CN101720770B - Bactericidal composition containing phenylate bacterium ester and probenazole - Google Patents
Bactericidal composition containing phenylate bacterium ester and probenazole Download PDFInfo
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- CN101720770B CN101720770B CN201010003087XA CN201010003087A CN101720770B CN 101720770 B CN101720770 B CN 101720770B CN 201010003087X A CN201010003087X A CN 201010003087XA CN 201010003087 A CN201010003087 A CN 201010003087A CN 101720770 B CN101720770 B CN 101720770B
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- probenazole
- bactericidal composition
- suspending agent
- bacterium ester
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- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 title claims abstract description 109
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 19
- 150000002148 esters Chemical class 0.000 title abstract description 4
- 241000894006 Bacteria Species 0.000 title abstract 3
- 239000000843 powder Substances 0.000 claims abstract description 32
- 239000000375 suspending agent Substances 0.000 claims abstract description 25
- 241000221785 Erysiphales Species 0.000 claims abstract description 9
- 206010039509 Scab Diseases 0.000 claims abstract description 7
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 4
- 235000013311 vegetables Nutrition 0.000 claims abstract description 4
- 238000009736 wetting Methods 0.000 claims description 26
- 239000004562 water dispersible granule Substances 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 239000003899 bactericide agent Substances 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000004563 wettable powder Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 41
- 230000003449 preventive effect Effects 0.000 description 20
- 238000012360 testing method Methods 0.000 description 19
- 239000002131 composite material Substances 0.000 description 17
- 240000008067 Cucumis sativus Species 0.000 description 9
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 9
- 239000000575 pesticide Substances 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 239000002270 dispersing agent Substances 0.000 description 7
- -1 polyoxyethylene Polymers 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- 239000000080 wetting agent Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000945 filler Substances 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229920001732 Lignosulfonate Polymers 0.000 description 4
- 240000001987 Pyrus communis Species 0.000 description 4
- 235000014443 Pyrus communis Nutrition 0.000 description 4
- 240000003377 Shepherdia canadensis Species 0.000 description 4
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 4
- 238000012271 agricultural production Methods 0.000 description 4
- 150000004996 alkyl benzenes Chemical class 0.000 description 4
- 229940077388 benzenesulfonate Drugs 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
- 241000233679 Peronosporaceae Species 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 235000009754 Vitis X bourquina Nutrition 0.000 description 3
- 235000012333 Vitis X labruscana Nutrition 0.000 description 3
- 240000006365 Vitis vinifera Species 0.000 description 3
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- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 230000002528 anti-freeze Effects 0.000 description 3
- 239000002518 antifoaming agent Substances 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- 150000007942 carboxylates Chemical class 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000007859 condensation product Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 229920005646 polycarboxylate Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 2
- 241000235349 Ascomycota Species 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000006540 mitochondrial respiration Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000005800 Kresoxim-methyl Substances 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000003495 flagella Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000004308 thiabendazole Substances 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 229960004546 thiabendazole Drugs 0.000 description 1
- 235000010296 thiabendazole Nutrition 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a bactericide composition having a synergy action, and the effective active ingredients of the bactericide composition contain phenylate bacterium ester and probenazole, wherein the proportion by weight of the phenylate bacterium ester and the probenazole is 1-40:10-80, and wettable powder, water dispersible powder and a suspending agent can be prepared by adding an auxiliary agent and an excipient into the effective active ingredients, and mainly used for controlling powdery mildew, gray mold, anthracnose and scabs of vegetables and fruit trees.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains ZJ0712 and probenazole.
Technical background
(kresoxim～methyl) is the methoxy acrylic new type bactericide with independent intellectual property right that China formulates voluntarily to ZJ0712.Molecular formula: C
20H
22O
4, chemical name: (E) 2-[2-(2,5-dimethyl phenoxy toluene)-phenyl]-3-methoxy-methyl acrylate.
ZJ0712 belongs to the cell mitochondrial respiration inhibitor, and shift through the electronics in the pathogen physiological activity and suppress mitochondrial respiratory, and the supply of interference cell energy, make the pathogen cell death.Tool protection and therapeutic action, toxicity is low, and active high, fungicidal spectrum is wide, and the plurality of plant diseases that sac fungi, flagellum mattress and imperfect fungus are caused has the better prevention effect, particularly powdery mildew of cucumber and downy mildew of garpe is had very excellent preventive effect.
Probenazole (thiabendazole) belongs to benzimidazole, and molecular formula is C
10H
7N
3S, chemical name: α-(4-thiazolyl)-1H-benzimidazole.
Probenazole belongs to benzimidazole, and mechanism of action is to suppress mitochondrial respiration of fungi and cell proliferation.Inhale conduction in having, root is executed the conduction of Shi Nengxiang top, but can not conduct to base.Antibacterial activity is limited to sac fungi, basidiomycetes, imperfect fungus, and to oomycetes and zygomycete non-activity.
No matter be ZJ0712, probenazole or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of different effects mechanism is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.ZJ0712 is different with the probenazole mechanism of action, and each other composite have good synergistic effect within the specific limits.And composite about ZJ0712 and probenazole do not see relevant report at present at home and abroad as yet.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains ZJ0712 and probenazole.
The present invention realizes through following technical scheme:
A kind of bactericidal composition that contains ZJ0712 and probenazole, wherein ZJ0712 and probenazole weight ratio are 1～40: 10～80.
The described bactericidal composition that contains ZJ0712 and probenazole, wherein the weight ratio of ZJ0712 and probenazole is 1～30: 15～70.
The described bactericidal composition that contains ZJ0712 and probenazole, wherein the weight ratio of ZJ0712 and probenazole is 5～20: 30～60.
The described bactericidal composition that contains ZJ0712 and probenazole is processed wetting powder, water dispersible granules or suspending agent.
When processing wetting powder, composition comprises following constituent content: ZJ0712 1～40%, probenazole 10～80%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
ZJ0712, probenazole, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into ZJ0712 probenazole wetting powder product.
When processing water dispersible granules, composition comprises following constituent content: ZJ0712 1～40%, probenazole 10～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, filler 10～90%.
ZJ0712, probenazole, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that article are quantitatively sent the fluidized bed granulation dryer to, makes ZJ0712 probenazole water dispersible granules product.
Comprise following constituent content when composition is processed suspending agent: ZJ0712 1～30%, probenazole 10～50%, dispersant 2～10%, wetting agent 2～10%, antifoaming agent 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, deionized water add to 100%.
Dispersant, wetting agent, antifoaming agent, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear; Add ZJ0712, probenazole; Ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes ZJ0712 probenazole suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, the aluminium chloride.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described antifoaming agent is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, gray mold, anthracnose, the scab of control vegetables and fruit tree.
Beneficial effect of the present invention: (1) present composition effective active composition ZJ0712 and probenazole belong to the bactericide of two kinds of different effects mechanism, and both are mixed each other and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single agent, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, gray mold, anthracnose, the scab of vegetables and fruit tree.
Embodiment
The present invention is explained further that the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Practice example one and implement the prescription example
Embodiment 1 80% ZJ0712 probenazole wetting powder
ZJ0712 40%, probenazole 40%, alkylaryl APEO 5%, soapberry powder 3%, spaonin powder 2%, kaolin 10%, mixture carries out comminution by gas stream, makes 80% ZJ0712 probenazole wetting powder.
Embodiment 2 60% ZJ0712 probenazole wetting powders
ZJ0712 10%, probenazole 50%, lignosulfonates 4%, lauryl sodium sulfate 4%, white carbon 8%, kaolin 24%, mixture carries out comminution by gas stream, makes 60% ZJ0712 probenazole wetting powder.
Embodiment 3 45% ZJ0712 probenazole wetting powders
ZJ0712 6%, probenazole 39%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F3%, white carbon 8%, bentonite 39%, mixture carries out comminution by gas stream, makes 45% ZJ0712 probenazole wetting powder.
Embodiment 4 35% ZJ0712 probenazole wetting powders
ZJ0712 5%, probenazole 30%, lignosulfonates 3%, sldium lauryl sulfate 2%, white carbon 5%, diatomite 55%, mixture carries out comminution by gas stream, makes 35% ZJ0712 probenazole wetting powder.
Embodiment 5 80% ZJ0712 probenazole water dispersible granules
ZJ0712 10%, probenazole 70%, tea are withered 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 8%, mixed 80% ZJ0712 probenazole water dispersible granules.
Embodiment 6 75% ZJ0712 probenazole water dispersible granules
ZJ0712 30%, probenazole 45%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 12%, the mixed 75% ZJ0712 probenazole water dispersible granules that gets.
Embodiment 7 65% ZJ0712 probenazole water dispersible granules
ZJ0712 5%, probenazole 60%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 4%, citric acid 1%, starch 25%, the mixed 65% ZJ0712 probenazole water dispersible granules that gets.
Embodiment 8 55% ZJ0712 probenazole water dispersible granules
ZJ0712 20%, probenazole 35%, alkylphenol-polyethenoxy are phonetic 5%, DBSA 2%, calcium chloride 1%, starch 20%, diatomite 17%, mixed 55% ZJ0712 probenazole water dispersible granules.
Embodiment 9 50% ZJ0712 probenazole suspending agents
ZJ0712 5%, probenazole 45%, alkyl benzene sulfonate calcium salt 5%, Sodium Polyacrylate 2%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, the mixed 50% ZJ0712 probenazole suspending agent that gets.
Embodiment 10 30% ZJ0712 probenazole suspending agents
ZJ0712 2%, probenazole 28%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, the mixed 30% ZJ0712 probenazole suspending agent that gets.
Embodiment 11 21% ZJ0712 probenazole suspending agents
ZJ0712 1%, probenazole 20%, polyoxyethylene carboxylate 4%, spaonin powder 5%, silicone compound 0.1%, polyvinyl alcohol 0.4%, propane diols 2%, deionized water add to 100%, the mixed 21% ZJ0712 probenazole suspending agent that gets.
Embodiment 12 10% ZJ0712 probenazole suspending agents
ZJ0712 1.5%, probenazole 8.5%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, the mixed 10% ZJ0712 probenazole suspending agent that gets.
Practice example two: ZJ0712 and probenazole are composite to the powdery mildew of cucumber Toxicity Determination
Test medicine provides by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation.
After the effective inhibition concentration scope of each medicament was confirmed in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament powdery mildew of cucumber.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is following:
Wherein: a, b are respectively ZJ0712 and probenazole shared ratio in combination
A is a ZJ0712
B is a probenazole
Result of the test is as shown in table 1:
Table 1 ZJ0712, probenazole and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
Can know that by table 1 ZJ0712, probenazole are to the EC of powdery mildew of cucumber
50Be respectively 0.12mg/L and 53.28mg/L.The virulence of ZJ0712 is higher than the virulence of probenazole.1: 1,1: 5,1: 10,1: 20,1: 30 synergy ratio of ZJ0712 and probenazole proportioning is respectively 1.60,1.93,2.23,1.80,1.55; Explaining that ZJ0712 and probenazole were mixed in the scope at 1: 1～1: 30 all shows obvious synergistic effect; Wherein synergy ratio SR is maximum when ZJ0712 and probenazole weight ratio are 1: 10, and synergistic effect is the most obvious.
Embodiment uses triphen kresoxim-methyl and the probenazole and the composite apple mildew test of pesticide effectiveness of preventing and treating thereof
This EE is the Luochuan County suburb in Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 40% probenazole wetting powder (commercial), 10% ZJ0712 suspending agent (commercial).
The investigation apple mildew state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated the apple mildew disease index respectively and calculated preventive effect in 10 days, 20 days after the dispenser for the third time.Experimental result is as follows:
Table 2 ZJ0712, probenazole and the composite apple mildew test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | Extension rate | 10 days preventive effects (%) behind the medicine for the second time | 20 days preventive effects (%) behind the medicine for the second time |
| 80% ZJ0712 probenazole wetting powder | 30000 times | 87.34 | 93.24 |
| 55% ZJ0712 probenazole water dispersible granules | 12000 times | 89.76 | 95.22 |
| 21% ZJ0712 probenazole suspending agent | 1800 times | 88.32 | 93.23 |
| 40% probenazole wetting powder | 1200 times | 50.13 | 62.14 |
| 10% ZJ0712 suspending agent | 5000 times | 68.51 | 71.64 |
Can be found out that by table 2 can effectively prevent and treat apple mildew after ZJ0712 and probenazole are composite, control efficiency all is superior to contrasting medicament, the lasting period is long.In the test scope of medication, the target crop is had no adverse effects, and apple anthracnose, ring spot are had preventive effect preferably.
Practice example four: ZJ0712 and probenazole and the composite control grape grey mould test of pesticide effectiveness thereof
This EE is in suburb, Ningxia Province Yinchuan City, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 40% probenazole wetting powder (commercial), 10% ZJ0712 suspending agent (commercial).
The investigation grape grey mould state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated the downy mildew of garpe disease index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 3 ZJ0712, probenazole and the composite control grape grey mould test of pesticide effectiveness thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 45% ZJ0712 probenazole wetting powder | 6000 times | 89.36 | 96.05 | 95.57 |
| 75% ZJ0712 probenazole water dispersible granules | 22000 times | 88.54 | 95.16 | 93.35 |
| 10% ZJ0712 probenazole suspending agent | 1800 times | 90.36 | 96.07 | 94.13 |
| 40% probenazole wetting powder | 1000 times | 56.25 | 62.30 | 60.38 |
| 10% ZJ0712 suspending agent | 5000 times | 75.36 | 82.42 | 81.42 |
Can find out by table 3, ability effectively preventing downy mildew of garpe after ZJ0712 and probenazole are composite, control efficiency all is superior to contrasting medicament, and dosage is little, and the lasting period is long.In the test scope of medication, the target crop there is not harm.
Practice example five: ZJ0712, probenazole and the composite control cucumber anthracnose test of pesticide effectiveness thereof
This EE is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 40% probenazole wetting powder (commercial), 10% ZJ0712 suspending agent (commercial).
Investigation cucumber anthracnose state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 4 ZJ0712, probenazole and the composite control cucumber anthracnose test of pesticide effectiveness thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the second time | 14 days preventive effects (%) behind the medicine for the second time |
| 60% ZJ0712 probenazole wetting powder | 8 gram/mus | 89.72 | 96.08 |
| 80% ZJ0712 probenazole water dispersible granules | 7 gram/mus | 90.16 | 93.32 |
| 30% ZJ0712 probenazole suspending agent | 20 gram/mus | 89.30 | 95.59 |
| 40% probenazole wetting powder | 50 gram/mus | 53.44 | 66.34 |
| 10% ZJ0712 suspending agent | 10 gram/mus | 80.28 | 85.45 |
Can find out that by table 4 can effectively prevent and treat cucumber anthracnose after ZJ0712 and probenazole are composite and take place, control efficiency all is superior to contrasting medicament, in this test scope of medication, the target crop is had no adverse effects.
Practice example six: ZJ0712 and probenazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This EE is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 40% probenazole wetting powder (commercial), 10% ZJ0712 suspending agent (commercial).
In the dispenser of pear tree their early stage, dispenser in per 7 days once, altogether dispenser is 3 times, investigation disease index before the dispenser was investigated disease index respectively in 7 days, 15 days, 30 days after the dispenser for the third time, and the calculation correction preventive effect, result of the test is following:
Table 5 ZJ0712 and probenazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 15 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 35% ZJ0712 probenazole wetting powder | 6500 times | 89.62 | 94.78 | 94.17 |
| 65% ZJ0712 probenazole water dispersible granules | 10000 times | 90.16 | 95.64 | 94.35 |
| 50% ZJ0712 probenazole suspending agent | 8000 times | 89.52 | 95.57 | 94.13 |
| 40% probenazole wetting powder | 1500 times | 63.34 | 72.13 | 68.38 |
| 10% ZJ0712 suspending agent | 6000 times | 79.75 | 83.06 | 81.42 |
Can find out by table 5, ZJ0712, probenazole ability effectively preventing pear scab, control efficiency all is superior to contrasting medicament, and dosage is little, in the test scope of medication, the target crop is not had harm.
Claims (3)
1. bactericidal composition that contains ZJ0712 and probenazole, the weight ratio that it is characterized in that bactericidal composition effective active composition ZJ0712 and probenazole is 1: 1～1: 30.
2. the bactericidal composition that contains ZJ0712 and probenazole according to claim 1 is characterized in that: bactericidal composition is processed wetting powder, water dispersible granules or suspending agent.
3. the bactericidal composition that contains ZJ0712 and probenazole according to claim 1 is used to prevent and treat the purposes of vegetables and fruit tree, and described disease is powdery mildew, gray mold, anthracnose, scab.
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