CN101951871A - 包含着色抗氧化剂的局部组合物 - Google Patents
包含着色抗氧化剂的局部组合物 Download PDFInfo
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- CN101951871A CN101951871A CN2008801216345A CN200880121634A CN101951871A CN 101951871 A CN101951871 A CN 101951871A CN 2008801216345 A CN2008801216345 A CN 2008801216345A CN 200880121634 A CN200880121634 A CN 200880121634A CN 101951871 A CN101951871 A CN 101951871A
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Abstract
描述了一种用来传递令人期望的颜色的局部组合物。该适于传递的颜色是稳定的，并且所形成的着色剂包含抗氧化剂如番茄红素和第二着色剂(其是染料或者颜料)。该局部组合物是稳定的，尽管它们不含产生甲醛的防腐剂。
Description
发明领域
本发明涉及一种包含着色剂的局部组合物，该着色剂是抗氧化剂。更具体地，本发明涉及一种用于影响令人期望的肤色的局部组合物(topical composition)，其中该局部组合物包含大于一种的着色剂。所用的第一着色剂是染料或者颜料，所用的第二着色剂是抗氧化剂和logP大于12.5的亲脂性类胡萝卜素(carotenoid)。当在环境温度存储时，该局部组合物令人惊讶地具有60-90的L*值和-50到50的色调值(huevalue)至少大约3个月。此外，这样的组合物令人惊讶地在没有常规防腐剂存在时是稳定的，已知的是该常规防腐剂会释放出有毒化合物如甲醛。
发明背景
适于改变角质蛋白(keratinaceous)物质如哺乳动物皮肤和指甲的外观的化妆品组合物经常是令人期望的。女人倾向于更喜欢能够赋予哑光外观(matte apperance)的化妆品。哑光妆饰(matte finish)倾向于克服由于油性皮肤所造成的光泽效果，并且经常产生通常与无机微粒有关的物理皮肤发光效果。实际上，吸附性填料如滑石，二氧化硅，高岭土和其他无机微粒已经用来通过它们的光学性质而实现了这样的效果。这种效果并不总是令人期望的，因为许多消费者感觉到传统的组合物过白，并且在使用之后产生了一种不自然的外观。此外，消费者更喜欢在他们的皮肤上(特别是他们的脸上)使用具有天然成分的组合物。实际上，使用具有天然存在于皮肤中的成分的组合物是非常令人期望的，因为该组合物具有在产品中保持稳定的令人期望的颜色。
存在着日益增加的对开发这样一种局部组合物的兴趣，该组合物在使用之后产生了令人期望的肤色。本发明因此涉及一种用于影响令人期望的肤色的局部组合物，其中该局部组合物包含大于一种着色剂。该组合物包含第一着色剂(其是染料或者颜料)和第二着色剂(其是抗氧化剂和亲脂性类胡萝卜素，具有大于12.5的logP)。本发明的局部组合物令人惊讶地不具有通常与氧化的类胡萝卜素有关的棕色颜色，并且当在环境温度存储时，具有60-90的L*值和-50到50的色调值(hue value)至少大约3个月。本发明的局部组合物是稳定的，虽然存在着这样的事实，即，它基本上不含常规防腐剂，已知的是该常规的防腐剂释放出有毒化合物如甲醛。
附加信息
已经公开了用于制造化妆品组合物的努力。在US 2004/0071745中，描述了具有至少一种类胡萝卜素和至少一种异类黄酮(isoflavonoid)的组合物，其中该组合物的目的是处理老化的皮肤迹象。
已经公开了制造化妆品组合物的其他努力。在US5 834 445中，描述了含环糊精络合的β-胡萝卜素和未络合的β-胡萝卜素的组合物。
已经公开了制造化妆品组合物的仍然其他的努力。在US2006/0171909中，描述了带有胶囊化染料的化妆品组合物。
上面的附加信息没有描述这样一种局部组合物，其包含天然存在于皮肤中的着色抗氧化剂，例如logP大于12.5的亲脂性类胡萝卜素。特别是该附加信息没有描述这样一种局部组合物，其具有60-90的稳定的L*值和-50到50的色调值，其中该组合物的颜色是至少一种的染料或者颜料与logP大于12.5的亲脂性类胡萝卜素相结合的结果。
发明内容
在第一方面，本发明涉及一种影响肤色的组合物，其包含：
(a)第一着色剂，其包含染料，颜料或者二者；和
(b)第二着色剂；
该第二着色剂是一种抗氧化剂，并且包含logP大于12.5的亲脂性类胡萝卜素，其中当在环境温度存储时，该组合物具有60-90的L*值和-50到50的色调值(hue value)至少3个月，并且此外，其中第一着色剂(a)与第二着色剂(b)的重量比满足a/b＝0.004-1,000。
在第二方面，本发明涉及一种消费级着色剂组合物，其包含：
(a)第一着色剂，其包含染料，颜料或者二者；和
(b)第二着色剂，其包含logP大于12.5的亲脂性类胡萝卜素；
其中第一着色剂(a)与第二着色剂(b)的重量比满足a/b＝0.004-1,000。
在第三方面，本发明涉及一种用本发明的第一方面来影响肤色的方法。
在一个特别优选的方面，该用于影响肤色的组合物和所述的着色剂组合物基本上不含释放甲醛的防腐剂。
本发明另外的方面从下面的说明以及其后的实施例中将变得更加显而易见。
作为此处使用的，值L*表示用于亮度(luminance/lightness)的CIELAB颜色坐标。色调被定义为表示[tan-1(b*/a*)]，其中a*是红色/绿色的CIELAB颜色坐标，b*是黄色/蓝色颜色坐标。“基本上不含”意思是小于0.015％，和优选0-小于0.01重量％，基于用于影响肤色的组合物或者消费级着色剂组合物的总重量。
释放甲醛的防腐剂表示适于在终端组合物中产生H2CO的防腐剂。这样的防腐剂包括例如quarternium-15，咪唑烷基脲(imidozolidinylurea)，重氮烷基咪唑脲(diazolidinyl urea)，DMDM乙内酰脲，溴硝基丙二醇等等。
作为此处使用的，皮肤表示脸上和身上的皮肤。本发明的组合物可以是基础物质(base)或者是作为最终使用的组合物销售的。这样的组合物可以以任何可消费的能够接受的形式来销售，例如条(bar)，液体，棒(stick)，滚搽配料(roll-on formulation)，霜剂(cream)，织物施用配料(fabric applied formulation)，摩丝，洗液(lotion)，药膏化妆品(ointment cosmetic)或者粉底(foundation)。
具体实施方式
对于可用于本发明的染料和/或颜料唯一的限制是其对于局部施用来说是安全的，与亲脂性类胡萝卜素是相容的，并且适用于产生具有此处所述颜色特性的组合物。这样的染料和/或颜料优选是在全部的化妆品组合物中所允许的那些，包括可与嘴唇接触的那些。
可用于本发明的各类的染料和/或颜料的示例性的非限制性的例子包括颜料红4，食品红1，酸性橙7，颜料红57，食品黄3，酸性红33，食品红12，酸性黄23，食品黄4，食品绿3，食品蓝2，酸性蓝9，溶剂红43，酸性红87，溶剂红48，酸性红92，溶剂紫13，酸性紫43，溶剂绿3，酸性绿25，还原红1，颜料金属1，颜料蓝29，颜料白21，颜料白22，颜料白14，颜料白31，颜料棕6，或者颜料红101，颜料102，颜料棕6，颜料黄42，颜料黄43，颜料黑11，颜料白18，颜料紫16，颜料白6，颜料白4，及其混合物等等。在一种优选的实施方案中，该第一着色剂是在Ponceau Sx(CAS 4548-53-2)名称下销售的红色(偶氮)染料(食品红1)，其可市售获自供应商例如Sensient Technologies，Spectrum Chemicals & Laboratory Products以及Alfa Chem。
适用于本文中的第二着色剂仅仅受限于以下程度：其可用于化妆品组合物中，并且是logP大于12.5的亲脂性类胡萝卜素(即着色抗氧化剂)。适用于本发明的各种类型的类胡萝卜素的示例性非限制性例子包括β-胡萝卜素(carotene)，番茄红素(lycopene)，叶黄素(lutein)，虾青素(astaxanthin)，β-隐黄质(cryptoxanthin)，及其混合物等等。但是，在一种优选的实施方案中，此处所用的类胡萝卜素是番茄红素，其可获自供应商例如DSM Nutritional Products and Parry Nutraceuticals。
通常，第一着色剂与第二着色剂的重量比等于0.004-1,000。优选第一着色剂与第二着色剂的重量比是1∶6-6∶1，和最优选是1∶3-3∶1，包括其中所含的全部比例。在一种特别优选的实施方案中，本发明所用的总着色剂(第一和第二着色剂)小于0.4％，和优选小于0.25％，和最优选小于0.1％，基于该局部组合物的总重量。
任选的添加剂可以加入到本发明的局部组合物中，目的是产生期望的最终使用的组合物。例如这样的最终使用的局部组合物可以任选的包含皮肤调节剂。那些试剂可以选自保湿剂(humectants)，去角质剂(exfoliants)或者润肤剂(emollients)。
保湿剂是多羟基醇，目的是保湿(moisturizing)，减脱(reducing)，去皮(scaling)和刺激皮肤积屑的除去。典型的多羟基醇包括聚亚烷基二醇(polyalkylene glycols)和更优选亚烷基多元醇(alkylene polyols)和它们的衍生物。示例性的是丙二醇，二丙二醇，聚丙二醇，聚乙二醇，山梨糖醇，甘油，羟丙基山梨糖醇，己二醇，1，3-丁二醇，1，2，6-己烷三醇，乙氧基化甘油，丙氧基化甘油及其混合物。最优选该保湿剂是甘油。保湿剂量的范围(如果使用)可以是该局部组合物的0.01-15重量％，优选0.01-10重量％，最理想为0.75-5重量％。
适用于本发明的局部组合物的去角质剂可以选自α-羟基羧酸，β-羟基羧酸和这些酸的盐。通常在使用时，该去角质剂占局部组合物的0.1-6重量％。最优选的是乙醇酸，乳酸和水杨酸和它们的铵盐。可以使用多种C2-C30α-羟基羧酸。合适的例子包括：α-羟基乙酸；α-羟基丙酸；α-羟基己酸；α-羟基辛酸；α-羟基癸酸；α-羟基十二烷酸；α-羟基十四烷酸；α-羟基十六烷酸；α-羟基十八烷酸；α-羟基二十烷酸；α-羟基二十二烷酸；α-羟基二十六烷酸；和α-羟基二十八烷酸。
当调节剂是润肤剂时，它可以选自烃，脂肪酸，脂肪醇和酯，由此该润肤剂(当使用时)典型的占局部组合物总重量的0.1-25重量％。矿脂(petrolatum)是最优选的烃类润肤调节剂。能够使用的其他烃包括矿物油，聚烯烃例如聚癸烯，和石蜡例如异十六烷(例如Permethyl和Permethyl
)。适用的脂肪酸和醇(作为润肤剂)通常具有10-30个碳原子。示例性的这类是壬酸/醇，月桂酸/醇，肉豆蔻酸/醇，棕榈酸/醇，硬脂酸/醇，异硬脂酸/醇，羟基硬脂酸/醇，油酸/醇，亚油酸/醇，蓖麻油酸/醇，花生酸/醇，山萮酸/醇和芥子酸/醇。适用于本发明所制备的局部组合物的油性酯润肤剂可以是选自下面种类的一种或多种的那些：
1.甘油三酸酯例如植物和动物脂肪和油。例子包括蓖麻油，可可油，红花油，棉花籽油，玉米油，橄榄油，鳕鱼肝油，杏仁油，鳄梨油，棕榈油，芝麻油，角鲨烯，Kikui油和大豆油。
2.乙酸甘油酯，例如乙酰基化的甘油一酸酯。
3.乙氧基化的甘油酯，例如乙氧基化的单硬脂酸甘油酯。
4.具有10-20个碳原子的脂肪酸的烷基酯。脂肪酸的甲基，异丙基和丁基酯在本文中是有用的。例子包括月桂酸己基酯，月桂酸异己基酯，棕榈酸异己基酯，棕榈酸异丙酯，肉豆蔻酸异丙酯，油酸癸基酯，油酸异癸基酯，硬脂酸十六烷基酯，硬脂酸癸基酯，异硬脂酸异丙酯，己二酸二异丙酯，己二酸二异己基酯，己二酸二己基癸基酯，癸二酸二异丙酯，乳酸十二烷酯，乳酸十四烷酯和乳酸十六烷酯。
5.具有10-20个碳原子的脂肪酸的链烯基酯。其例子包括肉豆蔻酸油醇酯，硬脂酸油醇酯和油酸油醇酯。
6.醚-酯例如乙氧基化脂肪醇的脂肪酸酯。
7.多羟基醇酯。乙二醇单-和二-脂肪酸酯，二甘醇单-和二-脂肪酸酯，聚乙二醇(200-6000)单-和二-脂肪酸酯，丙二醇单-和二-脂肪酸酯，聚丙二醇2000单油酸酯，聚丙二醇2000单硬脂酸酯，乙氧基化的丙二醇单硬脂酸酯，单-和二-脂肪酸甘油基酯，多甘油多脂肪酯，乙氧基化的单硬脂酸甘油基酯，1，2-丁二醇单硬脂酸酯，1，2-丁二醇二硬脂酸酯，聚氧乙烯多元醇脂肪酸酯，山梨聚糖脂肪酸酯，和聚氧乙烯山梨聚糖脂肪酸酯是令人满意的多羟基醇酯。
8.蜡酯例如蜂蜡，鲸蜡，肉豆蔻酸十四烷醇酯和硬脂酸十八烷醇酯。
本发明的局部组合物应当包含明显量的水。这样的组合物经常包含下面量的水：50-90重量％，优选55-85重量％，由此本发明的局部组合物可以是油包水或者水包油乳液的形式。
可以使用的其他润肤剂通常被分类为硅氧烷或者硅衍生物。示例性的非限制性的例子包括材料例如聚二甲基硅氧烷，环戊硅氧烷，交联的基于硅氧烷的聚合物及其混合物。
表面活性剂可以是按照本发明所制备的局部组合物的其它任选的添加剂。它们可以选自非离子，阴离子，阳离子或者乳化剂。当使用时，它们的用量可以是局部组合物的0.1-25重量％。示例性的非离子表面活性剂是烷氧基化的化合物，基于C10-C22脂肪醇和酸，和山梨聚糖。这些材料可以例如在Neodol商标下获自Shell ChemicalCompany。在Pluronic商标下由BASF Corporation销售的聚氧丙烯-聚氧乙烯共聚物有时候也是有用的。获自Henkel Corporation的烷基糖苷也可以用于本发明中。
阴离子类型的表面活性剂包括脂肪酸皂，月桂基硫酸钠，月桂基醚硫酸钠，烷基苯磺酸酯，单-和二-烷基酸磷酸酯和脂肪酰基羟乙基磺酸钠。
两性表面活性剂包括这样的材料如二烷基氧化胺和不同类型的甜菜碱(例如椰油酰胺丙基甜菜碱)。
适用于本发明的局部组合物的仍然的其他任选的添加剂包括增稠剂。这样的增稠剂通常被分类为羧酸聚合物，交联的聚丙烯酸酯聚合物，聚丙烯酰胺聚合物等等。典型的增稠剂包括交联的丙烯酸酯(例如Carbopol 982或者Carbopol Ultrex 10)，疏水改性的丙烯酸酯(例如Carbopol 1382)，纤维素衍生物和天然胶。其中有用的纤维素衍生物是羧甲基纤维素钠，羟丙基甲基纤维素，羟丙基纤维素，羟乙基纤维素，乙基纤维素，含聚丙烯酰胺的增稠剂(如SepigelTM305)和羟甲基纤维素。适于本发明的胶包括瓜尔胶，黄原胶，硅酸镁铝(Veegum)，菌核，角叉菜胶，果胶和这些胶的组合。增稠剂的量范围可以是0.0001-5重量％，通常为0.001-1重量％，最佳的是0.01-0.5重量％，基于该局部组合物的总重量，并且包括在其中所含的全部的范围。
典型的，本发明的局部组合物中所用的任选的添加剂共同占到了该局部组合物的小于30重量％，和优选小于15重量％，和最优选小于10重量％，基于该局部组合物的总重量，并且包括在其中所含的全部的范围。
任选的但是特别优选的添加剂(其可以用于本发明的局部组合物中)包括遮光剂或者紫外光遮挡材料。示例性的化合物是PABA，和肉桂酸和水杨酸的衍生物。例如，还可以使用甲氧基肉桂酸辛基酯和2-羟基-4-甲氧基苯甲酮(也称作氧苯酮)。甲氧基肉桂酸辛基酯，对甲氧基肉桂酸2-乙基己基酯(2-ethylhexyl-p-methoxycinnamate)(Parsol
)，和2-羟基-4-甲氧基苯甲酮全部都是市售的。可以使用的其他包括奥克立林(octocrylene)，丁基甲氧基二苯甲酰甲烷(Parsol
)和苯基苯并咪唑磺酸。优选的紫外光遮挡剂是Parsol
和Parsol
特别是它们的下面重量比的混合物：1∶6-6∶1，和优选1∶5-5∶1，和最优选1∶4-4∶1，包括在其中所含的全部的范围。当期望时，本发明所用的紫外光遮挡剂典型的量是0.5-10重量％，和优选0.75-6重量％，和最优选1-5重量％，基于该局部组合物的总重量，并且包括在其中所含的全部的范围。
甚至其他任选的但是特别优选的添加剂(其可以用于本发明的局部组合物中)包括物理散射剂(例如TiO2和/或ZnO)，皮肤增亮剂例如烟酰胺，香豆素衍生的化合物4-羟基苯基丙酮酸酯，3-丙酰基苯并噻唑-2-酮，其混合物等等，皮肤护理螯合剂(例如EDTA)，受益剂(benefitagents)例如亚油酸，视黄醇及其衍生物或者其混合物，其他抗氧化剂例如维生素C，维生素E，及其衍生物(例如抗坏血酸磷酸钠和乙酸维生素E)，其混合物等等。当使用时，这些其他特别优选的任选的添加剂共同占局部组合物的0.01-12重量％，和优选0.1-7重量％，基于该局部组合物的总重量，并且包括在其中所含的全部的范围。
防腐剂可以期望地混入到本发明的组合物中，来对抗潜在有害的微生物的生长，并因此是仍然另外的一类任选的但是特别优选的添加剂。虽然在水相中微生物倾向于生长，但是微生物也可以驻留在油相中。同样，优选将在水和油二者中可溶的防腐剂用于本发明的组合物中。合适的传统防腐剂是对羟基苯甲酸的烷基酯。用于本发明中的特别优选的防腐剂是对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，脱羟基乙酸钠(sodium dehydroxyacetate)，苯氧基乙醇和苄醇。防腐剂优选的用量是局部组合物的0.01-3重量％。在一种特别优选的实施方案中，所用的防腐剂是对羟基苯甲酸甲酯，对羟基苯甲酸丙酯或其混合物，并且所用的防腐剂与紫外光遮挡剂的重量比是1∶8-8∶1，和优选1∶6-6∶1，和最优选1∶4-4∶1，包括在其中所含的全部的范围。
也可以包括次要的辅助成分例如香味剂，消泡剂和着色剂，每个处于它们的有效量来达到它们各自的功能。
当制备本发明的组合物时，可以混合期望的成分，没有特定的次序，并且通常在从环境温度到65℃的温度和在大气压下进行。但是，在一种优选的实施方案中，将水加入油中。
根据本发明所制备的局部组合物的粘度典型的是2,000-400,000cps，和优选是3,000-300,000cps，和最优选5,000-225,000cps，该粘度是在1s-1的剪切速率和环境温度，用扭力受控的平行板流变仪(例如在Ares名称下由T.A.Instruments所销售的那些)测量的。
此处所用的着色剂可以是通过常规技术进行胶囊化的(如果期望是其中任一个或者二者)。这样的技术包括使用环糊精，由此该常规的技术进一步描述在Eur.J.Org.Chem.2005，第4051-4059页。
当使用本发明的局部组合物时，典型的指导消费者大约每5cm2的皮肤使用大约0.1g的组合物，目的是产生健康的和令人期望的肤色。
对于本发明组合物的包装没有限制，并且可以包括瓶子(bottle)，管子(tube)，箔包装(foil wrap)，滚球涂药器(roll-ball applicator)，压挤容器(squeeze container)或者带盖子的广口瓶(lidded jar)。
提供下面的实施例来说明本发明，并且目的并非限制权利要求的范围。
实施例1
本发明的局部组合物是通过合并下面的成分来制备的：
| 成分 | 在配方中的重量百分比 |
| 保湿剂 | 0.1-3.0 |
| 表面活性剂 | 0.0-20 |
| 第一着色剂* | .0001-.0003 |
| 润肤剂 | 2-5 |
| 增稠剂 | 0.0-0.3 |
| 防腐剂** | 0.2-0.5 |
| 物理散射剂 | 0.3-1 |
| 抗氧化剂(第二着色剂)*** | 0.001-0.002 |
| 皮肤增亮剂**** | 1-4 |
| 遮光剂/UV吸收剂 | 1-2 |
| 香味剂 | 0.2-0.4 |
| 维生素C | 0.0-0.3 |
| 维生素E | 0.2-1.2 |
| 水 | 平衡量 |
*食品红1(Ponceau SX)
**对羟基苯甲酸甲和丙酯
***番茄红素10％混合物，来自DSM Nutritional Products
****烟酰胺
实施例2
将类似于实施例1所制备的那些的局部组合物在环境温度存储3个月。出乎意料的，包装中的和使用(在3个月之后)的组合物的颜色基本上保持了与首次制备组合物时的颜色相同。当制备并且在存储之后，该局部组合物满足本文中所述的L*和色调特性。
Claims (18)
1.一种消费级着色剂，其包含：
(a)第一着色剂，其包含染料、颜料或者二者；和
(b)第二着色剂，其包含logP大于12.5的亲脂性类胡萝卜素；
其中第一着色剂(a)与第二着色剂(b)的重量比满足a/b＝0.004-1,000。
2.根据权利要求1的消费级着色剂，其中该着色剂完全由第一着色剂和第二着色剂组成。
3.根据权利要求1或者权利要求2的消费级着色剂，其中该亲脂性类胡萝卜素选自β-胡萝卜素，番茄红素，叶黄素，虾青素，β-隐黄质及其混合物。
4.一种影响肤色的局部组合物，其包含：
(a)第一着色剂，其包含染料、颜料或者二者；和
(b)第二着色剂；
其中该第二着色剂是抗氧化剂，并且包含logP大于12.5的亲脂性类胡萝卜素，
其中第一着色剂(a)与第二着色剂(b)的重量比满足a/b＝0.004-1,000，和
其中当在环境温度存储时，该组合物具有60-90的L*值和-50到50的色调值至少3个月。
5.根据权利要求4的局部组合物，其中第一着色剂选自颜料红4，食品红1，酸性橙7，颜料红57，食品黄3，酸性红33，食品红12，酸性黄23，食品黄4，食品绿3，食品蓝2，酸性蓝9，溶剂红43，酸性红87，溶剂红48，酸性红92，溶剂紫13，酸性紫43，溶剂绿3，酸性绿25，还原红1，颜料金属1，颜料蓝29，颜料白21，颜料白22，颜料白14，颜料白31，颜料棕6，或者颜料红101，颜料102，颜料棕6，颜料黄42，颜料黄43，颜料黑11，颜料白18，颜料紫16，颜料白6，颜料白4及其混合物。
6.根据权利要求4或者权利要求5的局部组合物，其中该第二着色剂选自β-胡萝卜素，番茄红素，叶黄素，虾青素，β-隐黄质及其混合物。
7.根据权利要求4-6中任一项的局部组合物，其中第一着色剂与第二着色剂的重量比是1∶6-6∶1。
8.根据权利要求7的局部组合物，其中第一着色剂与第二着色剂的重量比是1∶3-3∶1。
9.根据权利要求4的局部组合物，其中该第一着色剂基本上由红色染料组成，该第二着色剂基本上由番茄红素组成。
10.根据权利要求4-9中任一项的局部组合物，其中该局部组合物基本上不含释放甲醛的防腐剂。
11.根据权利要求4-10中任一项的局部组合物，其中该局部组合物进一步包含物理散射剂。
12.根据权利要求4-11中任一项的局部组合物，其中该局部组合物进一步包含防腐剂和紫外光遮挡剂，该防腐剂包含对羟基苯甲酸甲酯、对羟基苯甲酸丙酯或者二者，该紫外光遮挡剂包含丁基甲氧基二苯甲酰甲烷和对甲氧基肉桂酸2-乙基己基酯。
13.根据权利要求12的局部组合物，其中该局部组合物包含0.01-3重量％的防腐剂和0.5-6重量％的紫外光遮挡剂。
14.根据权利要求4-13中任一项的局部组合物，其中该第一着色剂，第二着色剂或者二者是胶囊化的。
15.根据权利要求13的局部组合物，其中该防腐剂和紫外光遮挡剂的重量比是1∶8-8∶1。
16.根据权利要求4-15中任一项的局部组合物，其中该组合物进一步包含皮肤增亮剂。
17.根据权利要求16的局部组合物，其中该皮肤增亮剂是烟酰胺。
18.一种影响消费者肤色的方法，其包含步骤：将权利要求4-17中任一项的局部组合物施用到消费者的皮肤上。
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| CN2008801216345A Expired - Fee Related CN101951871B (zh) | 2007-12-21 | 2008-12-12 | 包含着色抗氧化剂的局部组合物 |
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| Country | Link |
|---|---|
| US (2) | US20090162306A1 (zh) |
| EP (1) | EP2219588A1 (zh) |
| CN (1) | CN101951871B (zh) |
| AR (1) | AR071740A1 (zh) |
| CL (1) | CL2008003837A1 (zh) |
| TW (1) | TW200938231A (zh) |
| WO (1) | WO2009080572A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105755892A (zh) * | 2016-03-07 | 2016-07-13 | 云南瑞升烟草技术（集团）有限公司 | 一种含虾青素的卷烟纸 |
| CN109789058A (zh) * | 2016-10-03 | 2019-05-21 | 宝洁公司 | 包含颜色稳定的磨料颗粒的皮肤清洁组合物 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103391725B (zh) * | 2011-02-18 | 2015-09-30 | 富士胶片株式会社 | 含类胡萝卜素的组合物 |
| EP2829263B1 (en) * | 2012-02-24 | 2020-10-28 | FUJIFILM Corporation | Oil-in-water emulsion composition |
| JP2013173696A (ja) * | 2012-02-24 | 2013-09-05 | Fujifilm Corp | リコピン含有組成物 |
| WO2014028032A1 (en) * | 2012-08-17 | 2014-02-20 | Jafer Limited | Topical skin care composition |
| TW201705040A (zh) * | 2015-07-17 | 2017-02-01 | Tair Jiuh Enterprise Co Ltd | 基於人臉影像的人臉膚色的偵測與資料庫建立方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834445A (en) * | 1989-08-11 | 1998-11-10 | Sikorski; Christopher | Process for preparing decolorized carotenoid-cyclodextrin complexes |
| IL110098A (en) * | 1993-08-13 | 1998-02-08 | Johnson & Johnson Vision Prod | Method of double-sided printing of a laminate and product obtained thereby |
| US5756362A (en) * | 1993-10-12 | 1998-05-26 | Cornell Research Foundation, Inc. | Liposome-enhanced immunoaggregation assay and test device |
| US5789154A (en) * | 1993-10-12 | 1998-08-04 | Cornell Research Foundation, Inc. | Liposome-enhanced immunoassay and test device |
| JPH08143418A (ja) * | 1994-11-17 | 1996-06-04 | Daiwa Kasei Kk | 化粧料 |
| US6358752B1 (en) * | 1996-09-27 | 2002-03-19 | Cornell Research Foundation, Inc. | Liposome-enhanced test device and method |
| DE19649062A1 (de) * | 1996-11-27 | 1998-05-28 | Basf Ag | Flüssige, mit Öl mischbare Carotinoid-Zubereitungen |
| US5863546A (en) * | 1997-03-02 | 1999-01-26 | Swinehart; James M | Cosmetic composition |
| DE19802134A1 (de) * | 1998-01-21 | 1999-07-22 | Basf Ag | Verwendung von Carotinoid-Aggregaten als Färbemittel |
| US6356752B1 (en) * | 1998-07-31 | 2002-03-12 | Avaya Technology Corp. | Wireless telephone as a transaction device |
| FR2799370B1 (fr) * | 1999-10-07 | 2005-08-19 | Oreal | Utilisation du lycopene dans des compositions destinees a traiter les signes cutanes du vieillissement |
| US6576460B1 (en) * | 1999-10-28 | 2003-06-10 | Cornell Research Foundation, Inc. | Filtration-detection device and method of use |
| GB2356386A (en) * | 1999-11-17 | 2001-05-23 | Tagra Biotechnologies Ltd | Microencapsulation |
| JP2003516340A (ja) * | 1999-12-10 | 2003-05-13 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 化粧組成物および皮膚の美白法 |
| FR2811561B1 (fr) * | 2000-07-13 | 2003-03-21 | Oreal | Composition, notamment cosmetique, renfermant la dhea et/ou un precurseur ou derive chimique ou biologique de celle-ci, et un inhibiteur de metalloproteinase |
| FR2815859B1 (fr) * | 2000-10-26 | 2003-02-28 | Oreal | Utilisation de l'association d'au moins un carotenoide a activite provitaminique a et d'au moins un carotenoide sans activite provitaminique a pour traiter les signes du vieillissement |
| FR2815861B1 (fr) * | 2000-10-26 | 2003-02-28 | Oreal | Utilisation de l'association d'au moins un carotenoide et d'au moins un isoflavonoide pour traiter les signes cutanes du vieillissement |
| FR2815863B1 (fr) * | 2000-10-26 | 2003-02-28 | Oreal | Composition comprenant l'association d'au moins un extrait d'au moins un vegetal du genre rosmarinus et d'au moins un carotenoide |
| FR2817739B1 (fr) * | 2000-12-12 | 2005-01-07 | Oreal | Composition cosmetique coloree transparente ou translucide |
| FR2818135B1 (fr) * | 2000-12-15 | 2003-02-14 | Oreal | Composition, notamment cosmetique, renfermant la 7-hydroxy dhea et/ou la 7-ceto dhea et au moins un carotenoide |
| FR2826266B1 (fr) * | 2001-06-26 | 2005-02-25 | Oreal | Composition cosmetique ou dermatologique comprenant une association entre un compose de la famille des n-acylaminoamides et au moins un inhibiteur de metalloproteinases matricielles |
| US20030133960A1 (en) * | 2001-11-30 | 2003-07-17 | L'oreal | Cosmetic and dermatological uses of a retinoid and/or a carotenoid and acexamic acid |
| DE10226700A1 (de) * | 2002-06-15 | 2004-01-08 | Cognis Deutschland Gmbh & Co. Kg | Verwendung von Astaxathin |
| DE60319727T2 (de) * | 2002-10-21 | 2009-03-12 | L'oreal | Verfahren zum auflösen lipophiler verbindungen, und kosmetische zusammensetzung. |
| US20050048016A1 (en) * | 2003-07-02 | 2005-03-03 | L'oreal | Composition containing a silicone elastomer and a block silicone copolymer |
| US20050058611A1 (en) * | 2003-08-22 | 2005-03-17 | L'oreal | Preventing and/or combating collagen fiber degradation induced under conditions of natural exposure to sunlight |
| ATE477789T1 (de) * | 2003-10-03 | 2010-09-15 | Green Meadows Res Llc | Zubereitungen die lotusextrakte und methyldonatoren enthalten |
| DE102004055291A1 (de) * | 2003-12-09 | 2005-07-14 | Merck Patent Gmbh | Gefärbte mikrostrukturierte Effektpigmente |
| US20050186290A1 (en) * | 2003-12-10 | 2005-08-25 | L'oreal | Use of aquaglyceroporin modulators as slimming agent |
| US20050175653A1 (en) * | 2004-01-29 | 2005-08-11 | L'oreal | Composition, process of making, uses thereof |
| US20060134226A1 (en) * | 2004-11-16 | 2006-06-22 | Todd Leonard | Compositions useful to treat ocular neovascular diseases and macular degeneration |
| US20060171909A1 (en) * | 2005-02-03 | 2006-08-03 | The Procter & Gamble Company | Cosmetic compositions comprising colorants with low free dye |
| US7993662B2 (en) * | 2005-06-14 | 2011-08-09 | Kokyu Alcohol Kogyo Co., Ltd. | Transparent solid oil cosmetics |
| WO2008074654A2 (en) * | 2006-12-19 | 2008-06-26 | L'oreal | Method for colouring the skin of men |
-
2007
- 2007-12-21 US US12/004,572 patent/US20090162306A1/en not_active Abandoned
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2008
- 2008-12-09 TW TW097147842A patent/TW200938231A/zh unknown
- 2008-12-12 CN CN2008801216345A patent/CN101951871B/zh not_active Expired - Fee Related
- 2008-12-12 EP EP08864830A patent/EP2219588A1/en not_active Withdrawn
- 2008-12-12 WO PCT/EP2008/067466 patent/WO2009080572A1/en active Application Filing
- 2008-12-19 AR ARP080105579A patent/AR071740A1/es unknown
- 2008-12-19 CL CL2008003837A patent/CL2008003837A1/es unknown
-
2010
- 2010-03-01 US US12/714,963 patent/US20100158963A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105755892A (zh) * | 2016-03-07 | 2016-07-13 | 云南瑞升烟草技术（集团）有限公司 | 一种含虾青素的卷烟纸 |
| CN109789058A (zh) * | 2016-10-03 | 2019-05-21 | 宝洁公司 | 包含颜色稳定的磨料颗粒的皮肤清洁组合物 |
| CN109789058B (zh) * | 2016-10-03 | 2022-06-28 | 宝洁公司 | 包含颜色稳定的磨料颗粒的皮肤清洁组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101951871B (zh) | 2013-05-22 |
| US20100158963A1 (en) | 2010-06-24 |
| US20090162306A1 (en) | 2009-06-25 |
| CL2008003837A1 (es) | 2009-11-27 |
| EP2219588A1 (en) | 2010-08-25 |
| WO2009080572A1 (en) | 2009-07-02 |
| AR071740A1 (es) | 2010-07-14 |
| TW200938231A (en) | 2009-09-16 |
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