CN101450222A - Silver-containing alginic acid fiber with antibacterial effect and preparation method thereof - Google Patents
Silver-containing alginic acid fiber with antibacterial effect and preparation method thereof Download PDFInfo
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- CN101450222A CN101450222A CNA2008102495709A CN200810249570A CN101450222A CN 101450222 A CN101450222 A CN 101450222A CN A2008102495709 A CNA2008102495709 A CN A2008102495709A CN 200810249570 A CN200810249570 A CN 200810249570A CN 101450222 A CN101450222 A CN 101450222A
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- silver
- alginic acid
- acid fiber
- containing alginic
- water
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- 239000000835 fiber Substances 0.000 title claims abstract description 46
- 235000010443 alginic acid Nutrition 0.000 title claims abstract description 35
- 239000000783 alginic acid Substances 0.000 title claims abstract description 35
- 229960001126 alginic acid Drugs 0.000 title claims abstract description 35
- 229920000615 alginic acid Polymers 0.000 title claims abstract description 35
- 150000004781 alginic acids Chemical class 0.000 title claims abstract description 34
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 34
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 239000004332 silver Substances 0.000 title claims abstract description 33
- 229910052709 silver Inorganic materials 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 13
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000661 sodium alginate Substances 0.000 claims abstract description 11
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 11
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 11
- 229940100890 silver compound Drugs 0.000 claims abstract description 7
- 150000003379 silver compounds Chemical class 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims description 15
- -1 sodium zirconium phosphate chemical compound Chemical class 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000009987 spinning Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000004531 microgranule Substances 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 25
- 208000027418 Wounds and injury Diseases 0.000 abstract description 25
- 241000894006 Bacteria Species 0.000 abstract description 11
- 238000002474 experimental method Methods 0.000 abstract description 5
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 239000011859 microparticle Substances 0.000 abstract 1
- 239000004744 fabric Substances 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 9
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 238000005520 cutting process Methods 0.000 description 7
- 238000009395 breeding Methods 0.000 description 6
- 230000001488 breeding effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 4
- 229920004934 Dacron® Polymers 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 239000005020 polyethylene terephthalate Substances 0.000 description 4
- 238000009941 weaving Methods 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 238000009940 knitting Methods 0.000 description 3
- 230000000474 nursing effect Effects 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 102000004195 Isomerases Human genes 0.000 description 2
- 108090000769 Isomerases Proteins 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000000648 calcium alginate Substances 0.000 description 2
- 235000010410 calcium alginate Nutrition 0.000 description 2
- 229960002681 calcium alginate Drugs 0.000 description 2
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001002 morphogenetic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- YHKRPJOUGGFYNB-UHFFFAOYSA-K sodium;zirconium(4+);phosphate Chemical compound [Na+].[Zr+4].[O-]P([O-])([O-])=O YHKRPJOUGGFYNB-UHFFFAOYSA-K 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention provides silver-containing alginic acid fiber with an antibacterial effect and a preparation method thereof, aiming at solving the technical problems of improving the performance of the existing alginic acid fiber and providing silver-containing alginic acid fiber with an antibacterial effect. In order to achieve the purpose of solving the technical problems, the technical scheme is that the silver-containing alginic acid fiber with the antibacterial effect is characterized by comprising 90.0-99.9% of sodium alginate powder and 0.1-10% of water-insoluble silver compound micro-particles in percentage by weight. Experiments prove that the silver-containing alginic acid fiber has more obvious antibacterial effect than single alginic acid fiber, can effectively control the growth of bacteria on wounds, and is safe and nontoxic.
Description
Technical field
The present invention relates to field of medical materials, be specifically related to a kind of silver-containing alginic acid fiber and preparation method with antibacterial action.
Background technology
Wound is a kind of integrity and successional destruction to human body skin.In the daily life, the reason that forms wound is a lot, comprises the burn that is caused by factors such as machinery, electricity, heat, chemistry, or because patient's the morphogenetic wound of physiological disease.Often occur because chronic wounds such as the decubital ulcer that poor circulation causes, ulcer among the old people.In recent years, along with the aging of global population, the chronic ulcerative wound is in the whole world, and particularly American-European developed country presents the trend that significantly increases.
Medical dressing is the material of a kind of flap coverage, auxiliary wound healing.From 1980 so far, along with the progress of science and technology and the people deep understanding to wound healing process and wound care process, many novel materials are used in the production of medical dressing.Medical dressing by the alginic acid fibre preparation is a kind of typical high-tech medical dressing, and they have very high hygroscopicity, both can apply ointment or plaster easily on wound, also can peel off from wound easily.This high-tech medical dressing combines the high efficiency of high-effect and nursing process of high efficiency, the product of material, has greatly improved the nursing process of wound.
Alginic acid fibre and medical dressing are a kind of typical " wet method therapy " products.1981, the Courtaulds company of Britain pushed to market to the non-weaving cloth of calcium alginate fibre as medical dressing first, was widely used on being bled in the ulcer wound market of suppurating more in nursing.With after wound fluid contacts, calcium alginate fibre forms colloid by ion exchange, the moisture of its absorption is fixed in the fiber, thereby forms a moistening environment on wound surface, has promoted the agglutination of wound.
In the agglutination of wound, the pus and blood on the wound increases to the breeding of antibacterial a good environment is provided.Thereby the breeding of antibacterial increase make wound infection slow down wound healing rate, increase patient's misery.Antibacterial also can be entered in the medical dressing by the pus and blood on the wound, and enters when replacing dressing in the foul in the hospital, propagates in the lesion, causes when serious that the lesion infects.
Summary of the invention
The invention provides a kind of silver-containing alginic acid fiber and preparation method with antibacterial action, its technical problem to be solved is to improve the performance of existing alginic acid fibre, and a kind of silver-containing alginic acid fiber with antibacterial action is provided.
Another technical problem to be solved by this invention is to provide the preparation method of above-mentioned silver-containing alginic acid fiber.
In order to reach the purpose that solves the problems of the technologies described above, technical scheme of the present invention is, a kind of silver-containing alginic acid fiber with antibacterial action is characterized in that comprising that the percentage by weight prescription is that sodium alginate powder 90.0-99.9% and water-fast silver compound molecule 0.1-10% make.
Wherein said water-fast silver compound molecule is meant that particle diameter is the sodium zirconium phosphate chemical compound of 0.01～1.0 micron silver, and its silver content is 3.0-4.0%.
The preferred percentage by weight prescription of described silver-containing alginic acid fiber is: the sodium zirconium phosphate chemical compound of sodium alginate powder 99.0% and water-fast silver is 1.0%.
A kind ofly prepare above-mentioned preparation method, comprise the following steps: with silver-containing alginic acid fiber of antibacterial action
1., elder generation is dissolved in the deionized water solution according to the sodium alginate powder of above-mentioned percentage by weight formula ratio;
2., add water-fast silver compound microgranule, one-tenth spinning solution after stirring;
3., clamp-on 2%CaCl through spinneret orifice
2Form fiber in the aqueous solution, washing, after the drying promptly.
It is carrier that the present invention adopts alginic acid, is anti-biotic material with the molecule of the chemical compound of water-fast silver, and sodium alginate is being become fiber with deionized water solution dissolving back with the molecule mixing post-treatment of silver-colored chemical compound.Because the granule of chemical compound of silver is very little, can be in the course of processing by being distributed in behind spinneret orifice and the alginic acid coprecipitation among the formed alginic acid fibre.
The alginic acid fibre that the present invention produced has the performance of general fiber, can be processed to yarn, woven fabric, knitted fabric and non-woven fabric material, also can be with forming coating cotton thread after dacron or other fibre-coated.
The chemical compound of silver of the present invention particularly silver the sodium zirconium phosphate chemical compound in silver ion by the sodium zirconium phosphate combination, its carrier fibre is not had oxidisability, in the course of processing, can not make alginic acid fibre oxidation blackening.
After being processed to yarn, woven fabric, knitted fabric and non-woven fabric material; product of the present invention can form medical dressing by cutting packing back; the more wound of suppurating that is used to bleed plays and absorbs pus and blood on the wound, prevents bacterial growth breeding, protection wound and promote the effect of its healing.
The experiment proved that the alginic acid fibre antibacterial effect is more obvious separately for silver-containing alginic acid fiber of the present invention, can effectively control the growth of antibacterial on the wound, and safety non-toxic.
The specific embodiment
Embodiment 1
The sodium alginate powder of 50 grams is dissolved in the deionized water solution of 950 grams, the sodium zirconium phosphate compound powder that adds the silver of 0.5 gram, particle diameter less than 1 micron greater than 0.01 micron, form spinning solution through fully stirring the back, solution be 30 with dosing pump in hole count under the pressure, the aperture is to clamp-on on 150 microns the spinneret to contain 2%CaCl
2Form strand in the water-bath, obtain the ionic alginic acid fibre of argentiferous through washing and drying.The fiber of gained can be processed into fabric with the dacron of 75 dtexs with woven or knitting method at the yarn of doing on the coating machine to obtain after coating is handled, be processed into non-weaving cloth with non-interlaced fabric equipment after also can becoming 5 centimeter length to fibre cutting, through the gauze of cutting packing post-treatment one-tenth for the usefulness that cures the wound.
Embodiment 2
The sodium alginate powder of 49 grams is dissolved in the deionized water solution of 900 grams, the sodium zirconium phosphate compound powder that adds the silver of 1.0 grams, particle diameter less than 1 micron greater than 0.01 micron, form spinning solution through fully stirring the back, solution be 30 with dosing pump in hole count under the pressure, the aperture is to clamp-on on 150 microns the spinneret to contain 2%CaCl
2Form strand in the water-bath, obtain the ionic alginic acid fibre of argentiferous through washing and drying.The fiber of gained can be processed into fabric with the dacron of 75 dtexs with woven or knitting method at the yarn of doing on the coating machine to obtain after coating is handled, be processed into non-weaving cloth with non-interlaced fabric equipment after also can becoming 5 centimeter length to fibre cutting, through the gauze of cutting packing post-treatment one-tenth for the usefulness that cures the wound.
Embodiment 3
The sodium alginate powder of 55 grams is dissolved in the deionized water solution of 1000 grams, the sodium zirconium phosphate compound powder that adds the silver of 5 grams, particle diameter less than 1 micron greater than 0.01 micron, form spinning solution through fully stirring the back, solution be 30 with dosing pump in hole count under the pressure, the aperture is to clamp-on on 150 microns the spinneret to contain 2%CaCl
2Form strand in the water-bath, obtain the ionic alginic acid fibre of argentiferous through washing and drying.The fiber of gained can be processed into fabric with the dacron of 75 dtexs with woven or knitting method at the yarn of doing on the coating machine to obtain after coating is handled, be processed into non-weaving cloth with non-interlaced fabric equipment after also can becoming 5 centimeter length to fibre cutting, through the gauze of cutting packing post-treatment one-tenth for the usefulness that cures the wound.
In the agaropectin culture dish of a standard, excise an intermediary agaropectin, two semicircles about making.Coat the solution that is tried antibacterial then on one side, wide 50mm of 10mm long to be tried the dressing bar horizontal in the centre with the form of similar foot bridge, after middle vacancy adds the 0.5mL sterilized water, cultivated 24 hours then.Observed result.In this process, the water that agaropectin absorbs is absorbed by dressing, and antibacterial also can be spread along liquid.If dressing does not have bactericidal action, then can form bacterium colony on the agaropectin of resonable another side.Have the dressing of antibacterial action can stop gushing of antibacterial to be moved, the sample that does not have antibiotic effect then can make antibacterial move to another side from the one side that is coated with bacterium, and the breeding back forms tangible bacterium colony.
Silver ion has the excellent antibiotic bactericidal property.When antibacterial on the wound contacts, it can with active part sulfydryl on the pheron in the bacterial cell (-SH), amino (-NH
2) wait and react.This reaction makes pheron precipitation and loses activity, and makes the respiratory metabolism of pathogenetic bacteria be forced to stop, growth of antibacterial and breeding thereby be inhibited.
Silver ion also can combine the back with DNA and RNA and stop duplicating of they.Silver ion can lose activity the 6-phosphomannose isomerase by combining with cysteine in the protein.Because the 6-phosphomannose isomerase plays an important role in the building-up process of the cell wall of antibacterial, its destruction makes the losses of intracellular phosphate, glutamine and some other important oxygen part, therefore destroys the breeding of bacterial cell.Just because of silver can combine with a lot of positions in the cell, it all has very strong anti-microbial property to nearly all antibacterial, and can not produce repellence.
As a kind of medical material, silver ion is very low to the toxicity of human body, and the ionic colloid of argentiferous has been used to administer burn patient, plays the effect of antibiotic and sterilizing.
Silver ion also has very strong oxidisability.After adding contained organic carrier, silver ion can make the oxidation operation blackening freely, had reduced the anti-microbial property of product on the one hand, had also destroyed the attractive in appearance of product on the other hand.
Embodiment is compared experiment to be shown:
Embodiment does not add the experimental result of the alginic acid medical dressing of silver ion to staphylococcus aureus bridging experiment: half culture medium that is coated with bacterium liquid overgrows with bacterium, be not coated with in second half training base of bacterium liquid and grown the staphylococcus aureus bacterium colony near the dressing, antibacterial can be spread along dressing.
Embodiment contains silver ion alginic acid medical dressing to the put up a bridge experimental result of experiment of staphylococcus aureus: half culture medium that is coated with bacterium liquid overgrows with bacterium, is not coated with in second half culture medium of bacterium liquid and does not find the staphylococcus aureus bacterium colony.Because add the antibacterial action of the silver ion in the dressing, antibacterial can not be spread along dressing.
More than disclosed only be preferred embodiment of the present invention, can not limit the present invention's interest field certainly with this, therefore, the equivalent variations according to claim of the present invention is done still belongs to the scope that the present invention is contained.
Claims (4)
1, a kind of silver-containing alginic acid fiber with antibacterial action is characterized in that comprising that the percentage by weight prescription is that sodium alginate powder 90.0-99.9% and water-fast silver compound molecule 0.1-10% make.
2, the silver-containing alginic acid fiber with antibacterial action according to claim 1, it is characterized in that wherein said water-fast silver compound molecule is meant that particle diameter is the sodium zirconium phosphate chemical compound of 0.01～1.0 micron silver, its silver content is 3.0～4.0%.
3, the silver-containing alginic acid fiber with antibacterial action according to claim 1 and 2, it is characterized in that the preferred percentage by weight prescription of described silver-containing alginic acid fiber is: the sodium zirconium phosphate chemical compound of sodium alginate powder 99.0% and water-fast silver is 1.0%.
4, a kind of preparation has the preparation method of the silver-containing alginic acid fiber of antibacterial action, it is characterized in that comprising the following steps:
1., elder generation is dissolved in the deionized water solution according to the sodium alginate powder of claim 1 percentage by weight formula ratio;
2., add water-fast silver compound microgranule, one-tenth spinning solution after stirring;
3., clamp-on 2%CaCl through spinneret orifice
2Form fiber in the aqueous solution, washing, after the drying promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102495709A CN101450222A (en) | 2008-12-26 | 2008-12-26 | Silver-containing alginic acid fiber with antibacterial effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102495709A CN101450222A (en) | 2008-12-26 | 2008-12-26 | Silver-containing alginic acid fiber with antibacterial effect and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101450222A true CN101450222A (en) | 2009-06-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008102495709A Pending CN101450222A (en) | 2008-12-26 | 2008-12-26 | Silver-containing alginic acid fiber with antibacterial effect and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103170004A (en) * | 2012-04-23 | 2013-06-26 | 佛山市优特医疗科技有限公司 | Argentiferous antibacterial fiber, fabric, wound dressing and preparation method thereof |
| CN103637926A (en) * | 2013-11-29 | 2014-03-19 | 福建鑫华股份有限公司 | Non-woven fabric for facial mask base materials as well as preparation method thereof |
| CN104204314A (en) * | 2012-12-05 | 2014-12-10 | 博尔顿大学 | Polysaccharide fibres for wound dressings |
| WO2015011188A1 (en) | 2013-07-26 | 2015-01-29 | Micro-Macinazione S.A. | Fibroin-based pharmaceutical spray compositions for the treatment of skin lesions |
| CN105332084A (en) * | 2015-12-01 | 2016-02-17 | 东华大学 | Preparation method for copper oxide-loaded mesoporous zirconium phosphate antibacterial polylactic acid fiber |
| CN105369383A (en) * | 2015-12-01 | 2016-03-02 | 东华大学 | Preparation method of mesoporous zirconium phosphate supported copper oxide antibacterial polypropylene fiber |
| CN108295298A (en) * | 2018-01-25 | 2018-07-20 | 四川大学 | A kind of calcium alginate perforated membrane of the basic zirconium phosphate containing carrying metal ion and preparation method thereof |
| CN108892473A (en) * | 2018-10-17 | 2018-11-27 | 安徽省德邦瓷业有限公司 | A kind of antibacterial domestic ceramic |
| CN109898323A (en) * | 2019-03-11 | 2019-06-18 | 惠州华阳医疗器械有限公司 | A kind of medical antibacterial fiber and preparation method thereof, medical antibacterial dressing |
-
2008
- 2008-12-26 CN CNA2008102495709A patent/CN101450222A/en active Pending
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| CN103170004B (en) * | 2012-04-23 | 2016-08-31 | 佛山市优特医疗科技有限公司 | A kind of method preparing contg. silver fiber wound dressing |
| WO2013159668A1 (en) * | 2012-04-23 | 2013-10-31 | 佛山市优特医疗科技有限公司 | Silvery antibacterial fibre, texture, and wound dressing, and preparation method thereof |
| CN103170004A (en) * | 2012-04-23 | 2013-06-26 | 佛山市优特医疗科技有限公司 | Argentiferous antibacterial fiber, fabric, wound dressing and preparation method thereof |
| CN104204314A (en) * | 2012-12-05 | 2014-12-10 | 博尔顿大学 | Polysaccharide fibres for wound dressings |
| WO2015011188A1 (en) | 2013-07-26 | 2015-01-29 | Micro-Macinazione S.A. | Fibroin-based pharmaceutical spray compositions for the treatment of skin lesions |
| CN103637926A (en) * | 2013-11-29 | 2014-03-19 | 福建鑫华股份有限公司 | Non-woven fabric for facial mask base materials as well as preparation method thereof |
| CN103637926B (en) * | 2013-11-29 | 2016-08-31 | 福建鑫华股份有限公司 | A kind of face mask substrate material non-weaving cloth and preparation method thereof |
| CN105369383A (en) * | 2015-12-01 | 2016-03-02 | 东华大学 | Preparation method of mesoporous zirconium phosphate supported copper oxide antibacterial polypropylene fiber |
| CN105332084A (en) * | 2015-12-01 | 2016-02-17 | 东华大学 | Preparation method for copper oxide-loaded mesoporous zirconium phosphate antibacterial polylactic acid fiber |
| CN105369383B (en) * | 2015-12-01 | 2017-10-20 | 东华大学 | A kind of preparation method of Mesoporous zirconium phosphate loaded copper oxide antibacterial polypropylene fiber |
| CN108295298A (en) * | 2018-01-25 | 2018-07-20 | 四川大学 | A kind of calcium alginate perforated membrane of the basic zirconium phosphate containing carrying metal ion and preparation method thereof |
| CN108892473A (en) * | 2018-10-17 | 2018-11-27 | 安徽省德邦瓷业有限公司 | A kind of antibacterial domestic ceramic |
| CN108892473B (en) * | 2018-10-17 | 2021-01-22 | 福建省德化铠宇陶瓷有限公司 | Antibacterial domestic ceramic |
| CN109898323A (en) * | 2019-03-11 | 2019-06-18 | 惠州华阳医疗器械有限公司 | A kind of medical antibacterial fiber and preparation method thereof, medical antibacterial dressing |
| CN109898323B (en) * | 2019-03-11 | 2021-06-29 | 惠州华阳医疗器械有限公司 | Medical antibacterial fiber, preparation method thereof and medical antibacterial dressing |
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Application publication date: 20090610 |