CN100361705C - Chinese medicinal composition for treating chronic atrophic gastritis - Google Patents
Chinese medicinal composition for treating chronic atrophic gastritis Download PDFInfo
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- CN100361705C CN100361705C CNB200510107415XA CN200510107415A CN100361705C CN 100361705 C CN100361705 C CN 100361705C CN B200510107415X A CNB200510107415X A CN B200510107415XA CN 200510107415 A CN200510107415 A CN 200510107415A CN 100361705 C CN100361705 C CN 100361705C
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- atrophic gastritis
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Abstract
The present invention relates to a traditional Chinese medicine composition for treating chronic atrophic gastritis, which is composed of the following components by weight percentage of 3.5 to 4 % of processed pinellia tuber, 18 to 19 % of golden thread, 18 to 19 % of dried ginger, 9 to 9.5 % of ginseng, 18 to 19 % of baical skullcap root, 9 to 9.5 % of officinal magnolia bark, 3.5 to 4 % of olibanum and 18 to 19 % of prepared liauorice root. The traditional Chinese medicine composition can be used for treating the cold-heat jumble disease symptoms of chronic atrophic gastritis, and has 10% of clinical healing rate, 33% of effectual rate, 43% of effective rate and 87% of total effective rate.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis.
Background technology
Chronic atrophic gastritis is to be a kind of common digestive tract disease of feature with the atrophy of gastric mucosa body of gland, and WHO classifies it precancerous condition of gastric cancer as, does not also effect a radical cure the specific drug of chronic atrophic gastritis at present.Conventional Chinese medicine prescription such as Sini San (come from treatise on Febrile Diseases, be stated from " pharmacology of Chinese medical formulae " 58 pages), sanren decoction (comes from " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases ", be stated from " pharmacology of Chinese medical formulae teaching materials " 190 pages), Xiangsha Liujunzi decoction (comes from " Shi Fangge draws together ", be stated from " science of epidemic febrile disease of Chinese medicine " 231 pages), decoction made from radix adenophorea, tuber of dwarf lilyturf (comes from " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases ", be stated from " pharmacology of Chinese medical formulae " 231 pages) etc. execute and control the principle difference, but all can not comprehensively treat chronic atrophic gastritis.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis.The present invention can effectively contain gastric mucosa atrophy, hinders it and develops to cancer, has better curative effect.
A kind of Chinese medicine composition for the treatment of chronic atrophic gastritis of the present invention, according to monarch, minister,, make and carry out prescription: Rhizoma Pinelliae Preparatum is a monarch drug; Rhizoma Coptidis, Rhizoma Zingiberis, Radix Ginseng are ministerial drug; Radix Scutellariae, Cortex Magnoliae Officinalis, Olibanum are adjuvant drug; Radix Glycyrrhizae Preparata is a messenger drug; And the constituent of Chinese medicine composition and percentage by weight are: Rhizoma Pinelliae Preparatum 3.5%-4%, Rhizoma Coptidis 18%-19%, Rhizoma Zingiberis 18%-19%, Radix Ginseng 9%-9.5%, Radix Scutellariae 18%-19%, Cortex Magnoliae Officinalis 9%-9.5%, Olibanum 3.5%-4%, Radix Glycyrrhizae Preparata 18%-19%.
A kind of Chinese medicine composition system for the treatment of chronic atrophic gastritis of the present invention is according to the Chinese medicine and pharmacy theory, and according to monarch, minister, help, make and carry out prescription: Rhizoma Pinelliae Preparatum is a monarch drug; Rhizoma Coptidis, Rhizoma Zingiberis, Radix Ginseng are ministerial drug; Radix Scutellariae, Cortex Magnoliae Officinalis, Olibanum are adjuvant drug; Radix Glycyrrhizae Preparata is a messenger drug;
Below, according to the Chinese medicine and pharmacy theory, a kind of compatibility component for the treatment of the Chinese medicine composition of chronic atrophic gastritis of the present invention is further illustrated:
The Rhizoma Pinelliae is a monarch drug.Bring into play its invigorating the spleen and regulating the stomach, the eliminating stagnation painful abdominal mass that disappears, sending down the abnormal ascending QI removes the analgesic effect that expands, and cures mainly weakness of the spleen and stomach, coldheat complex spleen card; Rhizoma Coptidis assists to bring into play its heat clearing and damp drying in the monarch drug damp eliminating accent, transfers the thick intestinal of stomach, the effect of consolidating YIN dysentery relieving; Rhizoma Zingiberis is assisted monarch drug, brings into play its warming and invigorating the spleen and stomach, the expelling cold pathogen and lowering adverse QI analgesic effect; Radix Ginseng is assisted monarch drug, brings into play its invigorating middle warmer emergency effect; Radix Scutellariae is assisted the Rhizoma Coptidis heat clearing away, brings into play its heat clearing and damp drying, and consolidating YIN ends sharp effect; Cortex Magnoliae Officinalis is assisted the Rhizoma Pinelliae, Rhizoma Zingiberis warming middle-JIAO to send down the adverse QI, brings into play its promoting the circulation of QI to remove dampness, removes the removing food stagnancy effect of expanding; Olibanum assists the Rhizoma Pinelliae, Rhizoma Zingiberis suffering to loose, and brings into play its promoting the circulation of QI to relieve pain blood stasis dispelling effect; Radix Glycyrrhizae Preparata, on the one hand, assistant is help others and is joined invigorating middle warmer void, and on the other hand, coordinating the actions of various ingredients in a prescription is in harmonious proportion the property of medicine, is beneficial to nourishing the stomach.
Preparation method of the present invention is, the frankincense powder that 2/5 people of proportional quantity is participated in whole proportional quantities is broken into fine powder, and is standby.The Rhizoma Coptidis of proportional quantity decocts with water, filter, merging filtrate is evaporated to the clear paste of relative density 1.10-1.15 (25 ℃), precipitate with ethanol (making concentration of alcohol reach 65%-75%), stir, left standstill 24 hours, and filtered, decompression recycling ethanol also is concentrated into the thick paste of relative density 1.30-1.35 (50 ℃), 80 ℃ of dryings are ground into fine powder; The Rhizoma Zingiberis of proportional quantity is soaked, water vapour distillation volatile oil, and medicinal residues and distillation back water liquid are standby.The volatile oil beta-cyclodextrin inclusion compound, sucking filtration, precipitate dry for standby; Radix Scutellariae with above-mentioned medicinal residues and proportional quantity, Cortex Magnoliae Officinalis, Radix Glycyrrhizae Preparata, 3/5 Radix Ginseng of Rhizoma Pinelliae Preparatum and proportional quantity decocts with water, filter, filtrate and Rhizoma Zingiberis distillation back water liquid merge, be evaporated to the clear paste of relative density 1.10-1.15 (25 ℃), precipitate with ethanol (making concentration of alcohol reach 65%-75%), stir, left standstill 24 hours, filter, decompression recycling ethanol also is concentrated into the thick paste of relative density 1.30-1.35 (50 ℃), add above-mentioned fine powder, stir, 80 ℃ of dryings, be ground into fine powder, promptly get Chinese medicine composition of the present invention with Rhizoma Coptidis extract powder and clathrate mix homogeneously; The present invention can also continue to make any solid dosage forms with Chinese medicine technique known method, comprises capsule, tablet, powder or pill.
Use traditional Chinese medicine composition for treating chronic atrophic gastritis 60 examples of treatment chronic atrophic gastritis of the present invention, therapeutic effect is as follows:
With reference to Ministry of Public Health " new Chinese medicine treatment chronic atrophic gastritis clinical guidance principle ", " modern Chinese medicine internal medicine diagnoses and treatment ", " practical Chinese Internal Medicine ", high training medical college teaching material diagnostic criterias such as " internal medicine " treatment in whole nation chronic atrophic gastritis 60 examples, differential diagnosis in tcm belongs to simultaneous occurrence of cold and heat syndromes, clinical symptoms is glutted full vexed with stomach, distending pain, inappetence, belch, noisy pantothenic acid, big loose stool is thin or dry and hard, weak, become thin, eat pungent, cool, it is main that greasy food flatulence pain discomfort increases the weight of, picture of the tongue is with light red tongue or red, white and thin fur, yellow or greasy is main, and pulse condition is with deep and stringy pulse, carefully, slow is main.Among the 60 routine patients, clinical cure 6 examples account for 10%; Produce effects 20 examples account for 33%; Effective 26 examples account for 43%; Invalid 8 examples account for 13%, total effective rate 87%.
The specific embodiment
Embodiment 1: a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis of the present invention, and according to monarch, minister, help, make and carry out prescription: Rhizoma Pinelliae Preparatum is a monarch drug; Rhizoma Coptidis, Rhizoma Zingiberis, Radix Ginseng are ministerial drug; Radix Scutellariae, Cortex Magnoliae Officinalis, Olibanum are adjuvant drug; Radix Glycyrrhizae Preparata is a messenger drug; And the constituent of this Chinese medicine composition and percentage by weight thereof are: Rhizoma Pinelliae Preparatum 3.7%, Rhizoma Coptidis 18.5%, Rhizoma Zingiberis 18.5%, Radix Ginseng 9.3%, Radix Scutellariae 18.5%, Cortex Magnoliae Officinalis 9.3%, Olibanum 3.7%, Radix Glycyrrhizae Preparata 18.5%.
Embodiment 2:
A kind of Chinese medicine composition for the treatment of chronic atrophic gastritis of the present invention, according to monarch, minister, help, make and carry out prescription: Rhizoma Pinelliae Preparatum is a monarch drug; Rhizoma Coptidis, Rhizoma Zingiberis, Radix Ginseng are ministerial drug; Radix Scutellariae, Cortex Magnoliae Officinalis, Olibanum are adjuvant drug; Radix Glycyrrhizae Preparata is a messenger drug; And this Chinese medicinal capsule constituent and percentage by weight thereof are: Rhizoma Pinelliae Preparatum 3.5%, Rhizoma Coptidis 19%, Rhizoma Zingiberis 18%, Radix Ginseng 9.5%, Radix Scutellariae 18%, Cortex Magnoliae Officinalis 9.5%, Olibanum 4%, Radix Glycyrrhizae Preparata 18%.
Embodiment 3:
A kind of Chinese medicine composition for the treatment of chronic atrophic gastritis of the present invention, according to monarch, minister, help, make and carry out prescription: Rhizoma Pinelliae Preparatum is a monarch drug; Rhizoma Coptidis, Rhizoma Zingiberis, Radix Ginseng are ministerial drug; Radix Scutellariae, Cortex Magnoliae Officinalis, Olibanum are adjuvant drug; Radix Glycyrrhizae Preparata is a messenger drug; And this Chinese medicinal capsule constituent and percentage by weight thereof are: Rhizoma Pinelliae Preparatum 4%, Rhizoma Coptidis 18%, Rhizoma Zingiberis 19%, Radix Ginseng 9%, Radix Scutellariae 19%, Cortex Magnoliae Officinalis 9%, Olibanum 3.5%, Radix Glycyrrhizae Preparata 19%.
Preparation method embodiment 1:
Get Radix Ginseng 100g (3.7%) and be ground into fine powder with Olibanum 100g (3.7%), standby.Rhizoma Coptidis 500g (18.5%) decocts with water, filter, merging filtrate is evaporated to the clear paste of relative density 1.10-1.15 (25 ℃), precipitate with ethanol (making concentration of alcohol reach 65%-75%), stir, left standstill 24 hours, and filtered, decompression recycling ethanol also is concentrated into the thick paste of relative density 1.30-1.35 (50 ℃), 80 ℃ of dryings are ground into fine powder.Rhizoma Zingiberis 500g (18.5%) soaks, water vapour distillation volatile oil, and medicinal residues and distillation back water liquid are standby.The volatile oil beta-cyclodextrin inclusion compound, sucking filtration, precipitate dry for standby.With above-mentioned medicinal residues and Radix Scutellariae 500g (18.5%), Radix Ginseng 150g (5.6%), Cortex Magnoliae Officinalis 250g (9.3%), Radix Glycyrrhizae Preparata 500g (18.5%), Rhizoma Pinelliae Preparatum 100g (3.7%) decocts with water, filter, filtrate and Rhizoma Zingiberis distillation back water liquid merge, be evaporated to the clear paste of relative density 1.10-1.15 (25 ℃), precipitate with ethanol (making concentration of alcohol reach 65%-75%), stir, left standstill 24 hours, filter, decompression recycling ethanol also is concentrated into the thick paste of relative density 1.30-1.35 (50 ℃), add above-mentioned fine powder, stir, 80 ℃ of dryings, be ground into fine powder, promptly get Chinese medicine composition of the present invention with Rhizoma Coptidis extract powder and clathrate mix homogeneously.
Preparation method is executed example 2:
Get Radix Ginseng 115g (4%) and be ground into fine powder with Olibanum 115g (4%), standby.Rhizoma Coptidis 545g (19%) decocts with water, filter, merging filtrate is evaporated to the clear paste of relative density 1.10-1.15 (25 ℃), precipitate with ethanol (making concentration of alcohol reach 65%-75%), stir, left standstill 24 hours, and filtered, decompression recycling ethanol also is concentrated into the thick paste of relative density 1.30-1.35 (50 ℃), 80 ℃ of dryings are ground into fine powder.Rhizoma Zingiberis 515g (18%) soaks, water vapour distillation volatile oil, and medicinal residues and distillation back water liquid are standby.The volatile oil beta-cyclodextrin inclusion compound, sucking filtration, precipitate dry for standby.With above-mentioned medicinal residues and Radix Scutellariae 515g (18%), Radix Ginseng 155g (5%), Cortex Magnoliae Officinalis 270 (9.5%), Radix Glycyrrhizae Preparata 515g (18%), Rhizoma Pinelliae Preparatum 100g (3.5%) decocts with water, filter, filtrate and Rhizoma Zingiberis distillation back water liquid merge, be evaporated to the clear paste of relative density 1.10-1.15 (25 ℃), precipitate with ethanol (making concentration of alcohol reach 65%-75%), stir, left standstill 24 hours, filter, decompression recycling ethanol also is concentrated into the thick paste of relative density 1.30-1.35 (50 ℃), add above-mentioned fine powder, stir, 80 ℃ of dryings, be ground into fine powder, promptly get Chinese medicine composition of the present invention with Rhizoma Coptidis extract powder and clathrate mix homogeneously.
Treatment embodiment 1 Yuan of the present invention, man, 33 years old, people from Changchun.Suffer from flatulence, stomachache was become thin 1 year.Every and improper diet and having a stomachache is lain awake all night.Stomach is glutted usually, no appetite, and big dry stool is rare uncomfortable, easy catching a cold, health is become thin obviously.How tame hospital examines and is chronic atrophic gastritis in the city.Look into: tongue fur is red, and tongue is greasy in vain, deep-slow pulse.Tcm diagnosis is a syndrome of feeling fullness and distension in the upper abdomen, and dialectical genus coldheat complex connects the capsule decoction with the compound recipe summer and treated 1 month, and symptom obviously alleviates.Former side took nearly 3 months in a small amount, and symptom is completely without, weight increase.Follow up a case by regular visits to after 5 years, not recurrence again.
Treatment embodiment 2 Hao of the present invention, man, 45 years old, people from Changchun.Pain, distension in the stomach, year increased the weight of 1 year surplus in the of noisy 10.Because of it is the taxi driver, irregular eating, the hungry full uncomfortable morbidity that causes.Examined by the how tame hospital in city and to be chronic atrophic gastritis, it is invalid to take Chinese and western drugs.Inappetence is glutted in the stomach, noisy usually, and stomachache is withstood stomach with alleviating pain with hands when being everlasting driving.Big dry stool is rare uncomfortable, and is very easily tired, and sleep back fatigue can not be removed, and the health skeletonize is rubbed with hands and to be touched stomach and feel and relax.Look into light red tongue, yellow and thin fur and do thready pulse.Differential diagnosis in tcm is a gastric abscess, and card belongs to coldheat complex, controls with the compound recipe summer to connect the capsule decoction.After 2 weeks, symptom is obviously improved, and after 3 months, transference cure was followed up a case by regular visits to after 5 years, and recurrence again is not healthy and strong.
Claims (2)
1. Chinese medicine composition for the treatment of chronic atrophic gastritis, according to monarch, minister, help, make and carry out the compatibility component, it is characterized in that: Rhizoma Pinelliae Preparatum is a monarch drug; Rhizoma Coptidis, Rhizoma Zingiberis, Radix Ginseng are ministerial drug; Radix Scutellariae, Cortex Magnoliae Officinalis, Olibanum are adjuvant drug; Radix Glycyrrhizae Preparata is a messenger drug; And the constituent of Chinese medicine composition and percentage by weight are: Rhizoma Pinelliae Preparatum 3.5%-4%, Rhizoma Coptidis 18%-19%, Rhizoma Zingiberis 18%-19%, Radix Ginseng 9%-9.5%, Radix Scutellariae 18%-19%, Cortex Magnoliae Officinalis 9%-9.5%, Olibanum 3.5%-4%, Radix Glycyrrhizae Preparata 18%-19%.
2. a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis according to claim 1, the constituent and the percentage by weight thereof that it is characterized in that this Chinese medicine composition are: Rhizoma Pinelliae Preparatum 3.7%, Rhizoma Coptidis 18.5%, Rhizoma Zingiberis 18.5%, Radix Ginseng 9.3%, Radix Scutellariae 18.5%, Cortex Magnoliae Officinalis 9.3%, Olibanum 3.7%, Radix Glycyrrhizae Preparata 18.5%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9193756B2 (en) | 2008-02-19 | 2015-11-24 | National University Corporation Asahikawa Medical College | Adrenomedullin production enhancer |
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| CN108619480A (en) * | 2018-08-10 | 2018-10-09 | 重庆市渝北区中医院 | A kind of Chinese medicine composition that treating atrophic gastritis and its application |
| CN116942785B (en) * | 2023-08-29 | 2024-09-10 | 北京中医药大学 | Traditional Chinese medicine preparation for treating chronic atrophic gastritis and precancerous lesions of gastric cancer |
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| CN1531961A (en) * | 2003-03-18 | 2004-09-29 | 李政育 | Chinese medine for treating paraplegia |
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| CN1531961A (en) * | 2003-03-18 | 2004-09-29 | 李政育 | Chinese medine for treating paraplegia |
Non-Patent Citations (1)
| Title |
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| 改良半夏泻心汤治疗慢性萎缩性胃炎实验研究. 金东明，吴巍，孙树权等.长春中医学院学报，第17卷第3期. 2001 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9193756B2 (en) | 2008-02-19 | 2015-11-24 | National University Corporation Asahikawa Medical College | Adrenomedullin production enhancer |
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Assignee: Changchun Puhua Pharmaceutical Co., Ltd. Assignor: Changchun Institue of Applied Chemistry, Chinese Academy of Sciences Contract record no.: 2010220000048 Denomination of invention: Chinese medicine composite for treating chronic atrophic gastritis and preparation method thereof Granted publication date: 20080116 License type: Exclusive License Open date: 20060315 Record date: 20101116 |
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