CN101695550A - Pure Chinese medicinal preparation for adjuvant therapy of enteritis type canine parvovirus disease and preparation method thereof - Google Patents
Pure Chinese medicinal preparation for adjuvant therapy of enteritis type canine parvovirus disease and preparation method thereof Download PDFInfo
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- CN101695550A CN101695550A CN200910233588A CN200910233588A CN101695550A CN 101695550 A CN101695550 A CN 101695550A CN 200910233588 A CN200910233588 A CN 200910233588A CN 200910233588 A CN200910233588 A CN 200910233588A CN 101695550 A CN101695550 A CN 101695550A
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Abstract
The invention relates to a pure Chinese medicinal preparation for the adjuvant therapy of enteritis type canine parvovirus disease and a preparation method thereof. The preparation is characterized in that the preparation is prepared by mixing the following components in part by weight: 20 to 24 parts of cholla stem, 15 to 20 parts of red-knees herb, 8 to 12 parts of lightyellow sophora root, 10 to 15 parts of sturnus roseus, 8 to 12 parts of medicine terminalia fruit, 6 to 10 parts of indigowoad root, and 6 to 10 parts of common lophatherum herb. The preparation method thereof comprises the steps of: (1) weighing various components in a formula, performing the first water extraction on the mixture (the adding amount of water is 10 times the original weight of the formula, and the extraction time is 2 hours), and filtering the obtained solution to obtain a water extraction solution for later use; (2) performing secondary water extraction on residue in the step (1) (the adding amount of the water is 5 times the original weight of the formula, and the extraction time is 1 hour), and filtering the obtained solution to obtain a water extraction solution; and (3) merging the water extraction solutions, and concentrating the merged water extraction solution to the original weight of the formula. The pure Chinese medicinal preparation has the advantages of steady drug effect, remarkable therapeutic effect, low cost and convenient preparation.
Description
Technical field
The present invention relates to a kind of pure Chinese medicinal preparation and technology of preparing thereof that is used for the canine viral disease auxiliary treatment, a kind of specifically pure Chinese medicinal preparation that is used for adjuvant therapy of enteritis type canine parvovirus disease and preparation method thereof.
Background technology
Canine parvovirus disease is a kind of infectious disease with height contact that is caused by Canine parvovirus infection, and infectiousness is strong, and the mortality rate height is greatly threatening the life and health of dog class.The Canine Parvovirus resistance of factor to external world is stronger, can survive 1 hour in 60 ℃ of environment, virus still has infectivity in the environment of the inclined to one side alkali of meta-acid, and the virus on feces and solid pollutant can be survived the several months to the several years, and can keep infectious under cryogenic conditions for a long time.The age that is regardless of dog of canine parvovirus disease, kind, its infection rate can be up to 100%, and fatality rate can reach 10%～50%.Often prevent this disease clinically, yet the situation of immuning failure happens occasionally by the mode of vaccine immunity.This disease can be divided into enteritis type and myocarditis type clinically, and is the most common with enteritis type.When the viral infection of enteritis type takes place when, be hyper-immune serum or the injection of rehabilitation dog serum except taking specific treatment clinically, often cooperate some complementary therapies, as antibiotic, antiinflammatory, fluid infusion, heart tonifying, emesis, antidiarrheal, hemostasis.The morbidity of the enteritis type parvovirus infection of dog promptly began diarrhoea in about one day, caused serious situations such as endotoxicosis and disseminated inravascular coagulation, shock along with the development of the state of an illness very easily causes body serious dehydration, intestinal contents corruption.Therefore, scientifically solve the vital task that the antidiarrheal link is this disease of treatment targetedly.At present, what be used on the market that the auxiliary treatment canine parvovirus disease causes diarrhoea, dysentery mostly is antibiotic or chemosynthesis class medicine etc., and pure Chinese medicinal preparation evident in efficacy is considerably less.
Summary of the invention
At above-mentioned present situation, the invention provides safe, pure Chinese medicinal preparation and preparation method thereof efficiently of a kind of auxiliary treatment enteritis canine parvovirus, said preparation can fast, effectively be controlled the symptom of diarrhea that enteritis canine parvovirus causes.
The present invention is achieved by the following scheme:
A kind of pure Chinese medicinal preparation that is used for the canine parvovirus disease auxiliary treatment is made up of Radix et Caulis Opuntiae Dillenii, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, the Radix Pulsatillae, Fructus Chebulae, Radix Isatidis, Herba Lophatheri 7 flavor Chinese herbal medicine, and prescription weight proportion scope is: 20～24 parts of Radix et Caulis Opuntiae Dilleniis, 15～20 parts of Herba polygoni hydropiperis, 8～12 parts of Radix Sophorae Flavescentiss, 10～15 parts of the Radix Pulsatillaes, 8～12 parts of Fructus Chebulaes, 6～10 parts of Radix Isatidis, 6～10 parts of Herba Lophatheris.The weight proportion commonly used of each medical material of prescription is: 22 parts of Radix et Caulis Opuntiae Dilleniis, 17.5 parts of Herba polygoni hydropiperis, 10 parts of Radix Sophorae Flavescentiss, 12.5 parts of the Radix Pulsatillaes, 10 parts of Fructus Chebulaes, 8 parts of Radix Isatidis, 8 parts of Herba Lophatheris.
The pharmacology situation of each medical material is in the prescription of the present invention: (1) Radix et Caulis Opuntiae Dillenii: bitter in the mouth, cool in nature, be rich in compositions such as alkaloid, flavonoid such as flavonol, sterols such as sitosterol and oils and fats, protein, polysaccharide, trace element, have heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, benefiting stomach and stopping pain, antitussive effect, be used for stomach, duodenal ulcer, acute dysentery, cough, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald etc.; (2) Herba polygoni hydropiperis: acrid in the mouth, warm in nature, main component is polygodial, confertifolin, polygonone, persicarin etc., has expelling wind and removing dampness, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching effect.Be usually used in dysentery, gastroenteritis, diarrhoea clinically, rheumatic arthritis, treating swelling and pain by traumatic injury, dysfunctional uterine hemorrhage; Venom is controlled in external, skin eczema; (3) Radix Sophorae Flavescentis: cold in nature, bitter in the mouth, be rich in matrine, oxymatrine, sophor-anol, N-Methylcytisine etc., have the merit of heat clearing and damp drying, parasite killing diuresis, be used for hematodiarrhoea clinically, have blood in stool, jaundice urine retention, eczema, eczema, skin pruritus, scabies leprosy etc.; (4) Radix Pulsatillae: contain compositions such as Anemonin, triterpenoid saponin, have heat-clearing and toxic substances removing, cool the blood dissipate blood stasis effect, and can press down and kill staphylococcus aureus, bacillus pyocyaneus, Bacillus typhi and virus, fungus etc., and effects such as heart tonifying diuresis, hepatoprotective are arranged; (5) Fructus Chebulae: bitter, acid, puckery, property is put down, contain a large amount of tannins, main component is chebulinic acid, terchebin etc., have convergence, anti-diarrhea effect, Fructus Chebulae's water decoction except that to various dysentery bacteriums effectively, and stronger to bacillus pyocyaneus, diphtheria corynebacterium effect, staphylococcus aureus, escherichia coli, streptococcus pneumoniae, Hemolytic streptococcus, Bacillus proteus, bacillus typhi murium are all had inhibitory action; (6) Radix Isatidis: bitter, cold, be rich in the Isatis indigotica Fort. root and contain compositions such as indigo, indirubin, cupreol, Palmic acid, uridnine, hypoxanthine, uracil, qingdainone and daucosterol, have the merit of heat-clearing and toxic substances removing, removing heat from blood detumescence, cure mainly the card of multiple pestilence pyretic toxicity; (7) Herba Lophatheri: sweet in the mouth, light, cold in nature, contain triterpenes and steroid class material such as arundoin, Bai Maosu, freidelin, cupreol, stigmasterol, campesterol etc., have analgesic, diuresis, effect such as antibacterial, cure mainly that calentura is thirsty, vexed, hot urination, stranguria with turbid discharge, erosion of the oral mucosa tongue boil etc.
The preparation method of pure Chinese medicinal preparation of the present invention is: (1) takes by weighing each medical material by the prescription weight proportion, carries out first water and carries, and amount of water is 10 times of the former weight of prescription, and extraction time is 2 hours, filters, and makes the water extract, and is standby; (2) residue of step (1) is carried out secondary water and carry, amount of water is 5 times of the former weight of prescription, and extraction time is 1 hour, filters, and makes the water extract; (3) merge twice water extract, and be concentrated into the former weight of prescription etc. weight.
Pure Chinese medicinal preparation of the present invention has the following advantages: (1) pure Chinese medicinal preparation, and the property of medicine is gentle, to the intestinal mucosa nonirritant; (2) alleviate the dysentery symptom that parvovirus infections causes fast, repair intestinal mucosa; (3) oral administration, consumption is little, per kilogram of body weight medication 0.2ml, the following consumption of 5kg is not less than 1ml, and 2 times on the one, logotype 3 days; (4) efficacy stability, effect is lasting.
The specific embodiment
Below be embodiments of the invention, the actual use of the present invention is not limited to embodiment.
Embodiment one:
Adopt preparation method of the present invention to prepare said preparation, according to the weight proportion of crude drug Radix et Caulis Opuntiae Dillenii, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, the Radix Pulsatillae, Fructus Chebulae, Radix Isatidis, Herba Lophatheri 22: 17.5: 10: 12.5: 10: 8: 8 took by weighing each crude drug 22kg altogether, to carry amount of water be 220kg to water first, extraction time is 2 hours, filter, make the water extract; Add 110kg water once more and carry out secondary water and carry, extraction time is 1 hour, filters, and makes the water extract; Merge the water extract twice, be concentrated into 22kg, can obtain said preparation.
The pure Chinese medicinal preparation that will prepare by this mode, in in May, 2009 in Jingxi district, Beijing pet clinic, 60 pups, 13 adult dogs of testing the enteritis canine parvovirus of tests positive through colloidal gold strip are carried out partner treatment, according to per kilogram of body weight medication 0.2ml (the following consumption of 5kg is not less than 1ml), 2 times on the one, logotype 3 days, cure rate has reached 95.89%.
Embodiment two:
Adopt preparation method of the present invention to prepare said preparation, according to the weight proportion of crude drug Radix et Caulis Opuntiae Dillenii, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, the Radix Pulsatillae, Fructus Chebulae, Radix Isatidis, Herba Lophatheri 20: 15: 8: 10: 8: 6: 6 took by weighing each crude drug 30kg altogether, to carry amount of water be 300kg to water first, extraction time is 2 hours, filter, make the water extract; Add 150kg water once more and carry out secondary water and carry, extraction time is 1 hour, filters, and makes the water extract; Merge the water extract twice, be concentrated into 30kg, can obtain said preparation.
The pure Chinese medicinal preparation that will prepare by this mode, in in March, 2009 in the Nanjing, ground such as Wujin, Changzhou and Beijing amount to 8 tame pet clinics and have carried out clinical trial, amount to 131 sick dogs and carried out partner treatment suffering from enteritis canine parvovirus, gavage according to per kilogram of body weight 0.2ml (the following consumption of 5kg is not less than 1ml), carry out for 2 times on the one, wherein 96 examples the 2nd day dysentery symptom after medication promptly obviously alleviates, feces recovered normal substantially in the 3rd day, other has 27 sick dogs to occur being clearly better after 3 days in medication, and overall data shows, sick dog uses more early that the said preparation effect is unreasonable to be thought.
Embodiment three:
Adopt preparation method of the present invention to prepare said preparation, according to the weight proportion of crude drug Radix et Caulis Opuntiae Dillenii, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, the Radix Pulsatillae, Fructus Chebulae, Radix Isatidis, Herba Lophatheri 24: 20: 12: 15: 12: 10: 10 took by weighing each crude drug 50kg altogether, to carry amount of water be 500kg to water first, extraction time is 2 hours, filter, make the water extract; Add 250kg water once more and carry out secondary water and carry, extraction time is 1 hour, filters, and makes the water extract; Merge the water extract twice, be concentrated into 50kg, can obtain said preparation.
The pure Chinese medicinal preparation that will prepare by this mode, in in August, 2009 in the Nanjing, raise in and ground such as Changchun, Jilin amount to 13 tame pet clinics and carried out clinical trial, amount to 185 routine sick dogs and treat suffering from enteritis canine parvovirus, gavage according to per kilogram of body weight 0.2ml (the following consumption of 5kg is not less than 1ml), carry out for 2 times on the one, cooperate fluid infusion, antiinflammatory, emesis therapy simultaneously.Through statistics, 171 routine favourable prognosises are arranged, effective percentage has reached 92.43%.
Clinical trial certificate repeatedly, pure Chinese medicinal preparation of the present invention has comparatively ideal adjuvant treatment effect to enteritis canine parvovirus.
Claims (3)
1. a pure Chinese medicinal preparation that is used for adjuvant therapy of enteritis type canine parvovirus disease is characterized in that being made through extracting, concentrating by Radix et Caulis Opuntiae Dillenii, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, the Radix Pulsatillae, Fructus Chebulae, Radix Isatidis, Herba Lophatheri 7 flavor Chinese herbal medicine.The weight proportion scope of each crude drug is: 20～24 parts of Radix et Caulis Opuntiae Dilleniis, 15～20 parts of Herba polygoni hydropiperis, 8～12 parts of Radix Sophorae Flavescentiss, 10～15 parts of the Radix Pulsatillaes, 8～12 parts of Fructus Chebulaes, 6～10 parts of Radix Isatidis, 6～10 parts of Herba Lophatheris.
2. a kind of pure Chinese medicinal preparation that is used for adjuvant therapy of enteritis type canine parvovirus disease according to claim 1 is characterized in that crude drug optimization weight proportion is: 22 parts of Radix et Caulis Opuntiae Dilleniis, 17.5 parts of Herba polygoni hydropiperis, 10 parts of Radix Sophorae Flavescentiss, 12.5 parts of the Radix Pulsatillaes, 10 parts of Fructus Chebulaes, 8 parts of Radix Isatidis, 8 parts of Herba Lophatheris.
3. a kind of preparation method that is used for the pure Chinese medicinal preparation of adjuvant therapy of enteritis type canine parvovirus disease according to claim 1 and 2 is characterized in that carrying out as follows:
(1) Radix et Caulis Opuntiae Dillenii, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, the Radix Pulsatillae, Fructus Chebulae, Radix Isatidis, Herba Lophatheri are taken by weighing by the prescription weight proportion, carry out first water and carry, amount of water is 10 times of the former weight of prescription, and extraction time is 2 hours, filters, and makes the water extract, and is standby;
(2) residue of step (1) is carried out secondary water and carry, amount of water is 5 times of the former weight of prescription, and extraction time is 1 hour, filters, and makes the water extract;
(3) merge twice water extract, and be concentrated into the former weight of prescription etc. weight.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910233588A CN101695550A (en) | 2009-10-29 | 2009-10-29 | Pure Chinese medicinal preparation for adjuvant therapy of enteritis type canine parvovirus disease and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356833A (en) * | 2013-06-28 | 2013-10-23 | 镇江天和生物技术有限公司 | Compound preparation used for controlling nutritional diarrhea of weaned piglet |
| JP2021512880A (en) * | 2018-01-31 | 2021-05-20 | スーチュワン インル ウェイトー ファーマスーティカル テクノロジー カンパニー リミテッド | Use of Bulbul extract in the manufacture of drugs to treat viral and / or bacterial diseases |
-
2009
- 2009-10-29 CN CN200910233588A patent/CN101695550A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356833A (en) * | 2013-06-28 | 2013-10-23 | 镇江天和生物技术有限公司 | Compound preparation used for controlling nutritional diarrhea of weaned piglet |
| JP2021512880A (en) * | 2018-01-31 | 2021-05-20 | スーチュワン インル ウェイトー ファーマスーティカル テクノロジー カンパニー リミテッド | Use of Bulbul extract in the manufacture of drugs to treat viral and / or bacterial diseases |
| JP7021360B2 (en) | 2018-01-31 | 2022-02-16 | スーチュワン インル ウェイトー ファーマスーティカル テクノロジー カンパニー リミテッド | Use of light-vented bulbul extract in the manufacture of drugs to treat viral and / or bacterial diseases |
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Open date: 20100421 |