CN101316570A - Dentifrice composition - Google Patents
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- CN101316570A CN101316570A CNA2006800441008A CN200680044100A CN101316570A CN 101316570 A CN101316570 A CN 101316570A CN A2006800441008 A CNA2006800441008 A CN A2006800441008A CN 200680044100 A CN200680044100 A CN 200680044100A CN 101316570 A CN101316570 A CN 101316570A
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Abstract
Dentifrice compositions which provide chemical cleaning of the oral surfaces with a combination of surfactant, chelant, and pH; further this dentifrice composition can minimize the use of abrasives to provide a gentle cleaning of the oral surfaces.
Description
Invention field
The present invention relates to provide the Dentrifice composition of oral surfaces chemically cleaning.In addition, the invention still further relates to the method for a kind of treatment or prevention oral condition.Dentrifice composition of the present invention is suitable for the mankind or animal is used.
Background of invention
Satisfied Dentrifice composition can cleaning oral cavity surface, particularly sclerous tissues surface as tooth and remove residue.This cleaning helps to prevent tooth-decay and promotes gums health.In traditional Dentrifice composition, grinding agent helps the removal of epidermis thin film.This thin film comprises a thin acellular glycoprotein-mucin cover layer usually, and it just sticks on the enamel in a few minutes behind the cleaning of teeth.The existence of the various food dyes in the thin film is reasons of most of various tooth discoloration situations.
In addition, antiplaque agent also can be included in the Dentrifice composition.Antiplaque agent provides the beneficial effect except that the pellicle cleaning.The formation of dental plaque is dental caries, gums and periodontal disease and the main cause of falling tooth.Dental plaque is the mixed-matrix of antibacterial, epithelial cell, leukocyte, macrophage and other oral cavity exudate.But antibacterial secretase and the endotoxin relevant with dental plaque, it can stimulate gums and cause the inflammatory gingivitis.Stimulate increasingly along with gums is subjected to this process, they are tending towards hemorrhage, lose toughness and resilience force, and separate with tooth.This separation has caused the periodontal cavity hole, causes further gathering of residue, secretions and Geng Duo antibacterial/toxin then.This process finally causes the sclerous tissues in oral cavity and soft tissue all destroyed.
Use plurality of reagents to come cleaning oral cavity and reduce dental plaque and oral malodor is described in the following United States Patent (USP): 3,696,191,3,991,177,4,058,595,4,115,546,4,138,476,4,140,758,4,154,815,4,737,359,4,986,981,4,992,420,5,000,939,4,652,444,4,725,428,4,355,022, U.S. Patent application 02/105,898,03/128,313,03/223,209 and PCT patent application WO 86/02831.
Although have manyly, but still need improved products openly about being used for pellicle cleaning and the active compositions of antiplaque.The present invention has developed oral cavity composition, and it provides pellicle cleaning and antiplaque activity, the use of minimized grinding agent simultaneously; Thereby temperature is closed cleaning oral cavity surface, ground.Specifically, the present invention includes the oral cavity Dentrifice composition, it utilizes the combination of chelating agen, surfactant and pH that chemically cleaning is provided, and keeps the grinding agent of low content simultaneously or is substantially free of grinding agent.Except the cleaning oral cavity surface leniently, this compositions also can make the maximization of flavoring agent and cleaning effect, and does not increase the content of flavoring agent and cleaning additive; Because grinding agent such as silicon dioxide usually adsorb these additives.
Summary of the invention
The present invention relates to a kind of Dentrifice composition, described compositions comprises mouth care carrier, fluoride sources, at least 2.5% chelating agen, 0.5% to 5% surfactant, wherein said Dentrifice composition has at least 8 pH, and wherein said Dentrifice composition has at least 20 PCR, and is wherein produced by Chemical cleaning greater than 10% PCR value.
In another embodiment, the present invention relates to a kind of Dentrifice composition, described compositions comprises mouth care carrier, the grinding agent by the weight 0% to 10% of described total Dentrifice composition, fluoride, 2.5% to 15% chelating agen, 1% to 3% surfactant, and wherein said Dentrifice composition has the pH at least about 8.In some embodiments, described Dentrifice composition has at least 20 PCR, and is wherein produced by Chemical cleaning greater than 20% PCR value.
In other embodiments, the present invention can comprise the grinding agent by the weight 0% to 5% of described total Dentrifice composition.The Dentrifice composition that comprises chelating agen can minimize tooth erosion.
Detailed Description Of The Invention
A. definition
Term used herein " orally active material " is meant the material that beauty treatment, disease prevention or treatment beneficial effect are provided in the oral cavity.
Term used herein " tooth " is intended to comprise natural teeth, artificial tooth, tooth plate, tooth filling, tooth medicated cap, corona, bridge, dental implants etc., and any other forever or temporarily is fixed on hard surface artificial tooth in the oral cavity.
" safety and effective dose " used herein is meant in the determination range of rational medical treatment/dentistry, reagent (for example, the dental calculus preventing agent) the enough high disease that will treat with remarkable improvement of amount, but enough low to avoid serious adverse (rational effect/danger than).The safety and the effective dose of reagent (for example, dental calculus preventing agent) can change with following factor: the concrete disease of being treated, quilt are treated patient's age and health, the seriousness of disease, the persistent period of treatment, the characteristic of concurrent treatment, the concrete form of used source and the specific support that is used to use reagent.
" dentifrice " used herein or " Dentrifice composition " are meant paste, powder, gutta-percha and/or the liquid preparation that is used for the cleaning oral cavity surface.Dentifrice be a kind of be not to have a mind to swallow for therapeutic agent is taken by system, the Orally active material fully contacts all dental surfaces and/or the Orally administered composition of mucosal tissue but it stops time enough in the oral cavity.In addition, dentifrice also can refer to a kind ofly can have a mind to swallow but be not the product of swallowing for therapeutic agent is taken by system.
" oral disease " used herein is meant the disease or the disease in oral cavity, comprises dental caries, dental plaque, halitosis, tooth erosion, gingivitis and periodontal disease.Oral condition also is described in P﹠amp; G is in the WO 02/02096A2 that announced on January 10th, 2002.
" tooth surface " used herein or " dental surface " are meant between the fossa, crack, occlusal surface, breach, crackle, groove, scrobicula, gap, irregular, tooth and/or along the break-in face of the shiny surface of the medial surface of gums line, tooth and/or tooth or chew face.
" whole body health " used herein is meant the health of whole health, it is characterized in that reducing the risk of bigger general disease of generation and disease, these diseases and disease comprise the disease of cardiovascular diseases, apoplexy, diabetes, serious respiratory infections, premature labor and low birth weight (comprising branch puerperium nerve/growth dysfunction) and relevant increased mortality rate.It is believed that oral cavity infection can cause systemic infection.Antibacterial can be dyed other position of blood flow and health from oral instructions, thereby people's health is placed danger.Oral cavity infection can cause taking place many serious diseases, comprises heart disease, diabetes, respiratory infections and premature labor, birth weight deficiency.Reach and promotes whole body health to be further described in all among WO 02/02063A2, WO02/02096A2 in announcement on January 10th, 2002, the WO 02/02128A2 by the treatment oral cavity infection.
Except as otherwise noted, all hereinafter used percentage ratios and ratio are all by the weight of total Dentrifice composition.
Except as otherwise noted, all measurements of mentioning of this paper are all carried out under 25 ℃.
Except as otherwise noted, all the components percentage ratio, ratio and the content that the present invention mentions is all based on the actual amount of this composition, and do not comprise can with solvent, filler or other material of this composition combination as the commercially available prod.
B. hang down the chemically cleaning system of abrasive levels
The live part of the cleaning that is provided by creative Dentrifice composition is because the effect (hereinafter referred to as " chemically cleaning ") of chemicals, rather than because the physical grinding (hereinafter referred to as " grinding agent cleaning ") of the abrasive component of Dentrifice composition.This chemically cleaning has softened dental plaque and the biofilm that is deposited on the tooth, makes that these deposits are easier to be removed by scrubbing.This causes adopting scrubbing or adopting scrubs and adds a small amount of abrasive component such as silicon dioxide is removed deposit.Chemically cleaning by chelating agen content, surface-active contents and pH combination and/or use chelating surfactant and pH to provide.The cleaning that Dentrifice composition of the present invention provides is equivalent to or greater than the Dentrifice composition of (weight by described total Dentrifice composition surpasses 10% grinding agent) of the grinding agent with traditional content, keeps the grinding agent of low content or Dentrifice composition to be substantially free of grinding agent simultaneously.As used herein, the grinding agent of low content is meant that the content of grinding agent counts about 5% to about 10% by the weight of described total Dentrifice composition.As used herein, be substantially free of the content that grinding agent is meant grinding agent and count about 0 to about 5% by the weight of described total Dentrifice composition.The Dentrifice composition that comprises the Dentrifice composition of low content grinding agent or be substantially free of grinding agent can temperature close cleaning oral cavity surface, ground, minimizes wearing and tearing or scraping for oral surfaces simultaneously.Except temperature was closed cleaning oral cavity surface, ground, the abrasive levels that minimizes in the dentifrice also can reduce the amount that needed other component of required effective effect is provided.For example, known grinding agent such as silicon dioxide and flavor components, fluoride and cetylpyridinium chloride (hereinafter referred to as " CPC ") produce consistency problem.Therefore, minimize the stability that abrasive levels in the dentifrice can make the maximum effect of flavoring agent and CPC and improve fluoride.
The present invention uses the minimum chemically cleaning that grinding agent provided that protection to excessive tooth wear also can be provided, and comprises the excessive tooth wear that can occur because of tooth erosion.Chemically cleaning of the present invention will minimize any tooth erosion.Tooth erosion is by coarse or unsafe grinding agent and/or acid, as the tooth substrate that effect caused of acidic beverages and fruit juice from lip-deep permanent disappearance.Dentrifice composition of the present invention has the grinding agent of low content or is substantially free of grinding agent and still can provides essential cleaning.Can help to take care of one's teeth the not excessive wear and minimize any tooth erosion of the grinding agent of this low content.
Use the cleaning that Dentrifice composition produced to utilize pellicle cleaning ratio testing (hereinafter referred to as " PCR ") to measure.Using the creative oral cavity cleaning that Dentrifice composition produced to small part is that chemical property by Dentrifice composition is provided.Specifically, described chemical property can help to remove the epidermis thin film, and therefore this thin film removing not exclusively is the result that possible be included in the grinding agent in the Dentrifice composition.For example, in one embodiment, about 10% to about 100% PCR value is produced by chemically cleaning, and is produced by the grinding agent cleaning less than about 90% PCR value.In another embodiment, about 15% to about 100% PCR value is produced by chemically cleaning, and is produced by the grinding agent cleaning less than about 85% PCR value.In another embodiment, about 20% to about 100% PCR value is produced by chemically cleaning, and is produced by the grinding agent cleaning less than about 80% PCR value.In another embodiment, about 25% to about 100% PCR value is produced by chemically cleaning, and is produced by the grinding agent cleaning less than about 75% PCR value; And in another embodiment of the invention, about 50% to about 100% PCR value is produced by chemically cleaning, and is produced by the grinding agent cleaning less than about 50% PCR value.In other words, about 10% to about 75% cleaning is a chemically cleaning, and about 0 to about 75% cleaning is the grinding agent cleaning.In another embodiment, about 10% to about 50% cleaning is a chemically cleaning.In another embodiment, about 10% to about 25% cleaning is a chemically cleaning.In another embodiment, about 15% to about 50% cleaning is a chemically cleaning.In another embodiment, about 20% to about 50% cleaning is a chemically cleaning.
Utilization is to " In Vitro Removal of Stain With Dentifrice ", G.K.Stookey, T.A.Burkhard and B.R.Schemerhorn, J.DentalResearch, 61,1236-9, the PCR method of testing of describing in 1982 is revised a little and is measured PCR (pellicle cleaning ratio) cleaning value.Use the pellicle cleaning ratio testing method of revising that cleaning is carried out in-vitro evaluation.This method of testing is identical with described methods of people such as Stookey, just made following modification: (1) was applied to transparent artificial epidermis thin film on the cattle thin slice before using painted thin film, (2) use the solution heating, rather than in applying thin-film process radiation heating, (3) number of times comforted of brush is reduced to 1000 times and (4) concentration of slurry is that 1 part of dentifrice is to 3 parts of water.In order to measure owing to the PCR value percentage ratio of chemically cleaning, to carry out PCR with Dentrifice composition in the Dentrifice composition in the solution and the solution of removing grinding agent and test with respect to PCR value percentage ratio owing to the grinding agent cleaning.
Term defined herein " grinding agent " comprises when the Dentrifice composition water is diluted at 3: 1, stir, be placed in the centrifuge tube then with 1047.2 radian per seconds (10,000rpm) in room temperature ± 5 ℃ down rotation be deposited in any component of centrifuge tube bottom in the Dentrifice composition after 15 minutes.The component that is deposited in pipe bottom formation " piller " is the grinding agent of Dentrifice composition.Use the Dentrifice composition (hereinafter referred to as " Dentrifice composition of dilution) of water dilution in 3: 1 and reuse water 3: the 1 dilution back centrifugal supernatant that obtains of Dentrifice composition (being suspended in the solution on the piller) (hereinafter referred to as " supernatant ") to carry out the PCR test.PCR percentage ratio owing to chemically cleaning uses following formula to calculate:
(PCR of the Dentrifice composition of the PCR/ dilution of supernatant) * 100=
Percentage ratio by the PCR value that chemically cleaning produced
Dentrifice composition of the present invention comprises surfactant (about 0.5% to about 5%), chelating agen (about 2.5% to about 15%), and can comprise one or more following materials: dental plaque or mottle dedicated solvent (about 0.001% to about 10%), thickening agent (about 0.1% to about 5%), wetting agent (about 10% to about 55%), sweeting agent (about 0.1% to about 3%), flavoring agent (about 0.001% to about 10%), stain (about 0.01% to about 0.5%), grinding agent (about 0% to about 10%) and water (about 2% to about 45%).This Dentrifice composition also can comprise one or more additional caries preventive agents (about 0.05% to about 10% additional caries preventive agent) and anti-calculus agent (about 0.1% to about 13%).Certainly, dentifrice comprises complete aneroid component basically.
Other suitable carrier is disclosed in United States Patent (USP) 5,198, in 220 and 5,242,910.
1. chelating agen
The group that the following material of the optional freedom of chelating agen is formed: tartaric acid and its pharmaceutically useful salt, citric acid and alkali-metal citrate and their mixture.The complexation of chelating agen energy is present in the calcium in the bacteria cell wall.Chelating agen also can destroy dental plaque by remove calcium from the calcium bridge, and described calcium bridge helps to keep Biomass complete.Yet, may use the chelating agen that calcium was had strong affinity.This causes the tooth demineraliting, and this and target of the present invention and being intended that runs in the opposite direction.
In an embodiment of Dentrifice composition, the chelating agen alkali-metal citrate can comprise potassium citrate or sodium citrate and/or their mixture.In another embodiment, chelating agen is citric acid/alkali-metal citrate combination.In another embodiment, Dentrifice composition comprises alkali metal salts of tartaric acid.In another embodiment, Dentrifice composition comprises disodium tartrate, di-potassium tartrate, potassium sodium tartrate, sodium bitartrate and potassium hydrogen tartrate.In one embodiment, the content that is applicable to chelating agen of the present invention counts about 2.5% to about 15% by the weight of described total Dentrifice composition.In another embodiment, the content of chelating agen counts about 5% to about 10% by the weight of described total Dentrifice composition.In another embodiment, the content of chelating agen counts about 4% to about 7% by the weight of described total Dentrifice composition.In another embodiment, it is about 15,14,13,12,11,10,9,8,7,6,5,4,3% that the content of chelating agen is counted about 2.5,3,4,5,6,7,8,9,10,11,12,13,14% as many as by the weight of described total Dentrifice composition, and by their any combination of weight of described total Dentrifice composition.The tartrate chelating agen can use separately or be used in combination with other chelating agen.
Can use other chelating agen.These chelating agen can have about 10
1To 10
5The calcium binding constant, the cleaning action that reduces dental plaque and lithogenous improvement is provided.
The another kind of reagent that is suitable for use as chelating agen of the present invention is soluble pyrophosphate.The pyrophosphate that is used for the present composition can be any alkali metal pyrophosphate and/or their any combination.Concrete salt comprises four alkali metal pyrophosphates, two alkali metal binary acid pyrophosphates, three alkali metal, one acid pyrophosphate and their mixture, and wherein said alkali metal can be sodium or potassium.Salt can they hydration or not hydrated form use.In one embodiment, the effective dose that is used for the pyrophosphate of compositions of the present invention is enough to provide the pyrophosphate ion at least about 1.0%, about in another embodiment 1.5% to about this ion of 6%, about in another embodiment 3.5% to about 6%.Should be appreciated that pyrophosphate ion content for can be, and when definite final products pH, that can exist is pyrophosphate form rather than P2O7-4 (as (HP2O7-3)) to the amount (being the theoretical amount under the suitable pH) that described compositions provides.
Pyrophosphate is described in greater detail in Kirk ﹠amp; In " Encyclopedia ofChemical Technology " second edition the 15th volume of Othmer (Interscience Publishers, 1968).
The chelating agen that also is suitable for other possibility class of the present invention is the polycarboxylate of anionic polymerisation.These materials are well known in the art, they with its free acid, part is neutral or the form of complete neutral water-soluble alkali (for example potassium and sodium) salt or ammonium salt is used.In one embodiment, chelating agen is 1: 4 to 4: 1 copolymer of maleic anhydride or acid and another kind of polymerisable ethylenically unsaturated monomers, and described monomer comprises having about 30,000 to about 1, the methyl vinyl ether (methoxy-ethylene) of 000,000 molecular weight (M.W.).These copolymers for example obtain with trade name Gantrez AN 139 (M.W.500,000), AN 119 (M.W.250,000) and the S-97 pharmaceutical grade (M.W.70,000) of GAF ChemicalsCorporation.
Other effective polymeric polycarboxylate comprises 1: 1 copolymer such as maleic anhydride and ethyl acrylate, hydroxyethyl methylacrylate, N-vinyl-2-Pyrrolidone or ethylene, the latter for example can trade name Monsanto EMA No.1103, M.W.10,000 and EMA Grade 61 obtain and those of 1: 1 copolymer of acrylic acid and methyl methacrylate or hydroxyethyl methylacrylate, acrylic acid methyl ester. or ethyl acrylate, IVE or N-vinyl-2-Pyrrolidone.
Other effective polymeric polycarboxylate is disclosed in United States Patent (USP) 4,138,477 and 4,183, in 914, comprise the copolymer of maleic anhydride and styrene, isobutene. or ethyl vinyl ether, polyacrylic acid, poly-itaconic acid and poly, and molecular weight is low to moderate 1,000, the sulfo-acrylic acid oligomer of commodity UniroyalND-2 by name.
2. surfactant
For required cleaning is provided, Dentrifice composition of the present invention has the surface-active contents by the weight of described total Dentrifice composition about 0.5% to about 5%.In one embodiment, the content of surfactant counts about 1% to about 3% surfactant by the weight of described total Dentrifice composition.Suitable surfactant be in wide pH scope quite stable and form foamy those.Surfactant comprises nonionic, anion, both sexes, cation, amphion, synthetic detergent and their mixture.Many suitable nonionics and amphoteric surfactant are disclosed in United States Patent (USP) 3,988, and in 433 and 4,051,234, many suitable non-ionic surface active agents are disclosed in United States Patent (USP) 3,959, in 458.In one embodiment, surfactant is a sodium lauryl sulfate.
In one embodiment, use surfactant with chelating character.A kind of suitable chelating surfactant surfactant of phosphonate group (as comprise) is disclosed in the U.S. Patent Application Publication 2005/0153938; and comprise 2; 2-two phosphonos-5-hydroxyl-3-oxa--6-hexyl trimethyl ammonium chloride and 6-trimethyl ammonium hexyl 1-1, the 1-di 2 ethylhexyl phosphonic acid.In Dentrifice composition of the present invention, use chelating surfactant that the function of surfactant and/or the function of chelating agen can be provided simultaneously.This chelating surfactant can use by the content of the weight of total composition about 0.1 to about 5%, and can be included in the Dentrifice composition with the combination of existing surfactant and/or chelating agen in addition, or can be used to replace all or a part of surfactant and/or chelating agen.
3.pH
In one embodiment, the pH of Dentrifice composition as herein described about 6.5 to about 10 scope.In another embodiment, pH is about 8 to about 10.In another embodiment, pH is about 8.
4. fluorion
The present invention comprises the fluoride compound (as water miscible) of safety and effective dose.Fluorion is to be enough to the providing amount of fluorinion concentration to exist in compositions under 25 ℃, and/or in one embodiment can about by weight 0.0025% to about 5.0%, about by weight 0.005% to about 2.0% content uses so that the anti-caries effect to be provided in another embodiment.The material of various generation fluorion can be used as soluble fluoride source suitable in the present composition.The example of suitable generation fluorion material is disclosed in United States Patent (USP) 3,535, in 421 and 3,678,154.Representative fluoride ion sources comprises: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate and many other materials.In one embodiment, Dentrifice composition comprises stannous fluoride or sodium fluoride and their mixture.
5. optional member
A. dentifrice carrier
The carrier that is suitable for preparing Dentrifice composition of the present invention is well known in the art.Their selection is depended on as less important Considerations such as taste, cost and frame Tibetan stability.Dentifrice carrier can be used for toothpaste, gutta-percha, chewable tablet etc. (for example, abrasive material, surfactant, binding agent, wetting agent, flavoring agent and sweeting agent etc.), and is as United States Patent (USP) 3,988, disclosed in 433.
B. grinding agent
That Dentrifice composition of the present invention can comprise low content or be substantially free of grinding agent.Selected materials is compatible in interested Dentrifice composition and can the excessive wear dentine.If present, suitable grinding agent comprises that silicon dioxide for example comprises the granule condensation product of gel and precipitation, undissolved sodium hexametaphosphate, hydrated alumina, calcium carbonate, Bibasic Calcium Phosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, poly-calcium metaphosphate and resin abrasive material such as carbamide and formaldehyde.
The another kind of grinding agent that is used for Dentrifice composition of the present invention is particulate thermosetting polymer resin, as United States Patent (USP) 3,070, described in 510.Appropriate resin comprises for example tripolycyanamide, phenol, urea, tripolycyanamide-urea, carbamide, melocol, tripolycyanamide-melocol, cross-linked epoxy thing and cross-linked polyester.Also can use the mixture of grinding agent.
Can use polytype silica dental abrasives, can the excessive wear dentium nitor because they have fabulous cleaning of teeth and polishing performance or unique beneficial effect of dentine.The abrasive silica polishing material of this paper and other grinding agent can have in about 0.1 mean diameter to about 30 micrometer ranges, and in another embodiment, mean diameter is about 5 to about 15 microns.Grinding agent can be precipitated silica or silica gel, as United States Patent (USP) 3,538, and 230 and 3,862, the silica xerogel described in 307.Suitable silica xerogel is W.R.Grace ﹠amp; Company, the silica xerogel that Davison Chemical Division sells with trade name " Syloid ".Also can use precipitated silica material, as by J.M.HuberCorporation with trade name Zeodent
Those that sell.In one embodiment, can use called after Zeodent 109
Silicon dioxide.The type that can be used for the silica dental abrasives in the toothpaste of the present invention is described in greater detail in United States Patent (USP) 4,340, in 583.The example of suitable precipitated silica is a United States Patent (USP) 5,603, disclosed silicon dioxide in 920,5,589,160,5,658,553,5,651,958 and 6,740,311.
The content of the grinding agent in the Dentrifice composition described herein is generally about 0% to about 10% grinding agent by the weight of described Dentrifice composition.In another embodiment, described Dentrifice composition comprises the grinding agent by the weight of described total Dentrifice composition about 0.01% to about 10%.In another embodiment, described Dentrifice composition comprises the grinding agent by the weight of total composition about 0.1% to about 10%.In another embodiment, described Dentrifice composition comprises by the weight of described Dentrifice composition about 0% to about 5% grinding agent.In another embodiment, described Dentrifice composition comprises by the weight of described Dentrifice composition about 5% to about 10% grinding agent.In another embodiment, described Dentrifice composition comprises the grinding agent by the weight of described Dentrifice composition about 2.5% to about 5%.In another embodiment, described Dentrifice composition comprises the grinding agent by the weight of described Dentrifice composition about 1% to about 3%.In another embodiment, described Dentrifice composition comprise by the weight of described total Dentrifice composition greater than about 0.01,0.1,0.5,1,2,2.5,3,4,5,6,7,8,9% and less than about grinding agent of 10,9,8,7,6,5,4,3,2,1%.
C. dental plaque or mottle dedicated solvent
The cleaning of chemically cleaning system can be utilized and be exclusively used in that the solvent of dirt strengthens in the oral cavity.The example of these solvents include but not limited to limonene, PVP and for copolymer, monoethanolamine, 1-amylalcohol and the plant extract replaced as be filed in JIUYUE 1 day the U.S. Patent application 11/217,274 in 2005 disclosed those.
D. thickening agent
When preparation toothpaste or gel, be necessary to add some thickening materials so that for Dentrifice composition provides required denseness, release characteristics required when using is provided, provide frame to hide stability, and the stability etc. of Dentrifice composition is provided.Suitable thickening is the water soluble salt of carboxy vinyl polymer, carrageenin, hydroxyethyl-cellulose, LAPONITE and cellulose ether, as sodium carboxymethyl cellulose and carboxymethyl hydroxyethyl cellulose sodium.Also can use natural gum such as karaya, xanthan gum, Radix Acaciae senegalis and Tragacanth.The silicon dioxide of colloidal magnesium aluminum silicate or segmentation can be used as the part of thickening agent with the further texture that improves.
Yet except the polymeric polyether compound, thickening agent can comprise for example to contain 1 alkyl or end capped polyethylene glycol oxide of acyl group or polypropylene oxide (molecular weight is 300 to 1,000,000) to about 18 carbon atoms.
One class suitable thickening or gellant comprise a class homopolymer or the carbomer that acrylic acid and pentaerythritol alkyl ether or sucrose alkyl ether are crosslinked.Carbomer can Carbopol
Series is commercially available from B.F.Goodrich.Acrylate copolymer especially comprises Carbopol 934,940,941,956 and their mixture.
The copolymer of lactide and glycolide monomer, a kind of have about 1,000 to about 120,000 (number average) scope the copolymer of molecular weight, can be used for being delivered to active substance in the periodontal cavity hole or around the periodontal cavity hole as " gel carrier under the gum ".These polymer are described in United States Patent (USP) 5,198, in 220,5,242,910 and 4,443,430.
The consumption of thickening agent can be by the weight of described total Dentrifice composition about 0.1% to about 15%, or about 0.2% to about 6%, in another embodiment, is about 0.4% to about 5%.
E. wetting agent
The part of Dentrifice composition of the present invention is a wetting agent with another optional components of oral carrier.Wetting agent is used for preventing hardening when Dentrifice composition is exposed to air, makes Dentrifice composition give the oral cavity with damp, and for specific wetting agent, gives the sweet taste of Dentrifice composition with needs.The content of wetting agent (based on pure wetting agent) counts about 0% to about 70% by the weight of this paper Dentrifice composition, is about 5% to about 25% in another embodiment.Be applicable to that the wetting agent in the Dentrifice composition of the present invention comprises edible polyhydric alcohol such as glycerol, sorbitol, xylitol, butanediol, Polyethylene Glycol and propylene glycol, especially sorbitol and glycerol.
F. sweeting agent
Spendable sweeting agent comprises sucrose, glucose, glucide, aspartame, dextrose, levulose, lactose, mannitol, sorbitol, fructose, maltose, xylitol, saccharin salt, African hesperidium element, aspartame, D-tryptophan, dihydrochalcone, acesulfame and cyclamate, especially encircles sodium sulfonate and saccharin sodium and their mixture.Dentrifice composition of the present invention can comprise by the weight of described Dentrifice composition about 0.1% to about these materials of 10%, about in another embodiment 0.1% to about 1%.
Except sweeting agent, also can use coolant, sialorrhea agent, agent and numb agent the optional member of heating as Dentrifice composition of the present invention.The content that these materials are present in the described Dentrifice composition counts about 0.001% to about 10% by the weight of described Dentrifice composition, is about 0.1% to about 1% in another embodiment.
Coolant can be any various material.Be included in these materials is amide, menthol, ketal, glycol and their mixture.Be applicable to that the coolant in the Dentrifice composition of the present invention comprises alkylamino formyl reagent in the Meng, as the N-ethyl of commodity by name " WS-3 " to terpane-3-amide, be called the N of " WS-23 ", 2,3-trimethyl-2-isopropyl butyramide and their mixture.Other coolant is selected from the group of being made up of following material: menthol, the 3-1-menthoxypropane of being made by Takasago-1 that is called TK-10,2-glycol, the menthone glycerine acetal of being made by Haarmann andReimer that is called MGA and be called Frescolat by what Haarmann and Reimer made
Menthyl lactate.Term menthol used herein and menthyl comprise dextrorotation and the laevoisomer and their racemic mixture of these chemical compounds.TK-10 is described in United States Patent (USP) 4,459, in 425.WS-3 and other reagent are described in United States Patent (USP) 4,136, in 163.
Be suitable for sialorrhea agent of the present invention and comprise the Jambu that makes by Takasago
The suitable agent of heating comprises Fructus Capsici and nicotinate, as benzyl nicotinate.Suitable numb agent comprises benzocaine, lignocaine, clove bud oil and ethanol.
G. flavoring agent
Also suitable flavoring agent or flavor composition can be joined in the Dentrifice composition.Suitable flavoring agent includes but not limited to wintergreen oil, clove bud oil, menthol, the anethole, methyl salicylate, cineole, Cortex cinnamomi japonici (Ramulus Cinnamomi), acetic acid-1-menthyl ester, Salvia japonica Thunb., acetaminol, parsley oil, frambinone, α-Zi Luolantong, origanum, Fructus Citri Limoniae, orange, 1-ethoxy-2-hydroxy-4-propenyl benzene, Cortex Cinnamomi, vanillin, ethyl vanillin, heliotropine, 4-cis-heptenal, biacetyl, to the tert-butyl-phenyl methyl acetate, chocolate, green tea, and their mixture.In one embodiment, the group of the following material composition of the optional freedom of flavor composition: orange, Fructus Citri Limoniae, Cortex Cinnamomi, Herba Menthae Rotundifoliae, and their combination.Freshener also can be the part of flavor composition.The content that flavor composition is generally used in the described Dentrifice composition counts about 0.001% to about 10% by the weight of described Dentrifice composition.The preferred amount of flavor composition is about 0.01% to about 5% by weight, and more preferably from about 0.1% to about 3%, more preferably from about 0.5% to about 1.5%.Can add other medicinal substances extract, especially plant.Limiting examples comprises Fructus Vitis viniferae, Punica granatum L. and Pericarpium Citri tangerinae.Can use extract, flavoring agent, coolant, sialorrhea agent, antitack agent, antiplaque agent, tongue coating agent and other additive to help cleaning or slick tooth feel or impression.
H. improve looks or therapeutic active substance
Described Dentrifice composition also can comprise suitable beauty treatment and/or therapeutic active substance.These active substances comprise it has been generally acknowledged that can be used safely in the oral cavity and can the overall appearance in oral cavity and/or healthy aspect any material of change is provided, include but not limited to anti-calculus agent, fluoride sources, stannous ion source, brightening agent, antimicrobial, antiplaque agent, antiinflammatory, nutrient substance, antioxidant, antiviral agent, analgesic and anesthetis, H-2 antagonist, give component, pigment and coloring agent, aromatic and the sensory agent of clean feel and their mixture to tooth.When existing, beauty treatment and/or the content of therapeutic active substance in Dentrifice composition are about 0.001% to about 90% by the weight of described Dentrifice composition in one embodiment, be about 0.01% to about 50% in another embodiment, and be about 0.1% to about 30% in another embodiment.
It below is the non-limiting tabulation that can be used for the active substance among the present invention.
1) anti-calculus agent
Dentrifice composition of the present invention also can comprise anti-calculus agent, its content counts about 0.05% to about 50% by the weight of described Dentrifice composition in one embodiment, being about 0.05% to about 25% in another embodiment, is about 0.1% to about 15% in another embodiment.The group that the following material of the optional freedom of anti-calculus agent is formed: polyphosphate (comprising pyrophosphate) and salt thereof, poly-amino propane sulfonic acid (AMPS) and salt, polyolefin sulphonic acid ester and salt, polyvinyl phosphates and salt thereof; Polyolefin phosphate ester and salt thereof, bisphosphonates and salt thereof, phosphono alkyl carboxylic acid and salt, polyphosphonates and salt thereof, polyphosphonic acid vinyl acetate and salt thereof, polyolefin phosphonate ester and salt thereof, polypeptide and their mixture.In one embodiment, salt is alkali metal salt.Polyphosphate uses with its all or part of neutral water-soluble alkali metal salts such as potassium, sodium, ammonium salt and their form of mixtures usually.Inorganic polyphosphate comprises that alkali metal (for example, sodium) three polyphosphate, four polyphosphate, metal diaikyl are (for example, disodium) binary acid, trialkyl metal are (for example, trisodium) monoacid, potassium hydrogen phosphate, dibastic sodium phosphate and alkali metal (for example, sodium) hexametaphosphate and their mixture.The polyphosphate bigger than four polyphosphate occurs with amorphous glass attitude material usually.In one embodiment, polyphosphate is those of FMC Corporation manufacturing, and its commodity are called Sodaphos (n ≈ 6), Hexaphos (n ≈ 13) and Glass H (n ≈ 21, sodium hexameta phosphate) and their mixture.Can be used for pyrophosphate of the present invention and comprise alkali metal pyrophosphate, pyrophosphoric acid two, three and a potassium or sodium, two alkali metal pyrophosphates, four alkali metal pyrophosphates and their mixture.In one embodiment, pyrophosphate is selected from Sodium phosphate (Na3HP2O7), Sodium Acid Pyrophosphate (Na
2H
2P
2O
7), Dipotassium pyrophosphate, tetrasodium pyrophosphate (Na
4P
2O
7), tetrapotassium pyrophosphate (K
4P
2O
7) and their mixture.The polyolefin sulphonic acid ester comprises that olefin group wherein comprises those of 2 or a plurality of carbon atoms, and their salt.The polyolefin phosphonate ester comprises that olefin group wherein comprises those of 2 a plurality of carbon atoms.The polyphosphonic acid vinyl acetate comprises polyvinylphosphonic acid.Bisphosphonates and salt thereof comprise azo cycloalkanes-2,2-di 2 ethylhexyl phosphonic acid and salt thereof, azo cycloalkanes-2, the ion of 2-di 2 ethylhexyl phosphonic acid and salt thereof, piperidine-2,2-di 2 ethylhexyl phosphonic acid, aza-cyclopentane-2,2-di 2 ethylhexyl phosphonic acid, N-methyl-aza-cyclopentane-2,3-di 2 ethylhexyl phosphonic acid, EHDP (ethane-1-hydroxyl-1,1,-di 2 ethylhexyl phosphonic acid), AHP (azepan-2,2-di 2 ethylhexyl phosphonic acid), ethane-1-amino-1,1-diphosphate, dichloromethane-diphosphate or the like.Phosphono alkyl carboxylic acid or their alkali metal salt comprise PPTA (phosphono tricarballylic acid), PBTA (phosphinylidyne butane-1,2,4-tricarboxylic acids), are respectively acid or alkali metal salt.The polyolefin phosphate ester comprises that olefin group wherein comprises those of 2 or a plurality of carbon atoms.Polypeptide comprises poly-aspartate and polyglutamic acid.
2) stannous ion
Dentrifice composition of the present invention can comprise stannous ion source.Can provide stannous ion by stannous fluoride and/or other tin salt.Have been found that stannous fluoride helps to reduce gingivitis, dental plaque, sensitivity, and help to improve the beneficial effect of breathing.The stannous ion that provides in the Dentrifice composition will provide effect for the experimenter who uses described Dentrifice composition.Though effect can comprise the beneficial effect except that reducing gingivitis, and effect is defined as the metabolic obvious reduction of dental plaque on the spot.Provide the preparation typical case of this effect that the inferior stannum content that is provided by stannous fluoride and/or other tin salt is provided, its scope is about 3 in total Dentrifice composition, and 000ppm is to about 15, the 000ppm stannous ion.The amount of stannous ion is about 4, and 000ppm is to about 12, and 000ppm be about 5 in one embodiment, and 000ppm is extremely about 10,000ppm.Other tin salt comprises organic inferior stannum carboxylate, for example stannous acetate, the inferior stannum of gluconic acid, stannous oxalate, the inferior stannum of malonic acid, stannous citrate, ethylene sugar Tin monoxide, the inferior stannum of formic acid, stannous sulfate, the inferior stannum of lactic acid, stannous tartrate or the like.Other stannous ion source comprises halogenation inferior stannum, for example stannous chloride, Tin dibromide., Tin diiodide. and stannous chloride dihydride.In one embodiment, stannous ion source is a stannous fluoride, is the stannous chloride dihydride in another embodiment.The content of combination tin salt can be about 0.001% to about 11% by the weight of described Dentrifice composition.The content of tin salt can be about 0.01% to about 7% in one embodiment by the weight of described Dentrifice composition, is about 0.1% to about 5% in another embodiment, is about 1.5% to about 3% in another embodiment.
3) brightening agent
Can comprise brightening agent in the Dentrifice composition of the present invention as active substance.Be applicable to that the active substance that brightens is selected from the group of being made up of following material: alkali metal and alkaline earth metal peroxide, metal chlorite, the perborate that comprises monohydrate and tetrahydrate, perphosphate, percarbonate, peroxy acid and persulfate, as Ammonium persulfate., potassium, sodium and lithium, and their combination.Suitable peroxide compound comprises hydrogen peroxide, urea peroxide, calper calcium peroxide, urea peroxide, Magnesium dioxide, zinc peroxide, strontium peroxide and their mixture.In one embodiment, peroxide is a urea peroxide.Suitable metal chlorite comprises calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite.Other whitening active can be hypochlorite and chlorine dioxide.In one embodiment, chlorite is a sodium chlorite.In another embodiment, percarbonate is a SODIUM PERCARBONATE.In one embodiment, persulfate is a potassium hydrogen persulfate.The content of these materials depends on that respectively this molecule can provide available oxygen or the chlorine of bleaching mottle.The content of brightening agent is about 0.01% to about 40% by the weight of described Dentrifice composition in one embodiment, be about 0.1% to about 20% in another embodiment, be about 0.5% to about 10% in another embodiment, and be about 4% to about 7% in another embodiment.
4) antimicrobial
Can comprise antimicrobial in the Dentrifice composition of the present invention.This class material can include but not limited to: 5-chloro-2-(2, the 4-dichlorophenoxy)-phenol is referred to as triclosan usually; 8-oxyquinoline and salt thereof; Copper II chemical compound includes, but not limited to copper chloride (II), copper sulfate (II), copper acetate (II), copper fluoride (II) and Copper hydrate (II); Phthalic acid and salt thereof include but not limited to United States Patent (USP) 4,994, in 262 disclosed those, comprise magnesium phthalate one potassium; Chlohexidine; Win-21904; Hexatidine; Sanguinarine; Alkyl benzyl dimethyl ammonium chloride; Salicylamide; Domiphen bromide; Cetylpyridinium chloride (CPC); TPC (TPC); Chlorination N-myristyl-4-ethylpyridine (TDEPC); Octenidine; Iodine; Sulfonamide; Two biguanide; Phenol; Delmopinol; Octapinol and other sub-base derivatives of piperidine; Niacin preparation; Zinc or stannous ion agent; Nystatin; Grapefruit abstract; Fructus Mali pumilae extract; Thyme oil; Thymol; Antibiotic such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanamycin, cetylpyridinium chloride and clindamycin; The analog of above material and salt; Methyl salicylate; Hydrogen peroxide; Chlorous slaine; The mixture of all above materials.The content of antimicrobial components is by the weight of described Dentrifice composition about 0.001% to about 20%.In another embodiment, the content of antimicrobial is generally about 0.1% to about 5% by the weight of Dentrifice composition of the present invention.
5) antiplaque agent
Dentrifice composition of the present invention can comprise antiplaque agent, as tin salt, mantoquita, strontium salt, magnesium salt or dimethicone copolyol.The polydimethylsiloxane polyhydric alcohol is selected from the alkyl polydimethylsiloxane polyhydric alcohol of C12 to C20 and their mixture.In one embodiment, dimethicone copolyol is the cetyl dimethicone copolyol, and it is sold with trade name Abil EM90.The content of dimethicone copolyol is about 0.001% to about 25% by the weight of described Dentrifice composition in one embodiment, being about 0.01% to about 5% in another embodiment, is about 0.1% to about 1.5% in another embodiment.
6) antiinflammatory
Also can there be antiinflammatory in the Dentrifice composition of the present invention.This reagent can include but not limited to non-steroidal anti-inflammatory agents (NSAID) former times health, salicylate, propanoic acid, acetic acid and Fen Na ester.Described NSAID includes but not limited to, ketorolac, flurbiprofen, ibuprofen, naproxen, indometacin, diclofenac, etodolac, indometacin, sulindac, tolmetin, ketoprofen, fenoprofen, piroxicam, nabumetone, aspirin, diflunisal, meclofenamic acid salt, mefenamic acid, crovaril, Phenylbutazone and acetaminophen.The use of NSAID such as ketorolac is subjected to United States Patent (USP) 5,626, the protection of 838 claims.Wherein disclosed is the method that prevents and/or treats the constitutional and the recurrent squamous cell carcinoma of oral cavity or oropharynx by the NSAID to oral cavity or oropharynx local application effective dose.Suitable steroid antiinflammatory comprises corticosteroid, for example fluocinolone acetonide and hydrocortisone.
7) nutrient substance
Nutrient substance can improve oral condition, and can be included in the Dentrifice composition of the present invention.Nutrient comprises mineral, vitamin, oral nutritional supplements, enteral nutritional supplements and their mixture.Available mineral comprises calcium, phosphorus, zinc, manganese, potassium and their mixture.Vitamin can comprise with mineral, or uses separately.Suitable vitamins comprises vitamin C and D, thiamine, riboflavin, calcium pantothenate, nicotinic acid, folic acid, nicotiamide, pyridoxin, cobalamin, para-amino benzoic acid, bioflavonoids and their mixture.Oral nutritional supplements comprises aminoacid, lipotropic, fish oil and their mixture.Aminoacid includes but not limited to L-tryptophan, L-lysine, methionine, threonine, levocarnitine or L-carnitine and their mixture.Lipotropic includes but not limited to choline, inositol, betanin, linoleic acid, linolenic acid and their mixture.Fish oil contains a large amount of ω-3 (N-3) polyunsaturated fatty acid, eicosapentaenoic acid and docosahexenoic acid.Enteral nutritional supplements includes but not limited to the triglyceride of protein product, glucose polymer, Semen Maydis oil, safflower oil, medium chain.Mineral, vitamin, oral nutritional supplements and enteral nutritional supplements are described in greater detail in DrugFacts and Comparisons, Wolters Kluer Company, and St.Louis, Mo.,
In 1997, the 3-17 pages or leaves and the 54-57 page or leaf.
8) antioxidant
It has been generally acknowledged that antioxidant is useful in Dentrifice composition.Antioxidant is disclosed in the textbook, the The Handbook of Antioxidants (antioxidant handbook) of Cadenas and Packer for example,
1996, Marcel Dekker, all rights reserved for Inc..The antioxidant that can be used in the present composition includes but not limited to vitamin E, ascorbic acid, uric acid, carotenoid, vitamin A, flavonoid and polyphenol, herbaceous plant antioxidant, melatonin, amino indole, thioctic acid and their mixture.
9) analgesic and anesthetis
Analgesic or desensitizer also can be present in the Dentrifice composition of the present invention.Analgesic is a kind of like this material, and it palliates the agonizing sufferings by the painful threshold value of raising that works at maincenter, and does not hinder consciousness or change other sensory feel.This material can include but not limited to: strontium chloride; Potassium nitrate; Sodium fluoride; Chile saltpeter; Acetanilide; Phenacetin; Acetophen; N-(1-oxygen-2-sulfydryl-3-phenylpropyl) glycine; Spiradoline; Aspirin; Codeine; Thebaine; Left-handed phenol; Hydromorphone; Oxymorphone; Phenazocine; Fentanyl; Buprenorphine; Tetracaine hydrochloride; Nalbuphine; Pentazocine; Natural medicinal herbs such as Galla Chinensis, Herba Asari, cubebin, Rhizoma Alpiniae Officinarum, Radix Scutellariae, Radix Zanthoxyli and the Radix Angelicae Dahuricae.Also can there be anesthetis or local anesthetic, as acetaminophen, sodium salicylate, trolamine salicylate, lignocaine and benzocaine.These analgesic activity materials are described in detail in the Encyclopedia of Chemical Technology of Kirk-Othmer, and the 4th edition, the 2nd volume, Wiley-Interscience Publishers (1992) is in the 729-737 page or leaf.
10) H-1 and H-2 antagonist
The present invention also can choose wantonly and comprise optionally H-1 and H-2 antagonist, and it comprises United States Patent (USP) 5,294, disclosed chemical compound in 433.
11) pigment and coloring agent
Pigment can be joined in the Dentrifice composition of this paper, to demonstrate the position of Dentrifice composition actual contact more accurately.In addition, these materials are applicable to that the color that changes tooth is so that consumer satisfaction.These materials comprise such granule: when it was coated to dental surface, it can change this surface by absorption and/or luminous reflectance.When comprising these particulate thin film claddings on dental surface or tooth the time, these granules can provide the outward appearance beneficial effect.Also can add the outward appearance that pigment, dyestuff, coloring agent and color lake change this paper Dentrifice composition, cause product more desirable for consumers.In order to reach the desired special-effect of consumer, select suitable pigment content.For example, for black especially or the tooth of mottle arranged, with the typical case use capacity pigment so that the color of tooth shoal.On the other hand, when the speckle on single tooth or the tooth during, can use pigment to deepen the color of tooth than other tooth of light color.The content of pigment and coloring agent can by the gross weight of described Dentrifice composition about 0.001% to about 20% scope, be about 0.01% to about 15% in one embodiment, be about 0.1% to about 10% in another embodiment.
Pigment and coloring agent comprise inorganic Chinese white, inorganic color pigment, pearling agent, filler powder etc.; Patent application publication number 9[1997 referring to Japanese publication]-100215.Concrete example is selected from the group of being made up of following material: Talcum, Muscovitum, magnesium carbonate, calcium carbonate, magnesium silicate, the aluminium silicate magnesium salt, silicon dioxide, titanium dioxide, zinc oxide, red iron oxide, brown iron oxide, yellow iron oxide, black iron oxide, ammonium ferrocyanide ferrum, manganese violet, ultramarine pigment, nylon powder, polyethylene powders, the methacrylate powder, the polystyrene powder, the silk powder, crystalline cellulose, starch, the Muscovitum of titanation, ferrum oxide metatitanic acid Muscovitum, bismuth oxychloride, and their mixture.In one embodiment, pigment and coloring agent are selected from titanium dioxide, bismuth oxychloride, zinc oxide, Opatint D﹠amp; C is red 27, CI 16185:1 acid 27 color lake E123, CI 14720:1Carmosoisine aluminum color lake E122, red 7 color lakes or red 30 color lakes and their mixture.
12) additional activity material
Be applicable to that additional activity material of the present invention can include but not limited to the medicine of insulin, steroidal compounds, herbaceous plant and other plant origin.In addition, also can comprise gingivitis agent as known in the art or gums nursing agent.Can choose wantonly and comprise the component of giving the cleaning of teeth sense.These components can comprise for example sodium bicarbonate or Glass-H.Equally, think in some form of therapy, can use the combination of these mentioned reagent so that obtain optimum efficiency.Therefore, for example antimicrobial and antiinflammatory can be combined in the Dentrifice composition so that the combination effect to be provided.
Spendable optional reagent comprises known substances, as synthetic anionic polymer, comprises the copolymer (as Gantrez) of polyacrylate and maleic anhydride or maleic acid and methyl vinyl ether, as United States Patent (USP) 4,627, described in 977; And for example gather aminopropanesulfonic acid (AMPS), Zinc citrate trihydrate., polyphosphate (as three polyphosphate, hexametaphosphate), diphosphate (as EHDP; AHP), polypeptide (as poly-aspartate and polyglutamic acid) and their mixture.In addition, Dentrifice composition can comprise polymer support, as United States Patent (USP) 6,682,722 and 6,589,512 and U.S. Patent application 10/424,640 and 10/430,617 described in those.
13) alkali metal hydrogencarbonate
The present invention also can comprise alkali metal hydrogencarbonate.Alkali metal hydrogencarbonate is water miscible.Unless stabilized, otherwise it is tending towards release of carbon dioxide in Aquo System.In one embodiment, the sodium bicarbonate that is also referred to as yeast powder is an alkali metal hydrogencarbonate.Dentrifice composition of the present invention can comprise about 0.5% to about 30%, about in another embodiment 0.5% to about alkali metal hydrogencarbonate of 15%, about in another embodiment 0.5% to about 5%.
I. mix carrier
The water that uses when preparing commercially available suitable Dentrifice composition should have low ion concentration and not contain organic impurity.The content of water is generally about 5% to about 70% by the weight of this paper Dentrifice composition, is about 20% to about 50% in another embodiment.These water yields comprise that the free water of adding adds the water of being brought into by other materials (as by sorbitol).
Titanium dioxide also can join in the Dentrifice composition of the present invention.Titanium dioxide is a kind of white powder, and it can increase opacity to Dentrifice composition.The content of titanium dioxide is generally about 0.25% to about 5% by the weight of described Dentrifice composition.Titanium dioxide can have the Muscovitum cover layer.
Other optional reagent comprises the synthetic anionic polymer polycarboxylate, and they use with its free acid or partially or completely neutral water-soluble alkali (as potassium and sodium) or ammonium salts, and are disclosed in United States Patent (USP) 4,152,420,3,956,480,4,138,477,4,183,914 and 4, in 906,456.In one embodiment, copolymer can be 1: 4 to 4: 1 copolymer of maleic anhydride or acid and another kind of polymerizable ethylene linkage formula unsaturated monomer, and methyl vinyl ether (methoxy-ethylene) can have about 30,000 to about 1 specifically, 000,000 molecular weight (M.W.).These copolymers can be for example obtain with Gantrez AN 139 (M.W.500,000), the AN119 (M.W.250,000) of trade name GAF Corporation and S-97 pharmaceutical grade (M.W.70,000).
C. using method
The Dentrifice composition of the present invention of safety and effective dose can be locally applied to the mucosal tissue in oral cavity, the gingival tissues and/or the dental surface in oral cavity by several usual manners, is used for the treatment of or prevents the above-mentioned oral condition of mentioning.For example, gums/mucosal tissue and/or tooth are bathed in by in the liquid and/or foam that produces of brushing teeth with Dentrifice composition.Can chew a kind of masticable dentifrice tablet, thereby the tooth active substance is delivered to oral surfaces, described in U.S. Patent Application Publication 2004/0101493 and 2004/0101494.Can behind chewable tablet, brush teeth again then.Other limiting examples comprise with or need not gel or paste directly be coated on gums/mucosal tissue or on the tooth following oral care implement.
For the method for handling oral disease or disease (comprising dental caries), the Dentrifice composition of the present invention of safety and effective dose can be coated on the people's who needs it gums/mucosal tissue and/or the tooth at least about 10 seconds, about in another embodiment 20 seconds to about 10 minutes, about in another embodiment 30 seconds to about 60 seconds.Described method is usually directed to most of Dentrifice compositions that spue after this contact.The frequency of this contact can be for approximately weekly to every day approximately four times, in another embodiment for approximately on every Wendesdays time to every day approximately three times, and in another embodiment for approximately once a day to twice of every day approximately.The cycle of this processing is typically about one day to throughout one's life.For concrete oral care disease or disease, the persistent period of processing is depended on oral disease that need to handle or the seriousness of disease, the mode of specifically sending and the reaction of patient to handling of use.
D. method of testing
Pellicle cleaning ratio
Utilization is to " In Vitro Removal of Stain With Dentifrice ", G.K.Stookey, T.A.Burkhard and B.R.Schemerhorn, J.DentalResearch, 61,1236-9, the PCR method of testing of describing in 1982 is revised a little and is measured PGR (pellicle cleaning ratio) cleaning value.Use the pellicle cleaning ratio testing method of revising that cleaning is carried out in-vitro evaluation.This method of testing is identical with described methods of people such as Stookey, just made following modification: (1) was applied to transparent artificial epidermis thin film on the cattle thin slice before using painted thin film, (2) use the solution heating, rather than in applying thin-film process radiation heating, (3) number of times comforted of brush is reduced to 1000 times and (4) concentration of slurry is that 1 part of dentifrice is to 3 parts of water.
E. embodiment
Dentrifice composition of the present invention both can be used for the people, also can be used for other rudimentary animal (for example house pet, zoo animal or domestic animal).
Following non-limiting examples further describes the embodiment in the scope of the invention.In the case without departing from the scope of the present invention, a lot of changes of these embodiment are possible.
As described below, Dentrifice composition of the present invention comprises following component.
Wetting agent and thickening agent are joined in the mixing channel, begin then to stir.When thickening agent is evenly dispersed in the wetting agent, water is added in the mixing channel.Then add fluoride, sweeting agent, buffer agent, chelating agen, stain and titanium dioxide.If you are using, then under high-speed stirred and vacuum, grinding agent is added in the mixing channel.Surfactant and flavoring agent are joined in the compositions, continue to mix.Continue to mix about 5 minutes.Resulting composition can have about 8 pH.
Size disclosed herein and numerical value should not be understood that to be strictly limited to described exact numerical values recited.On the contrary, except as otherwise noted, each size is intended to represent described value and near the function equivalent scope of this value.For example, the size that is disclosed as " 40mm " is intended to mean " about 40mm ".
The relevant part of all references all is incorporated herein with way of reference in the detailed Description Of The Invention.Quoting of any document is unintelligible for being to its approval as prior art of the present invention.
Although illustrated and described the present invention with specific embodiments, it will be apparent to those skilled in the art that many other variations and modifications may be made in the case of without departing from the spirit and scope of protection of the present invention.Therefore, in additional claims, comprise all such changes and modifications that belong in the scope of the invention consciously.
Claims (10)
1. dentifrice, described dentifrice comprises:
A. mouth care carrier;
B. the fluoride sources of safety and effective dose;
C. at least 2.5% chelating agen;
D.0.5% to 5% surfactant;
Wherein said dentifrice has at least 8 pH, and wherein said dentifrice has at least 20 PCR value, and is wherein produced by chemically cleaning greater than 10% described PCR value.
2. dentifrice as claimed in claim 1, wherein said mouth care carrier comprises flavoring agent, the content of described flavoring agent by the weight of described total dentifrice in 0.5 to 1.5% scope.
3. dentifrice as claimed in claim 1, described dentifrice also comprises 0.01% to 10% grinding agent.
4. dentifrice as claimed in claim 1, wherein said pH are 8 to 10.
5. dentifrice as claimed in claim 1, wherein 20% to 100% described PCR value is produced by chemically cleaning, and preferred 50% to 100% described PCR value is produced by chemically cleaning.
6. dentifrice as claimed in claim 1, the content of wherein said chelating agen are 2.5% to 15%.
7. dentifrice as claimed in claim 1, the content of wherein said surfactant are 1% to 3%.
8. dentifrice as claimed in claim 1, wherein said dentifrice have at least 40 PCR value.
Chelating agen preparation as described above the described compositions of each claim to minimize the purposes aspect the tooth erosion.
10. dentifrice, described dentifrice comprises:
A. mouth care carrier;
B. the fluoride sources of safety and effective dose;
C.2.5% to 15% chelating agen;
D.1% to 3% surfactant;
E.0% to 10% grinding agent;
Wherein dentifrice has at least 8 pH value.
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CNA2006800441493A Pending CN101316571A (en) | 2005-11-29 | 2006-11-29 | Dentifrice composition free of abrasive material |
CNA2006800441898A Pending CN101316572A (en) | 2005-11-29 | 2006-11-29 | Dentifrice composition comprising binder system comprising hydrophilic clay material |
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CN104853730A (en) * | 2012-12-19 | 2015-08-19 | 高露洁-棕榄公司 | Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine |
CN113476318A (en) * | 2021-08-11 | 2021-10-08 | 吉林大学 | Organic mica antibacterial composition, oral cleaning and nursing product, and preparation method and application thereof |
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JP5097841B2 (en) | 2011-04-08 | 2012-12-12 | 花王株式会社 | Oral composition |
WO2014098825A1 (en) | 2012-12-19 | 2014-06-26 | Colgate-Palmolive Company | Oral care products comprising a tetrabasic zinc - amino acid - halide complex |
FR3074423B1 (en) * | 2017-12-01 | 2020-03-06 | Roquette Freres | USE OF DINAHYDROHEXITOL IN ORAL HYGIENE TO REDUCE THE DEVELOPMENT OF BACTERIAL STRAINS |
CN111528223A (en) * | 2020-03-31 | 2020-08-14 | 德清康邑日化贸易有限公司 | Composite antibacterial material with slow-release chlorine dioxide and preparation method thereof |
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2006
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104853730A (en) * | 2012-12-19 | 2015-08-19 | 高露洁-棕榄公司 | Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine |
CN104853730B (en) * | 2012-12-19 | 2019-05-14 | 高露洁-棕榄公司 | Two components compositions comprising four basic zinc amino acid halide complex and cysteine |
CN113476318A (en) * | 2021-08-11 | 2021-10-08 | 吉林大学 | Organic mica antibacterial composition, oral cleaning and nursing product, and preparation method and application thereof |
CN113476318B (en) * | 2021-08-11 | 2022-05-03 | 吉林大学 | Organic mica antibacterial composition, oral cleaning and nursing product, and preparation method and application thereof |
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