CN101491689A - Biodegradable composite superfine fiber medicine controlled-release felt and preparation technique thereof - Google Patents
Biodegradable composite superfine fiber medicine controlled-release felt and preparation technique thereof Download PDFInfo
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- CN101491689A CN101491689A CNA2009100105407A CN200910010540A CN101491689A CN 101491689 A CN101491689 A CN 101491689A CN A2009100105407 A CNA2009100105407 A CN A2009100105407A CN 200910010540 A CN200910010540 A CN 200910010540A CN 101491689 A CN101491689 A CN 101491689A
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Abstract
The invention discloses a biodegradable composite ultrafine fibrous drug control release felt and preparation technology thereof. The release felt is designed to solve technical problems that the prior dressing membranes have poorer mechanical strength in different degrees, are difficult to keep wound surfaces moistened, have unobvious treatment effect on the wound surfaces, are more expensive, have certain antigenicity, are adverse to large-range application, and the like. The release felt is prepared from the following materials in percentage by weight: 0 to 50 percent of chitosan, 49.9 to 99.9 percent of PLA or PLGA, and 0.1 to 25 percent of anti-inflammatory and bactericidal drug. The preparation technology for the release felt comprises the steps of: firstly, dissolving the chitosan and the PLA or the PLGA into a cosolvent trifluoroacetic acid to prepare into an even solution; secondly, adding a drug ingredient into the solution, and ensuring that the drug is fully dissolved and dispersed into the solution through ultrasonic oscillation; thirdly, utilizing electrospinning technology to prepare the ultrafine fibrous drug control release felt. The release felt is characterized in that the release felt has moderate mechanical strength, good air permeability, good hemostatic effect, moderate degradation speed, good anti-inflammatory and bactericidal effect, and simple preparation technology, keeps the wound surfaces moistened, and can be widely used for wound surface treatment of burn and wound as well as postoperative wound recovery treatment.
Description
Technical field:
The present invention relates to a kind of medicine controlled-release felt and preparation technology thereof, relate in particular to a kind of Biodegradable composite superfine fiber medicine controlled-release felt and preparation technology thereof.Can be widely used in burning, the Wound treating of wound and resuming treatment of postoperative wound.
Background technology:
Skin is the organ of human body maximum, if skin is subjected to large tracts of land damage, then can cause many parts even general problem, as metabolism aggravation, moisture and protein excessively scatter and disappear, immune system disorder etc., the serious entail dangers to life of going back.If wound surface covers suitable dressing, can effectively reduce the metabolic order of severity of patient's body superelevation, ease the pain, prevent bacterial infection, quicken wound healing.Therefore, people extensively explore the Wound dressing that can be used as skin barrier in recent years.Chinese patent [CN 1395968] discloses a kind of biological fluid dressing chitosan membrane and preparation method thereof.It is characterized in that through acidolysis, add adjuvants such as gelatin, glycerol, neutralize and filter through sodium bicarbonate again.But this fluid dressing membrane mechanical strength is relatively poor, is not easy to keep wound surface moistening.Chinese patent [CN 1554448] discloses the biological bleeding-stopping dressing of a kind of chitosan gelatin polyvinyl alcohol, is formulated by chitosan, gelatin, polyvinyl alcohol, glycerol.This dressing has hydrophilic, film property, tractive and haemostatic effect preferably, but wound surface is not had the obvious treatment effect.Chinese patent [CN 1380109] discloses a kind of chitosan, collagen and sodium alginate compounded spongy biological dressing and preparation technology thereof.This dressing good biocompatibility, adhesiveness is strong, has the active function and the anastalsis that promote wound healing.But its used type i collagen price is comparatively expensive, and has certain antigenicity, is unfavorable for widespread adoption.
Summary of the invention:
The invention provides a kind of Biodegradable composite superfine fiber medicine controlled-release felt, Biodegradable composite superfine fiber medicine controlled-release felt and preparation technology thereof is characterized in that: discharge felt and prepare by following percentage by weight: chitosan 0%-50%, PLA or PLGA 49.9%-99.9% and anti-inflammation and sterilization medicine 0.1%-25%;
The preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt, realize by following step: earlier chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, be prepared into homogeneous solution, add ingredient then, through sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to make composite superfine fiber medicine controlled-release felt again.
Characteristics of the present invention and beneficial effect: composite superfine fiber medicine controlled-release felt of the present invention has that mechanical strength is moderate, good permeability, haemostatic effect is good, degradation speed is moderate and can keep wound surface moistening, tangible anti-inflammation and sterilization effect arranged, and preparation technology is simple, can be widely used in the treatment of burning, wound and wound surface and resuming treatment of postoperative wound.
The biodegradable blend film of chitosan and PLA or PLGA has excellent biological compatibility, degradability, toughness and breathability, has the protection wound surface, attracts effects such as wound exudate, anti-inflammation and sterilization, hemostasis, analgesia, promotion wound healing and skin regeneration for large-area burns, wound.Improved its anti-inflammatory and blend film and antibacterials are combined with each other.
Adopting the preparation of electrospinning silk technology to discharge felt, realize spinning process or utilize high voltage electric field to realize spinning under electric field action, is a kind of specific form of electrostatic atomization (or electron spray), and method is simple, and is with low cost.Can satisfy medicine controlled-release felt adhesion and infiltrative requirement.
Description of drawings:
Fig. 1 contains the composite superfine fiber medicine controlled-release felt optical microscope photograph that 15% ring third kills star
Fig. 2 contains the release profiles that 15% ring third kills the composite superfine fiber medicine controlled-release felt of star
Fig. 3 contains the optical microscope photograph of the composite superfine fiber medicine controlled-release felt of 8% sulfadiazine
Fig. 4. contain the release profiles of the composite superfine fiber medicine controlled-release felt of 8% sulfadiazine
The specific embodiment:
Biodegradable composite superfine fiber medicine controlled-release felt and preparation technology thereof discharge felt and prepare by following percentage by weight: chitosan 0%-50%, PLA or PLGA 49.9%-99.9%% and anti-inflammation and sterilization medicine 0.1%-25%; Described chitosan is a medicated chitin, and molecular weight is below 10000, and deacetylation is 75%～95%.Described PLA or PLGA, molecular weight be 20,000-500,000.Described anti-inflammation and sterilization medicine is that oil-soluble or water miscible silver sulfadiazine, sulfadiazine, promise fluorine kill star or encircle third and kill the star medicine.
The preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt, realize by following step: earlier chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, be prepared into homogeneous solution, add ingredient then, through sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to make composite superfine fiber medicine controlled-release felt again.
A kind of spining technology that described electrospinning silk technology is meant the spinning process under electric field action or utilizes high voltage electric field to realize is a kind of specific form of electrostatic atomization (or electron spray), and method is simple, and is with low cost.Electrospinning silk equipment is made of several parts such as high tension generator, spinning liquid container, spinning nozzle and fiber receiving screens.Electrospinning silk process is as follows: with the spinning liquid spinning liquid container of packing into, and make chargedly, from the effusive solution of spinning nozzle, have the competition of Coulomb repulsion effect and surface tension of liquid.When electric field intensity is enough big, will overcome surface tension, fly out from the drop surface, form jet.In the process of comparative electrode flight, liquid stream constantly stretches, and solvent wherein volatilizees fast, promptly discharges felt thereby obtain solid fiber on the collection screen of ground connection.
Chitosan is that occurring in nature is only second to cellulosic second largest biological polyoses, also is the alkaline polysaccharide of the unique a large amount of existence of occurring in nature simultaneously.Biologically active of chitosan own and anastalsis can stop formation, the hypertrophy of connective tissue cell and the synthesizing of collagen protein of fibrin element.Poly-'alpha '-hydroxy acids such as PLA or PLGA is the biodegradable polymer of synthetic, have advantages such as good biocompatibility, mechanical strength be good, especially PLA by U.S. food and drug administration regard as can be applicable to clinical, as as operation suture thread and embedded material etc., and can go out good intermingling material with Preparation of Chitosan.Poly-'alpha '-hydroxy acids excellent mechanical intensity such as PLA or PLGA can remedy the defective of chitosan bad mechanical strength just.Therefore; chitosan and PLA or PLGA are made the composite ultrafine fiber felt have excellent biological compatibility, degradability, toughness, elasticity and breathability, have the protection wound surface, attract effects such as wound exudate, anti-inflammation and sterilization, hemostasis, analgesia, promotion wound healing and skin regeneration for large-area burns, wound.Improved its anti-inflammatory and composite ultrafine fiber felt and antibacterials are combined with each other.
(molecular weight is 10 to embodiment 1. with medicated chitin 40%, 000) and PLA 45% (molecular weight is 100,000) is dissolved in the trifluoroacetic acid, add anti-inflammatory drug ring third then and kill star 15%, sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to be prepared into composite superfine fiber medicine controlled-release felt again.Referring to Fig. 1 is the optical microscope photograph of this composite superfine fiber medicine controlled-release felt.Referring to Fig. 2 is the sustained release curve of this composite superfine fiber medicine controlled-release felt in 37 ℃ of phosphate buffers.
(molecular weight is 80 to embodiment 2. with medicated chitin 30% (molecular weight is 3000) and PLGA 60%, 000) is dissolved in the trifluoroacetic acid, add anti-inflammatory drug ring third then and kill star 10%, sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to be prepared into composite superfine fiber medicine controlled-release felt again.
(molecular weight is 150 to embodiment 3. with medicated chitin 20% (molecular weight is 8000) and PLA 72%, 000) is dissolved in the trifluoroacetic acid, add anti-inflammatory drug sulfadiazine 8% then, sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to be prepared into composite superfine fiber medicine controlled-release felt again.Accompanying drawing 3 is the optical microscope photograph of this composite superfine fiber medicine controlled-release felt.Accompanying drawing 4 is the release profiles of this composite superfine fiber medicine controlled-release felt in 37 ℃ of phosphate buffers.
(molecular weight is 50 to embodiment 4. with medicated chitin 10% (molecular weight is 3000) and PLGA 70%, 000) is dissolved in the trifluoroacetic acid, add anti-inflammatory drug sulfadiazine 20% then, sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to be prepared into composite superfine fiber medicine controlled-release felt again.
(molecular weight is 40 to embodiment 5. with medicated chitin 0% (molecular weight is 0) and PLGA 99.9%, 000) is dissolved in the trifluoroacetic acid, add anti-inflammatory drug ring third then and kill star 0.1%, sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to be prepared into composite superfine fiber medicine controlled-release felt again.
(molecular weight is 200 to embodiment 6. with medicated chitin 50% (molecular weight is 5000) and PLGA 49.9%, 000) is dissolved in the trifluoroacetic acid, add anti-inflammatory drug promise fluorine then and kill star 0.1%, sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to be prepared into composite superfine fiber medicine controlled-release felt again.
(molecular weight is 300 to embodiment 7. with medicated chitin 30% (molecular weight is 6000) and PLGA45%, 000) is dissolved in the trifluoroacetic acid, add anti-inflammatory drug silver sulfadiazine 25% then, sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technology to be prepared into composite superfine fiber medicine controlled-release felt again.
The deacetylation of the medicated chitin described in the foregoing description 1-7 is 75%～95%.The electrospinning silk equipment that is adopted is made of several parts such as high tension generator, spinning liquid container, spinning nozzle and fiber receiving screens.
Claims (8)
1, Biodegradable composite superfine fiber medicine controlled-release felt and preparation technology thereof is characterized in that: discharge felt and prepare by following percentage by weight: chitosan 0%-50%, PLA or PLGA49.9%-99.9% and anti-inflammation and sterilization medicine 0.1%-25%;
The preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt, realize by following step: earlier chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, be prepared into homogeneous solution, add ingredient then, through sonic oscillation, make medicine fully dissolve dispersion, utilize electrospinning silk technical equipment to make composite superfine fiber medicine controlled-release felt again.
2, Biodegradable composite superfine fiber medicine controlled-release felt according to claim 1 and preparation technology thereof is characterized in that: described release felt is to prepare by the percentage by weight of chitosan 40%, PLA 45% and anti-inflammation and sterilization medicine 15%.
3, Biodegradable composite superfine fiber medicine controlled-release felt according to claim 1 and preparation technology thereof is characterized in that: described release felt be by 30%, the percentage by weight preparation of PLGA 60% and anti-inflammation and sterilization medicine 10%.
4, Biodegradable composite superfine fiber medicine controlled-release felt according to claim 1 and preparation technology thereof is characterized in that: described release felt is to prepare by the percentage by weight of chitosan 20%, PLA 72% and anti-inflammation and sterilization medicine 8%.
5, Biodegradable composite superfine fiber medicine controlled-release felt according to claim 1 and preparation technology thereof is characterized in that: described release felt is to prepare by the percentage by weight of chitosan 10%, PLGA 70% and anti-inflammation and sterilization medicine 20%.
6, according to any one Biodegradable composite superfine fiber medicine controlled-release felt and the preparation technology thereof described in the claim 1-5, it is characterized in that: described chitosan is a medicated chitin, and molecular weight is below 10000, and deacetylation is 75%-95%.
7, according to any one Biodegradable composite superfine fiber medicine controlled-release felt and the preparation technology thereof described in the claim 1-5, it is characterized in that: described PLA or PLGA, molecular weight be 20,000-500,000.
8, according to any one Biodegradable composite superfine fiber medicine controlled-release felt and the preparation technology thereof described in the claim 1-5, it is characterized in that: described anti-inflammation and sterilization medicine is that oil-soluble or water miscible silver sulfadiazine, sulfadiazine, promise fluorine kill star or encircle third and kill star.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641520A (en) * | 2012-05-07 | 2012-08-22 | 吉林大学 | Preparation method of biological repair nano dressing containing wood frog skin polypeptide and being used for wounds and burn |
| CN103611187A (en) * | 2013-11-15 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Preparation method of tissue engineering scaffold for realizing time-ordered release of medicine |
| CN104452106A (en) * | 2014-11-20 | 2015-03-25 | 东华大学 | Preparing method for nanofiber membrane of composite silica-based drug-carrying nano particles |
| CN109289082A (en) * | 2018-11-22 | 2019-02-01 | 李忠 | A kind of absorbability medical hemostatic bibre material and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100463673C (en) * | 2006-03-08 | 2009-02-25 | 曾敬 | Compound medicine release controlling film of chitosan, sodium alginate and gelatin and its preparing process |
| CN101336892A (en) * | 2008-06-19 | 2009-01-07 | 济南基福医药科技有限公司 | Gel injection of sustained-released topology enzyme inhibitor and preparation method thereof |
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2009
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641520A (en) * | 2012-05-07 | 2012-08-22 | 吉林大学 | Preparation method of biological repair nano dressing containing wood frog skin polypeptide and being used for wounds and burn |
| CN103611187A (en) * | 2013-11-15 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Preparation method of tissue engineering scaffold for realizing time-ordered release of medicine |
| CN104452106A (en) * | 2014-11-20 | 2015-03-25 | 东华大学 | Preparing method for nanofiber membrane of composite silica-based drug-carrying nano particles |
| CN109289082A (en) * | 2018-11-22 | 2019-02-01 | 李忠 | A kind of absorbability medical hemostatic bibre material and preparation method thereof |
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| CN101491689B (en) | 2013-06-19 |
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