CN101628109A - Compound neomycin sulphate solution and preparation method thereof - Google Patents
Compound neomycin sulphate solution and preparation method thereof Download PDFInfo
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- CN101628109A CN101628109A CN200910305340A CN200910305340A CN101628109A CN 101628109 A CN101628109 A CN 101628109A CN 200910305340 A CN200910305340 A CN 200910305340A CN 200910305340 A CN200910305340 A CN 200910305340A CN 101628109 A CN101628109 A CN 101628109A
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- polygynax
- purified water
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- colistin sulfate
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Abstract
The invention discloses a compound neomycin sulphate solution and a preparation method thereof. The invention aims to provide a compound neomycin sulphate solution which has obvious effect on treating gastrointestinal infection of birds, treats symptoms and a root and reduces the medicine application frequency and a preparation method thereof. 100 L of solution comprises 2-15 kg of neomycin sulphate, 3-15 kg of colistin sulphate, 0.01-0.05 kg of scopolamine methobromide, 10 kg of alcohol with concentration of 95 percent and the balance of purified water. The invention adopts the neomycin sulphate and the colistin sulphate as antibacterial components, has double effects, can effectively reduce the medicine resistant rate of bacteria and has effect on common Gram negative bacteria causing intestinal infection; and the scopolamine methobromide inhibits glandular secretion, dries intestinal contents and lightens a dehydration symptom so as to have a rapid therapeutic effect.
Description
Technical field
The present invention relates to a kind of compound neomycin sulphate solution that is used for the treatment of fowl digestive tract bacterial infection and preparation method thereof.
Background technology
Fowl digestive tract bacterial infection is the normal disease that occurs of fowl, sick fowl shows as situations such as diarrhoea dysentery, main single or mixed infection causes by gram negative bacterias such as escherichia coli, Salmonellas, sick fowl undergrowth, morbidity rapidly, show as diarrhoea, dysentery, row's white, Lycoperdon polymorphum Vitt, yellow or yellow green loose stool, what have is water sample, sick fowl dehydration is serious, and mortality rate is very high.
At present, the trend of the oriented mixed type of disease, complicated development, pathogen is a resident bacterium in the body, and drug resistance is serious, single drug such as polygynax, colistin sulfate often because of its drug resistance makes therapeutic effect not good, bring very big loss to the raiser now.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat fowl digestive tract bacterial infection instant effect, and treating both the principal and secondary aspects of a disease reduces pathogen drug resistance probability, strengthens the fowl of curative effect and uses compound neomycin sulphate solution.
It is simple that another object of the present invention provides a kind of technology, and the above-mentioned fowl of realizing is easily used the preparation method of compound neomycin sulphate solution.
The present invention is achieved through the following technical solutions:
A kind of compound neomycin sulphate solution that is used for the treatment of fowl digestive tract bacterial infection is characterized in that, the consisting of of every 100L solution: polygynax 2～15kg, colistin sulfate 3～15kg, scopolamine methobromide 0.01～0.05kg, 95% ethanol 10kg, surplus is a purified water.
A kind of above-mentioned preparation method that is used for the treatment of the compound neomycin sulphate solution of fowl digestive tract bacterial infection is characterized in that, comprises the steps:
(1) 95% ethanol 10kg is joined among polygynax 2～15kg and the colistin sulfate 3～15kg, mix, polygynax and colistin sulfate are soaked into, after the infiltration, add purified water 70L, stirring is fully dissolved polygynax and colistin sulfate.
(2) get purified water 2L, dissolving scopolamine methobromide 0.01～0.05kg;
(3) combining step (1) and the prepared solution of step (2), mending purified water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution adjusting pH value to 4.0～5.0 promptly get compound neomycin sulphate solution of the present invention with mass percent concentration.
The preferable of wherein every 100L solution consists of: polygynax 5～10kg, and colistin sulfate 5～13kg, scopolamine methobromide 0.015～0.035kg, 95% ethanol 10kg, surplus is a purified water.
The best group of every 100L solution becomes: polygynax 7.7kg, and colistin sulfate 10kg, scopolamine methobromide 0.025kg, 95% ethanol 10kg, surplus is a purified water.
Wherein, employed hydrochloric acid, sodium hydroxide are commercially available SILVER REAGENT among the present invention.
The present invention has following technique effect:
Solution of the present invention is compound preparation, adopts polygynax and colistin sulfate as antimicrobial component, has double effects, can effectively avoid the problem of bacterial drug resistance, and the common gram negative bacteria that causes intestinal infection had presses down function extremely.Simultaneously, scopolamine methobromide can suppress glandular secretion, reduce the digestive tract liquid component, intestinal contents is become dry, and play low-hanging fruit, and treating both the principal and secondary aspects of a disease has reduced the medication number of times.
Fowl of the present invention is simple with the preparation method technology of compound neomycin sulphate solution, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) 95% ethanol 10kg is joined among polygynax 2kg and the colistin sulfate 15kg, mix, polygynax and colistin sulfate are soaked into, after the infiltration, add purified water 70L, stirring is fully dissolved polygynax and colistin sulfate.
(2) get purified water 2L, dissolving scopolamine methobromide 0.01kg.
(3) combining step (1) and the prepared solution of step (2), mending purified water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution adjusting pH value to 4.0～5.0 promptly get compound neomycin sulphate solution of the present invention with mass percent concentration.
Embodiment 2
(1) 95% ethanol 10kg is joined among polygynax 15kg and the colistin sulfate 3kg, mix, polygynax and colistin sulfate are soaked into, after the infiltration, add purified water 70L, stirring is fully dissolved polygynax and colistin sulfate.
(2) get purified water 2L, dissolving scopolamine methobromide 0.05kg;
(3) combining step (1) and the prepared solution of step (2), mending purified water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution adjusting pH value to 4.0～5.0 promptly get compound neomycin sulphate solution of the present invention with mass percent concentration.
Embodiment 3
(1) 95% ethanol 10kg is joined among polygynax 5kg and the colistin sulfate 13kg, mix, polygynax and colistin sulfate are soaked into, after the infiltration, add purified water 70L, stirring is fully dissolved polygynax and colistin sulfate.
(2) get purified water 2L, dissolving scopolamine methobromide 0.015kg.
(3) combining step (1) and the prepared solution of step (2), mending purified water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution adjusting pH value to 4.0～5.0 promptly get compound neomycin sulphate solution of the present invention with mass percent concentration.
Embodiment 4
(1) 95% ethanol 10kg is joined among polygynax 10kg and the colistin sulfate 5kg, mix, polygynax and colistin sulfate are soaked into, after the infiltration, add purified water 70L, stirring is fully dissolved polygynax and colistin sulfate.
(2) get purified water 2L, dissolving scopolamine methobromide 0.035kg.
(3) combining step (1) and the prepared solution of step (2), mending purified water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution adjusting pH value to 4.0～5.0 promptly get compound neomycin sulphate solution of the present invention with mass percent concentration.
Embodiment 5
(1) 95% ethanol 10kg is joined among polygynax 9kg and the colistin sulfate 7kg, mix, polygynax and colistin sulfate are soaked into, after the infiltration, add purified water 70L, stirring is fully dissolved polygynax and colistin sulfate.
(2) get purified water 2L, dissolving scopolamine methobromide 0.02kg.
(3) combining step (1) and the prepared solution of step (2), mending purified water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution adjusting pH value to 4.0～5.0 promptly get compound neomycin sulphate solution of the present invention with mass percent concentration.
Embodiment 6
(1) 95% ethanol 10kg is joined among polygynax 7.7kg and the colistin sulfate 10kg, mix, polygynax and colistin sulfate are soaked into, after the infiltration, add purified water 70L, stirring is fully dissolved polygynax and colistin sulfate.
(2) get purified water 2L, dissolving scopolamine methobromide 0.025kg.
(3) combining step (1) and the prepared solution of step (2), mending purified water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution adjusting pH value to 4.0～5.0 promptly get compound neomycin sulphate solution of the present invention with mass percent concentration.
Clinical trial:
Compound neomycin sulphate solution of the present invention both can be used for the chicken class, also can be used for duck, goose etc.Be laboratory animal below with the chicken, the effect that is used for the treatment of the solution of fowl digestive tract bacterial infection of the present invention is experimentized.
1. laboratory animal:
1000 of the ill one-tenth of picked at random chickens, body weight is about about 1kg.
2. experiment medicine
The compound neomycin sulphate solution our unit development of the embodiment of the invention 6 preparations;
7.7% neomycin sulphate solution our unit prepared in laboratory;
10% colistin sulfate solution our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 7.7% neomycin sulphate solution: drinking-water, every 1L water 1ml, 2 times on the one, logotype 5 days.
The C group is treated usage with 10% colistin sulfate solution: drinking-water, every 1L water 1ml, 2 times on the one, logotype 5 days.
The D group is treated usage with the compound neomycin sulphate injection of the embodiment of the invention 6 preparations: drinking-water, every 1L water 1ml, 2 times on the one, logotype 4 days.
After the treatment beginning, every day, chicken health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 is used for the treatment of compound neomycin sulphate solution treatment group, 7.7% neomycin sulphate solution treatment group and the 10% colistin sulfate liquid injection solution group of digestive tract bacterial infection and matched group difference extremely significantly (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | The symptom number of elements is arranged during end | Dead number of elements |
| ????A | Matched group | ??250 | ??0 | ??0 | ??132 | ??118 |
| ????B | The treatment of 7.7% neomycin sulphate solution | ??115 | ??135 | ??92 | ??123 | ??35 |
| ????C | The treatment of 10% colistin sulfate solution | ??98 | ??152 | ??85 | ??112 | ??53 |
| ????D | The solution treatment of the embodiment of the invention 6 | ??26 | ??224 | ??205 | ??25 | ??20 |
Claims (6)
1. a compound neomycin sulphate solution that is used for the treatment of fowl digestive tract bacterial infection is characterized in that, the consisting of of every 100L solution: polygynax 2～15kg, colistin sulfate 3～15kg, scopolamine methobromide 0.01～0.05kg, 95% ethanol 10kg, surplus is a purified water.
2. the compound neomycin sulphate solution that is used for the treatment of fowl digestive tract bacterial infection according to claim 1, it is characterized in that, consisting of of every 100L solution: polygynax 5～10kg, colistin sulfate 5～13kg, scopolamine methobromide 0.015～0.035kg, 95% ethanol 10kg, surplus is a purified water.
3. the compound neomycin sulphate solution that is used for the treatment of fowl digestive tract bacterial infection according to claim 1 is characterized in that, the consisting of of every 100L solution: polygynax 7.7kg, colistin sulfate 10kg, scopolamine methobromide 0.025kg, 95% ethanol 10kg, surplus is a purified water.
4. the described preparation method that is used for the treatment of the compound neomycin sulphate solution of fowl digestive tract bacterial infection of claim 1 is characterized in that, comprises the steps:
(1) 95% ethanol 10kg is joined among polygynax 2～15kg and the colistin sulfate 3～15kg, mix, polygynax and colistin sulfate are soaked into, after the infiltration, add purified water 70L, stirring is fully dissolved polygynax and colistin sulfate;
(2) get purified water 2L, dissolving scopolamine methobromide 0.01～0.05kg;
(3) combining step (1) and the prepared solution of step (2), mending purified water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution adjusting pH value to 4.0～5.0 promptly get compound neomycin sulphate solution of the present invention with mass percent concentration.
5. the preparation method that is used for the treatment of the compound neomycin sulphate solution of fowl digestive tract bacterial infection according to claim 4, it is characterized in that, consisting of of every 100L solution: polygynax 5～10kg, colistin sulfate 5～13kg, scopolamine methobromide 0.015～0.035kg, 95% ethanol 10kg, surplus is a purified water.
6. the preparation method that is used for the treatment of the compound neomycin sulphate solution of fowl respiratory tract, digestive tract bacterial infection according to claim 4, it is characterized in that, consisting of of every 100L solution: polygynax 7.7kg, colistin sulfate 10kg, scopolamine methobromide 0.025kg, 95% ethanol 10kg, surplus is a purified water.
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| CN200910305340A CN101628109A (en) | 2009-08-07 | 2009-08-07 | Compound neomycin sulphate solution and preparation method thereof |
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| CN200910305340A CN101628109A (en) | 2009-08-07 | 2009-08-07 | Compound neomycin sulphate solution and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104096217A (en) * | 2014-07-28 | 2014-10-15 | 山东省动物疫病预防与控制中心 | Drug for treating escherichia coli type disease of digestive tract of minks |
| CN104127430A (en) * | 2014-06-30 | 2014-11-05 | 邳州正康生物技术有限公司 | Veterinary florfenicol injection, and preparation method and application thereof |
| CN104645311A (en) * | 2015-03-06 | 2015-05-27 | 邳州正康生物技术有限公司 | Drinking agent for treating intestinal infection of livestock and poultry and preparation method of drinking agent |
| CN108904441A (en) * | 2018-07-26 | 2018-11-30 | 日照市牧邦畜牧科技有限公司 | A kind of stable neomycin sulphate solution and its preparation process |
| CN110772526A (en) * | 2019-10-12 | 2020-02-11 | 佛山市正典生物技术有限公司 | Neomycin sulfate solution and preparation method thereof |
-
2009
- 2009-08-07 CN CN200910305340A patent/CN101628109A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127430A (en) * | 2014-06-30 | 2014-11-05 | 邳州正康生物技术有限公司 | Veterinary florfenicol injection, and preparation method and application thereof |
| CN104096217A (en) * | 2014-07-28 | 2014-10-15 | 山东省动物疫病预防与控制中心 | Drug for treating escherichia coli type disease of digestive tract of minks |
| CN104096217B (en) * | 2014-07-28 | 2016-06-08 | 王贵升 | A kind of medicine treating mink escherichia coli type digestive tract disease |
| CN104645311A (en) * | 2015-03-06 | 2015-05-27 | 邳州正康生物技术有限公司 | Drinking agent for treating intestinal infection of livestock and poultry and preparation method of drinking agent |
| CN108904441A (en) * | 2018-07-26 | 2018-11-30 | 日照市牧邦畜牧科技有限公司 | A kind of stable neomycin sulphate solution and its preparation process |
| CN110772526A (en) * | 2019-10-12 | 2020-02-11 | 佛山市正典生物技术有限公司 | Neomycin sulfate solution and preparation method thereof |
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Application publication date: 20100120 |