CN101347483A - Chinese herbal medicinal composition for treating enterogastric disease and preparation method and use - Google Patents
Chinese herbal medicinal composition for treating enterogastric disease and preparation method and use Download PDFInfo
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- CN101347483A CN101347483A CNA2008102158917A CN200810215891A CN101347483A CN 101347483 A CN101347483 A CN 101347483A CN A2008102158917 A CNA2008102158917 A CN A2008102158917A CN 200810215891 A CN200810215891 A CN 200810215891A CN 101347483 A CN101347483 A CN 101347483A
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Abstract
The present invention relates to a Chinese herbal medicine combination for curing intestinal tract disease. The combination is prepared by the following Chinese herbal materials: birthwor root, flying goose, chicken's gizzard skin and Hai Piao Xiao. The present invention also relates to the preparation method of the combination and the usage for preparing the medicine and food curing gastroenteritis, gastric ulcer, gastric perforation and black eye socket. The product of the present invention improves the nutrition of patients with intestinal tract disease and at the same time has obvious curing effect on gastroenteritis, gastric ulcer, gastric perforation and black eye socket, and can be taken for a long term.
Description
Technical field
The present invention relates to the colourless transparent liquid of process distillation extraction from natural Chinese medicinal herb, have the nourishing the stomach of regulating the flow of vital energy, promote gastrointestinal function to recover, activate the regeneration of gastritis theca cell, be used for the treatment of gastritis, gastroenteritis, stomachache, gastric ulcer, gastropathy such as gastric perforation, black-eyed Chinese medicine composition and preparation method thereof also relates to the application of said composition in preparation gastroenteropathy medicine.
Background technology
Gastroenteropathy also is called gastroenteritis, comprises gastric ulcer (as gastric perforation etc.) and duodenal ulcer etc.The disease of gastrointestinal system such as flatulence, dyspepsia reaction are had a stomachache or the gastric perforation person, also belong to the category and the black eye of gastroenteropathy.Digestive system disease is refractory disease mostly, and morbidity is latent attacks, condition of illness dull pain, even ill, patient Chang Buneng oneself examines and knows, how seeks medical advice because of other diseases or is found during health examination.
Adopting the means of Chinese medicine to treat the gastroenteropathy disease, is a channel extremely leaved for development, and this is because therefore Chinese medicine characteristics such as to have the property of medicine gentle, applied widely are having its original effect aspect the gastroenteropathy treatment.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of gastroenteropathy, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
The Radix Aristolochiae 1-88 Octopus ocellatus Gray 30-150 that wafts in sudden goose 30-170 Endothelium Corneum Gigeriae Galli 30-170 sea
Preferably, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
The Radix Aristolochiae 1-88 Octopus ocellatus Gray 30-150 that wafts in sudden goose 30-170 Endothelium Corneum Gigeriae Galli 30-170 sea
Most preferably, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Octopus ocellatus Gray 30 wafts in Radix Aristolochiae 5 sudden goose 30 Endothelium Corneum Gigeriae Galli 40 seas.
Chinese medicine composition of the present invention can be made various types of pharmaceutical preparatioies according to actual needs, for example makes tablet, capsule, and beverage, bag tea, cookies, oral liquid or injection etc., preferred but be not limited to oral liquid.In order to prepare these preparations, can in compositions of the present invention, add conventional pharmaceutically acceptable auxiliaries as required, selection for adjuvant, those skilled in the art can carry out according to the requirement of dosage form, when for example preparing oral liquid, in the present composition, can add sweeting agent, flavoring agent and antiseptic.For the concrete selection of adjuvant, the present invention's specific restriction useless.
Another object of the present invention provides a kind of preparation method of the present composition, this method comprise clean, dry and above four flavor raw material of Chinese medicine are ground into coarse powder, cross No. two and sieve, put into the extraction pot of band distillator, add water 5-10 and doubly measure, soaked 2-5 hour, stir 2-5 time therebetween, each 10-20 minute, heating extraction 1-3 hour, it was an amount of to collect distillate, and cold preservation was placed 8-12 hour down, precipitation is filtered.
Subsequently, can preparation of compositions of the present invention be become various dosage forms according to the ordinary skill in the art.For example get filtrate, can add flavoring agent and/or antiseptic if desired, regulate pH value to 7.0, and adjust total amount with sodium hydroxide, embedding, sterilization, packing promptly gets oral liquid of the present invention.
The present invention adopts the preparation technology of the way of distillation, and the volatile ingredient straight run distillation in Radix Aristolochiae and all the other the 3 flavor medical materials is come out promptly, and technology is simple.So in fact the present invention is exactly the aqueous solution of various volatile ingredients.Preferably described water is distilled water.
Need to prove that method of the present invention is a kind of preferable preparation technique but not
Be limited to this.Product by the inventive method preparation has good stability.
For many years, adopt Chinese medicine composition of the present invention, particularly the oral liquid treatment gastroenteropathy obtains better curative effect, does not see any toxic and side effects.
Because gastroenteropathy is a dyspepsia is main disease, is monarch so adopt with the Radix Aristolochiae ventilation in the side, and sudden goose antiinflammatory is a minister, and Endothelium Corneum Gigeriae Galli is aid digestion to be assistant.Again and the waft effect of Xiao's nourishing the stomach of sea.
[composition] Radix Aristolochiae, sudden goose, Endothelium Corneum Gigeriae Galli etc.
[character] this product is an achromaticity and clarification liquid, gas perfume (or spice), mildly bitter flavor.
The regeneration of [function cures mainly] ventilation, antiinflammatory, promotion stomach functional rehabilitation, activation gastric ulcer place cell is used for the treatment of gastroenteropathy and black eye such as flatulence, gastroenteritis, gastric ulcer gastric perforation.
[usage and dosage] oral 10-30 milliliter, 2-3 time on the one or follow the doctor's advice.
Idol has dizzy sense after [untoward reaction] medication.
[points for attention] 1, period in a medicine are forbidden share with other Chinese medicine.2, period in a medicine is forbidden share with antiallergic agent.3, pungent, the seafood food of period in a medicine fasting.4, as taking other medicines, please Ref Dr or pharmacist before use this product.
For this reason, another object of the present invention provides a kind of present composition in preparation treatment gastroenteritis, gastritis, gastric ulcer, the application in the medicines such as gastric perforation.
Description of drawings
Accompanying drawing 1 is preparation technology's flow chart of oral liquid of the Chinese medicine composition of invention.
The specific embodiment
Embodiment 1
Oral liquid:
Clean, dry raw material of Chinese medicine and consumption:
The Radix Aristolochiae 1-88 Octopus ocellatus Gray 30-150 that wafts in sudden goose 30-170 Endothelium Corneum Gigeriae Galli 30-170 sea
Method for making: above four flavor raw material of Chinese medicine are ground into coarse powder, cross sieve No. two, put into the extraction pot of band distillator, add water 1600ml, soaked 2 hours, and stirred therebetween 3 times, each 10 minutes, heating extraction 1 hour, the collection distillate is an amount of, and cold preservation was placed 8-12 hour down, and precipitation filters.
Get filtrate, regulate pH value to 7.0, and adjust total amount to 1000ml with sodium hydroxide.Embedding, sterilization, packing, promptly.
Character: this product is an achromaticity and clarification liquid; Gas perfume (or spice), puckery, little hardship.
Differentiate: get this product 200ml, put in the round-bottomed flask, connect condensing tube (should be short and small) heating and be distilled to about 1 minute of boiling, when treating that crystallization appears in the condensing tube inwall, withdraw thermal source immediately, collect agglomerative crystallization on distillate (about 2-3ml) and the condensing tube inwall.
(1) it is an amount of to take by weighing the crystallization of separating out, and adds ethanol and makes dissolving, and make the solution that every 1ml contains 2.5mg, as need testing solution.According to ultraviolet-visible spectrophotometer method (appendix VA of Chinese Pharmacopoeia version in 2005) test, be blank with ethanol.Measure absorption curve between wavelength 230-350nm, its absorption curve should be consistent with the absorption curve of Radix Ginseng reference substance solution (1ml contains 2.5ml), at wavelength 289 ± 1nm place one maximum absorption band should be arranged.
(2) getting this product distillate, according to ultraviolet visible spectrophotometry (appendix VA of Chinese Pharmacopoeia version in 2005) test, is blank with water.Wavelength place at wavelength 250-350nm measures absorption curve, at 277 ± 1nm place, a maximum absorption band should be arranged.
Check: relative density should be not less than 0.9 (an appendix VII of Chinese Pharmacopoeia version in 2005 A).
PH value should be 5.5-7.5 (an appendix VII of Chinese Pharmacopoeia version in 2005 G).
Other should meet every regulation relevant under the mixture item (appendix IJ of Chinese Pharmacopoeia version in 2005).
Usage and consumption: oral, a 10-30 milliliter, 2-3 time on the one, or follow the doctor's advice.
Embodiment 2
Antipyretic beverage:
Clean, dry raw material of Chinese medicine and consumption:
The Radix Aristolochiae 1-88 Octopus ocellatus Gray 30-150 method for making of wafing in sudden goose 30-170 Endothelium Corneum Gigeriae Galli 30-170 sea:
Above four flavor raw material of Chinese medicine are ground into coarse powder, cross sieve No. two, put into the extraction pot of band distillator, add water 16000ml, soaked 2 hours, and stirred therebetween 3 times, each 10 minutes, heating extraction 1 hour, the collection distillate is an amount of, and cold preservation was placed 8-12 hour down, and precipitation filters.
Get filtrate, add an amount of sucrose dissolved, regulate pH value to 7.0, and adjust total amount to 10000ml with sodium hydroxide.Embedding, sterilization, packing, promptly.
Embodiment 3
Capsule, pill, bag tea:
Clean, dry raw material of Chinese medicine and consumption:
The Radix Aristolochiae 1-88 Octopus ocellatus Gray 30-150 method for making of wafing in sudden goose 30-170 Endothelium Corneum Gigeriae Galli 30-170 sea:
Above four flavor raw material of Chinese medicine are ground into fine powder, cross 120 mesh sieves, add proper amount of sugar or sucrose adjuvant, put into the extraction pot of band distillator, add water 1600ml, soaked 2 hours, stir therebetween 3 times, each 10 minutes, heating extraction 1 hour, it is an amount of to collect concentrate, and cold preservation was placed 8-12 hour down, precipitation filters.Get concentrate and beat fine powder, or raw material is broken into fine powder, add appropriate amount of auxiliary materials.Encapsulated, the dress tea-bag, pill, and other goods, sterilization, packing, promptly.
Embodiment 4
Injection:
Clean, dry raw material of Chinese medicine and consumption:
The Radix Aristolochiae 1-88 Octopus ocellatus Gray 30-150 method for making of wafing in sudden goose 30-170 Endothelium Corneum Gigeriae Galli 30-170 sea:
Above four flavor raw material of Chinese medicine are ground into coarse powder, cross sieve No. two, put into the extraction pot of band distillator, add water 1600ml, soaked 2 hours, and stirred therebetween 3 times, each 10 minutes, heating extraction 1 hour, the collection distillate is an amount of, and cold preservation was placed 8-12 hour down, and precipitation filters.
Get filtrate, regulate pH value to 7.0, and adjust total amount to 1000ml with sodium hydroxide.Embedding, sterilization, packing, promptly.
Embodiment 5
Clinical trial:
1. gastroenteritis
Gastroenteritis patient's 100 examples are comprehensively examined or check from clinical examination and three aspects of biopsy pathology; After treating a course of treatment, 45 routine patients' recoveries from illness are arranged, 43 routine patient's symptoms obviously alleviate, and 12 routine patients obviously do not improve; After treating two courses of treatment, 48 routine patients' recoveries from illness are arranged, 46 routine patient's symptoms obviously alleviate, and 6 routine patients obviously do not improve; After treating three courses of treatment, there are 51 routine patient's symptoms obviously to fully recover, 47 routine patients improve; 2 routine patients obviously do not improve.
2. gastric ulcer
Gastric ulcer patient 100 examples, from clinical symptoms, scope differs from the examination of two each side; After treating a course of treatment, 68 routine patients' recoveries from illness are arranged, 28 routine patient's symptoms obviously alleviate, and 4 routine patients do not improve; After treating two courses of treatment, 78 routine patients' recoveries from illness are arranged, 22 routine patient's symptoms obviously alleviate, and 0 example is not improved; After treating three courses of treatment, 89 routine patients' recoveries from illness, 11 routine patient's symptoms obviously alleviate, and 0 example is not improved.
3. gastric perforation
Epigastrium pain discomfort, stool has the black clot, and the tongue tongue is white, endoscopy two each examinations; Gastric perforation patient 100 examples, single from clinical observation: after treating a course of treatment, 16 routine patients' recoveries from illness, 84 routine patient's symptoms obviously alleviate, and 0 example is not improved; After treating for two each courses of treatment, 38 routine patients' recoveries from illness are arranged, 62 routine patient's symptoms obviously alleviate, and 0 example is not improved; After three courses of treatment, 100 example recoveries from illness.
4. black eye person
Long-term black eye person's 100 examples are examined or check from clinical examination pathology eyes black eye; After treating a course of treatment, 40 routine patients' recoveries from illness are arranged, 48 routine patient's symptoms obviously alleviate, and 12 routine patients obviously do not improve; After treating two courses of treatment, 58 routine patients' recoveries from illness are arranged, 36 routine patient's symptoms obviously alleviate, and 6 routine patients obviously do not improve; After treating three courses of treatment, there are 71 routine patient's symptoms obviously to fully recover, 27 routine patients improve; 2 routine patients obviously do not improve.
Therapeutic Method:
The oral liquid group of Chinese medicine composition of the present invention: every day 2 times, each 1,14 is a course of treatment, intermittently begins for second course of treatment after 2～3 days, uses 2-3 the course of treatment.
The oral liquid combined group of Chinese medicine composition of the present invention: every day 2 times, each 1,14 is a course of treatment, intermittently begins for second course of treatment after 2～3 days, uses 2-3 the course of treatment.It is oral to shake up the back when taking.
Matched group: do not take the oral liquid of Chinese medicine composition of the present invention, only with treatment chronic gastritis, gastroenteritis or gastric ulcer, gastric perforation and black-eyed conventional therapy medicated tea.
Discuss: the oral liquid of Chinese medicine composition of the present invention is a kind of pure Chinese herbal and crude drugs preparations, it is the colourless transparent liquid of process distillation extraction from natural Chinese medicinal herb, have ventilation nourishing the stomach, anti-inflammatory analgetic, promotion is functional rehabilitation, the regeneration that activates gastric ulcer place cell, is used for the treatment of diseases such as gastroenteritis, gastric ulcer, gastric perforation and black eye.
By observing oral liquid patients with gastric disease 400 examples with Chinese medicine composition of the present invention.Take effectively pain relieving behind this medicine, hemostasis, facilitating digestion raising is in various degree all arranged.The oral liquid group total effective rate 99% of Chinese medicine composition of the present invention, the oral liquid mixed type group total effective rate 99% of Chinese medicine composition of the present invention.Cooperate original therapeutic scheme can improve the remission rate of gastropathy.Thereby improved remission rate.The oral liquid of Chinese medicine composition of the present invention is safe in utilization, have no side effect.
Embodiment 6
Model case exemplifies:
Case one: poplar sends out: too much because of taking aspirin for a long time before and after nineteen eighty-two, frequent gastrorrhagia, 1 6-7 time, through hospitalization, two courses of treatment of Chinese herbal medicine of the present invention have been taken in the back when gastrorrhagia, and sb.'s illness took a favorable turn, hemorrhage stopping do not appeared 1 time blood in 13 years backward to dying.
Case two: Li Xinfu: the man, 70 years old, in July, 1985 was restive in Jinhua hospital gastrorrhagia, defecating hemorrhage 4 adds, and hematochrome drops to 2.5 gram households to be lifted and prepare funeral affairs in going home, after took Chinese herb medicine of the present invention 2 days, sb.'s illness took a favorable turn, and the 3rd day just can out-of-bed activity.
Case three: He Jiawei: man, 33 years old.Because of separating black stool, general weakness prepares to go to the hospital treatment, take Chinese patent medicine of the present invention after, found on the 3rd day that stool the first half partly deceived, and the latter half is yellow, spirit takes a turn for the better, and has not just gone to the hospital.
Case four: Cao Suqing, woman, 65 years old, because of gastrorrhagia, at Jinhua City People's treatment, more than 20 day haemophilia, descended the notice of being critically ill for 3 times, prepare the hospitalize of city center, Jinhua, took Chinese herb medicine of the present invention 3 days, every day 4 times before transferring from one hospital to another, the assistant director is to Jinhua central hospital check result, blood to be ending, and hematochrome rises to 6.8 grams from original 3.1, and being in hospital just directly leaves hospital has gone home to have had a rest.
Case five: envelope qin: the woman, 24 years old, service man KTV, because of gastrorrhagia, stomachache all day, general weakness is taken the same day in November, 2007 and is removed stomachache, with fully recovering after three courses of treatment.
Case six: Feng Bo: the man, 27 years old, service man KTV because of long-term gastropathy stomachache, took two rehabilitations course of treatment in December, 2007, has had a stomachache.
Case seven: Yang Xuqiang: the man, 38 years old, blue dish ornaments office worker, very heavy because of black eye, the eyes pneumonedema is taken prescription black eye two courses of treatment of the present invention and is disappeared, and it is normal to sleep.
Case eight: Xu Bin: man: 23 years old, the student of Normal University, very heavy because of black eye, the eyes pneumonedema is taken prescription black eye two courses of treatment of the present invention and is disappeared.
Medicine of the present invention is taken the compound prescription of Chinese herbal medicine of the present invention through routine patients up to a hundred (comprising gastroenteritis, gastric ulcer, gastric perforation and black eye etc.) patient, reflects fine.
Embodiment 7
Acute toxicity test:
The oral liquid of Chinese medicine composition of the present invention is a kind of pure Chinese medicinal preparation, it is the colourless transparent liquid of process distillation extraction from natural Chinese medicinal herb, have the regeneration of ventilation nourishing the stomach, anti-inflammatory analgetic, promotion stomach functional rehabilitation, activation gastric ulcer place cell, be used for the treatment of gastroenteropathy such as gastroenteritis, gastritis, gastric ulcer and gastric perforation.
Therefore, this medicine has been carried out acute toxicity test in mice, its acute toxicity test is reported as follows:
Choose 20 of NIH kind mices, ♀ ♂ half and half, body weight is 23.52 ± 2.20g (X ± S), press the dosage gastric infusion of 40ml/kg, one day twice, observed no abnormal phenomenon seven, do not have deadly, body weight increases to 27.57 ± 2.61g, and (X ± S) is than increasing weight 17.22% before the administration.
The oral liquid clinical medicine dose of Chinese medicine composition of the present invention is 5ml * 2=10ml every day, become body weight for humans by 60kg, then Cheng Ren oral dose is 10ml/60kg=0.167ml/kg, and mice dosage every day is 40 * 2=80ml/kg, and quite the 80/0.167=480 of people's consumption doubly.
The oral liquid formulations of Chinese medicine composition of the present invention is oral peace bottle, selects 10 of NIH kind mices, and with the dosage tail vein injection of every of 0.5ml, 8-10 at the uniform velocity injects second, observes 72 hours, and no abnormal phenomenon does not have dead.
Result of the test shows: the oral liquid toxicity of Chinese medicine composition of the present invention is less.
Embodiment 8
Long term toxicity test:
The oral liquid of Chinese medicine composition of the present invention is a kind of pure Chinese medicinal preparation, it is the colourless transparent liquid of process distillation extraction from natural Chinese medicinal herb, have ventilation nourishing the stomach, anti-inflammatory analgetic, promotion is functional rehabilitation, the regeneration that activates gastric ulcer place cell, is used for the treatment of diseases such as gastroenteritis, gastritis, gastric ulcer, gastric perforation and black eye.
Test report is as follows:
Material and method
60 of the Wistar rats of experimental animal: 7-8 health in age in week, male and female half and half are provided by Wenzhou Medical College's Experimental Animal Center.Observe a week before the test, adopt randomized blocks that rat is divided into three groups, 20 every group, male and female half and half, sub-cage rearing.Periodic logging rats eating amount is freely drunk water.Claim body weight weekly one time.
Tried thing and dosage: " oral liquid of Chinese medicine composition of the present invention " is the plurality of Chinese distillation extraction, the supernatant liquid of purification.
The dosage group is the requirement by acute toxicity testing result and new Chinese medicine toxicologic study guide, establishes two dosage groups of height and a matched group.High dose is 1200g/kg, is equivalent to 70 times of clinical application amount, and low dose group is 500g/kg, is equivalent to 30 times of clinical application amount.
Route of administration and method: adopt administration by gavage.Irritate body of stomach long-pending by body weight 1% wait not even depth administration of capacity.Every day 1 time, 6 days weekly, amounted to for 8 weeks.Press weekly body weight change during the administration and adjust dosage.
Observation index:
Ordinary circumstance: observe the outward appearance sign every day, behavioral activity, urine excrement situation, food-intake.Weigh weekly to observe and change.
Hematological examination: get 10 rats (male and female half and half) at random for every group, before administration, the 4th week and the 8th week after the administration, get blood at the tail vein, erythrocyte, leukocyte are tested by " national Clinical Laboratory rule of operation " requirement with indexs such as classification, platelet, reticulocyte and content of hemoglobin.
Blood biochemical is learned and checked: test proceeded to for the 4th week and the 8th week, in the blood vessel blood sampling of thigh portion, measured serum alanine transaminase (ALT), total bilirubin (T--BIL), blood urea nitrogen (BUN) and creatinine (CRE) four indices.
Rat is dissected and histopathologic examination: experiment finishes, get 10 rats (male and female half and half) for every group, thigh portion blood vessel sacrificed by exsanguination, the conventional dissection, observe the mode of appearance of each internal organs, color etc., and internal organs such as the heart, liver, spleen, lung, kidney, brain are weighed, calculate the percentage ratio of itself and body weight, i.e. organ coefficient.The pathology method is handled routinely then, the histopathologic examination of doing the heart, liver, spleen, lung, kidney, brain and femur.
Statistical procedures: adopt T check and F check.Data machine are as calculated handled.
The result:
General state and body weight change: during the administration, each treated animal general state, movable normal, the no abnormality seen reaction.Administration group and matched group food-intake are close substantially.Administration group and matched group body weight gain trend basically identical illustrate that long term administration do not have obvious influence to growth of animal.Male Mus or each administration group weight gain value of female Mus are compared no significant difference (P＞0.05) with matched group.
Hematological indices: rat hemogram check result is listed in table 1,2,3.Find out by table 1 and table 2, " oral liquid of Chinese medicine composition of the present invention " height, end dosage group erythrocyte, leukocyte and classification, platelet and content of hemoglobin be 4 week and 8 weeks before administration, after the administration, compare with matched group, P＞0.05 illustrates that medicine does not have obvious influence to above-mentioned each index.
Blood biochemical is learned index: test proceeded to for the 4th week and the 8th week, in the blood vessel blood sampling of thigh portion, measured serum alanine transaminase (ALT), total bilirubin (T--BIL), and blood urea nitrogen (BUN) and creatinine (CRE) four indices the results are shown in table 3.
Organ weights: each organizes organ weights such as the heart, liver, spleen, lung, kidney, brain and organ coefficient is listed in table 4.
Histopathologic examination: off-test, rat is dissected, and does not find the obvious change of organs such as the heart, liver, spleen, lung, kidney, brain.Histopathologic examination does not find that pathological change is arranged yet, and shows that long term administration do not have obvious damage to each organs and tissues.
Brief summary:
Continuous 8 weeks pour into " oral liquid of herbal composite of the present invention " to rat oral, and dosage is 70 times and 30 times of clinical consumption, and the rat general state is good, no abnormal performance, and each organizes bodyweight difference does not have significance, and the rat normal growth is not had obvious influence.
Continuous 8 all administrations, the rat reticulocyte significantly increases (table 2), learns other indexs of liquid and changes not significantly (table 4), illustrate " oral liquid of Chinese medicine composition of the present invention " but hemopoietic function improvement.
" oral liquid of Chinese medicine composition of the present invention " the long term toxicity test result show, finds no pathological change (table 1).
Above result of the test shows, " oral liquid of Chinese medicine composition of the present invention " life-time service, and no overt toxicity is safe Chinese medicine preparation.
Table 1, " oral liquid of Chinese medicine composition of the present invention " long term toxicity test hemogram result (X ± S)
Table 2, " oral liquid of Chinese medicine composition of the present invention " are to the influence of reticulocyte (%, X ± S)
| Group | Number of animals | Before the administration | 4 weeks after the administration | 8 weeks after the administration | P |
| Contrast | 10 | 2.05±1.13 | 1.40±0.69 | 2.18±1.34 | |
| Low dosage | 10 | 1.93±1.17 | 2.13±1.07 | 6.75±1.35 | ＜0.01 |
| High dose | 10 | 2.11±1.12 | 2.21±0.91 | 7.07±1.91 | ＜0.01 |
| P | ＞0 05 | ＞0 05 | ＞0 05 |
Table 3, differential blood count result (%, X ± S)
Table 4, blood biochemical are learned index determining result (X ± S)
Table 5, respectively organize relatively (X ± S) of organ coefficient
Embodiment 9
The stability of product of the present invention: carry out repeatedly stability test at various products of the present invention.Test comprises that high temperature quickens and room temperature is placed.Show that all product of the present invention has good stability.The oral liquid that shows one of product of the present invention embodiment 1 in the table 8 is at the steadiness of placing 18 months.
More than embodiments of the invention are had been described in detail, but described content only is preferred embodiment of the present invention, can not be considered to be used to limit practical range of the present invention.All equalizations of doing according to the present patent application scope change and improve etc., all should still belong within the patent covering scope of the present invention.
Claims (4)
1. Chinese herbal medicine combined food series for the treatment of gastroenteropathy, it is characterized in that comprising Endothelium Corneum Gigeriae Galli, also the egg capsule of a mantis is formed, each component and weight ratio thereof are: Radix Aristolochiae: sudden goose: Endothelium Corneum Gigeriae Galli: Octopus ocellatus Gray=1-88 wafts in the sea: 30-170: 30-170: 30-150 is made into capsule, pill, bag tea, oral liquid, antipyretic beverage, injection etc.
2. product of the present invention has pair flatulence, dyspepsia reaction, stomachache or gastric perforation person, and the category and the black eye treatment nourishing the stomach that also belong to gastroenteropathy obviously act on.
3. product effective percentage of the present invention is 99%.
4. onset in 1-10 minute when having a stomachache.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102158917A CN101347483A (en) | 2008-09-08 | 2008-09-08 | Chinese herbal medicinal composition for treating enterogastric disease and preparation method and use |
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| CNA2008102158917A CN101347483A (en) | 2008-09-08 | 2008-09-08 | Chinese herbal medicinal composition for treating enterogastric disease and preparation method and use |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103749851A (en) * | 2014-01-23 | 2014-04-30 | 蓝照斓 | Hypecoum erectum health-care tea |
| CN109875961A (en) * | 2019-03-19 | 2019-06-14 | 覃信发 | It is a kind of conducive to oral solution of stomach health and preparation method thereof and instructions of taking |
-
2008
- 2008-09-08 CN CNA2008102158917A patent/CN101347483A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103749851A (en) * | 2014-01-23 | 2014-04-30 | 蓝照斓 | Hypecoum erectum health-care tea |
| CN103749851B (en) * | 2014-01-23 | 2015-01-21 | 蓝照斓 | Hypecoum erectum health-care tea |
| CN109875961A (en) * | 2019-03-19 | 2019-06-14 | 覃信发 | It is a kind of conducive to oral solution of stomach health and preparation method thereof and instructions of taking |
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