CN101433314B - Health food with anti-fatigue and anti-oxidation functions - Google Patents
Health food with anti-fatigue and anti-oxidation functions Download PDFInfo
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Abstract
The invention provides an anti-fatigue and anti-oxidation composition consisting of rhodiola rosea extract, ginkgo leaf extract, tea polyphenol and lipoic acid. Compared with the effect of singly using rhodiola rosea extract or ginkgo leaf extract or tea polyphenol, the anti-fatigue and anti-oxidation composition provided by the invention has obvious enhancement effect. Moreover, the anti-fatigue and anti-oxidation composition has no toxic or side effect, and the animals have no mutagenic and teratogenic effects after being taken for a long time. Therefore, the anti-fatigue and anti-oxidation composition is safe and effective, and is suitable for the tired people with fast work rhythm, excessive use of brain and the like and the middle-aged and the elderly people to take for a long time.
Description
Technical field:
The present invention relates to field of food, relate in particular to a kind of health food with antifatigue, anti-oxidation function.
Background technology:
As everyone knows, the power of people's energy and physical efficiency directly has influence on the confidence of life and the development of cause.Yet fast changing modern society and the rhythm of life of accelerating day by day make many people significantly feel unable to do what one wishes.What typical symptoms feels dizzy, aches all over, does all out of spirits exactly, often insomnia, decrease of memory.And medically say the overdraw of this long-term just muscle power, overstrain one's nerves, chronic fatigue syndrome that stress causes greatly.It is this overtired that modern medicine is thought, belongs to the inferior health animation, is one of modern civilization disease, but do not cause enough attention so far.In the recent period the incidence straight line of hot issue " overworking death " rises on the medium, report too numerous to mention, and " overworking death " long-term overload operation of social people of this high competition nowadays just, the disastrous effect of falling sick from overwork.If the long-term life of people is irregular, it is bad often to work overtime, stay up late, have a rest, and the time has been grown and will cause anxiety, sexual function to descend, hypoimmunity, and mental depression, even cause depression and schizophrenia.If this fatigue continued three months or the longer time, health just symptoms such as low fever, abscess of throat, decreased attention, failure of memory may occur.And very serious chronicity fatigue is exactly the tendency of other illnesss probably." overworking death " that it has often been said is actual to be long-term excessive fatigue, the sudden death that illnesss such as initiation human body heart failure, lung decline, renal failure, cardiac muscle stalk, cerebral hemorrhage cause.The cause of the death of this sudden death mainly is coronary heart disease, aortic aneurysm, valvulopathy, cardiomyopathy and cerebral hemorrhage, has no difference with general sudden death.Only these sick potentialities are ignored overwork person, so that lead to serious consequence.But if there is not overworked this inducement, sudden death possibly just can not take place.
In addition, modern study shows that multiple disease and aging all are to be caused by one type of material that is called free radical.Free radical is meant atom, molecule or the group that contains unpaired electronics, owing to contain unpaired electron in the free radical, has the tendency of pairing, and situation is unstable, has the activity of height.Free radical must to contiguous atom or molecule be captured electronics and make oneself electronics paired if will stablize, but also therefore makes that atom or molecule that electronics is taken by force become new free radical, the initiation chain reaction.This process is exactly " oxidation ".Free radical in the body is mainly derived from the cellular biochemical reaction, and in addition, factors such as ultraviolet irradiation, ionising radiation, smoking and environmental pollution also can be brought out body and produced free radical.Free radical so it very easily reacts with other material, obtains or loses electronics owing to have unpaired valence electron, thereby destroys normal molecular structure in the organism.It is certified because the disease that free radical causes comprises cancer, cardiovascular and cerebrovascular disease, hepatopathy, Keshan disease, cataract, senile dementia, miocardial infarction, MOF etc.; Research confirms; Have at least the disease more than 70 kinds relevant, even we can say that free radical is " sources of ten thousand diseases " with free radical.Simultaneously the same with numerous disease, aging also has been proved to be closely related with existing of free radical.Old and feeble free radical theory is proposed in nineteen fifty-five by Harman the earliest, this theory thinks that it is because free-radical induced that the degeneration that increases along with the age changes, and existing in decades countless experimental facts confirmed should theory correctness.Though the radical pair body has very big harm, in very long evolution course, produced complete free radical defense system in the organism fortunately.Under normal circumstances, the generation of free radical is in dynamic equilibrium with removing in the body, and human body is also producing the polyphenoils of resisting free radical naturally when producing free radical inevitably, attack with the oxidation of offsetting the radical pair human body cell.As superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase endogenous anti-oxidants such as (Cat) are just arranged in the human body, excessive free radicals can be in time removed in their existence, keeps the balance of interior free yl concentration.Research proof, the antioxidant system of human body are the systems that can compare, have perfect and complicated function with immune system mutually, and the oxidation resistant ability of body is strong more, and just more healthy, life is also long more.But when body aging; Or free-radical generating is a little higher than usual, or because a certain link becomes weak, acute or chronic weakening appears in the ability of removing free radical in the body; Thereby when having removed not unnecessary free radical; The generation of free radical has just lost balance with elimination, and then superfluous free radical will be attacked and constitute histiocytic large biological molecule, destroys its chemical constitution.Along with destroying progressively going deep into of level, normal tissues form and functional integrity property will be destroyed.When degree of injury exceeded repair coverage or loses its compensatory capacity, the function of histoorgan just progressively got muddled and obstacle, showed body and was tending towards old and feeble gradually, and disease also takes place thereupon.This shows, suitably replenish anti-oxidant, remove in time that unnecessary free radical is a resist the disease in the body, delay old effective way.
Motherland's traditional medicine is precious deposits.Such record is arranged in China Tibetan medicine ancient books and records Four-Volume Medical Code for a long time: rhodiola root (hiding name " Suo Luomabao ") has the effect of strengthening by means of tonics, detoxifcation pain relieving.Rhodiola root is the Crassulaceae plant that is grown in the high and cold low-oxygen environment, and there is kind more than 90 in the whole world, and just there is kind more than 70 in China, and wild resource is very abundant.Modern age, the research to rhodiola root started from the sixties in 20th century.Tentatively from rhodiola plant, successively isolate the useful compound of kind more than 40 in recent years; Mainly contain rhodioside, flavonoids, organized enzyme, polysaccharide, 17 seed amino acids and 21 kinds of trace elements and multivitamin, have antifatigue, anti-ageing, anti-anoxic, suppress tumour, improve immunity and regulate various biological effects such as blood sugar blood pressure.The former Soviet Union once carried out screening study to nearly ten thousand kind of plant in space development in the works, adapted to special environment to help the astronaut.The selection result, rhodiola root is shown one's talent with functions such as its promotion energetic supersession, anti-anoxic, radioresistances, and has obtained " reusing ".Modern pharmacological research finds that rhodiola root can strengthen the Serum LDH vigor, reduces the blood lactic acid content, increases the deposit of hepatic glycogen, muscle glycogen, has the obvious anti-fatigue effect.
Ginkgo (Ginkgo biloba L) is the something lost plant in the most ancient middle living age, only deposits a section one and belongs to two kinds, has the title of gymnosperm " living fossil ".Though the earth in time immemorial through a series of great changes, fails ginkgo is become extinct as dinosaur all the time, scientists gives the credit to it self indomitable vitality to this existence miracle of ginkgo.Our ancestors use it for very early and prevent and cure diseases and the health care aspect, effects such as according to Shennong's Herbal record, ginkgo has moistening lung, relievings asthma, restoring consciouness.Really its research of carrying out the medicines and health protection aspect is started from the seventies, utilize ginkgo to process various preparations in the world, control cardiovascular and cerebrovascular disease and peripheral vessels dysfunction are obtained good curative effect.Think ginkgo leaf at present except containing compositions such as alkaloid, trace element, amino acid, its main active ingredient is ginkgo biloba p.e (GDE), i.e. flavones and terpene lactones compound.
Tea Polyphenols is the complex that from natural plants tealeaves, separates the polyphenol compound of purifying, and the biologically active of this compounds, health care also receive the very big concern of domestic and international medical circle.Its active component also is a Flavonoid substances.Discover; Contain compositions such as catechin, fat polyacid in the tealeaves and be referred to as Tea Polyphenols, Tea Polyphenols is a kind of natural with superior antioxygen property, and its anti-oxidant index is 10～20 times of anti-oxidant index that mix Ve; And has an effect of injury of anti-, radioresistance and the injury of radiotherapy property; Hematopoietic function to health has significant gain effect, can increase white blood cell, can effectively reduce the harm of radiation such as TV.Anticancer in addition, anti-ageing, remove a series of pharmacological functions such as human free radical, hypoglycemic, hypotensive, reducing blood lipid and bactericidal antiphlogistic.
Lipoic acid (Alpha Lipoic Acid) nineteen fifty-five discusses through international vitamin association and confirms as new vitamin substances; Has very strong biologically active; Participate in pyruvate oxidation decarboxylation to acetate in vivo and play catalytic action, as the protein transduction acyl group confactor of alpha-ketoacid dehydrogenase complex compound, or effective positive growth factor; Can be used as radioprotector and be used to prevent the infringement of ray, and the effect that reduces blood sugar in the body is arranged DNA.In recent years, find that it has powerful non-oxidizability effect.It is " Universal antioxidant ", i.e. universal antioxidant for external title.Particularly with V
C, V
ECombined application has powerful synergy to non-oxidizability.These article have following characteristics: (1) is converted into dihydrolipoic acid (reduced form) easily in cell; The most of mammalian cell picked-up dihydrolipoic acids of experiment proof also are discharged into the extracellular; Owing to exist simultaneously and the coordination that complements each other with two kinds of forms in the body; Therefore most of oxygen radical all can effectively be removed, and adds dihydrolipoic acid and can swash in vivo VE, VC and glutathione, more can bring into play the function of its powerful seizure oxygen radical; (2) solubility property is better in water and lipid; (3) can catch various oxygen radicals and with metal complex (Fe especially
2+And Cu
2+, in lipid peroxidation, play catalyst action, lipoic acid can reduce the peroxidating degree through complexing metal).
Summary of the invention:
The object of the present invention is to provide a kind of health food with antifatigue, anti-oxidation function, described this health food with antifatigue, anti-oxidation function will solve health food of the prior art and remove interior free yl, antifatigue, the not good technical problem of antioxidant effect.
The invention provides a kind of health food with antifatigue, anti-oxidation function, wherein each component and weight percent content are following:
Gadol extract 15～32%
Ginkgo biloba p.e 15～26%
Tea Polyphenols 10～32%
Lipoic acid 1～10%
Auxiliary material or carrier surplus
Further, the formulation of described food is any formulation of approving on the bromatology.
Further, the formulation of described food is that stomach dissolves or enteric capsule or tablet or pill or pulvis or particle electuary or oral liquid.
Further, described carrier is selected from excipient or lubricant or disintegrant or anti-oxidant.
The present invention adopts gadol extract, ginkgo biloba p.e, Tea Polyphenols and lipoic acid as raw material, can be made into various formulations, dissolves or formulations such as enteric capsule, tablet, pill, pulvis, particle electuary, oral liquid like stomach.As required, in preparation, can add various pharmaceutical carriers, like excipient, lubricant, disintegrant, anti-oxidant etc.The present invention utilizes synergistic function between the different component, brings into play the each component activity comprehensively, has significant antifatigue, antioxidation.
Antifatigue provided by the invention, antioxidant composition and single comparison with gadol extract or ginkgo biloba p.e or Tea Polyphenols have tangible enhancement effect.And antifatigue of the present invention, antioxidant composition do not have any toxicity, and animal is taken for a long time and do not see mutagenesis and teratogenesis.Therefore, antifatigue of the present invention, antioxidant composition are safely and effectively, are suitable for fatiguability persons such as work rhythm is fast, overstrain one's nerves and mid-aged population and take for a long time.
The specific embodiment:
Embodiment 1:
With each composition mixing, cross 80 mesh sieves, capsule charge after the vacuum drying, 500 milligrams every as following weight percent.
Gadol extract 15～32%
Ginkgo biloba p.e 15～26%
Tea Polyphenols 10～32%
Lipoic acid 1～10%
The starch surplus
Embodiment 2:
Be mixed with composition as following weight percent:
| Prescription 1 | Prescription 2 | Prescription 3 | Prescription 4 | Prescription 5 | Prescription 6 | Prescription 7 | Prescription 8 | |
| Gadol extract | 100 | 125 | 150 | 160 | 500 | 0 | 0 | 0 |
| Ginkgo biloba p.e | 80 | 90 | 100 | 130 | 0 | 500 | 0 | 0 |
| Tea Polyphenols | 100 | 125 | 150 | 160 | 0 | 0 | 500 | 0 |
| Lipoic acid | 30 | 40 | 50 | 50 | 0 | 0 | 0 | 0 |
| Starch | 190 | 120 | 50 | 0 | 0 | 0 | 0 | 500 |
Experimental example 3 anti-fatigue tests
Each compound composition is mixed with suspension with 2% cmc soln.
Selecting body weight for use is 80 of the male Wistar rats of 150 ± 7.5g; Be divided into 8 groups, 10 every group, freely ingest and drink water; Test group is irritated each compound composition of clothes (once a day through stomach tube respectively; Irritate clothes during early morning), dosage is the 1g/kg body weight, control group is irritated clothes equal-volume starch cmc soln (prescription 8).Continuous irrigation stomach and 3 weeks of raising.Carry out swimming test and pole-jump test by conventional method half an hour after irritating stomach the last time.The result sees table 1.
The table 1 anti-fatigue test result that respectively fills a prescription
| Prescription | Number of animals | The rats'swimming time (second) | The rat pole-climbing time (second) |
| 1 | 10 | 52.6±2.8 | 43.2±4.7 |
| 2 | 10 | 73.9±3.5 | 32.7±3.9 |
| 3 | 10 | 65.8±4.3 | 34.5±5.1 |
| 4 | 10 | 62.4±2.7 | 39.3±4.8 |
| 5 | 10 | 52.1±3.5 | 40.9±5.4 |
| 6 | 10 | 51.8±4.6 | 43.7±6.0 |
| 7 | 10 | 50.9±5.2 | 42.8±4.5 |
| 8 | 10 | 35.8±5.6 | 42.5±6.3 |
Result of the test shows that each prescription group is compared difference significance (P＜0.05) with blank group (filling a prescription 8 groups); Fill a prescription 2～4 groups and compare for 7 groups with prescription with 6 groups of blank groups, 5 groups of prescriptions, prescription, difference significance (P＜0.05) is the best with 3 the effect of filling a prescription.Also can find out simultaneously, take antifatigue of the present invention, antioxidant composition, promptly have obvious synergistic effect than single effective with gadol extract or ginkgo biloba p.e or Tea Polyphenols.
Experimental example 4 anti-oxidant tests
2,3,4 carry out anti-oxidant test to fill a prescription, and with the blank group relatively.
Each compound composition is mixed with suspension with 2% cmc soln.Selecting body weight for use is 40 of the male SD rats of 450 ± 50g; Be divided into 4 groups, 10 every group, freely ingest and drink water; Test group is irritated each compound composition of clothes (once a day through stomach tube respectively; Irritate clothes during early morning), dosage is the 1g/kg body weight, control group is irritated clothes equal-volume starch cmc soln (prescription 8).Continuous irrigation stomach and raising 30 days.The 31st day, 4 treated animals are plucked eyeball and got blood, and were centrifugal, get serum, measured following biochemical indicator: lipid peroxide catabolite MDA (MDA) content, (SOD) vigor of superoxide dismutase in the blood and glutathione peroxidase (GSH-Px) in the blood.The result sees table 2,3,4.
Table 2 sample is to the influence of the weight of animals
| Group | Number of animals | Initial body weight | Mid-term body weight | Final body weight |
| Fill a prescription 2 groups | 10 | 472±15 | 503±10 | 544±13 |
| Fill a prescription 3 groups | 10 | 480±11 | 509±8 | 556±14 |
| Fill a prescription 4 groups | 10 | 476±12 | 498±14 | 541±10 |
| Blank | 10 | 481±16 | 506±6 | 552±17 |
| Group |
The above results shows, compares each prescription group there was no significant difference with the blank group.
Lipid peroxide catabolite MDA (MDA) content in table 3 blood
| Group | Number of animals | MDA content (nmol/ml) |
| Fill a prescription 2 groups | 10 | 1.85±0.16 |
| Fill a prescription 3 groups | 10 | 1.76±0.10 |
| Fill a prescription 4 groups | 10 | 1.82±0.14 |
| The blank group | 10 | 2.65±0.17 |
The above results shows, compares with the blank group, and each prescription group has significant difference.
(SOD) vigor of superoxide dismutase in table 4 blood and glutathione peroxidase content
| Group | Number of animals | Superoxide dismutase activity (u/ml) | Glutathione peroxidase (nmol/ml) |
| Fill a prescription 2 groups | 10 | 181.4±12.3 | 121.5±6.8 |
| Fill a prescription 3 groups | 10 | 189.6±10.5 | 128.8±9.7 |
| Fill a prescription 4 groups | 10 | 183.2±14.1 | 124.9±7.5 |
| The blank group | 10 | 115.7±12.6 | 90.1±8.4 |
The above results shows, compares with the blank group, and each prescription group has significant difference.
2～4 groups of antioxidant effects of filling a prescription are obvious, are the best to fill a prescription 3 groups wherein.
Experimental example 5 acute toxicity tests
100 of Kunming mouses (body weight 18～22 grams), 20 of SD rats (body weight 180～220 grams), male and female half and half are divided into groups, and irritate the clothes present composition with following dosage respectively: the mouse dose groups is 2g/kg, 4g/kg, 6g/kg, 8g/kg and 10g/kg; The rat dose groups is 1g/kg, 2.5g/kg, 4.5g/kg and 10g/kg.Observed for 2 weeks after irritating stomach, the equal no abnormality seen of rat and mouse reacts, activity freely, none death.The result shows, the LD of rat and mouse
50Value is all greater than 10g/kg.
Experimental example 6 chronic toxicity tests
With 80 of SD rats, be divided into 4 groups, 20 every group, male and female half and half, test group dosage is respectively 0.10g/kg, 0.75g/kg and 1.5g/kg, mixes feed, and control group is the basal feed group.Observe after 30 days and put to death, do postmortem.The result: animal activity freely, hair luster, feed, stool and urine are normal.All there is not significant difference at aspects such as body weight gain, physiochemical indice, biochemical measurement indexs between each group.The postmortem result does not see the pathological change that there were significant differences.
Experimental example 7 mutagenesis and tertogenicity test
Kunming mouse (25～28 gram), test group dosage is respectively 1.25g/kg, 2.5g/kg and 5.0g/kg in the mutagenicity test, and test group dosage is respectively 2.5g/kg, 5.0g/kg and 7.5g/kg in the tertogenicity test.All with the negative control group of distilled water, the positive control group of endoxan 40mg/kg.Make marrow nuclear test and testicular chromosome aberration test respectively by " foodsafety poison lithium is learned assessment process and method ".The result: each test group micronuclear rates and negative control group do not have significant difference (p＞0.05), and micronuclear rates is significantly higher than each test group and negative control group (p＜0.01).Each test group chromosome aberrations rate and negative control group do not have significant difference (p＞0.05), are significantly higher than each test group and negative control group (p＜0.01).
Claims (3)
1. health food with antifatigue, anti-oxidation function, wherein each component and weight percent content are following:
Gadol extract 15～32%;
Ginkgo biloba p.e 15～26%;
Tea Polyphenols 10～32%;
Lipoic acid 1～10%;
The carrier surplus.
2. a kind of health food with antifatigue, anti-oxidation function as claimed in claim 1 is characterized in that: said food is gastric-dissolved capsule agent, enteric capsule, tablet, pill, pulvis, particle electuary or oral liquid.
3. a kind of health food with antifatigue, anti-oxidation function as claimed in claim 1, it is characterized in that: described carrier is selected from excipient, lubricant, disintegrant or anti-oxidant.
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| EP2364697A1 (en) * | 2010-03-12 | 2011-09-14 | Cor.Con. International S.r.L. | Antioxidant composition for reducing oxidative stress ascribable to the treatment with hormonal contraceptive drugs |
| CN102258196B (en) * | 2010-12-24 | 2013-03-06 | 天津天狮生物发展有限公司 | Health-care food with anti-oxidation function |
| CN103054040B (en) * | 2013-01-13 | 2014-05-21 | 浙江奥默生物医药有限公司 | Pharmaceutical composition for increasing hypoxia tolerance |
| CN104126803A (en) * | 2014-08-23 | 2014-11-05 | 柯金表 | Health-care product for supplementing nutrition of heart and brain, soothing heart and benefiting brain |
| CN104273534A (en) * | 2014-10-11 | 2015-01-14 | 中山百鸥医药科技有限公司 | Anti-fatigue health food |
| CN116637106A (en) * | 2022-02-15 | 2023-08-25 | 四川大学 | Health care product or medicine with antioxidation effect |
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