CN101970034B

CN101970034B - Patient interface assembly for respiratory therapy

Info

Publication number: CN101970034B
Application number: CN2008801250878A
Authority: CN
Inventors: T·J·邓斯摩尔; G·C·维斯; T·C·威尔施克; L·P·明焦内
Original assignee: Allegiance Corp
Current assignee: Sun Medical Group Holdings LLC
Priority date: 2007-11-19
Filing date: 2008-11-19
Publication date: 2013-01-23
Anticipated expiration: 2028-11-19
Also published as: NZ586099A; EP2217311A1; AU2008326430A1; WO2009067554A1; US20090126731A1; BRPI0819630A2; JP2011502737A; BRPI0820475A2; RU2449813C2; US20090126734A1; RU2010125146A; ZA201003550B; US8365727B2; JP2011502736A; RU2010125241A; AU2008326425B2; US10195381B2; WO2009067549A1; JP5470264B2; CN101970034A

Abstract

A patient interface assembly includes a housing that defines an inlet port and an outlet port. A jet pump receives pressurized gas flow from the inlet port and delivers the gas flow to the outlet port. A nebulizer is fluidly coupled to the outlet port and positioned to introduce medication into the gas flow and deliver medicated gas flow to a patient.

Description

The patient interface assembly that is used for respiratory therapy

Cross reference to related application

The sequence number that the application submitted to based on November 19th, 2007 is No.60/988,977 U.S. Provisional Patent Application and require the rights and interests of this U.S. Provisional Patent Application, and it is the U.S. Patent application No.12/274 of " respiratory treatment systems with electrodynamic mechanical type driver " that the application relates to the exercise question of submitting on the same day with this temporary patent application, 066, the whole content of these two applications all is cited as a reference at this.

Technical field

Disclosure content of the present invention relates to respiratory treatment systems and device.Particularly, the present invention relates to patient interface (interface) assembly, thereby described patient interface assembly is configured to be attached to the respiratory treatment systems delivering medicament.

Background technology

There is at present the various respiratory therapy equipment to can be used for assisting, treating or improve patient's respiratory health.For example, Positive Airway Pressure (PAP) has been proved to be and can be conducive to improve oxygenation, increases vital capacity and alleviates congestive heart disease people's venous return, thereby effectively improves bronchial sanitary condition.Recently, PAP also is considered to effectively to promote migration and the cleaning of the secretions (for example mucus) of patient pulmonary.With regard to this respect, the expiration phase Positive Airway Pressure (EPAP) that exists with the higher-order of oscillation form of patient's air column is a kind of technology that is considered to be conducive to remove secretions.Usually, HFO has reduced external saliva viscosity, and this has further produced positive influences to the cleaning of bringing out by the cough of simulating in the body.HFO can be via the power (being chest physiotherapy (CPT)) that is applied on patient's chest wall, or by power being applied directly to the mode of patient airway (being respiratory therapy, such as the vibration of high frequency air flue), be transferred or form.Many patients and care-giver preferably use the respiratory therapy mode, this be because the obstacle of this mode still less and be easier to control.For this purpose, PAP bronchus health technology emerges and as the another kind of effective optional mode of CPT, thereby makes pulmonary produce expansion and make secretions produce migration.

Multiple HFO therapy system can provide above-mentioned respiratory therapy (knocking treatment in the high frequency lung) (and other treatment and/or ventilation).Usually, knocking (HFIP) system comprises handheld apparatus in the high frequency lung, and described handheld apparatus has been set up the patient respiration circuit, and positive pressure gas body source (such as air source, oxygen source etc.) is connected to described patient respiration circuit communicatively by fluid.With regard to this respect, described system further comprises actuator unit, described actuator unit acts on the barotropic gas of supply, has formed the concussion pressure distribution or has otherwise made gas gap ground flow into the patient respiration circuit, and therefore realized the knocking ventilation of patient pulmonary.For this scheme, patient breathes by the mouthpiece (or face shield) of breathing circuit, and this further is delivered to high flow capacity " microexplosion is split " gas that produces patient's air flue.The knocking air flow of pulsation periodically increases patient's airway pressure.

Present HFO therapy system also can with nebulizer use in case with vaporific drug conveying to patient.This nebulizer can by fluid communication be connected to actuator unit and carry and to pass the patient interface circuit in order to will add the gas of medicine.In the conventional configuration of patient interface circuit, medicine is carried in the surrounding air in device and is delivered to patient in order to will be added with the gas of medicine.These configurations help medicine " abate (knock down) ", and the medicine that wherein accumulates in this device has increased, and the medication amount that is transported to patient has been reduced.Therefore, need to provide a kind of respiratory treatment systems of improvement, patient interface assembly particularly so that with drug conveying to patient.

Summary of the invention

The theory that the present invention proposes relates to a kind of patient interface assembly for carry respiratory therapy to patient.Described assembly comprises the housing that limits ingress port and outlet port.Described ingress port can be attached to actuator unit in order to receive the flow of pressurized gas that is produced by described actuator unit.The ejector pump reception that is arranged in the described housing is delivered to described outlet port from the flow of pressurized gas of described ingress port and with described flow of pressurized gas.Nebulizer is attached to described outlet port by fluid communicatively so that the gas flow that receives flow of pressurized gas, introduces medicine in the described gas flow and will be added with medicine is delivered to patient.

The many aspects of described patient interface assembly can further be introduced in the system and method in order to respiratory therapy is provided.In addition, other side also can be added in the described assembly, be removed from described assembly and/or produce modification in described assembly.For example, described housing can comprise and carries in port, expiration port, nebulizer port and the pressure port one or more.Further, described ejector pump can be slided in described housing and be comprised carrier area, throat region and/or expansion area.

Description of drawings

Fig. 1 is the schematic diagram of respiratory treatment systems;

Fig. 2 to Figure 14 is the schematic diagram of other respiratory treatment systems;

Figure 15 and Figure 16 are the views of the first embodiment of patient interface; With

Figure 17 is the view of the second embodiment of patient interface;

Figure 18-Figure 20 is the view of the 3rd embodiment of patient interface;

Figure 21 is the view of adapter, and described adapter has a plurality of ports in order to the actuator unit fluid is attached to patient interface communicatively.

The specific embodiment

Fig. 1 is the schematic diagram of an embodiment of respiratory treatment systems 20, described respiratory treatment systems comprises actuator unit 22 and as the patient interface 24 of patient interface circuit, and described patient interface is in use set up and led to and from patient 25 breathing catheter.Particularly, described breathing catheter extends to patient 25 air flue (such as mouth, nasal sinuses etc.), in one embodiment, can be that patient 25 sets up the breathing catheter towards air flue by means of intubation.In addition, if necessary, then system 20 both can in the situation that arrange that ventilator uses can be in the situation that there be ventilator to use yet.The below will be described the details of all parts.Yet, usually, actuator unit is suitable for being connected to communicatively pressurized-gas source (such as air source, oxygen source etc.) 26 (general Reference numeral) by fluid, and comprises controller 28 so that control is arranged on the operation of the one or more electronic valves between suction line 30 and the outlet line 32 communicatively by fluid.More particularly, the flow of pressurized gas that is in suction line 30 places from gas source 26 is acted on by this electronic valve (one or more) in order to form or supply required stream/pressure via outlet line 32 to patient interface 24.

As mentioned below, actuator unit 22 can comprise a plurality of different parts or feature, and system 20 can comprise other optional parts such as nebulizer 34.One type the nebulizer that can be used in the system 20 is can be from Cardinal Health of Dublin, and Ohio obtains BrandMisty Max 10TM nebulizer.In the situation that use nebulizer 34, auxiliary line 35 extends to nebulizer 34 from actuator unit 22.Can use controller 28 to handle driver element 22 in order to via this auxiliary line 35 required stream/pressure is supplied to nebulizer 34.In any case system 20 can both provide high-frequency pressure pulse (for example knocking treatment) by means of the patient that is operating as of actuator unit 22, but and compare frequency of delivery and the pressure that provides wider with the actuator unit based on pneumatic operated valve of routine.Patient's pressure line 36 can be set in order to the patient interface fluid returned communicatively be connected to actuator unit 22, thereby so that can measure and/or monitor patients interface device 24 in pressure.Controller 28 can be configured to control the air conveying of carrying out to patient 25 based on the pressure of measuring in patient interface 24.Actuator unit 22 can comprise further electronic valve (one or more), thereby described electronic valve operates and for example patient's pressure line 36 purged and therefore prevent fluid in patient's pressure line 36 interior excessive buildup, but so that pressure transducer auto zero etc.In one embodiment, actuator unit 22 can be connected to the center processing station, such as nurse station, so that the out of Memory of carrying the information relevant with the operation of actuator unit 22 and/or conveying and patient to be correlated with.

More particularly as shown in Figure 2, actuator unit 22 can comprise a plurality of other parts except controller 28, and each described parts is maintained in the portable housing 37 or by described housing and keeps.For example, for a kind of configuration shown in Figure 2, actuator unit 22 comprises electronic valve 40 (for example proportional solenoid), and described electronic valve is configured to act on the gas-pressurized of supply in the process that forms the continuous high frequency pressure pulse.Another kind of optional mode is also to use the replenishing and/or substituting as electronic valve 40 of a plurality of switching mode electromagnetic valves.Electronic valve 40 also can be configured so that optionally to act on the gas-pressurized of supply, thereby realizes the conveying of baseline pressure, Positive Airway Pressure (PAP), continuous Positive Airway Pressure (CPAP) etc.Also can use the Positive Airway Pressure of other form, such as two horizontal PAP (BiPAP), this provides two kinds of stress levels.In any situation, PAP is controlled by the manifold sensor that is in the actuator unit 22, and CPAP then is controlled by the patient's pressure transducer that is attached to communicatively patient's pressure line 36 by fluid.Electronic valve 40 is connected between suction line 30 and the outlet line 32 communicatively by fluid, and is attached to controller 28 in the electronics mode.Therefore controller 28 is controlled the operation of electronic valve 40 based on the program that is kept by keeper 28 (for example software and/or hardware).With regard to this respect, controller 28 can be controlled the power (and other parts hereinafter described) that is delivered to electronic valve 40, and the electric supply installation (not shown) is electrically coupled to controller 28.Electric supply installation can present various ways, as is maintained at accumulator in the housing 37, is used for being connected to the power line of conventional wall type power supply etc.

Electronic valve 40 comprises or limits entrance side 42 and outlet side 44.Entrance side 42 is connected to the inside suction line 46 that is in housing 37 inside communicatively by fluid, and outlet side 44 is connected to the inside outlet line 48 that is in housing 37 inside communicatively by fluid.Inner suction line 46 is attached to communicatively suction line 30 by fluid and inner outlet line 48 is attached to outlet line 32. communicatively by fluid.For this structure, the gas flow that will be provided for subsequently suction line 30 is delivered to electronic valve 40.Electronic valve 40 can present various ways, and the electronic valve of these forms is suitable for introducing or forming the high-frequency pressure pulse when the flow of pressurized gas that acts on from gas source 26.More particularly, for those embodiment that system 20 is suitable for using with " standard " gas source gas pressure (for example being maintained at oxygen or air under the pressure that is in the 40-70psi scope) that provides in hospital, electronic valve 40 is configured to open in response to the signal that comes self-controller 28 repeatedly and stop that inner openings (namely, allow and prevent that gas from passing through described electronic valve), thus the pulsating pressure with larger frequency and pressure limit formed.For example, for some configurations, electronic valve 40 can produce the frequency that is in the 1-25Hz scope.Also can realize other frequency, for example be lower than 1Hz and/or greater than 25Hz (for example up to 30Hz or 40Hz).

Compare with the actuator unit based on the Aerated reciprocal valve of routine, the electronic valve 40 of disclosure content of the present invention provides significant advantage aspect running frequency and the pressure limit controlling more accurately and improve.In addition, pneumatic operated valve needs charging, could provide larger initial pressure pulse for patient thus.Further, by controlling electronic valve 40 in the electronics mode, so that any variation of the gas pressure that occurs at gas source 36 places has little or no impact to the pulse profile that electronic valve 40 produces, thus so that when carrying consistent treatment, avoided occurring undesirable high pressure.Further, with the controlled valve 40 of electronics mode can earthquake pressure operation mode process in " stall ", therefore avoided occurring in the existing pneumatic operated valve actuator unit for patient provides the phenomenon of high pressure consistently, this constant high-pressure can bring problem, does not wish to occur.In addition, by the parameter in the monitor driver unit 22, actuator unit 22 has prevented from not wishing the appearance of situation and/or providing alarm in order to inform the care-giver, has improved thus safety.Electronic valve 40 also can be provided so that realizes continuous Positive Airway Pressure when needed.Electronic valve 40 can further be configured to reduce dead volume.In a particular embodiment, dead volume is reduced to less than two cubic inches.

Except above-mentioned electronic valve 40, actuator unit 22 comprises optional purging electronic valve 50, and described purging electronic valve is attached to electronically controller 28 and is subject to the control of this controller.In one embodiment, purging electronic valve 50 can be electromagnetic valve.For a kind of configuration shown in Figure 2, purge that electronic valve 50 is connected to the inside suction line 46 in parallel with electronic valve 40 communicatively by fluid and in order to the patient's pressure line 46 that leads to actuator unit 22 from patient interface 24 is purged.Purge electronic valve 50 and have the entrance side 52 that is connected to communicatively inner suction line 46 by fluid, and be connected to communicatively the outlet side 54 of blow line 56 by fluid.Blow line 56 is attached to patient's pressure line 36 communicatively by fluid, thereby can operate in order to clear up the fluid that may accumulate in patient's pressure line 36 liquid and/or other granule of particularly being discharged by patient 25 so that purge electronic valve 50.

For this purpose, patient sensor automatic zero set electronic valve 60 (for example electromagnetic valve) can be provided so that and purge the electronic valve synergism.Automatic zero set electronic valve 60 is by being attached to controller 28 and being subject to the control of this controller and comprising entrance side 62, outlet side 64 and discharge side 66 in the electronics mode.In normal course of operation, automatic zero set electronic valve 60 is in " opens " position normally, thereby so that fluid can flow to patient's pressure transducer 67 from patient's pressure line 36, the below will be described in more detail this.When patient's pressure line 36 was purged, automatic zero set electronic valve 60 was closed and patient's pressure transducer 67 is attached to ventilation line 68 communicatively by fluid, and described ventilation line is led to environment (for example fluid leads to the outside of housing 37 communicatively).Next, blow down valve 50 is opened, thereby so that patient's pressure line 36 can be purged.In case patient's pressure line 36 is purged, and blow down valve 50 is closed, and then automatic zero set electronic valve 6 is opened as in being in normal operating state.

Automatic zero set electronic valve 60 also can be used for patient sensor 67 is calibrated, and this for example is to carry out when the startup of system 20.For patient's pressure transducer 67 is calibrated, pressure transducer 67 should be able to be read ambient pressure thereby automatic zero set electronic valve 60 is closed, and this is because it is connected to environment via ventilation line 68 communicatively by fluid.Another kind of mode is that patient's pressure transducer 67 can be adjusted to reference atmosphere pressure.If necessary, then patient's pressure line 36 can be purged in this adjustment process.After having carried out calibration, automatic zero set electronic valve 6 is opened as in being in normal operating state.

The additional optional feature of actuator unit 22 is auxiliary valves 70.Auxiliary valve 70 can be electronic valve (for example electromagnetic valve) or pneumatic operated valve.Auxiliary valve 70 limits entrance side 72 and outlet side 74, and is attached to controller 28 and is subject to the control of this controller by the electronics mode.Entrance side 72 is connected to inner suction line 46 communicatively by fluid, and described suction line is in parallel with electronic valve 40 and purging electronic valve 50.Yet outlet side 74 is not connected to inner outlet line 46.The substitute is, outlet side 74 is connected to inner auxiliary line 78 communicatively by fluid, and described inner auxiliary line extends in housing 37, in order to optionally be attached to auxiliary line 35.For this structure, auxiliary valve 70 thereby control flow to the gas flow of nebulizer 34, and therefore can be known as " nebulizer flow valve (neb flow valve) ".The below will describe in more detail to nebulizer 34.Yet generally, under the atomizer operating pattern, 28 pairs of nebulizer flow valves of controller operate and make it reach open mode, allow thus gas flow to flow to nebulizer 34.

As shown in Figure 2, electronic valve 40, purge electronic valve 50, automatic zero set electronic valve 60 and nebulizer flow valve 70 and can be set up as the part of manifold 80 or be connected to described manifold.Manifold 80 builds three parallel gas flow passages that suction line 46 internally extends out effectively, and electronic valve 40 allows the inner outlet line 48 of gas flow, purge electronic valve 60 and allow gas flow feedback line 36 and nebulizer flow valve 70 to allow 35 (by means of the operations of controller 28) of gas flow auxiliary line, as mentioned above.

Can at valve 40 " upstream " optional volumetric spaces chamber 88 be set along inner suction line 46.Volumetric spaces chamber 88 is as accumulator or reservoir, so that storage is from the fluid of suction line 30.The Pressure Drop that produces when therefore, volumetric spaces chamber 88 can be reduced in one or more valve of opening in the

valve

40,50 and 70.For example, when opening purging electronic valve 50, the fluid in the volumetric spaces chamber 88 can be used to reduce from volumetric spaces chamber 88 to the Pressure Drop of the entrance side that purges electronic valve 50.

In order to tackle the possible pressure oscillation from gas source 26, actuator unit 22 can further comprise the optional pressure regulator 90 that is arranged on valve 40 " upstream " along inner suction line 46.Pressure regulator 90 can be mechanically or the controlled device of electronics mode, this device is configured so that the pressure of the flow of pressurized gas that will enter is regulated down to required pressure, therefore so that no matter what kind of pressure gas source 26 places provide, keeping system 20 can both produce consistent pneumatic output.Thereby, may between diverse location, change even have realized that the pressure of actual gas source 26, actuator unit 22 still can will produce consistent pneumatic output between Different hospital.

Actuator unit 22 set additional optional features shown in Figure 2 are connected to the filter 100 of inner suction line 46 communicatively by fluid at valve 40 " upstream ".Filter 100 can present various ways, and usually is configured to remove and is carried at from the fragment in the gas flow of gas source 26 or dampness.In certain embodiments, filter 100 is the types that dewater, and is arranged on communicatively the upstream of pressure regulator 90 by fluid.

If necessary, then actuator unit 22 can further comprise input electronic valve (for example electromagnetic valve) 102, and described valve limits entrance side 104 and outlet side 106.Input electronic valve 102 is connected to inner suction line 46 at filter 100 " upstream " communicatively by fluid.In addition, input the control that electronic valve 102 is attached to controller 28 by the electronics mode and is subject to this controller.Input electronic valve 102 can be used as promptly " closes " valve operation, and can move to closed condition when internal pressure is higher than preset bounds or patient's pressure above predetermined value, closes towards the stream of actuator unit 22.Input electronic valve 102 is in " cutting out normally " position and will optionally operates in order to allow fluid to flow to outlet side 106 from entrance side 104 under the guiding that comes self-controller 28.When driver 22 was not in running status, input electronic valve 102 was closed.The result is, can reduce pressure and accumulate in potential risk in manifold 80 and/or the housing 37.

In a further embodiment, electronics breather valve 108 and ventilation line 109 can be connected between inner suction line 46 and the environment communicatively by fluid, in order to prevent that by the mode of opening breather valve 108 pressure from accumulating in the inner suction line 46.Breather valve 108 can be electronic valve, and described electronic valve is attached to controller 28 by the electronics mode and is subject to the control of described controller.Breather valve 108 limits entrance side 112 and outlet side 114.Entrance side 112 is attached to communicatively inner suction line 46 by fluid and exports 114 and is attached to communicatively breather valve 109 by fluid.Breather valve 108 is in the position of " normally opening ", thereby allows fluid to flow to outlet side 114 from entrance side 112.In the normal course of operation of actuator unit 22, breather valve 108 will move to the closed position under the effect of controller 28.In another embodiment, electronic valve 40, purge electronic valve 50 and/or nebulizer flow valve 70 and can be operated in order to reduce pressure in the inner suction line 46.

For these structures, actuator unit 22 is suitable for acting on the gas from one or more gas with various source 26.For example, this gas source can be oxygen, from the forced air of compressor, from oxygen that accounts for certain mark (fractional oxygen) of blender etc.In addition, based on the type of gas source, the standard of particular country etc., these gas sources can have the adapter of number of different types.In view of this, suction line 30 is connected to one or more opening connectors 110 that enter communicatively by fluid alternatively, and each adapter 110 is configured so that fluid is connected to independently source of supply 26 communicatively.For example, one of them adapter can be set up fluid and is connected with the pressurization oxygen source, and another adapter can be set up fluid with pressurized air source and is connected, and allows thus gas in actuator unit 22 interior mixing.In addition, adapter can be suitable for being attached to the blender of carrying the oxygen that accounts for certain mark that sucks.In embodiment as shown in the figure, the single adapter and this adapter that only are provided with in the adapter 110 are connected to suction line 30.Adapter 110 is attached to inner suction line 46 communicatively by fluid subsequently.

As mentioned above, controller 28

control valves

40,50,60,70,102 and 108 operation.With regard to this respect, in certain embodiments, controller 28 has used feedback information in the operating process of controlling.In view of this, actuator unit 22 further comprises the optional manifold pressure sensor 120 that is connected to communicatively inner outlet line 48 by fluid.Manifold pressure sensor 120 can present various ways, the pressure in can the sensing inner outlet line 48 of the sensor of these forms.In any case, manifold pressure sensor 120 is attached to controller 28 by the electronics mode, sends the information signal that is illustrated in the pressure that senses in the outlet line 32, and therefore provides closed loop feedback to controller 28.Whether in an example, manifold pressure sensor 120 is used to monitor provides required PAP level to patient.

As mentioned above, patient's pressure transducer 67 also can form and be used as the information source of controller 28.Patient's pressure transducer 67 can present various ways, and is connected to communicatively patient interface 24 by fluid so that the pressure in the sensing patient interface 24 by patient's pressure line 36 and automatic zero set electronic valve 60.Just as described in greater detail belowly, patient interface 24 can be configured to be provided for receiving the convenient port of patient's pressure line 36, and described port further is attached to patient's pressure transducer 67 (described sensor is kept by housing 37) communicatively by fluid.In any case, patient's pressure transducer 67 is attached to controller 28 by the electronics mode, and sends the signal that is illustrated in the pressure that patient interface 24 places sense.In an example, patient's pressure transducer 67 is used to monitor and whether required CPAP setting has been offered patient.If flow measurement means or vital capacity determination means are incorporated in the actuator unit 22, then also can use other parameter, as be transported to patient's flow or pulsed quantity, for controller 28 provides feedback.

Actuator unit 22 further comprises one or more display systems 130 alternatively in order to show information for the care-giver.In an example, display system 130 can be liquid crystal display.Display system (one or more) is attached to controller 28 by the electronics mode and is subject to the control of this controller, and can comprise graphic user interface (GUI) 132.As mentioned below, GUI 132 can turn round in order to show a plurality of performance informations (such as current pulse profile, minimum pressure and maximum pressure etc. are shown in patterned mode).

Actuator unit 22 comprises user input apparatus (or interface) 140, and described device is attached to controller 28 by the electronics mode.User interface 140 provides the ability that can select required operational mode as selector marker for the care-giver, as will be explained hereinafter.Therefore, user interface 140 can present many kinds of forms, and this comprises machinery (for example control knob) and/or vision (for example touch control panel device) device.

In the use procedure of system 20, suction line 30 is connected to source of supply (one or more) 26 by means of suitable adapter (one or more) 110 communicatively by fluid.Patient interface 24 is provided for the care-giver independently with actuator unit 22.The below will may be described by configuration the multiple of patient interface 24.Yet, generally, patient interface 24 can be disposable hand-held product, comprise arrival end 150 and the port of export 152, described arrival end is configured so that fluid is attached to the outlet line 32 that otherwise extends out from housing 37 communicatively, and patient breathes (and the port of export 152 can be connected to (or formation) patient respiration parts such as mouthpiece or face shield) by the described port of export.In one embodiment, outlet line 32.Auxiliary line 35 and patient's pressure line 36 are formed by pipeline respectively, and described pipeline can be provided with patient interface 24.

Every pipeline in the

pipeline

32,35 and 36 can end at connector component 156 (general designation), and described connector component is made into certain size in order to be bonded on the corresponding connector port 158 of actuator unit 22.For example, connector port 158 can be by housing 37 carryings, and can set up the fluid connection towards outlet line 32, patient's pressure line 36 and/or auxiliary line 35, thereby so that the operator only needs single Connection Step get final product (being about to connector component 156 inserts in the connector ports 158).Another kind of optional mode is that connector port 158 can be integrally formed with housing and/or manifold.Under any circumstance, but connector component 156 all the fixed relationship of every pipeline in the

holding tube line

32,25 and 36 so that the mode that is communicated with fluid simply is connected to actuator unit 22.In addition, connector component 156 can comprise that the mechanism of quicking break is to be convenient to being fastened to connector component 156 on the connector port 158 and to discharge described connector component from described connector port.

Connector component 156 can further comprise the identifier on the storage medium 160 that is stored in any type, and such as the RFID label, this label has indicated the performance of actuator unit 22.For this purpose, actuator unit 22 can further comprise device 162 in order to receive from storage medium 160, such as the RFID label reader, information, described storage medium is electrically coupled to controller 28.Storage medium 160 can comprise further information, and described information can be transferred into controller 28 by installing 162.For example, storage medium 160 can be associated with specific predetermined treatment agreement, and therefore controller 28 can move in combination with required treatment agreement.In addition, on storage medium 160, also can store out of Memory, such as patient information, compatibility information etc.Another kind of optional mode is, can use information conveyance that the means of communication of any other type will be relevant with patient interface 24 to actuator unit 22.Spendable a kind of example communication means are contact serial line interfaces, for example by Maxim Integrated Products, the 1-that Inc.of Sunnyvale, California provide Serial Memory Products.In this example, can eliminate owing to main hardware disturbs with contact the potential radiofrequency signal that causes producing from direct between the hardware, this direct contact can produce described interference.

In any case, in the situation that patient interface 24 is connected to communicatively outlet line 32 and is connected to this patient's pressure transducer 67 in the situation that be provided with patient's pressure transducer 67 (via patient's pressure line 36) by fluid, care-giver thereby manipulation should be moved device unit 22 in order to respiratory therapy is delivered to patient.With regard to this respect, actuator unit 22 provides alternatively at least six kinds of operator schemes, has comprised the automatic zero set pattern, has kowtowed blow mode, baseline mode, Positive Airway Pressure (PAP) pattern, purge mode and nebulizer pattern.Every kind of pattern in these patterns all can be implemented independently of one another, perhaps also can implement simultaneously two or more patterns wherein.The below will be explained in more detail every kind of operator scheme.One or more patterns in these patterns also can be implemented by controller 28, and as limiting ground in the predetermined protocol, this agreement is easy to be implemented by the care-giver.

As the start-up point, actuator unit 22 is constructed alternatively, thereby so that

electronic valve

40,50,70 and 102 defaultly is defaulted as normal " cutting out " states, gas flow can not occur by

corresponding valve

40,50,70 and 102 situation under described state.Electronic valve 60 and 108 default normally " opening " states that are defaulted as, under described state, gas flow is by valve 60,108.Particularly, the outlet side 64 of valve 60 is attached to entrance side 112 by the outlet side 114 that fluid is attached to entrance side 62 and valve 108 communicatively communicatively by fluid.When system's 20 quilt " energising ", can start the automatic zero set pattern, in order to patient's pressure transducer 67 is calibrated.Under moving zeroing pattern, automatic zero set electronic valve 60 is closed, thereby so that patient's pressure transducer 67 can read ambient pressure, this is because patient's pressure transducer 67 is attached to environment via ventilation line 68.Based on the reading of patient's pressure transducer 67, can regulate, so that the known ambient pressure of patient's pressure transducer 67 records.In case patient's pressure transducer 67 is conditioned as required, then automatic zero set electronic valve 60 is opened.

Receive when kowtowing the indication of blow mode from care-giver's needs at (via user input 140), controller 28 operating electronic valves 40 open and close rapidly, therefore pressure pulse are applied to from suction line 30 to flow in the gas of outlet line 32.With regard to this respect, the motor machine configuration of electronic valve 40 is so that controller 28 can accurately be controlled the pressure pulse profile that is transferred, and this can be based on the reading from manifold pressure sensor 120.Therefore, the pulse gas stream that is transported to patient interface 24 via outlet line 32. can have a kind of frequency and/or the pressure in multiple different frequency and/or the pressure, and the behavior in service of this frequency or pressure and electronic valve 40 matches.If necessary, then can be pulse gas stream and replenish baseline mode in order to keep pulmonary to open again.As a reference, different frequency is different with pressure on the impact that patient produces.For example approximately the frequency of 20Hz is considered to reduce the viscosity of mucus, be in the 8-15Hz scope frequency then with normal CBF be match and therefore can effectively make the secretions migration.The frequency that is in the 2-5Hz scope is considered to make pulmonary's expansion and oxygen is delivered to alveolar, has simulated simultaneously the situation of " little cough " and mucus has been produced shear action.Therefore, according to required therapeutic outcome, the care-giver can (via user interface 140) implement required agreement/frequency.

In some instances, the care-giver understands required agreement (for example aspect pressure and/or the frequency) and can input desirable value (one or more) at user interface 140 places in order to implemented by controller 28 subsequently.For other embodiment, arrange by one or more agreements that may apply controller 28 is carried out pre-programmed.For example, controller 28 can comprise memorizer, and storage has kept agreement settings storehouse in described memorizer.The selection of agreement can be based on many factors.In one embodiment, if adopt sensing flux and/or vital capacity determination means, then can be based on the measured value selection protocol that obtains by these means.When required agreement has been selected at user interface 140 places, controller 28 automatic " loading " predetermined set, thus so that compare with the actuator unit of routine, the care-giver is in training required aspect the operating system 20 still less and be easier to arrange.For example, a kind of predetermined required agreement can comprise the PAP pattern of carrying out two minutes, subsequently carry out the knocking treatment of two minutes 20Hz, carry out the knocking treatment etc. of two minutes 2Hz subsequently.

Another kind of optional mode is or in addition, storage medium 160 (for example RFID label) can be stored specific required setting, and controller 28 be read and be communicated to this setting can by device 162 (for example RFID reader).Further, guaranteed through the feature of pre-programmed no matter what kind of aceognosia the care-giver has, patient can obtain consistent and uniformly treatment.Owing to provide consistent and uniformly treatment, so the care-giver can determine whether produced variation in patient airway (for example having strengthened pulmonary opens again) according to the variation of patient's pressure transducer 67.This and device/driver in the market are diametical, and device/driver in the market can't arrange or use in essence.Some devices need the care-giver to handle needle-valve to come the control impuls profile.When the intensity of attempting changing in the start-up system, frequency also will produce change, and this is so that be difficult to change independently intensity and frequency.Even when less adjusting has only been made in the needle-valve position, resulting pulse profile also will produce undesirable variation.This is so that existing apparatus is difficult to carry consistent expection treatment.

Except the pre-programmed setting or as the another kind of optional mode of this set, the care-giver can programme in order to store one or more required treatment agreements to controller 28.These programs can both be implemented strict identical therapeutic process in order to guarantee with actuator unit 22 by colleague's (for example in hospital arranges) input of care-giver or care-giver in whole hospital scope and in all respiratory therapies.If necessary, then this information can directly be stored on the storage medium and be adjusted as required in the manufacturing of actuator unit 22 and/or assembling process.For example, prepare children's but not adult when using when system, can use different parameters, in order to carry out different treatments and/or alarm setting.

Except that input based on the user and/or predetermined setting operation electronic valve 40, in certain embodiments, controller 28 is further programmed so that the exemplifying embodiment routine, and the resonant frequency of patient pulmonary (may implement the most effectively to treat under this resonant frequency) is " set " in described routine.More particularly, this example routine comprises that making controller 28 operating electronic valves 40 also is reduced to lower pulsation rate (for example 2Hz) gradually in order to originally produce the pulsation rate (for example 20Hz) of higher frequency.This process is repeated under higher gradually pressure.If necessary, then can by under the upper frequency pulsation rate, starting and be reduced to the mode of lower pulsation rate, reduce this pulsation rate.

In this example routine, the swing in patient thoracic cavity is monitored in order to determine and the resonant frequency of given patient or the pulsation rate frequency that " the most effectively implementing a little " realized best fit according to the information signal that is sent by pressure transducer 67,120.In one embodiment, accelerometer can be attached to patient's thoracic cavity and the expression signal that move in the thoracic cavity is provided.This thoracic cavity movable signal can be based on being transferred in order to determine that the frequency pulse rate of optimization frequency is monitored.

Can replenish the knocking operator scheme by the baseline operator scheme.Baseline mode provides required pressure, and wherein 40 pairs of electronic valves stop on the suction line 46 fluid generating portion ground that flows to inner outlet line 48 internally.Pressure is provided in order to keep patient airway to be in open mode in the process of carrying (for example repeatedly carrying between the air flow outburst) percussion-type treatment.

For said process, can carry out pre-programmed to controller 28 or preset by one or more treatment agreements, described agreement is included in PAP pressure is delivered in patient's the process electronic valve 40 is operated.A kind of typical non-limiting protocol procedure can comprise: 1) low pressure operation PAP pattern reaches 5 minutes (that is, electronic valve 40 is opened); 2) in the frequency of 20Hz and under low pressure move electronic valve 40 and reach 3 minutes; 3) under low pressure moving electronic valve 40 reached 3 minutes in order to produce the shock pulse of kowtowing that frequency is 2Hz; With 4) in the frequency of 5Hz and under high pressure move electronic valve 40 and reach 5 minutes.Multiple other agreement is applicable equally.

In the situation that needs carry out PAP treatment, controller 28 operates so that it " opens " required degree electronic valve 40 when receiving the care-giver and select the corresponding signal of PAP at user interface 140 places.With regard to this respect, the required pressure of PAP treatment can be by user selection (or pre-programmed), and whether controller 28 monitoring have reached required pressure from the information of manifold pressure sensor 120 in order to determine the setting of the electronic valve 40 realized.Another kind of optional mode is, or in addition, can be based on treatments such as the information conveyance CPAP that receives from patient's pressure transducer 67, Bi-PAP.

Purge mode can be performed in combination with above-mentioned automatic zero set pattern.In addition, purge mode can be independent of the automatic zero set pattern and is performed.For patient's pressure line 36 is purged, automatic zero set electronic valve 60 moves to the closed position, thereby cuts off the stream that leads to outlet side 64 from entrance side 62.In this, patient's pressure transducer 67 is attached to ventilation line 68 communicatively by fluid, and described ventilation line is led to beyond the portable housing 37.Therefore, patient's pressure transducer 67 reads atmospheric pressure, and its feedback that provides for controller 28 can be delayed and/or patient's pressure transducer 67 can be conditioned under the automatic zero set pattern as ground is discussed.The fluid that is used to from suction line 30 is blown away the liquid in patient's pressure line 36 and/or other accumulation thereby purging electronic valve 50 is opened subsequently.After patient's pressure line 36 was purged, purging electronic valve 50 is closed and automatic zero set electronic valve 60 moves to open position subsequently, thereby allowed direction of flow patient pressure transducer 67.

Under the nebulizer pattern, nebulizer 34 is connected to communicatively nebulizer flow valve 70 (this carries out via auxiliary line 35) and is connected to patient interface 24 by fluid.For example, single adapter 156 above-mentioned can be set up the necessary fluid connection of leading to actuator unit 22 by connector port 158.In certain embodiments, patient interface 24 and nebulizer 34 are configured so that nebulizer 34 fluids are connected to the outlet port 152 of patient interface 24 communicatively, and nebulizer 34 is arranged on the position of separating with actuator unit 22.In any case, by nebulizer 34 being arranged on " downstream " of patient interface 24, so that the vaporific medicine that is produced by nebulizer 34 can not pass through patient interface 24, greatly reduce thus the probability that the aerosol abate in the geometric construction of patient interface 24, occurs.For example, compare with the patient interface design of routine, the configuration that is positioned at the nebulizer 34 of patient interface 24 " downstream " can be delivered to patient with the mass body more than five times that reaches the mass body breathed (for example vaporific medicine) of suction.

In the situation that nebulizer 34 is by being connected communicatively by fluid as described above, controller 28 is when receiving the care-giver in the corresponding selection that user interface 140 places make, nebulizer flow valve 70 is operated in order to allow gas flow auxiliary line 35, and so flow directionization device 34.With regard to this respect, controller 28 can remain on electronic valve 40 under the closed condition, thereby so that only has the nebulizer treatment to be transported to patient.Another kind of optional mode is and as the required ground of care-giver, electronic valve 40 can be operated simultaneously (and nebulizer flow valve 70 is opened at least in part) in case with vaporific drug conveying to patient, the treatment of this course of conveying and knocking carries out in combination, in the situation that knocking and limit treatment and/or PAP treat combine carry out and/or in the predetermined protocol process, carry out.

Carry in the operating process of knockings, PAP or nebulizer treatment in system 20, controller 28 is programmed in order to keep required output from electronic valve 40 by means of the information that receives from patient's pressure transducer 67 and/or manifold pressure sensor 120.Therefore manifold pressure sensor 120 provides feedback, thereby so that controller 28 can be monitored the output of electronic valve 40, forms closed-circuit system, thereby so that controller 28 can be as required with the operation of cumulative mode control valve 40.This feature has further been guaranteed and required or correct pulsating pressure (if be under the baseline mode, then or with baseline pressure) can be delivered to patient in consistent and constant mode.

67 monitoring of patient's pressure transducer are transported to patient's pressure." determine " that at controller 28 the patient's pressure and/or the manifold pressure that sense have surpassed in the situation of predetermined value, controller 28 automatically starting

electronic valves

40,70 and/or 102 operation and make it become closed condition.In addition, the pressure that is transported to patient can be conditioned based on the pressure that is sensed by patient's pressure transducer 67.In an example, available patient's pressure transducer 67 and/or vital capacity determination means detect patient's air-breathing respiration phase and expiration respiration phase, and described means send to controller 28 with information.In kowtowing the blow mode operating process, can be by carrying knocking treatment so that the mode of shock pulse is kowtowed in conveying in the patient inhales stage at expiratory phase operation electronic valve 40.If maximum patient's pressure known (for example as the technical staff stipulates ground), then electronic valve 40 can further be operated based on maximum patient's pressure and air-breathing/expiration phase.Another kind of optional mode is to make required effect maximization thereby can use the vital capacity determination means to detect patient's breathing and change treatment air-breathing or that expiration phase is carried.

Also can adopt other measuring device with information conveyance to controller 28 in order to show and/or the operation of control actuator unit 22.For example, can use spirometer to measure the air capacity that sucks and/or breathe out by patient.This spirometer can be incorporated in the patient interface 24 and be used for determining patient because the improvement (for example, the air capacity of patient's exhalation is higher may show that patient has obtained improvement) that the part of lung has obtained cleaning and/or recovered to produce.

As mentioned above, display system 130 can be handled in order to show much information for the care-giver as required by controller 28.Except showing that various operations control arranges (for example operational mode, selected pressure (one or more) and/or frequency), actual pressure or gas flow or the information relevant with this actual pressure or gas flow that represents to be transported to patient can be determined and show to controller 28.For example, controller 28 can be programmed in order to record pressure and the computing information that is sensed by patient's pressure transducer 67, and such as minimum pressure, average pressure, maximum pressure and/or pressure trend, and this information is displayed on the reality system 130.Display protocol can change, and in certain embodiments, controller 28 is programmed in order to be updated periodically shown information (for example per second upgrades once), and record obtains for the first period maximum pressure of (for example last second) of data.

Actuator unit 22 also can comprise a plurality of optional alerts feature of being handled by controller 28.For example, if detected the pressure that surpasses the preset pressure limit at manifold pressure sensor 120 and/or patient's pressure transducer 67, then controller 22 be programmed in case handle this siren (such as audio frequency siren, visual alarm device etc.) thus give the alarm and be programmed so that the treatment agreement of implementing to descend is step by step also closed

electronic valve

40,70 and 102 alternatively to the care-giver.These sirens can be adjusted to by user the setting of any type, thereby inform variety of event based on various situations (for example having crossed adjustable threshold value).

System 20 peculiarly provides the numerous features that can be used for respiratory therapy is delivered to patient.In other embodiments, can increase as required, change or eliminate feature.For example, Fig. 3 shows therapy system 170, wherein purges electronic valve 50, automatic zero set electronic valve 60, input electronic valve 102 and ventilation electronic valve 108 and all is cancelled together with volumetric spaces chamber 88.In addition, therapy system 170 comprises and is attached to independently a plurality of adapters 110 of source of supply.An adapter in these adapters can be set up fluid and is connected with the pressurization oxygen source, and another adapter can be set up fluid with pressurized air source and is connected.Further, adapter can be attached to the oxygen source of the suction oxygen that accounts for certain mark that is produced by gas mixer.In another embodiment, gas mixer can be incorporated in the housing 37.In addition, therapy system 170 also comprises secondary electron valve 172 and breather valve 174.

Secondary electron valve 172 can have the structure similar to electronic valve 40 and be attached to controller 28 and be subject to the control of described controller by the electronics mode.Electronic valve 40 and secondary electron valve 172 can be used to running in order to carry independently the knocking treatment and the PAP treatment, thereby so that a valve is mainly used in baseline treatment and/or PAP treatment mainly for delivery of knocking treatment and another valve.In addition, secondary electron valve 172 also can be used for improving the intensity set point in the knocking therapeutic process with the collaborative running of roughing valve the time.Secondary electron valve 172 also can with respect to electronic valve 40 be interlock carry out the setting of higher frequency in order to allow knocking treatment to carry.

In embodiment as shown in the figure, secondary electron valve 172 is positioned in parallel with electronic valve 40 and nebulizer flow valve 70.The secondary electron valve comprises the outlet side 178 that is attached to communicatively the entrance side 176 of inner suction line 46 by fluid and is attached to communicatively inner outlet line 48 by fluid.In Fig. 3, electronic valve 40 is configured to carry the knocking treatment, and secondary electron valve 172 is configured to carry the PAP treatment.Therefore, controller 28 turn round so as when the needs knocking is treated, to drive electronic valve 40 and turn round so as when needs PAP treat driving secondary electron valve 172.Further, controller 28 can be handled secondary electron valve 172 and it is in open under (or partially opening) state in the knocking operating process of electronic valve 40, in order to knocking treatment and the baseline pressure (for example under baseline mode) that is higher than ambient pressure are provided.

Ventilation electronic valve 174 is attached to controller 28 by the electronics mode and is subject to the control of described controller, and comprises entrance side 180 and outlet side 182.Ventilation electronic valve 174 is as urgent " suction " valve, and entrance side 180 is attached to communicatively inner outlet line 48 by fluid and outlet side 182 is connected to ventilation line 184 communicatively by fluid.Ventilation line 184 is led to environment.When controller 28 has determined that internal pressure is higher than preset limit, ventilation electronic valve 174 is handled and is reached open mode, allows the gas flow in the inner outlet line 48 to be discharged from (and therefore not being transported to patient interface 24 or patient) from system 170.Another kind of optional mode is, ventilation electronic valve 174 can be arranged on any position and can move under " normally opening " or " normally cutting out " state along inner suction line 46 or outlet internal pipeline 48.For example, ventilation electronic valve 174 can be arranged on proportional solenoid 40,172 " upstream " (for example being arranged on the position similar to breather valve shown in Figure 2 108 along inner suction line 46).Even further, the ventilation electronic valve 174 can with inner suction line 46 or inner outlet line 48 in arbitrary pipeline in line (namely, entrance side 180 and outlet side 182 are connected to corresponding inner suction line 46 or inner outlet line 48 communicatively by fluid), under normal " opening " state, operate.For this structure, when detecting the situation that has overpressure condition, 28 pairs of electronic valves 174 of controller are handled and are made it arrive shutoff device, have therefore prevented that gas flow/pressure is transported to patient.

Fig. 4 shows the ground respiration therapy system 190 according to disclosure content of the present invention, and described respiratory treatment systems comprises some parts in the parts of said system 20 (Fig. 2).Particularly, system 190 comprises actuator unit 22 and patient interface 24.Actuator unit 22 further comprises controller 28 and electronic valve 40.Gas flow/pressure that electronic valve 40 is regulated between suction line 30 and the outlet line 32.Controller 28 operating electronic valves 40 are in order to provide aforesaid knocking treatment.In addition, thus controller 28 can further be programmed alternatively so that operating electronic valve 40 provides baseline pressure and/or Positive Airway Pressure (PAP) as required.

Fig. 5 schematically shows another the optional respiratory treatment systems 200 according to disclosure content of the present invention.Except actuator unit 22 was configured so that only to be connected to air source 202, system 200 was similar in other side and system 170 (Fig. 3).Therefore, (compare with two or more adapters 110 shown in Figure 3) and only be provided with single adapter 110.

Fig. 6 shows 200 similar another respiratory treatment systems 210 with system, and actuator unit 22 is configured so that only fluid is connected to oxygen source 212 communicatively.

For another optional structure shown in Figure 7, respiratory treatment systems 220 is provided, except having cancelled filter 100 (Fig. 3), system 220 is similar in other side and aforementioned system 170 (Fig. 3).

Fig. 8 shows another respiratory treatment systems 230, and except having cancelled manifold 80 (Fig. 3), system 230 is similar in other side and system shown in Figure 3 170.Therefore, adopted independently pipeline so that electronic valve 40, secondary electron valve 172 and nebulizer flow valve 70 link to each other communicatively with suction line 30 fluids.Another kind of optional mode is, the part manifold can be set, and is connected communicatively that (for example, manifold only is connected with the nebulizer flow valve with electronic valve 40,172 and is set up being connected that fluid is communicated with thereby only set up fluid with the some of them valve.)

For another optional respiratory treatment systems 240 shown in Figure 9, cancelled optional pressure regulator 90 (Fig. 3).For this structure, alternatively can be by the control of controller 28 realizations to input pressure, described controller is based on handling (one or more) electronic valve 40 and/or 172 in the information of patient's pressure transducer 67 and/or the generation of manifold pressure sensor 120 places.

Figure 10 schematically shows another respiratory treatment systems 250, and described system is similar with system shown in Figure 3 170 equally in many aspects.Yet different from system 170 is that actuator unit 22 has omitted secondary electron valve 172 (Fig. 3).For this structure, electronic valve 40 can be handled in order to positive airway pressure (PAP) is provided when needed by controller 28.

For another optional respiratory treatment systems 260 shown in Figure 11, the parts relevant with aerosol have been removed.Therefore, nebulizer flow valve 70 (Fig. 3) and corresponding auxiliary line 35 (Fig. 1 and Fig. 3) are removed.Although Figure 11 reflects the situation that nebulizer 34 (Fig. 3) has been removed, be appreciated that independently the atomiser unit (not shown) can be arranged independently and is connected to communicatively patient interface (although not being activated the control of device unit 22) by fluid.

Figure 12 schematically shows another optional respiratory treatment systems 270, and this system is same and system shown in Figure 3 170 is similar.Yet for respiratory treatment systems 270, ventilation electronic valve 174 (Fig. 3) is removed with relevant ventilation line 184 (Fig. 3).Can realize emergency cut-off (when the extreme pressure condition occurring) by controller 28, described controller operating electronic valve 40,172 makes it enter closed condition.

For another optional respiratory treatment systems 280 shown in Figure 13, optional manifold pressure sensor 120 (Fig. 3) is removed.Controller 28 can be based on from the information of patient's pressure transducer 67 and/or in response to the instruction of user's input the operation of closing electronic valve 14 being controlled.

Figure 14 schematically shows another optional typical respiratory treatment systems 290.Except having cancelled display system 130 (Fig. 3), system 290 is similar with aforementioned system 170 (Fig. 3).

As mentioned above, patient interface 24 can present the various ways that can use with actuator unit 22.Any structure that the most generally, gas flow/pressure can be delivered to patient all is acceptable.Patient interface 24 can be disposable, and can comprise a plurality of design features for delivery of respiratory therapy.Generally speaking, patient interface 24 limits at least one inner chamber (for example, two intracavity pipelines, two or more single intracavity pipelines etc.) that is connected to head.Advance the side (for example arrival end 150) of passing two intracavity pipelines and arrive head from the fluid (via outlet line 32) of actuator unit 22, at described head place, described fluid is combined via mouthpiece or other parts with the surrounding air that carries and is transported to patient, and described other parts are for example for being connected to the face shield of the port of export 152.The opposite side of two intracavity pipelines is connected to pressure port in the position that the patient end with head is close to.Pressure port is further adapted for fluid and is connected to communicatively patient's pressure line 36.In one embodiment, patient's pressure transducer can directly be incorporated in the patient interface 24, and wherein patient interface 24 will only need single intra-cavity.In this example, can be the means that patient interface 24 is set to the means of patient sensor power supply and is used for data are sent to actuator unit 22.If need to carry out treatment by aerosol, then nebulizer 34 can be connected to communicatively by fluid the port of export 162 of patient's head 24, and mouthpiece is connected to the opposite side of nebulizer via T shape adapter, and wherein can be transported to nebulizer 34 via auxiliary line 35 by separate port from the flow of actuator unit 22.

Other internal feature that patient interface 24 comprises alternatively comprises Venturi tube or venturi tubulose assembly (for example, movable Venturi tube or fixing Venturi tube).Another kind of optional mode is that patient interface 24 can comprise non-venturi design, for example has the nozzle of fixed orifice or has the nozzle that mixes throat and do not have bubbler.Patient interface 24 can comprise or can not comprise and carries valve or outlet valve.Further, other useful parts of patient interface 24 can comprise dual-jet configuration with basic diverter, be suitable for realizing that Koln reaches the configuration of effect and other design of surrounding air carrying function is not provided.Similarly, any feature in these patient interface features or all features are optional, and are not that the operation of system 20 of the disclosure content according to the present invention is necessary.

Figure 15 and Figure 16 show the first exemplary embodiments of patient interface.Especially, Figure 15 is that decomposition view and Figure 16 of patient interface 300 are cutaway views.Patient interface 300 comprises housing 302 and a plurality of parts that are arranged in this housing 302.Patient interface 300 limits a plurality of ports, for example pulse of air ingress port 304, carry port 306, outlet connector port 308, discharge port 310 and pressure port 312.Pulse of air enters ingress port 304 and surrounding air is inhaled in the housing 302 by carrying port 306 from driver 22 (Fig. 1).Air flow is transported to outlet connector port 308 subsequently, and described outlet connector port can be configured to be attached to patient's mouthpiece or nebulizer.The air of being breathed out by patient is back advanced and is passed outlet connector port 308 and be discharged from by discharging port 310.Pressure port 312 can be attached to patient's pressure line 36 (Fig. 1), thereby so that can be by the pressure in actuator unit 22 (Fig. 1) the measurement patient interface 300.

Particularly, pulse of air enters ingress port 304 by end cap 320, and described end cap comprises connector component 322 and central tube 32.End cap 320 is positioned in the internal holes 325 that is arranged in the housing 302.Connector component 322 can be connected to outlet line 32 (Fig. 1).Ingress port 304 is attached to central tube 324 in order to air is delivered to described central tube communicatively by fluid.Flexible membrane 326 is set up from pipeline 324 to keeper the fluid-encapsulated path of 328 corresponding pipeline 327, and described path ends at nozzle 329 places.Air enters Venturi tube assembly 330 from nozzle 329 subsequently.Keeper 328 and Venturi tube assembly 330 have formed ejector pump jointly.Ejector pump is slidably disposed in the housing 302, can moves in complex way with respect to ingress port 304 and outlet connector port 308.Spring 332 makes ejector pump setover towards ingress port 304 and away from outlet connector port 308.In addition, O shape ring 334 is provided so that and forms sealing between the inner sealing surface 338 of Venturi tube assembly 330 and housing 302.Surrounding air can enter housing 302 by being arranged on the single-pass check-valves 340 that carries in the port 306.Single-pass check-valves 340 allows the surrounding air inflow to carry in the port 306, but has prevented that gas from flowing out from carrying port 306.

Especially referring to Figure 16, Venturi tube assembly 330 has formed carrier area 342, throat region 344 and expansion area 346, so that will from the air of ingress port 304 with combine from the air that carries port 306 and the air of combination be delivered to inner chamber 350, described inner chamber is attached to outlet connector port 308 communicatively by fluid.In embodiment as shown in the figure, carrier area 342 limits towards ingress port 304 and the entrance opening 352 that carries port 306.Throat region 344 limits gradually thin convergence portion, described part make fluid in Venturi tube assembly 330 in accordance with regulations route advance.Expansion area 346 limits gradually thin divergent portion, and the diameter of described part increases towards inner chamber 350 from throat region 344, ends at exit opening 356 places.Although Venturi tube assembly 330 also can use other configuration, in Figure 15 and Venturi tube assembly 330 shown in Figure 16, the air flow in accordance with regulations route part of passing convergence flows to divergent portion, flows to inner chamber 350.

In operating process, the pulse gas stream that is produced by driver 22 (Fig. 1) enters by ingress port 304.Pulse of air has applied power at diaphragm 326, and described diaphragm produces crooked in order to power (that is, the edge on the throat region is with respect to the power to right of Figure 16) is applied on the ejector pump (that is, keeper 328 and Venturi tube assembly 330).Pulse of air enters slip Venturi tube assembly 330 at nozzle 329 places.More particularly, enter carrier area 342 from the air flow of nozzle, wherein throat region 344 has formed vacuum, thereby surrounding air is further sucked via carrying port 306.The pulse of air of combining and surrounding air are directed in the throat region 344.When the power of crooked diaphragm 326 was compressed spring 332, the ejector pump of slip was towards outlet connector port 308 slips or mobile.This slip movement continues, and leans against on the described inner sealing surface until the front end of Venturi tube assembly 330 (that is, the O shape by 330 carryings of Venturi tube assembly encircles 334) contacts and seals with the inner sealing surface 338 of housing 302.Thereby in the sealing position, air flow/pressure pulse effectively is delivered to outlet connector port 308 and therefore is transported to patient.In addition, Venturi tube assembly 330 is closed expiration port 310 effectively at the sealing station place.When the power on the diaphragm 326 reduces (when pressure pulse finishes), diaphragm 326 and spring 332 make Venturi tube assembly 330 stressed away from inner sealing surface 338, have opened the path between outlet connector port 308 and expiration port 310.Therefore, patient can be easy to by outlet connector port 308 and expiration port 310 expiration (that is, slip ejector pump is not directly resisted the air flow of being breathed out by patient when moving away sealing station).

In a further embodiment, housing 302 comprises the gradual sealing member 358 (Figure 15) that the cut-out section by housing 302 forms.Gradual sealing member 358 is gradually carefully directly to seal (namely by expiration port 310) in order to prevent between outlet connector port 308 and environment.That is, the size in the aperture of sealing member 358 moves closer to inner sealing surface 338 along with Venturi tube assembly 330 and reduces gradually.Therefore, between outlet connector port 306 and environment, seal gradually.

In another optional embodiment, outlet valve can separate with the Venturi tube assembly.The Venturi tube assembly that in this example, can strengthen the control of outlet valve and can realize fixing.In another embodiment, outlet valve can be cancelled.

Outlet connector port 308 can be configured to receive patient's mouthpiece or nebulizer (nebulizer that is appreciated that connection like this can further carry patient's mouthpiece).The connection of nebulizer (for example nebulizer 34 shown in Figure 1) is to carry out in Venturi tube assembly 330 and the downstream of carrying port 306.That is, be not carried in the pulse of air simultaneously with surrounding air via the fluid that outlet connector port 308 flows out from nebulizer.The substitute is the pulse gas stream that vaporific medicine directly is delivered to patient, had before been made up and the surrounding air carrying of carrying.By nebulizer being arranged on the downstream of outlet connector port 308, so that alleviated the granule abate situation of mist medicine in patient interface 300 interior appearance.Especially, prevented in patient interface 300 interior generation medicine abates, thereby can arrive patient so that more can breathe mass body.For example, when nebulizer is arranged on the connector port downstream, compare with medicine directly is carried in the housing 302, but the mass percent that is transported to patient's respiratory medications (for example salbutamol) is wanted large several times (for example five times or more).

Expiration port 310 as shown in the figure comprises opening 359 so that the port 310 that prevents from exhaling because carelessness is sealed, is for example sealed up by people's hands or finger.In addition, suitable filter (not shown) can be positioned at expiration port 310 interior in order to filter out undesirable pollutant, make it can not arrive the care-giver.Filter can present various ways, such as bacterial filter, high efficiency particulate air(filter), viral filter etc.

Pressure port 312 can be provided with suitable connection means 360, and described means are connected to patient's pressure line 36 (Fig. 1).As mentioned above, driver 22 can be measured pressure in patient's pressure line 36 by the mode of working pressure sensor 67.The pressure that records can be used to control the one or more valves that are associated with driver 22.When patient's pressure line 36 is purged, fluid expulsion and entering in the inner chamber 350.Because nebulizer 34 can be positioned at the downstream of patient interface 300, so can the more medicine of deposition in patient's pressure line 36.Therefore, the purging that patient's pressure line 36 is carried out may be favourable.

Figure 17 shows the second exemplary embodiments of patient interface 400.Patient interface 400 comprises the parts similar to Figure 15 and patient interface shown in Figure 16 300.In addition, patient interface 400 comprises the nebulizer port 402 that directly combines with outlet connector port 308.In this way, nebulizer can be attached directly to patient interface 400 by fluid communicatively by nebulizer port 402 and in the downstream position of Venturi tube assembly 330.Integrated nebulizer port 402 and Venturi tube assembly 330 are relevant and insert compatible nebulizer and reduced dead volume so that the care-giver can set rapidly regularly, have improved thus the efficient of system.

Figure 18-Figure 20 shows the 3rd embodiment of patient interface 500.Patient interface 500 comprises a plurality of parts identical with patient interface 300, and (Figure 15-Figure 16), wherein similar parts are by labelling similarly.As patient interface 300, patient interface 500 comprises the housing 502 that limits ingress port 504 and outlet connector port 508.Yet, replace arranging port independently so that what realize carrying and discharge is that housing 502 comprises that the monoblock type that is positioned along the length of housing 502 discharges/carry port 510.In operating process, air can be carried at integral port 510 interior (namely in Venturi tube assembly 330 upstreams) and be discharged from (namely in Venturi tube assembly 330 downstreams) by expiration part 510b by the part 510a that carries of this integral port 510.As shown in figure 19, if necessary, then filter (for example bacterial filter, high efficiency particulate air(filter), viral filter) 512 can be positioned in the integral port 510 and enter in the housing 502 in order to prevent undesirable pollutant.

Figure 20 shows the section of patient interface 500, there is shown a plurality of parts that are arranged in the housing 502.Element in the housing 502 is similar to the method for operation of element in the housing 302 and similarly show these elements, such as pressure port 312, diaphragm 326, keeper 328, nozzle 329, Venturi tube assembly 330, spring 332, O shape ring 334, inner sealing surperficial 338 and inner chamber 350 etc. in Figure 20.In Figure 20, in the interior section of housing 502, cut out gradual sealing member 558.Particularly, gradual sealing member 558 is formed in the inner sealing surface 338 and mode of operation is similar to gradual sealing member 358 shown in Figure 15.In addition, connection means 560 and housing 502 are integrally formed and with respect to having tilted alignment with the coaxial axis of ingress port 504 and outlet connector port 508.

Figure 21 shows typical adapter 600, and described adapter is configured so that connector block 602 synergism with actuator unit.Adapter 600 can be used for patient interface is connected to rapidly actuator unit.Adapter 600 comprises port 604,606 and 608, and described port is connected to the corresponding eyelet 610,612 and 614 of connector block 602 communicatively by fluid.In addition, port 604,606 and 608 can be attached to patient's pressure line 36, outlet line 32 and auxiliary line 35 by fluid respectively

communicatively.In case pipeline

32,35 and 36 is connected to adapter 600, then port 604,606,608 can be positioned in the eyelet 610,612 and 614.In addition, adapter 600 comprises

tab

620 and 622, these tabs respectively with

tab receiving unit

630 and 632

synergism.Tab

620 and 622 can be elastic component, and described elastic component can be pressed towards each other and be inserted in tab receiving unit 630 and 632.The hook that is in tab 620, place, 622 end can engage with tab receiving unit 630,632 subsequently, thereby adapter 600 is secured on the connector block 602.

Although the front is described disclosure content of the present invention in conjunction with the preferred embodiments, one of ordinary skill in the art should be realized that: can make change to form of the present invention and details in the situation of the spirit and scope that do not depart from disclosure content of the present invention.

Claims

1. patient interface assembly that is used for carrying to patient respiratory therapy, described patient interface assembly comprises:

Housing, described housing limits ingress port, outlet port and expiration port, described ingress port is configured to be attached to driver, described driver is delivered to described ingress port with flow of pressurized gas, described expiration port is configured so that air is discharged from described housing, and described air is received from described patient via described outlet port;

Ejector pump, described ejector pump are arranged in the described housing and are positioned and be delivered to described outlet port in order to receive from the described flow of pressurized gas of described ingress port and with described flow of pressurized gas; With

Nebulizer, described nebulizer are attached to described outlet port by fluid communicatively in order to receive the described flow of pressurized gas that flows out from described outlet port, medicine is introduced the gas flow that also will be added with medicine in the described flow of pressurized gas flow to described patient.

2. patient interface assembly according to claim 1, wherein said housing comprise connected communicatively by fluid in case the reception environment air carry port, and wherein said ejector pump is configured so that and will combines from the described flow of pressurized gas of described ingress port with from the described surrounding air that carries port.

3. patient interface assembly according to claim 1, and further comprise the filter that is arranged in the described expiration port.

4. patient interface assembly according to claim 1, and further comprise the integral port that the inside that makes described housing and surrounding air fluid link communicatively, described integrated end interruption-forming the surrounding air fluid is connected to communicatively the carrying port and the surrounding air fluid is connected to communicatively the expiration part of the described inside of described housing in the downstream of described ejector pump of described inside of described housing in the upstream of described ejector pump.

5. patient interface assembly according to claim 1, wherein said ejector pump comprises the Venturi tube assembly, described Venturi tube assembly limits carrier area, throat region and expansion area.

6. patient interface assembly according to claim 1, wherein said ejector pump can be slided along the certain orientation with respect to described ingress port and described outlet port in described housing.

7. patient interface assembly according to claim 6, and comprise that further spring, described spring are positioned in the described housing so that described ejector pump produces biasing towards described ingress port.

8. patient interface assembly according to claim 6, and further comprise diaphragm, described diaphragm is configured to produce deflection in response to the flow of pressurized gas that is transported to described ingress port, so that described ejector pump is along stressed towards the direction of described outlet port.

9. patient interface assembly according to claim 6, and comprise gradual sealing member, described gradual sealing member is positioned in the described housing, thereby so that, when described ejector pump when described outlet port slides, between described expiration port and described outlet port, form gradually and seal.

10. patient interface assembly according to claim 1, wherein said housing comprises the nebulizer port in order to described nebulizer fluid is attached to described housing communicatively.

11. one kind is used for to the system that patient carries respiratory therapy, described system comprises:

Actuator unit, described actuator unit is configured to carry flow of pressurized gas;

Patient interface, described patient interface is attached to communicatively described actuator unit and comprises ingress port by fluid, the outlet port, the expiration port and be positioned in described ingress port and described outlet port between ejector pump, wherein said ingress port is positioned so that the described flow of pressurized gas and the described expiration port that receive from described actuator unit are configured so that air is discharged from described patient interface, described air is received from described patient, and described ejector pump is positioned and is delivered to described outlet port in order to receive from the gas flow of described ingress port and with gas flow; With

12. system according to claim 11, wherein said patient interface limits and carries port, wherein said ejector pump is configured so that and will combines from the flow of pressurized gas of described ingress port with from the described surrounding air that carries port, thereby the gas flow of combination is delivered to described outlet port.

13. system according to claim 11, wherein said ejector pump comprises the Venturi tube assembly, and described Venturi tube assembly limits carrier area, throat region and expansion area.

14. system according to claim 11, wherein said patient interface comprises that housing and wherein said ejector pump can be along the certain orientation slips with respect to described ingress port and described outlet port in described housing.

15. system according to claim 14, wherein said housing further comprises spring, and described spring is suitable for making described ejector pump to produce biasing towards described ingress port.

16. system according to claim 14, wherein said housing comprises the nebulizer port in order to described nebulizer fluid is attached to described housing communicatively.

17. system according to claim 11, wherein patient's pressure line is attached to described actuator unit and the described patient interface between described ejector pump and described outlet port communicatively by fluid.