CN101700029B - Bactericidal composition containing SYP-7017 and carbendazim - Google Patents

Abstract

The invention discloses a bactericidal composition containing SYP-7017 and carbendazim, which consists of SYP-7017 and carbendazim, has high bactericidal activity and can retard the generation and the development of drug resistance of pathogens, reduce the overall dosage on unit area and further realize the purposes of economy, high efficiency and environmental protection. The bactericidal composition has high effects of preventing and treating the plant fungal diseases, and the two medicaments have significant synergy; the bactericidal composition can replace part of high-price pesticides for use, reduce the dosage, effectively reduce the ecological damage and the environmental pollution and improve the yield and the quality of crops; the SYP-7017 and the carbendazim in the bactericidal composition have low toxicity and are safe to people and animals, beneficial organisms and environmental safety; and the bactericidal composition can retard the drug resistance of the bacteria to the single medicament.

Description

A kind of bactericidal composition containing chlorpyrexate and carbendazim

technical field

The invention relates to the field of agricultural fungicides, in particular to a fungicidal composition containing clostristrobin and carbendazim.

Background technique

Chinese invention patent application (CN1814590A) and PCT patent application (WO2006081759A1) disclose a new class of compounds with fungicidal activity, wherein the No. 13 compound is shown in structural formula I:

The Chinese common name of the compound of formula I is chlorazoxystrobin, chemical name: N-methoxy-N-[2-[[(3,5,6-trichloropyridin-2-yl)oxy]methyl]benzene Base] methyl carbamate is an efficient broad-spectrum fungicide. For wheat, cucumber powdery mildew, rice blast, rice false smut, rice sheath blight, rice bakanae disease, wheat sheath blight, wheat head blight, wheat root rot, corn big and small spot, rape fungus Sclerotinia, tomato gray mold, apple rot, melon anthracnose, cucumber wilt, cotton verticillium wilt, cotton wilt and other pathogens have high antibacterial activity. The main mechanism of action is to affect the synthesis of melanin.

Carbendazim has the following structural formula:

Chemical name: Methyl N-benzimidazol-2-ylcarbamate, which is a common crop fungal disease control agent in China. The main mechanism of action is to interfere with the formation of spindles in cell mitosis. Plant diseases caused by most of the fungi such as Septoria, Sclerotinia, Verticillium and Rhizoctonia have certain control effects.

Clostristrobin is a methoxyacrylate compound, and carbendazim is a carbamate compound. The mechanism of action of the two is single. If used alone for a long time, the fungus will develop resistance and the control effect will decrease.

Contents of the invention

The invention provides a bactericidal composition containing chlorpyrastrobin and carbendazim, which has high bactericidal activity, delays the occurrence and development of drug resistance of pathogens, and reduces the total dosage per unit area, thereby realizing economical and high efficiency , The purpose of environmental protection.

Technical scheme of the present invention is:

A kind of bactericidal composition containing chlorpyrexate and carbendazim, it is characterized in that: described bactericidal composition is made up of cloxafin and carbendazim; The mass ratio is 1:0.5-50.

The bactericidal composition containing chlorpyrexate and carbendazim is characterized in that: the bactericidal composition is prepared as a water suspension, an oil suspension, a hot mist, a suspoemulsion, or as a main raw material component. Wet powder, granule, water dispersible granule, effervescent tablet, granule or microcapsule suspension.

The bactericidal composition containing chlorpyrexate and carbendazim is characterized in that: the bactericidal composition is used to prevent and treat fungal diseases of crops.

The bactericidal composition containing chlorampacillin and carbendazim is characterized in that the mass ratio of the chlorazstrobin and carbendazim is 1: (1-36).

The bactericidal composition containing chlorampacillin and carbendazim is characterized in that the mass ratio of the chlorazstrobin and carbendazim is 1: (4-21).

The bactericidal composition containing chlorazstrobin and carbendazim is characterized in that the mass ratio of the chlorazstrobin and carbendazim is 1: (6-13.5).

The present invention combines two types of fungicides with different mechanisms of action, i.e., the methoxyacrylate fungicide Chloroprexate and the carbendazim fungicide with good systemic conductivity, and processes them into a product that is easy to use in production. The formulation reduces the risk of pathogenic fungi developing resistance to a single fungicide, reduces costs, and prolongs the service life of each component in the fungicide composition.

Chloroprexstrobin described in the present invention belongs to methoxyacrylate fungicides, with novel structure and unique mode of action; carbendazim is a carbamate fungicide, which mainly interferes with mitosis; the combination of the two has the advantages in actual use. The bactericidal activity is high, and the two types of agents have different structural types and different mechanisms of action. The combination of the two can delay the emergence and development of pathogen drug resistance to a greater extent, and reduce the total dosage per unit area, thereby Realize the invention goal of economy, high efficiency and environmental protection.

Significant effect and advantage of the present invention are:

The present invention has a higher control effect on fungal diseases of crops, and there is an obvious synergistic effect between the two components; it can replace some high-priced pesticide varieties, reduce the dosage of pesticides, effectively reduce ecological damage and environmental pollution, and can improve the quality of crops. Yield and quality: Chloroprexstrobin and carbendazim in the present invention are all of low toxicity, and are safe to humans, animals, beneficial organisms, and the environment; they can delay the resistance of germs to a single agent.

Detailed ways

First measure the EC ₅₀ (biological efficacy and safety index of the drug on the target) of two single compounds (hereinafter referred to as the drug) of cclostrobin and carbendazim, and set the combination of the two drugs according to the Horsfall method according to the EC ₅₀ of the two single drugs Proportion, and according to the Horsfall synergy coefficient C value, determine the appropriate composition ratio, and then verify it according to Sun Yunpei's method.

The test object is strawberry powdery mildew, but not limited thereto. The test adopts leaf disc moisturizing and green keeping method. Each treatment was repeated 4 times, and each treatment was quantitatively sprayed with 2mL of the potter tower, and after the sedimentation treatment, it was taken out and dried naturally, and the strawberry powdery mildew pathogenic conidia powder was inoculated 24 hours after the treatment, and the inoculated strawberry leaf dish was moved to the incubator (22°C, 10000LUX light for 16h and 18°C for 8h in darkness alternately, relative humidity kept at 75-85%), 10 days after inoculation, investigate the control effect. Through the linear regression analysis between the probability value of the control effect and the logarithmic value of the serial drug concentration, the EC ₅₀ of each drug was obtained, and the Horsfall synergy coefficient C and Sun Yunpei CTC value were calculated. The calculation method of C value and CTC value is as follows:

Assuming that a and b are the actual bacteriostatic rate of the two agents A and B at the _EC50 dose, if the proportions of A and B in the composition are pA and pB respectively, then:

Expected antibacterial rate (p) = a·pA+b·pB

Synergistic coefficient (C) = actual bacteriostatic rate (P) / expected bacteriostatic rate (p)

Horsfall believes that: when C>1, synergism, when C<1, antagonism, and Horsfall believes that the greater the C value, the greater the synergy of the compound.

CTC＝100·(1/composition EC ₅₀ )/∑(single drug content/corresponding drug EC ₅₀ )

Sun Yunpei believes that: CTC>120 is a synergistic effect; CTC<80 is an antagonistic effect; between them is an additive effect.

Table 1. The Horsfall determination result of the composition of Chloroprexstrobin and Carbendazim to Strawberry Powdery Mildew

From the above data, it can be analyzed that the control effects of different ratios of cclostrobin and carbendazim compositions on strawberry powdery mildew are different. On the whole, the ratios have increased in the range of 1:1 to 1:36. effect, the maximum synergistic ratio is 1:9,

CTC determination results of epiclostrobin and carbendazim composition against strawberry powdery mildew

In order to be further verified, the toxicity of the 1:9 composition of cloxacillin and carbendazim to strawberry powdery mildew was measured by Sun Yunpei's method, and the results are listed in Table 2. As can be seen from Table 2, the synergistic effect is extremely significant , the CTC value reaches 176.9, which is consistent with the results obtained by the above determination method.

The superiority of this composition that the field control effect of table three and following examples further illustrates:

Table 3. Field efficacy of 35% chlorazstrobin · carbendazim suspension concentrate (1:9) in controlling several diseases*

*See the following examples for the field control effects of other diseases.

The present invention will be further described below in conjunction with the examples, but not limited thereto.

Example 1

Add 5g of Chloroprexate, 45g of Carbendazim, 8g of Sodium Lignosulfonate, 4g of Diffusion Agent Sodium Methylenebis-Naphthalenesulfonate, and white carbon black to 100g, and mix them. powder. 80-100g of the wettable powder per mu is used to prevent and control strawberry powdery mildew, and the control effect can reach 97.53%, which is higher than the conventional dosage of triazole fungicides triadimefon, propiconazole, difenoconazole and kresoxim-methyl .

Example 2

Chloroprexate 3.5g, carbendazim 31.5g, sodium lignosulfonate 5g, fatty alcohol polyoxyethyl ether 2g, phenylethylphenol formaldehyde resin polyoxyethylene ether 3g, antifreeze urea 6g, anti-settling Add 0.1 g of xanthan gum, add an appropriate amount of water to 100 g, mix, wet sand mill, and homogenize to obtain a water suspension. 100g of this water suspension per mu is used to prevent and treat strawberry powdery mildew, and the control effect can reach 94.67%, which is higher than the conventional dosage of triazole fungicides triadimefon, propiconazole, difenoconazole and kresoxim-methyl. And can overcome the phytotoxicity problem of triazole fungicides. 100-120g per mu is used to control 81% of rice false smut, which is equivalent to propiconazole, and the control effect on rice sheath blight and rice blast is over 93.33%, which is better than the conventional dosage of Jinggangmycin and tricyclazole . The effect of dressing or soaking seeds according to 0.2-0.3% of the seed quantity to prevent and control rice bakanae disease can reach more than 90%.

Example 3

Add 6g of Chloroprexate, 54g of Carbendazim, 5g of Fatty Alcohol Polyoxyethyl Ether, 3g of Nonylphenol Polyoxyethylene Ether, 1.2g of Starch, 2g of Sodium Bicarbonate, 10g of Bentonite, and Kaolin to 100g, mix and airflow Granulate after pulverization to obtain water-dispersible granules. The water dispersible granule is 75-80g per mu, and it is used to prevent and control wheat powdery mildew and scab, and the control effect can reach 87.67%, which is better than the constant control effect of carbendazim and triadimefon; it is used to prevent and control grape black pox Disease effect can reach more than 90%. The effect of preventing and controlling watermelon blight is more than 85%.

Example 4

Chloroprexate 4g, carbendazim 34g, polyoxyethylene sorbitan oleate 6g, lignosulfonate 2g, polyalkoxylated alcohol 6g, fatty alcohol polyoxyethylene ether 5g, polydimethylsiloxane Oxane 0.05g, rapeseed oil or salad oil to 100g, mixed and wet pulverized by a sand mill to obtain an oil suspension. The oil is suspended, and when used as a hot fog agent, use 100g per mu to 50g of diesel or salad oil (used as a fuming agent) to prevent and treat corn spot disease, strawberry powdery mildew, and anthracnose with a hot fog machine; or use conventional medical equipment for water Spraying prevents corn spot disease and rust, and the control effect is more than 91.8%.

Example 5

Mix and airflow crush 5g of cloclostrobin, 20g of carbendazim, 6g of sodium lauryl sulfate, 9g of pull-off powder, 6g of sodium benzoate, and 15g of bentonite to pass through a 400-mesh sieve, and pass through a 80-mesh sieve after drying and crushing. 20g of citric acid and 20g of potassium carbonate are mixed and compressed into tablets in a tablet machine to obtain 25% effervescent tablets. The effervescent tablet can be automatically disintegrated in water to form a uniform suspension, and the effect of preventing and treating rape sclerotinia and pear anthracnose by spraying with 100-150 g of the effervescent tablet per mu can reach more than 87%.

Claims (5)

1. a bactericidal composition containing chlorpyrexate and carbendazim, is characterized in that: described bactericidal composition is to contain chloropyrexate and carbendazim; The mass ratio is 1:1-36. 2. a kind of bactericidal composition containing chlorpyrexate and carbendazim according to claim 1, is characterized in that: described bactericidal composition is prepared into water suspension, oil suspension, Wettable powder, water dispersible granule, effervescent tablet. 3. The fungicidal composition containing chlorpyrexate and carbendazim according to claim 1, characterized in that: said fungicidal composition is used for preventing and treating fungal diseases of crops. 4 . The bactericidal composition containing chlorazstrobin and carbendazim according to claim 1 , characterized in that: the mass ratio of the chlorazstrobin and carbendazim is 1:4-21. 5 . The bactericidal composition containing chlorazstrobin and carbendazim according to claim 1 , characterized in that: the mass ratio of the chlorazstrobin and carbendazim is 1:6-13.5.