CN101757010A - Medicaments for preventing and curing poultry coccidiosis - Google Patents
Medicaments for preventing and curing poultry coccidiosis Download PDFInfo
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- CN101757010A CN101757010A CN200810195462A CN200810195462A CN101757010A CN 101757010 A CN101757010 A CN 101757010A CN 200810195462 A CN200810195462 A CN 200810195462A CN 200810195462 A CN200810195462 A CN 200810195462A CN 101757010 A CN101757010 A CN 101757010A
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- maduramicin
- coccidiosis
- medicaments
- nicarbazin
- coccidium
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Abstract
The invention relates to medicaments for preventing and curing poultry coccidiosis. The medicaments comprise the following raw materials in percentage by weight: 0.45-0.55 percent of maduramicin, 12-12.5 percent of nicarbazin and the balance of corn meal, wherein the maduramicin and the nicarbazin have the synergistic effect; the acting peak period of the maduramicin to coccidium is in an early period of sporozoite and first-generation schizont, and the nicarbazin acts on second-generation schizont and has the peak period on the fourth day after infections, thus after the maduramicin and the nicarbazin are used together, the whole vegetative propagation period of the coccidium is covered. The medicaments has wider coccidium resistant spectrum and more effectively reduces toxic and side effects.
Description
Technical field
The present invention relates to a kind of medicine that is used to prevent and treat coccidiosis of domestic fowls.
Background technology
Coccidiosis of domestic fowls is because Eimeria infects poultry small intestinal and caecum, cause intestinal mucosal injury, form courageous and upright blemish, often can cause the mortality rate of fowl group 50-70%, even have up to 100%, because the long-term puzzlement of coccidiosis, serious obstruction the development of aviculture, cause huge harm for the birds aquaculture.
Chicken coccidiosis is that eimeria tenella parasitizes the intestinal epithelial cell of chicken and the parasitic disease that causes, clinically with dysentery, become thin, anemia, feed intake drop to principal character.Primary disease is mainly in 3-6 chicken group in age in week, broiler pilosity, and summer, pilosity endangered seriously, and having become influences one of the crucial disease of benefit of raising chickens.Chicken coccidiosis infringement intestinal epithelial cell causes the digestive tract malabsorption, and feed conversion rate reduces.Sick morbidity is extensive, and chicken coccidiosis and chicken are with depositing, and just there is the existence of chicken coccidiosis in every place of raising chickens, can fall ill when condition is suitable, causes large quantities of death.Destroy the intestinal natural cover for defense, the secondary bacterial infection, dead aggravation can reach 80%, and according to statistics, its sickness rate has been occupied the first place.
Maduramicin belongs to unit price glucosides polyether ionophore antibiotic.Be that present anticoccidial effect is the strongest, with the minimum polyethers anticoccidial drug of concentration, be widely used in the broiler coccidiosis, all have good pressing down to kill effect according to test, murder by poisoning huge to chicken, tender, heap type and Bu Shi Eimeria, its anticoccidial effect is better than anticoccidial drugs such as monensin, Salinomycin, first class Salinomycin.
The anticoccidial mechanism of Maduramicin is because Na+, the K+-ATP enzyme of the excited spore of energy increase zygoblast Na+ ion concentration, and the increase of Na+ ion must cause the Cl-ion to increase, thereby makes zygoblast suction swelling and vacuolation.Because coccidiosis does not have the Osmoregulation organelle.Internal penetration is pressed and is changed, and must cause the coccidiosis harmful effect.Test shows, Maduramicin to the early stage zygoblast of coccidiosis, trophozoite and the 1st generation schizont inhibitory or killing effect is all arranged.In vivo test shows to broiler with the Maduramycin Ammonium of 14C labelling, and 5mg/kg spice concentration rapidly disappears after stopping feeding in vivo, and the half-life is about 21h in tissues such as liver, kidney, muscle, skin fat.
Though having, Maduramicin efficiently drives the coccidiosis effect, narrow to the safety range of broiler, surpass 6mg/kg feedstuff concentration, can obviously suppress the growth of meat chicken rate, 8mg/kg feedstuff concentration is fed chicken, and part chicken group is molted, and two times of treatment concentration (10mg/kg) cause that then chickling is poisoned to death.
Summary of the invention
Technical problem to be solved by this invention provides a kind of medicine that is used to prevent and treat coccidiosis of domestic fowls, and its therapeutic effect is good and toxic and side effects is little.
For solving above technical problem, the present invention takes following technical scheme:
A kind of medicine that is used to prevent and treat coccidiosis of domestic fowls, in the medicine gross weight, the composition of raw materials of this medicine is that Semen Maydis powder is formed by Maduramicin 0.45～0.55%, nicarbazine 12～12.5% and surplus.
Because the enforcement of above technical scheme, the present invention compared with prior art has following advantage:
The present invention is the composition of medicine of Maduramicin, nicarbazine and Semen Maydis powder, and wherein, Maduramicin belongs to unit price glucosides polyether ionophore antibiotic, is that present anticoccidial effect is the strongest, with the minimum polyethers anticoccidial drug of concentration; Nicarbazine is '-dinitrosym-diphenylurea and hydroxyl two first class pyrimidine complex, and two kinds of compositions can be absorbed by the poultry digestive tract respectively, and are distributed widely in tissue and the body fluid, and 48h innerlich anwenden after worm is asked in infection can effectively suppress coccidiosis and grow.Maduramicin and nicarbazine have synergism, Maduramicin is to the commitment of coccidiosis effect peak phase at zygoblast and first generation schizont, and promptly at metainfective 0-48 hour, and nicarbazine acts on second filial generation schizont, metainfective again the 4th day of peak phase is so both share.Effect has covered whole asexual propagation cycle of coccidiosis, and the anticoccidial spectrum is wider, and is more effective and reduced toxic and side effects.
The specific embodiment
Below in conjunction with specific embodiments, the present invention will be described in detail, but be not limited to this embodiment.
According to the medicine that is used to prevent and treat coccidiosis of domestic fowls of present embodiment, this medicine is a raw material with Maduramicin 0.5g, nicarbazine 12.5g and Semen Maydis powder 87g, after pulverizing, screening, drying, weighing, batching, mutually mixed.
This medicine is carried out exposure experiments to light, accelerated test and room temperature to keep sample and investigates test, through check, every index has no significant change, three batch sample exposure experiments to light 10 days, accelerated test 6 months and long-term room temperature keep sample and investigate 36 months, and every indexs such as character, related substance, content have no significant change.This product stability is described better, experimental result sees Table 1 to table 3.
Table 1. exposure experiments to light result (intensity of illumination 4500 ± 500lx)
Table 2. accelerated test result (40 ± 2 ℃ of RH75 ± 5%)
Table 3. long-term experiment is investigated result (25 ± 2 ℃ of RH 60 ± 5%)
In the present invention's prescription, Maduramicin belongs to unit price glucosides polyether ionophore antibiotic.Be that present anticoccidial effect is the strongest, with the minimum polyethers anticoccidial drug of concentration, be widely used in the broiler coccidiosis, all have good pressing down to kill effect according to test, murder by poisoning huge to chicken, tender, heap type and Bu Shi Eimeria, its anticoccidial effect is better than anticoccidial drugs such as monensin, Salinomycin, first class Salinomycin.
Nicarbazine is '-dinitrosym-diphenylurea and hydroxyl two first class pyrimidine complex, and two kinds of compositions can be absorbed by the poultry digestive tract respectively, and are distributed widely in tissue and the body fluid.The active peak phase of nicarbazine the 2nd generation schizont, be mainly used in prevention caecum coccidiosis (Eimeria tenella) and heap type, huge, murder by poisoning, Bu Shi Eimeria (small intestinal coccidiosis), according to test, 48h innerlich anwenden behind the worm is asked in infection, can effectively suppress coccidiosis grows, its recommended dose seldom or not influences immunity to coccidiosis power body, has chemical sproof coccidiosis also effective to Amprolium.[2]
Maduramicin and nicarbazine have synergism.Maduramicin is to the commitment of coccidiosis effect peak phase at zygoblast and first generation schizont, promptly at metainfective 0-48 hour.And nicarbazine acts on second filial generation schizont, and metainfective again the 4th day of peak phase is so both share.Effect has covered the whole asexual propagation cycle of coccidiosis.Anticoccidial spectrum is wider, and is more effective and reduced toxic and side effects.
Claims (1)
1. medicine that is used to prevent and treat coccidiosis of domestic fowls, it is characterized in that: in the medicine gross weight, the composition of raw materials of this medicine is that Semen Maydis powder is formed by Maduramicin 0.45～0.55%, nicarbazine 12～12.5% and surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810195462A CN101757010A (en) | 2008-10-31 | 2008-10-31 | Medicaments for preventing and curing poultry coccidiosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810195462A CN101757010A (en) | 2008-10-31 | 2008-10-31 | Medicaments for preventing and curing poultry coccidiosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101757010A true CN101757010A (en) | 2010-06-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810195462A Pending CN101757010A (en) | 2008-10-31 | 2008-10-31 | Medicaments for preventing and curing poultry coccidiosis |
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| CN (1) | CN101757010A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404520A (en) * | 2013-06-19 | 2013-11-27 | 牡丹江师范学院 | Rodenticide |
| ES2501367R1 (en) * | 2014-06-02 | 2015-02-18 | Universitat De Lleida | COCCIDIOSIS TREATMENT METHOD |
-
2008
- 2008-10-31 CN CN200810195462A patent/CN101757010A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404520A (en) * | 2013-06-19 | 2013-11-27 | 牡丹江师范学院 | Rodenticide |
| ES2501367R1 (en) * | 2014-06-02 | 2015-02-18 | Universitat De Lleida | COCCIDIOSIS TREATMENT METHOD |
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Open date: 20100630 |