CN101468057A - Compound Chinese medicine preparation for treating yellow-white dysentery of piglet - Google Patents
Compound Chinese medicine preparation for treating yellow-white dysentery of piglet Download PDFInfo
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- CN101468057A CN101468057A CNA2007100932504A CN200710093250A CN101468057A CN 101468057 A CN101468057 A CN 101468057A CN A2007100932504 A CNA2007100932504 A CN A2007100932504A CN 200710093250 A CN200710093250 A CN 200710093250A CN 101468057 A CN101468057 A CN 101468057A
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- dysentery
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Abstract
The invention discloses a composite traditional Chinese medicine - Jingen injection for treating piglet yellow and white dysentery. The traditional Chinese medicine is formed by extracting and separating the effective ingredients from honeysuckle and isatis root using the modern traditional Chinese medicine extraction technique and is a pure natural green veterinary medicine capable of clearing away the heat-evil and expelling superficial evils with antibiotic and anti-inflammatory effect. The Jingen injection is used for treating livestock and poultry diarrhea, dysentery, etc. due to E. coli, Salmonella, Clostridium perfringens infection, especially for piglet yellow and white dysentery. The composite traditional Chinese medicine has features of convenient use, obvious curative effect and stable quality, without drug resistance, medicine residue and side effect.
Description
Technical field
The present invention relates to a kind of clinical practice that is used for the treatment of the Chinese traditional compound medicine of yellow and white dysentery of piglet, belong to Chinese veterinarian's medicine control livestock and poultry goods field.
Background technology
Colibacillosis of piglet is the general name of the class piglet infectious disease that caused by Escherichia coli.Because the difference of pathogenicity escherichia coli type, the difference of a pig trophophase, physiological function and immune state, the colibacillosis of piglet often are divided into four kinds: i.e. yellow scour of piglet, piglet pujos blancos, diarrhea of weaned piglets and baby pig edema.Yellow scour of piglet mainly betides the newborn piglet in 1 age in week, is a kind of common transmittable disease of newborn piglet, is feature to draw yellow watery stools and rapid death clinically.Piglet pujos blancos is non-septicemia, the acute infectious intestinal disease that betides 10～30 ages in days, and having stench pulpous state loose stool with milk ejection white or canescence is feature, the sickness rate height, and mortality rate is low, grows but have a strong impact on growth in piglets.Document announcement is arranged, have 48% to be to cause in U.S.'s newborn piglet dysentery by escherichia coli; Taiwan has 15～25% piglet so disease to breed, and is annual with a toll of 3.6～6.9 hundred million yuan; The direct economic loss that China's colibacillosis of pigs 1～June in 1997 morbidity causes reaches more than 5,000 ten thousand yuan.Since nineteen ninety-five, only the yellow and white dysentery of piglet sickness rate of the domestic large scale of pig farm in Sichuan field just reaches 20～60%, and indivedual large scale of pig farm fields are because of HUANGBAI(sic) dysentery and other diseases mixed infection, and its piglet mortality rate is up to more than 60%.Other has report, and large scale of pig farm field ablactational baby pig survival rate is 73.4%, and wherein colibacillosis of piglet is to cause its dead major reason.
At present, the most frequently used, the most convenient in large scale of pig farm field, also be that one of effectively preventing measure is to prevent and treat with antibacterials.It is various in style that the antibacterials of treatment colibacillosis of piglet are sold on market, owing to frequently change dressings in the clinical treatment, and arbitrarily strengthen drug dose, the life-time service of single variety, all easily induce escherichia coli to produce drug resistance, thereby run into the invalid difficult problem of control, bring serious economy loss to production.
Summary of the invention
The objective of the invention is to be: overcome deficiency of the prior art, for veterinary clinic provides a kind of administration that both made things convenient for, economic, safe, evident in efficacy again veterinary drug novel formulation.
For achieving the above object, the present invention is implemented by following scheme: the present invention is by Flos Lonicerae, Radix Isatidis two flavor medical materials, through its effective ingredient of extraction separation, and the pure Chinese medicine that is prepared from by modern preparation technique.
Preparation of the present invention has heat-clearing and toxic substances removing, antimicrobial and anti-inflammation efficacy, treatment yellow and white dysentery of piglet instant effect, cure rate height, and safety, noresidue.
The specific embodiment
Below by testing the beneficial effect of further setting forth preparation of the present invention, these tests comprise the extracorporeal bacteria inhibitor test of preparation of the present invention and clinical efficacy test etc.
Embodiment 1: the extracorporeal bacteria inhibitor test of preparation of the present invention
List of references is introduced, and adopts cup-plate method to test.(bacteria containing amount is 9.85 * 10 to draw the bacterium liquid that has prepared
8/ ml) 0.25ml on nutrient agar panel, evenly is coated with aseptic L shaped Glass rod, 3 Oxford cups through sterilization of equidistant placement add medicinal liquid (concentration is 225.0mg/ml) respectively, and indicate mark on this agar plate, in 37 ℃ of cultivations 24 hours, observe and also measure antibacterial circle diameter.The results are shown in Table 1.And adopt the agar doubling dilution to carry out MIC and measure, the results are shown in Table 2.
Table 1 bacteriostatic experiment result
As shown in Table 1, golden root injection when 225.0mg/ml to escherichia coli O
8K
88ac, Salmonella SO
3C
78, staphylococcus aureus CMCC (B) 26003, clinical separating Escherichia coli AF-07d, AF-painstaking effort a antibacterial circle diameter be respectively 28.60,28.30,16.37,16.67,16.10mm.
Table 2 MIC result of the test
| Numbering | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Concentration (mg/ml) | 225.00 | 112.50 | 56.25 | 28.13 | 14.06 | 7.03 | 3.52 | 1.76 | 0.88 | 0.44 |
| O 8K 88ac | — | — | — | — | — | — | + | + | + | + |
| SO 3C 78 | — | — | — | — | — | — | + | + | + | + |
| CMCC(B) 26003 | — | — | — | — | + | + | + | + | + | + |
| AF-07d | — | — | — | — | + | + | + | + | + | + |
| AF-painstaking effort a | — | — | — | — | + | + | + | + | + | + |
As shown in Table 2, golden root injection is to escherichia coli O
8K
88ac, Salmonella SO
3C
78Be respectively 7.03mg/ml, 7.03mg/ml, 28.13mg/ml with the MIC of staphylococcus aureus CMCC (B) 26003, the MIC of clinical separating Escherichia coli AF-07d, AF-painstaking effort a is respectively 28.13mg/ml, 28.13mg/ml.
By above-mentioned result of the test as can be known, preparation of the present invention---golden root injection not only has good restraining and killing action to the escherichia coli that cause yellow and white dysentery of piglet, and to Salmonella SO
3C
78With staphylococcus aureus CMCC (B) 26003 reference cultures and clinically isolatingly have chemical sproof escherichia coli good effect is all arranged.
Embodiment 2: the clinical efficacy test of preparation of the present invention
Test method: select 120 of the close Rongchang County pigs of parity, age in days, the young number of nest, be divided into 4 groups at random, every group 30, be respectively CHUANXINLIAN ZHUSHEYE matched group (B group), golden root injection low dose group (C group), middle dosage group (D group), high dose group (E group), choose 30 ages in days simultaneously, healthy piglet that parity is close makes normal healthy controls (A group), the dosage of CHUANXINLIAN ZHUSHEYE is the 5ml/ head, the dosage of gold root injection basic, normal, high dosage group is respectively 1,2, the 4ml/ head, intramuscular injection, 2 times on the one, 3 days is a course of treatment.
Duration of test, clinical manifestation of viewing test animal and physical signs as the mental status, appetite, feces, body temperature, breathing, pulse etc., and itemized record, are observed 7d after treating a course of treatment.
The clinical efficacy criterion:
Cure: course of treatment of continuous use, sick pig cardinal symptom disappears, and feces is shaped, and recovery such as spirit, diet desires, body temperature normally.No longer recurrence is judged to healing in the 7d.The ratio that only accounts for the total group test pig according to the healing pig is calculated cure rate.
Produce effects: course of treatment of continuous use, sick pork chop excrement number of times reduces, and feces is than former retrogradation, and spirit, diet are desired, body temperature obviously improves, and are judged to produce effects, and the ratio that accounts for the total group test pig according to a produce effects pig quantity is calculated obvious effective rate.
Invalid: course of treatment of continuous use, sick pig is not felt any better, and diet desire, mental status, defecation situation do not have obvious change, even it is only dead pig to occur, and it is invalid to be judged to, and the ratio that accounts for the total group test pig according to invalid pig is calculated inefficiency.
Weightening finish: the body weight of every pig during according to on-test and when finishing, calculate the gain in weight (10d) of every pig, calculate the average weight gain amount and the standard deviation of every group of test pig then.The relative weight gain rate is to calculate by the ratio of each medication therapy groups with the average weight gain of normal healthy controls group, and wherein the normal healthy controls group is made as 100%.
Itemized record are respectively organized test data, carry out the significance test of data after the off-test with biostatistics's principle, wherein cure rate, obvious effective rate, the inefficiency x of each group
2Check, the relative weight gain rate is checked with t.Result of the test sees Table 3.
Table 3 is respectively organized the curative effect situation of experimental animal
| Group | Cure rate (head) (%) | Obvious effective rate (head) (%) | Effective percentage (head) (%) | Inefficiency (head) (%) | 10d increase weight (kg) | The relative weight gain rate (%) * |
| A | — | — | — | — | 1.82±1.10 | 100.0 |
| B | 21(70.00) | 3(10.00) | 24(80.00) | 6(20.00) | 1.32±1.08 | 70.35 |
| C | 17(56.67) | 6(20.00) | 23(76.67) | 7(23.33) | 1.24±1.20 | 68.13 |
| D | 25(83.33) | 0(0.00) | 25(83.33) | 5(16.67) | 1.33±1.04 | 72.93 |
| E | 26(86.67) | 1(3.33) | 27(90.00) | 3(10.00) | 1.36±1.17 | 74.73 |
By table 3 result of the test as can be known, the cure rate of CHUANXINLIAN ZHUSHEYE matched group is 70%, and the cure rate of the basic, normal, high dosage group of golden root injection is respectively 56.67%, 83.33%, 86.67%.From the test clinical observation result as can be seen, this compound preparation is to the treatment of natural infection escherichia coli case, generally through the treatment of a course of treatment (3d), all can obtain effect preferably, clinical manifestation reduces for the defecation number of times, feces becomes dry, is shaped, fur is clean, and spirit is clearly better, and is active, appetite strengthens, weight increase etc.Result of the test shows that preparation of the present invention has significant clinical efficacy.
Although relate to a kind of Chinese traditional compound medicine that is used for the treatment of yellow and white dysentery of piglet and carried out special description disclosed with reference to embodiment, the embodiment of foregoing description is illustrative and not restrictive.
Claims (4)
1, a kind of Chinese traditional compound medicine that is used for the treatment of yellow and white dysentery of piglet is characterized in that: with Flos Lonicerae and Radix Isatidis two flavor medical material prescriptions, form through its refining effective ingredients of extraction separation.
2, Chinese traditional compound medicine according to claim 1 is characterized in that: be used for the treatment of the yellow scour of piglet that caused by coli-infection, clinical manifestation is for discharging yellow pulpous state, including the loose stool of curdled milk small pieces.
3, Chinese traditional compound medicine according to claim 1 is characterized in that: be used for the treatment of the piglet pujos blancos that caused by coli-infection, clinical manifestation is discharged milky or linen pulpous state, pasty state feces for to suffer from diarrhoea suddenly, and tool is stench, and property is glutinous greasy.
4, according to claim 1 or claim 2,3 described compound Chinese medicinal preparation, it is characterized in that: be used for the treatment of poultry damp-heat dysentery.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100932504A CN101468057A (en) | 2007-12-29 | 2007-12-29 | Compound Chinese medicine preparation for treating yellow-white dysentery of piglet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100932504A CN101468057A (en) | 2007-12-29 | 2007-12-29 | Compound Chinese medicine preparation for treating yellow-white dysentery of piglet |
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|---|---|
| CN101468057A true CN101468057A (en) | 2009-07-01 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657296A (en) * | 2012-05-25 | 2012-09-12 | 江西赣达牧业有限公司 | Traditional Chinese medicine health-care type feed for suckling pigs |
| CN103933156A (en) * | 2014-04-08 | 2014-07-23 | 毛玉麟 | Antibacterial plant active composition and extraction and preparation method thereof |
| CN106177221A (en) * | 2016-08-18 | 2016-12-07 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for treating swine escherichia coli diarrhoea and preparation method thereof |
| CN106619963A (en) * | 2015-10-29 | 2017-05-10 | 李荣国 | Antivirus injection for pigs and method for antivirus injection |
| CN112641006A (en) * | 2020-12-18 | 2021-04-13 | 长春市畜牧总站（长春市畜禽产品质量安全中心） | Compound additive for treating white scour of piglets and using method thereof |
-
2007
- 2007-12-29 CN CNA2007100932504A patent/CN101468057A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657296A (en) * | 2012-05-25 | 2012-09-12 | 江西赣达牧业有限公司 | Traditional Chinese medicine health-care type feed for suckling pigs |
| CN103933156A (en) * | 2014-04-08 | 2014-07-23 | 毛玉麟 | Antibacterial plant active composition and extraction and preparation method thereof |
| CN106619963A (en) * | 2015-10-29 | 2017-05-10 | 李荣国 | Antivirus injection for pigs and method for antivirus injection |
| CN106177221A (en) * | 2016-08-18 | 2016-12-07 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for treating swine escherichia coli diarrhoea and preparation method thereof |
| CN112641006A (en) * | 2020-12-18 | 2021-04-13 | 长春市畜牧总站（长春市畜禽产品质量安全中心） | Compound additive for treating white scour of piglets and using method thereof |
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Open date: 20090701 |