CN101559074B - Coccidiostat-decoquinate dry suspension for livestock and poultry and preparation method thereof - Google Patents
Coccidiostat-decoquinate dry suspension for livestock and poultry and preparation method thereof Download PDFInfo
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- CN101559074B CN101559074B CN2009100690839A CN200910069083A CN101559074B CN 101559074 B CN101559074 B CN 101559074B CN 2009100690839 A CN2009100690839 A CN 2009100690839A CN 200910069083 A CN200910069083 A CN 200910069083A CN 101559074 B CN101559074 B CN 101559074B
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- Prior art keywords
- decoquinate
- coccidiostat
- dry suspension
- poultry
- preparation
- Prior art date
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- 229960001878 decoquinate Drugs 0.000 title claims abstract description 28
- 239000000725 suspension Substances 0.000 title claims abstract description 27
- 244000144977 poultry Species 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 244000144972 livestock Species 0.000 title abstract 2
- JHAYEQICABJSTP-UHFFFAOYSA-N decoquinate Chemical compound N1C=C(C(=O)OCC)C(=O)C2=C1C=C(OCC)C(OCCCCCCCCCC)=C2 JHAYEQICABJSTP-UHFFFAOYSA-N 0.000 claims abstract description 38
- 238000003756 stirring Methods 0.000 claims abstract description 11
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 6
- 235000011067 sorbitan monolaureate Nutrition 0.000 claims description 6
- 235000011837 pasties Nutrition 0.000 claims description 4
- 239000003224 coccidiostatic agent Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 4
- 239000003651 drinking water Substances 0.000 abstract description 3
- 235000020188 drinking water Nutrition 0.000 abstract description 3
- 238000007873 sieving Methods 0.000 abstract description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 3
- 239000010446 mirabilite Substances 0.000 abstract 3
- 239000002736 nonionic surfactant Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 208000003495 Coccidiosis Diseases 0.000 description 6
- 206010023076 Isosporiasis Diseases 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 3
- 230000001165 anti-coccidial effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000002563 ionic surfactant Substances 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- BXHCJLRTXPHUGH-UHFFFAOYSA-N 2-oxo-1h-pyridine-4-carboxylic acid Chemical compound OC(=O)C=1C=CNC(=O)C=1 BXHCJLRTXPHUGH-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000223924 Eimeria Species 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001842 enterocyte Anatomy 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 239000002297 parasiticide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000001563 schizont Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a coccidiostat-decoquinate dry suspension for livestock and poultry and a preparation method thereof. The coccidiostat comprises the following main components in portion by weight: 2 to 6 portions of decoquinate, 5 to 20 portions of non-ionic surfactant, and 30 to 90 portions of glauber salt. The preparation method comprises the following steps that: the decoquinate is added into the non-ionic surfactant, and the mixture is stirred evenly; and then the glauber salt is added into the mixture, and a finished product is prepared by stirring evenly, drying, crushing and sieving. The dry suspension is prepared from the decoquinate by adding the non-ionic surfactant and the glauber salt, solves the service restriction problem that the decoquinate fails to be taken by drinking water, greatly improves the clinical application range of decoquinate medicaments, and has broad application prospect.
Description
Technical field
The invention belongs to field of veterinary, relate to poultry and use coccidiostat, especially poultry are used coccidiostat-decoquinate dry suspension and preparation method thereof.
Background technology
Coccidiosis is an important diseases of world's birds aquaculture, is that the various parasites by eimeria cause that these parasites breed in enterocyte, destroys the intestinal mucosa integrity, reduces digestion, the absorbability of intestinal.The coccidiosis condition of disease causes the reduction of poultry growth rate and feed conversion rate, and it causes 6～10% birds mortality rate, and the global economy that causes is thus lost and reached multi-million dollar every year.The control of coccidiosis at present is mainly based on medicine, and chemicals is still the main means of control, but the chemicals life-time service is easy to generate drug resistance, and therefore, research and development are efficient, low toxicity, broad-spectrum parasiticide new drug will have huge market.Since the seventies in 20th century, deccox just has been widely used in the control of the coccidiosis of fowl in many countries, American Pharmacopeia has been included 1～10% deccox pre-mixing agent, but never use in China, the U.S. in 2006 is refined to come company at China's list marketing deccox at first, domestic and international market list marketing at present mainly be 6% deccox pre-mixing agent.
Deccox (decoquinate) is that a kind of very effective quinolones poultry are used anticoccidial drug, deccox the coccidiosis life cycle promptly begin in early days play a role, thereby avoid the poultry intestinal to suffer damage, it is mainly by the stage is suppressed sporocyst in the early stage, mid-term stage is killed early stage schizont and is played a role, and deccox plays a role at the asexual reproductive phase of coccidiosis.After deccox enters the zygoblast cell, stop its growth by disturbing DNA to synthesize.Deccox has good stable, under suitable temperature and humidity condition, can in 4 years, keep stay in grade, and toxicity is low, better tolerance, use 80 times of recommended amounts still to compare safely and with the maduramicin ammonium that belongs to efficient coccidiostat equally, have unrivaled safety.Therefore, deccox has vast market prospect as a kind of novel low toxicity wide spectrum coccidiostat.
Although no matter deccox all has very big advantage in anticoccidial effect and safety, but because its dissolubility extreme difference, water insoluble and other organic solvents so be difficult to be made into soluble powder or solution, have seriously restricted deccox range of application clinically.
Summary of the invention
The objective of the invention is to solve the deccox administration problem of can not drinking water, a kind of dissolubility is provided, and good, with low cost poultry are used coccidiostat-decoquinate dry suspension;
Another object of the present invention provides the preparation method of above-mentioned poultry with coccidiostat-decoquinate dry suspension.
The objective of the invention is to be achieved through the following technical solutions:
A kind of poultry are used coccidiostat-decoquinate dry suspension, and its component constitutes and parts by weight are respectively:
Deccox 2～6
Non-ionic surface active agent 5～20
Matrii Sulfas Exsiccatus 30～90.
And described ionic surfactant pack is drawn together SPE-200, SPE-600 or Span-20.
A kind of poultry comprise the steps: with the preparation method of coccidiostat-decoquinate dry suspension
(1) deccox with 2～6 weight portions adds in 5～20 weight portion non-ionic surface active agents, stirs into even pastel;
(2) add 30～90 parts of Matrii Sulfas Exsiccatus in above-mentioned even pastel, stir, oven dry is pulverized, and sieves, and promptly makes finished product decoquinate dry suspension finished product.
And described ionic surfactant pack is drawn together SPE-200, SPE-600 or Span-20.
And described sieving is 65～100 mesh sieves.
Advantage of the present invention and beneficial effect are:
1, the dry suspension that the present invention relates to is made dry suspension by interpolation non-ionic surface active agent, Matrii Sulfas Exsiccatus with deccox, solved the use restricted problem of deccox because of the administration of can not drinking water, improved the clinical application range of deccox medicine greatly, application prospect has widely been arranged.
2, the poultry that the present invention relates to are used decoquinate dry suspension, and preparation technology is simple, the cheap and wide material sources of cost of material, and the company that is fit to multiple scale produces, and huge commercial promise is arranged.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1:
One stud bird is used coccidiostat-decoquinate dry suspension, and its component constitutes and parts by weight are respectively:
Deccox: 4
SPE-200： 10
Matrii Sulfas Exsiccatus: 50.
Fowl with the preparation method of coccidiostat-decoquinate dry suspension is:
(1) deccox with 4 weight portions joins among the 10 weight portion SPE-200, stirs into even pasty state, and is standby;
(2) add 50 parts of Matrii Sulfas Exsiccatus in the even pastel that step (1) is made, stir, oven dry is pulverized, and crosses No. 5 sieves (80 order), promptly makes the finished product decoquinate dry suspension.
Embodiment 2:
One stud bird is used coccidiostat-decoquinate dry suspension, and its component constitutes and parts by weight are respectively:
Deccox: 6
SPE-600： 13
Matrii Sulfas Exsiccatus: 65.
Fowl with the preparation method of coccidiostat-decoquinate dry suspension is:
(1) deccox with 6 weight portions joins among the 13 weight portion SPE-600, stirs into even pasty state, and is standby;
(2) add 65 parts of Matrii Sulfas Exsiccatus in the even pastel that step (1) is made, stir, oven dry is pulverized, and crosses No. 5 sieves (80 order), promptly makes the finished product decoquinate dry suspension.
Embodiment 3:
One stud bird is used coccidiostat-decoquinate dry suspension, and its component constitutes and parts by weight are respectively:
Deccox: 6
Span-20： 15
Matrii Sulfas Exsiccatus: 75.
Fowl with the preparation method of coccidiostat-decoquinate dry suspension is:
(1) deccox with 6 weight portions joins among the 15 weight portion Span-20, stirs into even pasty state, and is standby;
(2) add 75 parts of Matrii Sulfas Exsiccatus in the even pastel that step (1) is made, stir, oven dry is pulverized, and crosses No. 5 sieves (80 order), promptly makes the finished product decoquinate dry suspension.
Settling volume is than testing the result:
Suspended matter begins height: H
0The final height of suspended matter: H settling volume ratio: H/H
0
According to regulation of " Chinese veterinary drug allusion quotation " version in 2005, judge the whether qualified main standard of dry suspension preparation for its settling volume compares should not be less than 0.9, so the embodiment product is qualified dry suspension.
Claims (2)
1. poultry are used coccidiostat-decoquinate dry suspension, it is characterized in that: its component constitutes and parts by weight are respectively:
Deccox: 6
Span-20：?15
Matrii Sulfas Exsiccatus: 75.
2. the preparation method of a poultry usefulness coccidiostat-decoquinate dry suspension as claimed in claim 1 is characterized in that: comprise the steps:
(1) deccox with 6 weight portions joins among the 15 weight portion Span-20, stirs into even pasty state, and is standby;
(2) add 75 parts of Matrii Sulfas Exsiccatus in the even pastel that step (1) is made, stir, oven dry is pulverized, and crosses sieve No. 5, and 80 orders are promptly made the finished product decoquinate dry suspension.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100690839A CN101559074B (en) | 2009-06-01 | 2009-06-01 | Coccidiostat-decoquinate dry suspension for livestock and poultry and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100690839A CN101559074B (en) | 2009-06-01 | 2009-06-01 | Coccidiostat-decoquinate dry suspension for livestock and poultry and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN101559074A CN101559074A (en) | 2009-10-21 |
| CN101559074B true CN101559074B (en) | 2011-03-30 |
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| CN2009100690839A Active CN101559074B (en) | 2009-06-01 | 2009-06-01 | Coccidiostat-decoquinate dry suspension for livestock and poultry and preparation method thereof |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008435B (en) * | 2010-08-25 | 2012-01-11 | 齐鲁动物保健品有限公司 | Avian decoquinate oral suspension and preparation method thereof |
| CN102406600A (en) * | 2011-09-30 | 2012-04-11 | 上海恒丰强动物药业有限公司 | Decoquinate solution and preparation method thereof |
| CN103494774B (en) * | 2013-09-30 | 2017-01-18 | 瑞普（天津）生物药业有限公司 | Preparation method of decoquinate dry suspension |
| CN105708804A (en) * | 2016-01-21 | 2016-06-29 | 陈小媚 | Decoquinate dry suspension and preparation method thereof |
| CN106667898B (en) * | 2017-02-22 | 2020-12-22 | 佛山市南海东方澳龙制药有限公司 | Decoquinate preparation and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1457782A (en) * | 2003-05-17 | 2003-11-26 | 南昌弘益科技有限公司 | Dry spaxxacin suspension agent for resisting bacterial infection and its preparing method |
| CN1781479A (en) * | 2004-12-02 | 2006-06-07 | 和记黄埔医药企业有限公司 | Chinese small iris seed agent dispersion system and its preparing method |
-
2009
- 2009-06-01 CN CN2009100690839A patent/CN101559074B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1457782A (en) * | 2003-05-17 | 2003-11-26 | 南昌弘益科技有限公司 | Dry spaxxacin suspension agent for resisting bacterial infection and its preparing method |
| CN1781479A (en) * | 2004-12-02 | 2006-06-07 | 和记黄埔医药企业有限公司 | Chinese small iris seed agent dispersion system and its preparing method |
Non-Patent Citations (1)
| Title |
|---|
| 王震红,杨永刚,蒋煜.关于干混悬剂_混悬颗粒共性问题的探讨.《中国药事》.2007,第21卷(第9期),692-694,726. * |
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| CN101559074A (en) | 2009-10-21 |
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| C06 | Publication | ||
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Challenge (Tianjin) Animal Pharmaceutical Co., Ltd. Assignor: Tianjin Challenge Biological Technology Co., Ltd. Contract record no.: 2012120000015 Denomination of invention: Coccidiostat-decoquinate dry suspension for livestock and poultry and preparation method thereof Granted publication date: 20110330 License type: Exclusive License Open date: 20091021 Record date: 20120314 |
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| ASS | Succession or assignment of patent right |
Owner name: TIAOZHAN IANJIN NIMAL PHARMCEUTICAL CO., LTD. Free format text: FORMER OWNER: TIANJIN CHALLENGE BIOLOGICAL TECHNOLOGY CO., LTD. Effective date: 20120509 |
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Effective date of registration: 20120509 Address after: 300380 Tianjin City Zhang Xiqing economic and Technological Development Zone Industrial Park Road No. 16 nest fortress Patentee after: Challenge (Tianjin) Animal Pharmaceutical Co., Ltd. Address before: 300380 Tianjin City Zhang Xiqing economic and Technological Development Zone Industrial Park Road No. 16 nest fortress Patentee before: Tianjin Challenge Biological Technology Co., Ltd. |
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| TR01 | Transfer of patent right |
Effective date of registration: 20170907 Address after: 300380 Tianjin city Xiqing District Zhangjiawo Huiyuan Industrial Park Road No. 16 Patentee after: TIANJIN ZHONGSHENG TIAOZHAN BIOTECHNOLOGY CO., LTD. Address before: 300380 Tianjin City Zhang Xiqing economic and Technological Development Zone Industrial Park Road No. 16 nest fortress Patentee before: Challenge (Tianjin) Animal Pharmaceutical Co., Ltd. |
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| TR01 | Transfer of patent right | ||
| CB03 | Change of inventor or designer information |
Inventor after: Ji Kun Inventor after: Liu Haiyu Inventor after: Wang Jian Inventor after: Zhang Zhigang Inventor after: Cheng Xuejiao Inventor before: Ji Kun Inventor before: Wang Jian Inventor before: Zhang Zhigang Inventor before: Cheng Xuejiao |
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| CB03 | Change of inventor or designer information |