CN101406450B - Technique for preparing compound amoxicillin oil suspension injection - Google Patents
Technique for preparing compound amoxicillin oil suspension injection Download PDFInfo
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- CN101406450B CN101406450B CN2007101897480A CN200710189748A CN101406450B CN 101406450 B CN101406450 B CN 101406450B CN 2007101897480 A CN2007101897480 A CN 2007101897480A CN 200710189748 A CN200710189748 A CN 200710189748A CN 101406450 B CN101406450 B CN 101406450B
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Abstract
The invention discloses a preparation process for compound recipe amoxicillin oil suspensoid injection. The preparation process comprises the following steps: (1) heating, sterilizing and cooling down neutual soybean oil, adding aluminum stearate into the soybean oil to prepare gel, heating the gel, diluting the gel through the filtrated and sterilized soybean oil, and filtrating the gel for standby; and (2) taking amoxicillin and clavulanic acid according to a recipe, mixing the amoxicillin and the clavulanic acid with the factice, grinding the mixture in a mortar, adding lecithin into the mixture while grinding till the mixture is ground evenly, adding the factice and the like into the mixture, adding benzyl alcohol, span and vitamin E into a graduated cylinder, and stirring the mixture, adding the factice and the like into the graduated cylinder, packaging and sealing the mixture and obtaining the compound recipe amoxicillin oil suspensoid injection. The compound recipe amoxicillinoil suspensoid injection has the advantages that the compound recipe amoxicillin oil suspensoid injection has a long-acting slow-releasing action, and antibacterial activity against bacteria capable of resisting single recipe amoxicillin, ampicillin, ceftiofur, and the like, that is, the compound recipe amoxicillin oil suspensoid injection can effectively treat bacterial infection capable of generating ESBLs. The preparation process is simple and convenient.
Description
Technical field
The present invention relates to a kind of medicine, relate in particular to a kind of technique for preparing compound amoxicillin oil suspension injection.
Background technology
The amoxicillin is the wide spectrum semisynthetic penicillin of veterinary clinic widespread usage, can be used for treating escherichia coli, Salmonella, pasteurellosis bacillus, digestive tract such as Bacillus proteus, respiratory tract and urinary tract infection.Along with its extensive use, the amoxicillin Resistant strain is constantly occurred, drug resistance mechanism mainly is to produce beta-lactamase, the beta-lactamase ring of hydrolysis amoxicillin and make the latter lose antibacterial activity.Clavulanic acid, sulbactam sodium are irreversibility state of conflict beta-lactamase inhibitors, can suppress bacteriogenic beta-lactamase, make the sensitivity of antibacterial recovery to the amoxicillin, improve the antibacterial activity of amoxicillin.
The amoxicillin with clavulanic acid preparation has tablet, capsule, breast injection, water suspensoid injectio and water suspension for oral administration etc. on the veterinary abroad.Amoxicillin water suspendible long-acting injection is arranged, but its prescription forms and process conditions are secret part abroad.Amoxicillin with clavulanic acid water suspensoid injectio patent is arranged, no amoxicillin with clavulanic acid oil suspensoid injectio patent abroad.All do not have oily suspendible long-acting injection listing both at home and abroad, do not see patent and technical standard that the amoxicillin oil suspension long-acting injection is arranged yet.And domestic existing soluble powder, breast injection still do not have the water of independent intellectual property right suspendible are arranged, the listing of oily suspendible long-acting injection, also do not have corresponding patent.All there are not ampicillin with sulbactam sodium water, the listing of oily suspendible long-acting injection both at home and abroad.Except that the usage of amoxicillin with clavulanic acid injection closes at " veterinary drug guide for use ", do not seen corresponding technical standard.The oily suspendible long-acting injection that present domestic veterinary go up to use needs import, and cost height (10% 100ml wholesale price is up to 120 yuan) has limited the scope of its application.The control of pig, cattle, horse domestic animal bacterial disease presses for has a broad antifungal spectrum, and antibacterial activity is strong, and administration number of times is few, stress be little, and cheap ampicillin with sulbactam sodium, amoxicillin with clavulanic acid long-acting injection.
Summary of the invention
Purpose of the present invention just is to provide a kind of technique for preparing compound amoxicillin oil suspension injection of better effects if.
Purpose of the present invention can realize by following measure:
Preparation technology's method of the present invention is as follows:
(1), with neutral soybean oil 100 ± 5mL, place pressure cooker or pressure sterilizing cabinet to be heated to 115.5-126.5 ℃, after sterilizing 30 minutes-1 hour, take out 20-30mL and put and be chilled to 60～80 ℃, add stearic acid aluminum 2 ± 0.2 and restrain in wherein, be made into the gel of 6.5%-10%, and heat to 110-120 ℃, keeping 30 minutes-1 hour, the soybean oil that reuse filters, sterilizes is diluted to 2 ± 0.2% factice, filter, standby;
(2), get any and amoxicillin 15 ± 1.0 grams in clavulanate potassium 3.75 ± 0.3 gram or sulbactam sodium 7.5 ± 0.5 grams, and it is mixed with the 20-30mL factice by prescription, grinding then, adding lecithin 0.05-0.07 restrains while grinding, until grinding well; Afterwards, with any is transferred in the graduated cylinder in ground amoxicillin and clavulanate potassium or the sulbactam sodium, and add factice 30-40mL, when the factice temperature is not less than 70-80 ℃, benzyl alcohol 1 ± 0.1mL, Arlacel-80 0.15-0.2 gram, vitamin E 0.15-0.3 gram are added in the graduated cylinder, the limit edged stirs, and adds to 100 ± 2ml with factice; To decide measured solution again and in agitator, stir 30-45 minute, with its abundant mixing; At last solution is sub-packed in while stirring in the ampoule of sterilizing-drying in sealing by fusing or the vial and seals, promptly.
Prescription is as follows in the preparation method of the present invention:
100ml suspension main component:
100 ± 5mL soybean oil
Amoxicillin 15 ± 1.0 grams
Clavulanate potassium 3.75 ± 0.3 grams or sulbactam sodium 7.5 ± 0.5 grams
Phosphatidase 10 .05-0.07 gram
Aluminium stearate 2.0 ± 0.2 grams
Span-80 0.15-0.3g
Benzyl alcohol 1 ± 0.1mL
Vitamin E 0.15-0.3 gram.
Other are conventional batching.
Preparation method of the present invention is as follows:
(1). with neutral soybean oil 100 ± 5mL, place pressure cooker or pressure sterilizing cabinet to be heated to 120-126.5 ℃, after sterilizing 30 minutes-45 minutes, take out 25-30mL and put and be chilled to 60～80 ℃, add stearic acid aluminum 2 ± 0.2 and restrain in wherein, be made into the gel of 6.5%-8%, and heat to 110-120 ℃, keeping 30 minutes-40 minutes, the soybean oil that reuse filters, sterilizes is diluted to 2 ± 0.2% factice, filter with No. 3 sintered glass funnels or glass filter bulbs or glass filter bulb rod, standby;
(2). get any and amoxicillin 15 ± 1.0 grams in clavulanate potassium 3.75 ± 0.3 gram or the sulbactam sodium 7.5 ± 0.5 by prescription, and it is mixed with the 25-30mL factice, grind in mortar, adding lecithin 0.05-0.06 restrains while grinding, until grinding well; Afterwards, ground amoxicillin/clavulanate potassium (or sulbactam sodium) is transferred in the graduated cylinder, and add factice 35-40mL, when the factice temperature is not less than 70-80 ℃, benzyl alcohol 1 ± 0.1mL, Arlacel-80 0.15-0.2 gram, vitamin E 0.1 5-0.2 gram are added in the graduated cylinder, the limit edged stirs, and adds to 100 ± 2ml ml with factice; To decide measured solution again and in agitator, stir 30-40 minute, with its abundant mixing; At last solution is sub-packed in while stirring in the ampoule of sterilizing-drying in sealing by fusing or the 100ml vial and seals, promptly.
The product that adopts technology of the present invention to make is compared with other dosage form, and the great advantage of product of the present invention is:
1. has the long-acting slow-release effect, 1 medication course of treatment 2 times.
2. amoxicillin gram oil suspension injection has antibacterial activity to the antibacterial of anti-folk prescription amoxicillin, ceftiofur etc., can effectively treat the bacterial infection that produces super wide spectrum enzyme (ESBLs).
3. preparation method is easy, constant product quality.
The specific embodiment
The present invention does with detailed description below in conjunction with embodiment:
Embodiment 1
Preparation technology's method of the present invention is as follows:
(1), with neutral soybean oil 95mL, place pressure cooker or pressure sterilizing cabinet to be heated to 115.5 ℃, sterilize after 30 minutes, take out 20mL and put and be chilled to 60 ℃, add stearic acid aluminum 1.8 and restrain in wherein, be made into 6.5% gel, and heat to 110 ℃, keeping 30 minutes hours, the soybean oil that reuse filters, sterilizes is diluted to 1.8% factice, filter, standby;
(2), get any and amoxicillin 14 grams in clavulanate potassium 3.45 gram or sulbactam sodium 7 grams, and it is mixed with the 20mL factice by prescription, grinding then, adding lecithin 0.05 restrains while grinding, until grinding well; Afterwards, with any is transferred in the graduated cylinder in ground amoxicillin and clavulanate potassium or the sulbactam sodium, and add factice 30mL, when the factice temperature is not less than 70 ℃, with benzyl alcohol 0.9mL, Arlacel-80: 0.15 gram, vitamin E 0.15 gram add in the graduated cylinder, the limit edged stirs, and adds to 98ml with factice; To decide measured solution again and in agitator, stir 30 minutes, with its abundant mixing; At last solution is sub-packed in while stirring in the ampoule of sterilizing-drying in sealing by fusing or the vial and seals, promptly.
The present invention selects stabilizing agents such as suitable wetting agent, suspending agent, dispersant, prepares the long lasting compound amoxicillin oil suspension injection of safety and stability (100mL contains amoxicillin 15 grams, clavulanate potassium 3.75 grams or sulbactam sodium 7.5 ± 0.5 grams) with dispersion method.The even particle size distribution of this suspension injection, the particulate relative volume of particle diameter 3-5 μ m is about 70%, and the volume settling ratio is greater than 0.9, and is effective to the bacterial infection of anti-ceftiofur. to the intramuscular injection of pig fowl bacterial disease, every 24-48h 1 time, each medication course of treatment 2 times.
Embodiment 2
Preparation technology's method of the present invention is as follows:
(1), with neutral soybean oil 100mL, place pressure cooker or pressure sterilizing cabinet to be heated to 120 ℃, sterilize after 45 minutes, take out 25mL and put and be chilled to 65 ℃, add stearic acid aluminum 2 and restrain in wherein, be made into 8% gel, and heat to 115 ℃, keeping 45 minutes, the soybean oil that reuse filters, sterilizes is diluted to 2% factice, filter, standby;
(2), get any and amoxicillin 15 grams in clavulanate potassium 3.75 gram or sulbactam sodium 7.5 grams, and it is mixed with the 20mL factice by prescription, grinding then, adding lecithin 0.06 restrains while grinding, until grinding well; Afterwards, with any is transferred in the graduated cylinder in ground amoxicillin and clavulanate potassium or the sulbactam sodium, and add factice 35mL, when the factice temperature is not less than 75 ℃, benzyl alcohol 1mL, Arlacel-80 0.17 gram, vitamin E 0.2 gram are added in the graduated cylinder, the limit edged stirs, and adds to 100ml with factice; To decide measured solution again and in agitator, stir 40 minutes, with its abundant mixing; At last solution is sub-packed in while stirring in the ampoule of sterilizing-drying in sealing by fusing or the vial and seals, promptly.
Embodiment 3
Preparation technology's method of the present invention is as follows:
(1), with neutral soybean oil 105mL, place pressure cooker or pressure sterilizing cabinet to be heated to 126.5 ℃, sterilize after 1 hour, take out 30mL and put and be chilled to 80 ℃, add stearic acid aluminum 2.2 and restrain in wherein, be made into 10% gel, and heat to 120 ℃, keeping 1 hour, the soybean oil that reuse filters, sterilizes is diluted to 2.2% factice, filter, standby;
(2), get any and amoxicillin 16 grams in clavulanate potassium 4.05 gram or sulbactam sodium 8 grams, and it is mixed with the 30mL factice by prescription, grinding then, adding lecithin 0.07 restrains while grinding, until grinding well; Afterwards, with any is transferred in the graduated cylinder in ground amoxicillin and clavulanate potassium or the sulbactam sodium, and add factice 40mL, when the factice temperature is not less than 80 ℃, with benzyl alcohol 1.1mL, Arlacel-80: 0.2 gram, vitamin E 0.3 gram add in the graduated cylinder, the limit edged stirs, and adds to 102ml with factice; To decide measured solution again and in agitator, stir 45 minutes, with its abundant mixing; At last solution is sub-packed in while stirring in the ampoule of sterilizing-drying in sealing by fusing or the vial and seals, promptly.
Embodiment 4
Preparation technology's method of the present invention is as follows:
Prescription is as follows in the preparation method:
100ml suspension main component:
100 ± 5mL soybean oil
Amoxicillin 15 ± 1.0 grams
Clavulanate potassium 3.75 ± 0.3 grams or sulbactam sodium 7.5 ± 0.5 grams
Phosphatidase 10 .05-0.07 gram
Aluminium stearate 2.0 ± 0.2 grams
Span-80 0.15-0.3g
Benzyl alcohol 1 ± 0.1mL
Vitamin E 0.15-0.3 gram.Other adjuvants should adopt conventional ingredient.
Preparation technology is with embodiment 1.
Embodiment 5
Preparation method of the present invention is as follows:
(1). with neutral soybean oil 100mL, place pressure cooker or pressure sterilizing cabinet to be heated to 123.5 ℃, sterilize after 42 minutes, take out 29mL and put and be chilled to 75 ℃, add stearic acid aluminum 2 and restrain in wherein, be made into 7.5% gel, and heat to 1108 ℃, keeping 38 minutes, the soybean oil that reuse filters, sterilizes is diluted to 2% factice, filter with No. 3 sintered glass funnels or glass filter bulbs or glass filter bulb rod, standby;
(2). get any and amoxicillin 15 grams in clavulanate potassium 4 gram or sulbactam sodium 4 grams by prescription, and it is mixed with the 28mL factice, grind in mortar, adding lecithin 0.055 restrains while grinding, until grinding well; Afterwards, ground amoxicillin/clavulanate potassium (or sulbactam sodium) is transferred in the graduated cylinder, and added factice 38mL, when the factice temperature is not less than 78 ℃, benzyl alcohol 1mL, Arlacel-80 0.18 gram, vitamin E 0.16 gram are added in the graduated cylinder, and the limit edged stirs, and adds to 100ml with factice; To decide measured solution again and in agitator, stir 37 minutes, with its abundant mixing; At last solution is sub-packed in while stirring in the ampoule of sterilizing-drying in sealing by fusing or the 100ml vial and seals, promptly.
Claims (2)
1. technique for preparing compound amoxicillin oil suspension injection, it is characterized in that: its preparation technology is as follows:
(1), with neutral soybean oil 100 ± 5mL, place pressure cooker or pressure sterilizing cabinet to be heated to 115.5-126.5 ℃, after sterilizing 30 minutes-1 hour, take out 20-30mL and put and be chilled to 60～80 ℃, add stearic acid aluminum 2 ± 0.2 and restrain in wherein, be made into the gel of 6.5%-10%, and heat to 110-120 ℃, keeping 30 minutes-1 hour, the soybean oil that reuse filters, sterilizes is diluted to 2 ± 0.2% factice, filter, standby;
(2), get any and amoxicillin 15 ± 1.0 grams in clavulanate potassium 3.75 ± 0.3 gram or sulbactam sodium 7.5 ± 0.5 grams, and it is mixed with the 20-30mL factice by prescription, grinding then, adding lecithin 0.05-0.07 restrains while grinding, until grinding well; Afterwards, with any is transferred in the graduated cylinder in ground amoxicillin and clavulanate potassium or the sulbactam sodium, and add factice 30-40mL, when the factice temperature is not less than 70-80 ℃, benzyl alcohol 1 ± 0.1mL, Arlacel-80: 0.15-0.2 gram, vitamin E 0.15-0.3 gram are added in the graduated cylinder, the limit edged stirs, and adds to 100 ± 2ml with factice; To decide measured solution again and in agitator, stir 30-45 minute, with its abundant mixing; At last solution is sub-packed in while stirring in the ampoule of sterilizing-drying in sealing by fusing or the vial and seals, promptly.
2. technique for preparing compound amoxicillin oil suspension injection according to claim 1 is characterized in that: described preparation technology is as follows:
(1) with neutral soybean oil 100 ± 5mL, place pressure cooker or pressure sterilizing cabinet to be heated to 120-126.5 ℃, after sterilizing 30 minutes-45 minutes, take out 25-30mL and put and be chilled to 60～80 ℃, add stearic acid aluminum 2 ± 0.2 and restrain in wherein, be made into the gel of 6.5%-8%, and heat to 110-120 ℃, keeping 30 minutes-40 minutes, the soybean oil that reuse filters, sterilizes is diluted to 2 ± 0.2% factice, filter with No. 3 sintered glass funnels or glass filter bulbs or glass filter bulb rod, standby;
(2) get any and amoxicillin 15 ± 1.0 grams in clavulanate potassium 3.75 ± 0.3 gram or the sulbactam sodium 7.5 ± 0.5 by prescription, and it is mixed with the 25-30mL factice, grind in mortar, adding lecithin 0.05-0.06 restrains while grinding, until grinding well; Afterwards, ground amoxicillin and clavulanate potassium or sulbactam sodium are transferred in the graduated cylinder, and add factice 35-40mL, when the factice temperature is not less than 70-80 ℃, benzyl alcohol 1 ± 0.1mL, Arlacel-80 0.15-0.2 gram, vitamin E 0.15-0.2 gram are added in the graduated cylinder, the limit edged stirs, and adds to 100 ± 2ml with factice; To decide measured solution again and in agitator, stir 30-40 minute, with its abundant mixing; At last solution is sub-packed in while stirring sealing by fusing in the ampoule of sterilizing-drying, promptly.
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| CN2007101897480A CN101406450B (en) | 2007-10-12 | 2007-10-12 | Technique for preparing compound amoxicillin oil suspension injection |
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| CN2007101897480A CN101406450B (en) | 2007-10-12 | 2007-10-12 | Technique for preparing compound amoxicillin oil suspension injection |
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| CN101406450B true CN101406450B (en) | 2010-08-25 |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101632660B (en) * | 2009-08-18 | 2010-09-08 | 海南永田药物研究院有限公司 | Suspensoid powder injection of amoxicillin sodium sulbactam sodium medicine composition and novel application thereof |
| CN101982173B (en) * | 2010-09-16 | 2012-07-25 | 华中农业大学 | Danofloxacin mesylate-amoxicillin suspension injection applicable to livestock and poultry as well as preparation and application thereof |
| CN102846606B (en) * | 2012-09-19 | 2014-05-14 | 上海同仁药业有限公司 | Method for preparing compound amoxicillin and potassium clavulanate injections |
| CN103127099B (en) * | 2013-03-14 | 2014-04-09 | 浙江华立南湖制药有限公司 | Amoxicillin potassium clavulanate dry suspension and production process thereof |
| CN103211827B (en) * | 2013-04-11 | 2014-11-26 | 黑龙江省汇丰动物保健品有限公司 | Compound amoxicillin oil suspension prescription and preparation method thereof |
| CN103316349B (en) * | 2013-06-21 | 2015-08-12 | 成都乾坤动物药业有限公司 | A kind of oil suspension stabilizing agent, oil suspension for animals and preparation method thereof |
| CN104611261A (en) * | 2015-01-29 | 2015-05-13 | 淮南市妇幼保健院 | Method for recovering sensitivity of ESBLs-producing multiple resistant bacteria |
| CN105769762A (en) * | 2016-05-11 | 2016-07-20 | 河南省乘风动物保健技术研究所 | Ampicillin suspension injection and preparation method thereof |
| CN106377499A (en) * | 2016-10-13 | 2017-02-08 | 成都乾坤动物药业股份有限公司 | Ampicillin oil suspension and preparation method thereof |
| CN106309365A (en) * | 2016-10-14 | 2017-01-11 | 成都乾坤动物药业股份有限公司 | Cefalexin oil suspension and preparation method thereof |
| CN106265505B (en) * | 2016-11-11 | 2019-06-25 | 成都乾坤动物药业股份有限公司 | A kind of amoxicillin and clavulanate potassium oil suspension and preparation method thereof |
| CN107261108B (en) * | 2017-07-04 | 2020-08-14 | 江西傲新生物科技有限公司 | Long-acting amoxicillin and colistin sulfate injection and preparation method thereof |
| CN113304110B (en) * | 2021-06-16 | 2022-09-23 | 郑州大学 | Diclofenac sodium oil suspension and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0010904A2 (en) * | 1978-10-27 | 1980-05-14 | Beecham Group Plc | Intramammary compositions and process for their preparation |
| CN1189100A (en) * | 1995-05-03 | 1998-07-29 | 史密丝克莱恩比彻姆有限公司 | Composition comprising amoxycillin and clavulanic acid |
| EP1078627A1 (en) * | 1999-08-20 | 2001-02-28 | Smithkline Beecham Laboratoires Pharmaceutiques | Pharmaceutical formulation comprising amoxycillin and clavulanate |
-
2007
- 2007-10-12 CN CN2007101897480A patent/CN101406450B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0010904A2 (en) * | 1978-10-27 | 1980-05-14 | Beecham Group Plc | Intramammary compositions and process for their preparation |
| CN1189100A (en) * | 1995-05-03 | 1998-07-29 | 史密丝克莱恩比彻姆有限公司 | Composition comprising amoxycillin and clavulanic acid |
| EP1078627A1 (en) * | 1999-08-20 | 2001-02-28 | Smithkline Beecham Laboratoires Pharmaceutiques | Pharmaceutical formulation comprising amoxycillin and clavulanate |
Non-Patent Citations (4)
| Title |
|---|
| John D. Nelson et al.Pharmacokinetics of Potassium Clavulanate in Combinationwith Amoxicillin in Pediatric Patients.Antimicrobial Agents And Chemotherapy21 4.1982,21(4),681-682. |
| John D. Nelson et al.Pharmacokinetics of Potassium Clavulanate in Combinationwith Amoxicillin in Pediatric Patients.Antimicrobial Agents And Chemotherapy21 4.1982,21(4),681-682. * |
| 陈雷.HPLC法测定阿莫西林克拉维酸钾混悬剂中的含量.江苏药学与临床研究9 3.2001,9(3),17-18. |
| 陈雷.HPLC法测定阿莫西林克拉维酸钾混悬剂中的含量.江苏药学与临床研究9 3.2001,9(3),17-18. * |
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