CN101810198A - Salicylic acid-iodine disinfector and preparation method thereof - Google Patents
Salicylic acid-iodine disinfector and preparation method thereof Download PDFInfo
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- CN101810198A CN101810198A CN201010163672A CN201010163672A CN101810198A CN 101810198 A CN101810198 A CN 101810198A CN 201010163672 A CN201010163672 A CN 201010163672A CN 201010163672 A CN201010163672 A CN 201010163672A CN 101810198 A CN101810198 A CN 101810198A
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Abstract
The invention discloses a salicylic acid-iodine disinfector. The invention is characterized by comprising the following components in percentage by weight: 10-50% of salicylic acid, 0.5-2.5% of iodine, 10-50% of ethanol and 1-65% of water. The preparation method comprises the following steps: firstly dissolving the salicylic acid and the iodine in the components by the ethanol, adding the formed uniform liquid to a reaction kettle, adding water, stirring, and mixing for 2-5 hours to generate a homogeneous-phase clear liquid. The salicylic acid-iodine disinfector has the advantages of wide sterilization spectrum, strong sterilization capability, high action speed, good stability, safe application to human beings and animals and low environmental pollution degree, thereby being an environment-friendly salicylic acid-iodine disinfector.
Description
Technical field
The invention belongs to the disinfectant field, particularly a kind of compound salicylic acid-iodine disinfector that is used for livestock and poultry, aquaculture and public place sterilization and preparation method thereof.
Background technology
In recent years; because of factors such as environment and drug abuses; cause the various infectious diseases of livestock and poultry breeding industry to take place frequently; to such an extent as to relevant industries such as livestock and poultry breeding industry, veterinary drug production and operation are subjected to great impact; along with the layer of food security incident goes out, the propagation of zoonosis, the development of large-scale cultivation; and people " prevent overweighting controlling " continually strengthening of medication idea; press for and be used to improve feeding environment, prophylactic green safety disinfectant; should effectively kill virus, again livestock and poultry, aquatic products not had stress.
Iodine is used for the history in existing 150 years of body sterilizing, and since latter half in 19th century, many people have spoken highly of the usefulness of iodine as antibacterial agent, and this mainly is because it has the unexistent and inaccessiable bactericidal effect of many bactericide.Its has a broad antifungal spectrum, little to tissue toxicity, be widely used, that its sterilizing scope relates to is clinical, health, daily life, livestock and poultry cultivation, aquaculture, public place and drinking water etc., the iodine sterilizing medicine of different classes of, different dosage form, different efficacies just is being widely used in practice, as be used for the sterilization of human body skin, wound surface, mucomembranous surface, surgical instruments, Chi Shui, drinking water and the sanitized of tableware, be used for treating various human various diseases etc.
Salicylic acid that is septichen (o-hydroxybenzoic acid) are a kind of important organic synthesis raw materials.On pesticide producing, be used for the intermediate 4 hydroxy coumarin of the intermediate isopropyl salicylate of synthetic organophosphorus insecticide isocarbophos, Isofenphos methyl and rodenticide warfarin, coumatetralyl; In medical industry, salicylic acid except that itself as the Cidex-7, also as the intermediate of acetylsalicylic acid multiple medicines such as (aspirin); It also is the important source material of industry such as dyestuff, spices, rubber.How salicylic acid and iodine combination being utilized, is a problem that is worth discussion.
Summary of the invention
The purpose of this invention is to provide a kind of new disinfectant, have that fungicidal spectrum is wide, sterilizing ability is strong, speed of action is fast, good stability, to humans and animals safety, the environmental pollution degree is low, salicylic acid-iodine disinfector of advantages such as environmentally friendly type and preparation method thereof.
The present invention adopts following technical scheme to realize above-mentioned purpose:
Salicylic acid-iodine disinfector of the present invention is characterized in that: it contains following component, and the percentage by weight of each component is as follows:
Salicylic acid 10-50%,
Iodine 0.5-2.5%,
Ethanol 10-50%,
Water 1-65%.
Salicylic acid-iodine disinfector preparation method of the present invention is, at first flow into reactor with the uniform liquid after each component of dissolve with ethanol, adds an amount of water then, mixes about 2-5 hour, becomes the clear and bright liquid of homogeneous phase.
The beneficial effect that the present invention adopts above technical scheme to reach is:
Salicylic acid-iodine disinfector of the present invention is a kind of by salicylic acid, iodine, ethanol, the formulated liquid sterilization disinfectant of water, and it has the double sterilization effect of salicylic acid and Operand; Sterilizing ability is strong, speed of action is fast, good stability, and to humans and animals safety, the environmental pollution degree is low; Its preparation method is simple, and production cost is low, and product has use value widely.
Embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
Salicylic acid-iodine disinfector of the present invention, it contains following component, salicylic acid 10%, iodine 1%, ethanol 29%, water 60%; At first use salicylic acid and iodine in the dissolve with ethanol component, the uniform liquid that forms is flow into reactor, add water then and mix about 2 hours, become the clear and bright liquid of homogeneous phase and get final product.
Embodiment 2:
Salicylic acid-iodine disinfector of the present invention, it contains following component, salicylic acid 20%, iodine 0.5%, ethanol 29.5%, water 50% flow into reactor with the uniform liquid after each component of dissolve with ethanol, add an amount of water, mix then about 3 hours, become the clear and bright liquid of homogeneous phase.
Embodiment 3:
Salicylic acid-iodine disinfector of the present invention, it contains following component, salicylic acid 40%, iodine 1.5%, ethanol 10%, water 48.5% flow into reactor with the uniform liquid after each component of dissolve with ethanol, add an amount of water, mix then about 4 hours, become the clear and bright liquid of homogeneous phase.
Salicylic acid-iodine disinfector of the present invention can be embodied from following bactericidal assay from bactericidal effect:
1 material and method
1.1 test equipment
1.1.1 salicylic acid-iodine disinfector is provided by Zhengdian Biological Tech. Co., Ltd., Foshan City.
1.1.2 test strain Escherichia coli (8099) and staphylococcus aureus (ATCC6538) cultivated for the 6th～8 generation; Bacillus subtilis var (ATCC9372) cultivated for the 4th generation, the preparation brood cell.
1.2 method
1.2.1 staphylococcus aureus (ATCC6538) and Escherichia coli (8099) are got in the preparation of bacteria suspension
24h fresh cultured thing and bacillus subtilis var (ATCC9372) brood cell suspension, to be mixed with the bacteria suspension of experimental concentration standby with containing 10g/L peptone phosphate buffer dilution.
1.2.2 it is representative with Escherichia coli that neutralizer is selected test.Under 20 ℃ of conditions, establish parallel 6 groups of tests, undertaken by suspension quantitative disinfecting test program.1. thimerosal+bacteria suspension; 2. (thimerosal+bacteria suspension)+neutralizer; 3. neutralizer+bacteria suspension; 4. (thimerosal+neutralizer)+bacteria suspension; 5. dilution+bacteria suspension (normal bacterium contrast); 6. dilution+neutralizer+medium is as negative control.Result of the test is not grown bacterium or the only a few colony growth is only arranged with the 1st group; The 2nd group has colony growth, than the 1st group be many, but than the 3rd, 4,5 group for few; 3rd, 4,5 groups of bacterium numbers are similar, error rate≤10%; The 6th group of asepsis growth, for selected neutralizer and concentration thereof suitable.Test repeats 3 times.
1.2.3 the suspension quantitative disinfecting test is under 20 ℃ of conditions, 1: 1 mixing of organic chaff interference and bacteria suspension is standby, mix with the ratio (positive control is a hard water) of 4ml disinfectant in every test tube 1ml bacteria suspension, act on, draw 0.5ml bacterium medicine and add mixing in the 4.5ml neutralizer to the scheduled time.Neutralization 10min gets this liquid 1ml inoculation plate, pours into corresponding agar medium, cultivates 48h (bacillus subtilis black variety bud cell is 72h) for 37 ℃, calculates clump count, calculates and kills logarithm value.Test repeats 3 times.
2 results
2.1 neutralizer selects the test result of the test to show, under 20 ℃ of conditions, the aseptic PBS solution of 1% lecithin+1% Tween 80+0.5% sodium thiosulfate, the thimerosal residual action that can effectively neutralize residual, and neutralizer and neutralized reaction product do not have obvious influence to test bacterial growth and medium.
2.2 suspension quantitative disinfecting test result of the test shows that under 20 ℃ of conditions, available iodine is that 100mg/L thimerosal dilution acts on 3min respectively to Escherichia coli, staphylococcus aureus, kills logarithm value 〉=5.0; Available iodine be 500mg/L thimerosal dilution to bacillus subtilis black variety bud cell effect 5min, kill logarithm value 〉=5.0, see Table 1.
Table 1 salicylic acid-iodine disinfector bactericidal effect
Annotate: test temperature is 20 ℃, the negative control asepsis growth, and the result is 3 test mean values.
3 discuss
This experimental study salicylic acid-iodine disinfector available iodine is that the dilution of 500mg/L has good killing effect to microorganism.
Above embodiment is only in order to illustrate that technical scheme of the present invention is not intended to limit; Although with reference to preferred embodiment the present invention is had been described in detail, those of ordinary skill in the field are to be understood that.Still can make amendment or the part technical characterictic is equal to replacement the embodiment of invention; And not breaking away from the spirit of technical solution of the present invention, it all should be encompassed in the middle of the technical scheme scope that the present invention asks for protection.
Claims (2)
1. a salicylic acid-iodine disinfector is characterized in that, it contains following component, and the percentage by weight of each component is as follows:
Salicylic acid 10-50%,
Iodine 0.5-2.5%,
Ethanol 10-50%,
Water 1-65%, more than each component sum be absolutely.
2. the preparation method of the described salicylic acid-iodine disinfector of claim 1, it is characterized in that, at first use salicylic acid and iodine in the dissolve with ethanol component, the uniform liquid that forms is flow into reactor, add water then and mix about 2-5 hour, become the clear and bright liquid of homogeneous phase.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010163672.6A CN101810198B (en) | 2010-05-06 | 2010-05-06 | Salicylic acid-iodine disinfector and preparation method thereof |
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| CN201010163672.6A CN101810198B (en) | 2010-05-06 | 2010-05-06 | Salicylic acid-iodine disinfector and preparation method thereof |
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| CN101810198A true CN101810198A (en) | 2010-08-25 |
| CN101810198B CN101810198B (en) | 2015-01-28 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105557752A (en) * | 2016-03-03 | 2016-05-11 | 佛山市正典生物技术有限公司 | Iodine salicylate foam-type disinfectant and preparation method thereof |
| CN107306992A (en) * | 2017-09-01 | 2017-11-03 | 四川创美克科技有限公司 | A kind of salicylic acid-iodine powder disinfectant and preparation method thereof |
| CN107513014A (en) * | 2016-06-17 | 2017-12-26 | 佛山市正典生物技术有限公司 | A kind of salicylic acid-iodine complex compound, preparation method and application |
| CN107518001A (en) * | 2017-09-01 | 2017-12-29 | 四川创美克科技有限公司 | A kind of new disinfectant of alcohol containing iodo-salicylic acid and preparation method thereof |
| CN112640913A (en) * | 2020-12-30 | 2021-04-13 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112704080A (en) * | 2020-12-30 | 2021-04-27 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with stable component content and preparation method thereof |
| CN112806387A (en) * | 2020-12-31 | 2021-05-18 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
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| US3764669A (en) * | 1970-11-02 | 1973-10-09 | S Santorelli | Method of making microbiocidal complexes |
| CN1301537A (en) * | 1999-12-29 | 2001-07-04 | 范家忠 | Liniment for skin disease and use |
| CN1183934C (en) * | 2002-02-03 | 2005-01-12 | 沈志强 | Disinfectant |
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| US3764669A (en) * | 1970-11-02 | 1973-10-09 | S Santorelli | Method of making microbiocidal complexes |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105557752A (en) * | 2016-03-03 | 2016-05-11 | 佛山市正典生物技术有限公司 | Iodine salicylate foam-type disinfectant and preparation method thereof |
| CN107513014A (en) * | 2016-06-17 | 2017-12-26 | 佛山市正典生物技术有限公司 | A kind of salicylic acid-iodine complex compound, preparation method and application |
| CN107306992A (en) * | 2017-09-01 | 2017-11-03 | 四川创美克科技有限公司 | A kind of salicylic acid-iodine powder disinfectant and preparation method thereof |
| CN107518001A (en) * | 2017-09-01 | 2017-12-29 | 四川创美克科技有限公司 | A kind of new disinfectant of alcohol containing iodo-salicylic acid and preparation method thereof |
| CN112640913A (en) * | 2020-12-30 | 2021-04-13 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112704080A (en) * | 2020-12-30 | 2021-04-27 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with stable component content and preparation method thereof |
| CN112640913B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112704080B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with stable component content and preparation method thereof |
| CN112806387A (en) * | 2020-12-31 | 2021-05-18 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
| CN112806387B (en) * | 2020-12-31 | 2022-02-25 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
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| CN101810198B (en) | 2015-01-28 |
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