CN101647567B - Ganoderma lucidum liquid preparation and preparation method thereof - Google Patents
Ganoderma lucidum liquid preparation and preparation method thereof Download PDFInfo
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- CN101647567B CN101647567B CN200910187203A CN200910187203A CN101647567B CN 101647567 B CN101647567 B CN 101647567B CN 200910187203 A CN200910187203 A CN 200910187203A CN 200910187203 A CN200910187203 A CN 200910187203A CN 101647567 B CN101647567 B CN 101647567B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 48
- 240000008397 Ganoderma lucidum Species 0.000 title claims abstract description 34
- 235000001637 Ganoderma lucidum Nutrition 0.000 title claims abstract description 34
- 239000007788 liquid Substances 0.000 title claims abstract description 32
- 239000000284 extract Substances 0.000 claims abstract description 17
- 241000222336 Ganoderma Species 0.000 claims description 34
- 230000015572 biosynthetic process Effects 0.000 claims description 16
- 239000007787 solid Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000006228 supernatant Substances 0.000 claims description 14
- 238000000605 extraction Methods 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 9
- 238000002137 ultrasound extraction Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 238000002604 ultrasonography Methods 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 235000015097 nutrients Nutrition 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 4
- 206010006458 Bronchitis chronic Diseases 0.000 abstract description 2
- 206010019799 Hepatitis viral Diseases 0.000 abstract description 2
- 230000001154 acute effect Effects 0.000 abstract description 2
- 206010003119 arrhythmia Diseases 0.000 abstract description 2
- 230000006793 arrhythmia Effects 0.000 abstract description 2
- 208000006673 asthma Diseases 0.000 abstract description 2
- 206010006451 bronchitis Diseases 0.000 abstract description 2
- 208000007451 chronic bronchitis Diseases 0.000 abstract description 2
- 208000029078 coronary artery disease Diseases 0.000 abstract description 2
- 230000006378 damage Effects 0.000 abstract description 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 2
- 201000002364 leukopenia Diseases 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 201000001862 viral hepatitis Diseases 0.000 abstract description 2
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 235000021049 nutrient content Nutrition 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention provides a nutrient health-care product and a preparation method thereof, in particular to a liquid preparation form nutrient solution which uses natural wild ganoderma lucidum extract as the raw material and a preparation method thereof. The ganoderma lucidum liquid is prepared mainly from the wild ganoderma lucidum as the raw material, and aims to solve the problems that the prior ganoderma lucidum processing and application methods cause the waste and damage of most nutrient content of the ganoderma lucidum or products prepared by the prior process can not be fully utilized by human bodies, and the like. The ganoderma lucidum liquid preparation has obvious effect on improving the symptoms of chronic bronchitis, bronchial asthma, leucopenia, coronary disease, arrhythmia, acute viral hepatitis, panasthenia, diabetes and the like.
Description
One, technical field
The present invention relates to a kind of nutrient and healthcare products and preparation method thereof, especially refer to a kind of liquid formulation nutrient solution that natural Wild ganoderma extract makes for raw material and preparation method thereof that utilizes.
Two, background technology
People know that glossy ganoderma is the rarity in China's medical treatment treasure-house, the treasure that the mankind dream of.Since ancient times, glossy ganoderma is regarded as come back to life, prolong life not old " the celestial grass in the human world " by compatriots always, enjoys the good reputation of " kings of ten thousand medicines ".Thereafter the popular legend glossy ganoderma have come back to life, effect alive for evermore.Chinese tradition medical science is regarded as strengthening by means of tonics for a long time always, consolidate set upright, tonifying middle-Jiao and Qi, the precious health products of promoting longevity.Pharmacology and clinical research at all times all proves, the effect that glossy ganoderma truly has and prevents and cures diseases, promotes longevity.Now, glossy ganoderma is formally recorded by NF as medicine, and it is again the new resource food of state approval simultaneously, has no side effect, can medicine-food two-purpose.
The range of application of glossy ganoderma is very extensive.See with regard to differential diagnosis in tcm, because these article go into the five internal organs kidney help whole body QI of five ZANG-organs, so the no matter heart, lung, the dirty weakness of liver,spleen,kidney all can be obeyed it.Glossy ganoderma is cured the disease to plant and relates to each systems such as breathing, circulation, digestion, nerve, endocrine and motion; Contain inside and outside, woman, youngster, each section's disease of face.Its basic reason just is that glossy ganoderma strengthens the body resistance to consolidate the constitution, raise immunity, the huge effect that improves Abwehrkraft des Koepers.It is different from general medicine and certain disease is played therapeutic action; Also being different from general nutritional health food only replenishes and strengthens the deficiency of nutrient in a certain respect; But bidirectional modulation function of human body balance is on the whole transferred the internal body vigor, regulates human body metabolism function; Improve the autoimmunity ability, impel whole internal organ or organ function normalization.Just because of it has these functions, many people blindly use, because improper use or contained ratio are improper, not only cause wastage of material, do not reach expected effect on the contrary, and also can influence healthy sometimes.
Three, summary of the invention
1, goal of the invention: the invention provides a kind of ganoderma lucidum liquid preparation and preparation method thereof; Its purpose is exactly to cause a large amount of nutrient loss of glossy ganoderma or destruction in order to solve existing glossy ganoderma processing and methods for using them, and human body such as can not make full use of at the problem that the aspect exists.
2, technical scheme: the present invention realizes through following technical scheme:
A kind of ganoderma lucidum liquid preparation, it is characterized in that it be following raw materials according by weight being prepared from: 1～5 part of glossy ganoderma, 10～50 parts in water, wherein glossy ganoderma is a Wild ganoderma.
The preparation method of aforesaid ganoderma lucidum liquid preparation is characterized in that ganoderma lucidum liquid preparation prepares as follows:
(1) get 1～5 part of glossy ganoderma, clean up, pulverize, and to add parts by weight are water low temperature ultrasonic Extraction 2～4 times of 10～50 parts that temperature is 30 ℃～60 ℃, supersonic frequency is 18～21kHz, and ultrasound intensity is 400～1200W, each 20～60 minutes; Residue solid formation after extract and the extraction gives over to subsequent use;
(2) adopt the boiling machine HTHP to extract the residue solid formation in (1), temperature is 100 ℃～140 ℃, and the time is 120～160 minutes, and pressure is 0.1～0.36MPa; Carry out centrifugal treating then, rotating speed is 1500～3000r/min, continues 20～40 minutes, and the supernatant of getting after centrifugal is subsequent use;
(3) supernatant in extract and the step (2) in (1) is merged, dosing, filtration, pack, sterilization obtains ganoderma lucidum liquid preparation.
A kind of preparation method of ganoderma lucidum liquid preparation as stated is characterized in that: will remain solid formation when adopting the extraction of boiling machine HTHP, the temperature preferred values of choosing is 120 ℃, and the time preferred values is 133 minutes.
3, advantage and effect:
The invention has the advantages that the bioactivator that in low temperature environment, extracts in the glossy ganoderma, can guarantee the activity of most materials; Ultrasonic degradation is cracking glossy ganoderma cell film effectively, and the bioactivator in the glossy ganoderma is discharged fully, has effectively improved the dissolution rate of effective component of glossy ganoderma.
Lucidum liquid of the present invention is taken twice every day; Sooner or later respectively once; One day one bag, take symptoms such as chronic bronchitis on the 15th～45, bronchial astehma, leukopenia, coronary heart disease, arrhythmia cordis, acute viral hepatitis, neurasthenia, diabetes and improve significantly.
Chinese medicine glossy ganoderma of the present invention---function cures mainly: antitoxic heart-soothing and sedative, strengthening the spleen and stomach.Be used to have a delicate constitution, invigorating qi for tranquilization, relieving cough and asthma; Dizzy egersis, palpitation, void chatter cough, liver protecting, increase body immunity.
Four, the specific embodiment:
Below in conjunction with embodiment the present invention is further elaborated, but protection scope of the present invention is not limit by embodiment.
Embodiment one
A kind of ganoderma lucidum liquid preparation is characterized in that it is by 5 portions of glossy ganodermas, and 50 parts of water are by weight composition.
The preparation method of ganoderma lucidum liquid preparation of the present invention is following:
(1) get 5 parts of glossy ganodermas, clean up, pulverize, and to add parts by weight are water low temperature ultrasonic Extraction 4 times of 50 parts that temperature is 40 ℃, supersonic frequency is 20kHz, and ultrasound intensity is 800W, each 60 minutes; Residue solid formation after extract and the extraction gives over to subsequent use;
(2) adopt the boiling machine HTHP to extract the residue solid formation in (1), temperature is 140 ℃, and the time is 160 minutes, and pressure is 0.36MPa; Carry out centrifugal treating then, rotating speed is 1800r/min, continues 30 minutes, and the supernatant of getting after centrifugal is subsequent use;
(3) supernatant in extract and the step (2) in (1) is merged, dosing, filtration, pack, sterilization obtains ganoderma lucidum liquid preparation.
Embodiment two
A kind of ganoderma lucidum liquid preparation is characterized in that it is by 2 portions of glossy ganodermas, and 20 parts of water are by weight composition.
The preparation method of ganoderma lucidum liquid preparation of the present invention is following:
(1) get 2 parts of glossy ganodermas, clean up, pulverize, and to add parts by weight are water low temperature ultrasonic Extraction 3 times of 20 parts that temperature is 50 ℃, supersonic frequency is 18kHz, and ultrasound intensity is 400W, each 40 minutes; Residue solid formation after extract and the extraction gives over to subsequent use;
(2) adopt the boiling machine HTHP to extract the residue solid formation in (1), temperature is 120 ℃, and the time is 133 minutes, and pressure is 0.20MPa; Carry out centrifugal treating then, rotating speed is 2500r/min, continues 25 minutes, and the supernatant of getting after centrifugal is subsequent use;
(3) supernatant in extract and the step (2) in (1) is merged, dosing, filtration, pack, sterilization obtains ganoderma lucidum liquid preparation.
Embodiment three
A kind of ganoderma lucidum liquid preparation is characterized in that it is by 4 portions of glossy ganodermas, and 40 parts of water are by weight composition.
The preparation method of ganoderma lucidum liquid preparation of the present invention is following:
(1) get 4 parts of glossy ganodermas, clean up, pulverize, and to add parts by weight are water low temperature ultrasonic Extraction 2 times of 40 parts that temperature is 35 ℃, supersonic frequency is 21kHz, and ultrasound intensity is 1200W, each 30 minutes; Residue solid formation after extract and the extraction gives over to subsequent use;
(2) adopt the boiling machine HTHP to extract the residue solid formation in (1), temperature is 130 ℃, and the time is 140 minutes, and pressure is 0.27MPa; Carry out centrifugal treating then, rotating speed is 1900r/min, continues 20 minutes, and the supernatant of getting after centrifugal is subsequent use;
(3) supernatant in extract and the step (2) in (1) is merged, dosing, filtration, pack, sterilization obtains ganoderma lucidum liquid preparation.
Embodiment four
A kind of ganoderma lucidum liquid preparation is characterized in that it is by 1 portion of glossy ganoderma, and 10 parts of water are by weight composition.
The preparation method of ganoderma lucidum liquid preparation of the present invention is following:
(1) get 1 part of glossy ganoderma, clean up, pulverize, and to add parts by weight are water low temperature ultrasonic Extraction 4 times of 10 parts that temperature is 45 ℃, supersonic frequency is 19kHz, and ultrasound intensity is 600W, each 20 minutes; Residue solid formation after extract and the extraction gives over to subsequent use;
(2) adopt the boiling machine HTHP to extract the residue solid formation in (1), temperature is 100 ℃, and the time is 120 minutes, and pressure is 0.1MPa; Carry out centrifugal treating then, rotating speed is 2300r/min, continues 35 minutes, and the supernatant of getting after centrifugal is subsequent use;
(3) supernatant in extract and the step (2) in (1) is merged, dosing, filtration, pack, sterilization obtains ganoderma lucidum liquid preparation.
Embodiment five
A kind of ganoderma lucidum liquid preparation is characterized in that it is by 3 portions of glossy ganodermas, and 30 parts of water are by weight composition.
The preparation method of ganoderma lucidum liquid preparation of the present invention is following:
(1) get 3 parts of glossy ganodermas, clean up, pulverize, and to add parts by weight are water low temperature ultrasonic Extraction 2 times of 30 parts that temperature is 55 ℃, supersonic frequency is 21kHz, and ultrasound intensity is 1000W, each 50 minutes; Residue solid formation after extract and the extraction gives over to subsequent use;
(2) adopt the boiling machine HTHP to extract the residue solid formation in (1), temperature is 110 ℃, and the time is 150 minutes, and pressure is 0.14MPa; Carry out centrifugal treating then, rotating speed is 2800r/min, continues 40 minutes, and the supernatant of getting after centrifugal is subsequent use;
(3) supernatant in extract and the step (2) in (1) is merged, dosing, filtration, pack, sterilization obtains ganoderma lucidum liquid preparation.
Compare with traditional handicraft, the present invention has carried out the HTHP extraction again on the basis of glossy ganoderma being carried out the low temperature ultrasonic Extraction, and the recovery rate of glossy ganoderma effective active composition is improved greatly, and active ingredient is fully kept.Owing to only adopt water extracting method, the preparation process is etching apparatus not, simultaneously the purer safety of Ganodenna Lucidum P.E.
Warp repeatedly contrast experiment proves that adopt ganoderma lucidum liquid preparation preparation method as stated, the average recovery rate of glossy ganoderma water-soluble polysaccharide has improved 42.13% than traditional water method for distilling (extracting each 2～3 hours 3～5 times); Amino acid content on average improves 1.5 times; Other active components all improve 1～2 times like adenosine, peptide and micro-recovery rate.
Claims (2)
1. the preparation method of a ganoderma lucidum liquid preparation is characterized in that ganoderma lucidum liquid preparation prepares as follows:
(1) get 1～5 part of glossy ganoderma, clean up, pulverize, and to add parts by weight are water low temperature ultrasonic Extraction 2～4 times of 10～50 parts that temperature is 30 ℃～60 ℃, supersonic frequency is 18～21kHz, and ultrasound intensity is 400～1200W, each 20～60 minutes; Residue solid formation after extract and the extraction gives over to subsequent use;
(2) adopt the boiling machine HTHP to extract the residue solid formation in (1), temperature is 100 ℃～140 ℃, and the time is 120～160 minutes, and pressure is 0.1～0.36MPa; Carry out centrifugal treating then, rotating speed is 1500～3000r/min, continues 20～40 minutes, and the supernatant of getting after centrifugal is subsequent use;
(3) supernatant in extract and the step (2) in (1) is merged, dosing, filtration, pack, sterilization obtains ganoderma lucidum liquid preparation.
2. according to the preparation method of the said a kind of ganoderma lucidum liquid preparation of claim 1, it is characterized in that: in the time of will remaining the extraction of solid formation employing boiling machine HTHP, the temperature preferred values of choosing is 120 ℃, and the time preferred values is 133 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910187203A CN101647567B (en) | 2009-09-03 | 2009-09-03 | Ganoderma lucidum liquid preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910187203A CN101647567B (en) | 2009-09-03 | 2009-09-03 | Ganoderma lucidum liquid preparation and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101647567A CN101647567A (en) | 2010-02-17 |
| CN101647567B true CN101647567B (en) | 2012-10-03 |
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| CN200910187203A Expired - Fee Related CN101647567B (en) | 2009-09-03 | 2009-09-03 | Ganoderma lucidum liquid preparation and preparation method thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103446205A (en) * | 2012-05-29 | 2013-12-18 | 江中药业股份有限公司 | Composition for prevention and treatment of chemoradiotherapy induced leukopenia and its application |
| CN108578490A (en) * | 2018-07-11 | 2018-09-28 | 李喜范 | A kind of Chinese medicinal composition preparation and preparation method thereof for treating heart disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165032A (en) * | 1996-05-10 | 1997-11-19 | 中国科学院大连化学物理研究所 | Method for breaking cell wall of Ganoderma lucidum spore |
| CN1231925A (en) * | 1999-05-10 | 1999-10-20 | 牛天堂 | Method for breaking epispore of lucid ganoderma |
| CN101367881A (en) * | 2008-09-19 | 2009-02-18 | 南京农业大学 | High-efficiency preparation method for glossy ganoderma polysaccharide |
-
2009
- 2009-09-03 CN CN200910187203A patent/CN101647567B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165032A (en) * | 1996-05-10 | 1997-11-19 | 中国科学院大连化学物理研究所 | Method for breaking cell wall of Ganoderma lucidum spore |
| CN1231925A (en) * | 1999-05-10 | 1999-10-20 | 牛天堂 | Method for breaking epispore of lucid ganoderma |
| CN101367881A (en) * | 2008-09-19 | 2009-02-18 | 南京农业大学 | High-efficiency preparation method for glossy ganoderma polysaccharide |
Non-Patent Citations (2)
| Title |
|---|
| 胡斌杰等.灵芝多糖生物学功能及其提取方法研究.《黑龙江医药》.2007,第20卷(第3期),第207-209页. * |
| 蔡邦肖等.膜集成工艺浓缩灵芝水提液的研究.《食品与发酵工业》.2008,第34卷(第1期),第129-132页,第137页. * |
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