | 2010-08-06 | 2012-12-12 | 东莞市瑞德丰生物科技有限公司 | Germicide composition |
| WO2016204160A1 (en) * | 2015-06-15 | 2016-12-22 | 石原産業株式会社 | Soybean disease control composition and soybean disease control method |
| FR3037479B1 (en) * | 2015-06-19 | 2018-08-24 | Phyteurop S.A. | PROCESS FOR TREATING WOOD DISEASES OF PERENNIAL PLANTS |
| CN108739823A (en) * | 2018-06-21 | 2018-11-06 | 陕西上格之路生物科学有限公司 | Application of the bactericidal composition of containing fluazinam in prevention head blight and bakanae disease |
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Non-Patent Citations (1)
| Title |
|---|
| 胡军 等.防治白紫根霉病杀菌剂氟啶胺及其新施用方法.《世界农药》.2003,第25卷(第2期),47-48. * |
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