CN100340205C - Method and apparatus for treatment of mono-frequency tinnitus - Google Patents
Method and apparatus for treatment of mono-frequency tinnitus Download PDFInfo
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- CN100340205C CN100340205C CNB02828187XA CN02828187A CN100340205C CN 100340205 C CN100340205 C CN 100340205C CN B02828187X A CNB02828187X A CN B02828187XA CN 02828187 A CN02828187 A CN 02828187A CN 100340205 C CN100340205 C CN 100340205C
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
- H04R25/00—Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception
- H04R25/75—Electric tinnitus maskers providing an auditory perception
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Abstract
Reciprocal noise cancellation of a patient's (11) mono-frequency tinnitus tone is achieved utilizing an externally generated tone which is subjectively defined by a mono-frequency tinnitus patient (11) to match his/her tinnitus tone in frequency and amplitude. An externally generated sound wave, selectively designated by subjective observations of a patient to match the patient's tinnitus tone is first applied to the tinnitus patient via earphones (12) or a speaker system and then the same externally generated sound wave is sequentially phase shifted through a plurality of angularly shifted sequence steps (1-3) to shift or slide the external sound wave through at least a 180 degree phase shift of the generated signal as it is applied to the patient (11) to achieve a series of reductions of the patient's tinnitus tone and in one of such shifted steps a reciprocal, canceling relationship with the patient's tinnitus tone. The tinnitus treatment sequence of an externally generated sound wave and then the phase shifted externally generated tone achieve cancellation of the tinnitus tone of the patient as the sequential steps of the generated tone in effect slide across the tinnitus sound wave resulting in cancellation of the tinnitus tone. By replaying the sequential phase shifted segments of the patient treatment process a patient may utilize the previously recorded sequences in a patient self-treatment process.
Description
Relevant U. S. application cross reference
[0001] this application requires at the calendar year 2001 U.S. provisional application No.60/340 that formerly submitted in 18th of December, 271 rights and interests, and further with the U.S. application No.10/083 that submitted on March 1st, 2002,088 is relevant.The description of these two pieces of related applications and disclosed content are all incorporated by reference at this.
Technical field
[0002] the present invention relates to treatment, more particularly, relate to and utilize phase shift to eliminate the improvement clinical treatment method and apparatus that principle is treated the mono-frequency tinnitus patient tinnitus patient.
Background technology
[0003] tinnitus is defined as when not having external sound to occur individual institute sound sensed, and often with intermittently or continue fizz, the tinkle of bells, roar, pipe, the form of clicking occurs.Claim that according to American Tinnitus Association tinnitus is perplexing and surpasses 5,000 ten thousand American, and wherein surpass 1,200 ten thousand people and suffer the torment of tinnitus so serious, make them have to seek medical attention, and many people can not orthobiosis.
[0004] tinnitus often is called as the tinkle of bells in the ear, is surpassing in the middle of 65 years old the American according to estimates, and tinnitus can appear in about 50% people.Generally speaking, tinnitus has many different forms, and these forms may be relevant with its potential origin cause of formation.Tinnitus might cause by wound, medicine, impaired hearing, normal ageing process or other unknown cause, or associated.
[0005] method of treatment tinnitus all concentrates on the tinnitus noise shielding with patient's impression before.Though shield technology in the past can not alleviate the problem of tinnitus patient, has done significant research.In the research report in the tinnitus academic conference of Oregon, person in charge Jack Vernon (Jack Vernon) in audition research center, Oregon statement: in the research of patient's tinnitus, have tangible importance during the sound that the pass of phase place and tone (tone) ties up to tinnitus shields and be vital.Vernon continues to observe, and people can not suppress to eliminate the idea of tinnitus by the phase place of suitably adjusting the external sound that uses in the middle of the shielding.
[0006] in the comment that the early stage tinnitus treatment of Wegel is found, mentions, the slight off resonance of shielding external sound generate one with tinnitus sound together as the sensation of beating time, Vernon is reported, in the research to 100 patients, he only can detect slight as the sensation of beating time in 4 examples.Therefore, Vernon is summed up: what Wegel found probably is not use one pure tone owing to Wegel as the sensation of beating time, and the scale confusion that has been to use the noise of a narrower frequency range to cause causes.In a word, Vernon is observed: phase controlling has proved further carries out patient's research, is effective to obtain shielding parameter for the tone tinnitus treatment.Vernon is about carrying out the report of suitable phase controlling in order to treat tinnitus patient, delivered at first in 1991 and be that title is collected in 1997 editions Shulman ' s treaties and begins never to change with " diagnosis of tinnitus and treatment " from it.
[0007] doctor Choy has reported in his above mentioned U. S. application from utilizing the extraneous tinnitus sound that generates to carry out the favourable patient data of the not visible clinical research of 180 degree phase shifts.The patient who is higher than 79% acceptance research claims or has eliminated tinnitus noise, has perhaps reduced the level of tinnitus noise considerably.
[0008] current medical procedures and electronics/acoustic instrument all can not or be assisted the frequency and the amplitude of the tinnitus noise of objective definite patient experiences.Also can not subjectively determine on the mono-frequency tinnitus tone of patient's reality certain any instantaneous phase.
[0009] current tinnitus treatment state makes tinnitus patient very worried, because in order to offset the actual tinnitus noise of patient, the medical knowledge of current state and audition/electronic machine also do not allow a people to determine objectively which point of patient's virtual interior living tinnitus sound wave tinnitus tone (sine wave) the sinusoidal wave insertion of external phase shift to be eliminated patient's real tinnitus noise.
Summary of the invention
[0010] in a plurality of possible embodiment of the present invention, utilize by the mono-frequency tinnitus patient is subjective and determine, with the tone that the external world that is complementary with his/her tinnitus noise frequency and amplitude generates, realized anti-phase noise cancellation to patient's mono-frequency tinnitus tone.According to applicant's a new equipment and an aspect of method, will at first impose on tinnitus patient by earphone or broadcast system by the sound wave of patient's subjective observation being specified selectively the external world's generation that is complementary with patient's tinnitus tone.Then, by a plurality of angular deflection sequence step the sound wave that the identical external world generates is carried out phase shift continuously, make in the scope of 180 degree phase shifts of the signal that is generated the skew of the sound wave in the external world at least or slide, in such bias step, when it is applied to the patient, obtain the counteracting relation opposite with patient's tinnitus tone.The tone that the tinnitus treatment sequence of the sound wave that the external world generates and the external world through phase shift then generate has been realized the elimination to patient's tinnitus tone, when the sequence step warp of the tone that generates effectively slides with tinnitus sound wave quadrature, causes tinnitus tone to be eliminated.
[0011] applicant's inventive apparatus and method can be provided in the portable self-treatment storage device, this device comprises the sequence of the tinnitus treatment tone segments of record, for example, the extraneous tone that generates and in patient's treatment clinical course or thereafter according to the successive phase shift steps of patient's clinical data record.By the continuous phase shift fragment in the playback patient treatment program, the sequence that the patient notes before can utilizing in the patient self-treatment process.
Description of drawings
[0012] annexed drawings set forth different embodiments of the invention, and be the part of description.Illustrated embodiment is an example of the present invention, does not limit the scope of the invention.
[0013] Fig. 1 is the block diagram of mono-frequency tinnitus therapy equipment according to an embodiment of the invention.
[0014] Fig. 2 A, 2B, 2C, 2D and 2E diagram show a series of sine waves of phase shifted cancellation principle according to an embodiment of the invention.
[0015] Fig. 3 A, 3B and 3C have diagrammatically illustrated adding up and offsetting of assumed patient tinnitus waveform according to embodiments of the invention, and the waveform of the extraneous side-play amount angle θ with arbitrary assumption that generates.
[0016] Fig. 4 is the logic diagram of having illustrated another embodiments of the invention that are suitable for generating Heal Thyself tinnitus record.
[0017] Fig. 5 illustrates another embodiment of Heal Thyself tinnitus process.
[0018] Fig. 6 has illustrated the embodiment of Heal Thyself recording disc draft of the present invention.
[0019] Fig. 7 has illustrated the logical flow chart of the s phase shift treatment draft that is used to assess the applicant according to an embodiment of the invention.
[0020] Fig. 8 A, 8B has illustrated according to an embodiment of the invention the layout of self-treatment protocol and the different time line of embodiment continuously with 8C.
[0021] Fig. 9 has illustrated the different qualities of the objective determination of applicant's phase shift tinnitus treatment draft and the logic diagram of step according to an embodiment of the invention.
[0022] in institute's drawings attached, the indication of identical Reference numeral similar but components identical not necessarily.
The specific embodiment
[0023] in order to remedy current deficiency in diagnosis and treatment tinnitus patient, particularly single-frequency (single-tone) tinnitus, the applicant has developed a kind of new, more effective phase place that has overcome many shortcomings of the prior art and has eliminated Therapeutic Method and device.For a long time, need a kind of effective treatment to reduce widely, alleviate always or eliminate the usually very weak state of tinnitus of mono-frequency tinnitus patient.
[0024] with reference now to Fig. 1, it shows a preferred embodiment that is used for mono-frequency tinnitus patient's phase shift treatment system with the form of block diagram.Sound generator 10, for example, Agilent33120A type forcing function generator or any waveform generator that can buy that is equal to are connected in the input of patient's earphone 12 and oscillograph 14, and this oscillograph for example can have been bought from Eektronics company in the U.S..Rising tone tone generator 16 also is connected in another input of oscillograph 14.
[0025] sound generator 10 has a plurality of knobs that can regulate 18 and 20 and lead-out terminal 24.As will at length illustrating with reference to figure 3 below, require mono-frequency tinnitus patient 11 to use knob 18 and 20 to adjust the frequency and the amplitude of the acoustical signal that sound generators 10 generate respectively, impose on the output of earphone 12 and tinnitus single-frequency sound that the patient hears is complementary up to sound generator.
[0026] " the sound typing " of this subjectivity is preferably on the not visible basis and repeats repeatedly, and just, the patient can't see oscillograph 14.Can between patient 11 and oscillograph 14 and sound generator 10, place dividing plate 36.In addition, perhaps the display that does not have patient 11 to observe on sound generator 10 perhaps shields or hiding any such display patient 11.In this manner, if the patient can subjectively repeatedly select tinnitus noise and the sound generator 10 of roughly the same parameter to mate his or she perception, just should be confident of believing the tinnitus noise that the output of sound generator 10 is accurately experienced near patient 11.
[0027] preferably carries out record for the personal voice typing data in each step in the self-typing step by the audiologist or the doctor that participate in.In addition, can generate identical output, thereby be complementary with the output of first sound generator 10 by regulating rising tone tone generator 16.The output of first sound generator 10 and rising tone tone generator 16 can compare on oscillograph 14, thereby guarantees that they are identical.As hereinafter described, can use the output of rising tone tone generator 16 to prepare patient 11 treatment record.
[0028] sound wave elimination principle is that by having the second sinusoidal wave superposition of identical frequency and amplitude, for example addition is implemented when the primary sinusoid has the phase shift of 180 degree.Sound wave is eliminated in electric and measuring technique and is known, and is widely used in the many technical fields that comprise audiology, mechanics and electronics.For single-frequency tinnitus, the patient should be able to regulate the tinnitus noise that the output of first sound generator 10 makes it hear near him or she.
[0029] can describe as follows and will have same frequency and amplitude, but the phase relation of two waveforms is known nothing for some common points first waveform and second waveform adder, thus reach the method that effect is eliminated in phase shift.Sound generator 10 is set to have first scale of frequency f 1 and amplitude A (millivolt that for example shows) on sound generator 10, and is connected in first input of multichannel oscilloscope 14.Second generator 16 also is set to have the identical scale of identical amplitude, and its output is connected to second input of oscillograph 14.
[0030] with reference to figure 2A-2E, can see the phase place of regulating sinusoidal wave f by series of steps, this sine wave is expressed as f
1... f
m, f
1With f
mAddition and (Fig. 2 E) neutralize or offset initialize signal f
1As illustrated, work as f
mWith f
1When phase phase difference 180 is spent, f
1With f
mAddition and cancelling out each other.For tinnitus patient regrettably, the structure of human auditory system and work than top on the basis of multichannel oscilloscope 14 the simple addition of the sound waveform of two illustrated tones more complex.
[0031] the audiology field is known is, the human and animal can quite accurately determine the direction apart from their far sound wave, and with regard to a certain degree, they can also estimate the distance of sound source.In the audiology field, carried out many experiments, wanted to analyze and implement the localized structure of so-called two ears in human and the animal body.Have two main factors to help people to determine the direction of the sound that transmits: (1) relative intensity (2) in two ears of hearer is for sine tone, phase contrast between two ears perhaps arrives the phase contrast between the sound wave of hearer's left ear and auris dextra respectively.Thereby understand that easily the hearing system of the mankind or animal can be distinguished the phase shift of complicated sound basically, and can clearly distinguish the phase shift of the sound of pure tone or single-frequency.Such auditory analysis is based on frequency, and for the frequency more than the 1KHZ, most of observers tend to determine from the ear of that side that receives bigger sound the direction of sound source.Thereby in general, carry out auditory localization for being what to determine very much for a certain frequency range in several kilo hertzs the scope by phase contrast.Such as discussed below, with reference to figure 3, in implementing tinnitus treatment, not only determine the tone quality of tinnitus signal, and definite tinnitus patient whether in two ears, only in the ear or in the head at them and do not relate to any ear (when asking about them and whether hear tinnitus such as many people said) lining hear his/her tinnitus, these all are very important.
[0032] refers again to Fig. 1, will further specify the structure and the operation of preferred embodiment of applicant's the device that is used for the treatment of the single-frequency tinnitus patient.Phase-shift network 30 can be any kind that the technical staff knows in audition and the electric field, is used for applying a required phase shift to first sound generator 10.Alternative is that sound generator 10 can have the output waveform phase-shift characterisitc.In order to select wave form phase shift feature, the operator can regulate required phase shift (weighing with angle), for example 10 degree, 20 degree etc., and this can influence required skew as shown in Figure 2, for example Δ
1, Δ
2Deng, perhaps can use suitable recloser.
[0033] as shown in Figure 1, switch 32 can be selectively sends to the output of first sound generator 10 in patient's the earphone 12.In another selectable position, switch 32 is with the output of phase-shift network, and promptly the signal from first sound generator 10 adds that phase shift sends in patient's the earphone 12.If sound generator 10 does not have phase-shift characterisitc, so just use independent phase-shift network 30.Earphone 12 is preferably and can have bought the high-quality earphone that trade mark is QuietComfort from the Bose company of for example State of Massachusetts, US.
[0034] as illustrated, switch 32 is after-applied in earphone 12 with the output offset of sound generator 10.As illustrated in top, from the increase of the continuous phase shift of the sine wave tone of generator 10 with respect to f
1Be to generate continuously, as shown in Figure 2, thereby pass through as f
2, f
3... f
mIllustrated step realizes 180 anti-phase degree phase cancellation relations.
[0035], there is shown a kind of tinnitus tone P (t) and the extraneous tone I (t) that produces diagrammatic representation with the theory of its mathematical equation representation addition separately with the patient with reference now to Fig. 3 A.As mentioned above, patient's tinnitus tone P (t) can not be detected by existing electronics or acoustic wave apparatus, still, discusses for convenience and analyzes, and it is expressed as the sine wave of characteristic frequency f (t).As explained above, the waveform I (t) of the waveform separately of patient's tinnitus tone P (t) and generation is based on the patient with his/her tinnitus tone oneself typing, and compares with the output of sound generator 10, as illustrated in conjunction with Fig. 1.
[0036] Fig. 3 B has illustrated representative P (t) and I's (t) and S's (t) single sine wave has initial offset or pitch angle θ, as shown in Fig. 3 A.Represent with mathematics equivalence value S (t) by it.Fig. 3 C has illustrated the amplitude of sine wave of the arithmetic sum of the ripple I (t) that representative patient tinnitus ripple P (t) and input generate.Shown in Fig. 3 C, arithmetic sum S (t) with two offset wave forms P (t) of aforementioned angular deflection amount θ and I (t) has the instantaneous amplitude less than patient's tinnitus tone sound wave, this is owing to exist the tinnitus tone cause the patient to reduce or counteracting that the angle of phase displacement θ that eliminates realizes, as and S (t) waveform on 2 π/3 such shown between 4 π/3 angles.Thereby, for shown in about 1/3rd scope of 360 degree in for, partial offset has appearred.By increasing the skew of extraneous tinnitus treatment tone I (t), when input treatment tone I (t) reaches 180 degree antiphases, we can offset or eliminate fully patient's tinnitus tone P (t) in theory, as shown in Figure 2, as described above like that, it and patient's tinnitus tone P (t) quadrature.For being had more completely, the tinnitus tone that reduces in theory and eliminate the patient understands, can be with reference to figure 3A, and 3B and 3C and following mathematical definition and relevant equation:
Patient's sine wave:
P(t)＝P
0?sin2πf?t
P wherein
0Be amplitude, f is a frequency, and t is the time
Sine wave input from generator:
I(t)＝I
0?sin(2πf?t-θ)
Wherein θ is the phase shift radian of P (t) and I (t), π radian=180 °, 2 π=360 °
P (t) and I (t) and:
S(t)＝P(t)+I(t)＝(P
0?sin2πf?t)+I
0?sin(2πf?t-θ)
Suppose P
0=I
0, so
S(t)＝P
0[sin2πf?t+sin(2πf?t-θ)]
＝[2?P
0?cos(1/2θ)]·[sin(2πf?t-1/2θ)]
＝A?sin(2πf?t-1/2θ)
Wherein A is the amplitude with ripple
Thereby,
A＝2?P
0?cos(1/2θ)，
Sin (2 π f t-1/2 θ) is the sine wave with ripple, and
1/2 θ is the phase shift with ripple.
[0037], there is shown the logic diagram of the embodiment of the preparation of self-treatment disk 40 in the treatment clinical course that tinnitus patient is gone to a doctor with reference now to Fig. 4.Sound generator 10 is preferably similar to the 26S Proteasome Structure and Function described in top Fig. 1.As mentioned above, after tinnitus patient oneself typing, in a series of time series steps that increase progressively, to carry out suitable phase shift from the signal of sound generator 10 regulates, thereby apply the treatment tone segments that phase shift increases progressively to tinnitus patient by earphone 12, in a treatment cycle, the phase shift sum that increases progressively reaches at least 180 degree or bigger.In a preferred embodiment, can be 6 degree or 20 degree with respect to the phase shift that increases progressively of preset coordinates, or other recruitment (will be described in detail with reference to figure 8).
[0038] the tinnitus treatment tone can show on monitor or oscillograph 14-4, the tinnitus treatment tone f that makes the clinicist to monitor to increase progressively from initial tinnitus tone f to skew
mSkew, as shown in Figure 2.In the patient treatment draft, when it imposes on the patient by earphone 12, the increase of the audio signal of the patient treatment tone that audio frequency or digital memory 42 records are initial and each phase shift of initial therapy tone.What be connected to memory element 42 is CD writer or other similar audio recording device 44, and it produces Heal Thyself record or disk 40 corresponding to the output of storage device 42.In other words, memory element 42 is coupled to online transmission/receptor 46, and this transmission/receptor 46 can comprise the computer that can network or be connected to the Internet or the server of WWW.Then, can set up communication line 48 with transmission/receiving element 46 by the Internet or WWW.This circuit 48 can be selectively sends to patient's home computer or remote clinic 49 with the patient treatment data of given patient.
[0039], shown in the figure embodiment of the device of the Heal Thyself system that is suitable for domestic that can use with an alternative embodiment of the invention with reference now to Fig. 5.The tinnitus self-treatment disk 40 of distributing to a specific patient is separately followed his or her tinnitus treatment and is consigned to the patient in the clinic, as described with reference to figure 4.In other words, audio treatment data can by with 48 home PCs 49 that are transferred to the patient that are connected of the Internet or WWW.As shown in Figure 5, switch 52 optionally is coupled to the output of PC49 or CD Player 54 patient's earphone 12.Thereby, utilizing self-treatment disk 40, patient 11 can avoid the tinnitus puzzlement easily at his or her family.
[0040], schematically shows the layout of CD disk according to another embodiment of the invention with reference now to Fig. 6.CD disk 40 can comprise and have a plurality of audio recording grooves planar, the circular body 60 of (for example 62 and 64), and the audio recording groove is circular substantially, is arranged at least one surface.CD disk 60 can be any type of knowing that can buy.Dish 60 preferably has fixed replacement position or original position 66.Tinnitus treatment data can be recorded on the disk 40 by any well-known audio or digital method.Similarly, tinnitus treatment data can be stored in any other can the device of recording audio data on, comprise tape, floppy disk or CD, semiconductor memory etc., but be not limited to this.In addition, tinnitus treatment data can be stored with any audio form, comprises CD, MP3, wave file (.wav) etc., but is not limited to this.
[0041], there is shown applicant's the logical flow chart of illustrative embodiment of objective estimated data's new method that is used to generate phase shift tinnitus treatment draft with reference now to Fig. 7.As mentioned above, applicant's treatment draft is the successful candidates that at first screen to determine the mono-frequency tinnitus s phase shift treatment in potential tinnitus patient, and initial screening can be carried out in conjunction with the medical science agreement of MATTP or equivalence.In addition, audiometrist can be used as the part of treatment and implements, and perhaps implements before or after treatment.In step 1, require selected single-frequency patient subjectively his/her tinnitus sound frequency to be carried out " sound typing ", for example adopt aforesaid adjustable sonic generator 10, frequency and amplitude to his/her tinnitus tone on not visible basis quantize.Preferably, require the patient that patient's subjectivity " sound typing " is repeated to guarantee several times that the patient is subjectively with the tone of the output of his/her tinnitus tone and frequency generator and the accuracy that amplitude is mated.
[0042] in step 2, the clinicist of participation or doctor physician utilize the data in the step 1 to generate identical with patient's tinnitus tone substantially suitable extraneous sinusoidal wave treatment tone.Then, the treatment tone that generates is offset in time to increase progressively by a plurality of successive substantially the same predetermined processes and reaches 180 degree, wherein, in treatment cycle or scope, the waveform that generates carries out a series of eliminations by so successive phase shift, and final and patient's tinnitus tone becomes anti-phase elimination relation, as below will further specifying with reference to figure 8 and 9.
[0043] in step 3, tinnitus patient can accept PET after completing steps 2 or functional MR I brain scan is estimated the tinnitus activity that the patient is current objectively, so that after the treatment of the people's that accepts applications phase shifted cancellation, the elimination of quantitative Analysis patient tinnitus tone or reduce amplitude substantially objectively.These processes are implemented as the part of many ongoing clinical researches.Recently, the researcher of Denmark, Sweden and France has confirmed the positive role of PET brain scan in the auditory cortex of tinnitus patient.The brain scan that should be realized that tinnitus patient can be before the phase shift tinnitus treatment carries out, among or a period of time afterwards implement, to obtain the patient treatment data of extra objective tinnitus patient.
[0044], shown in the figure a series of sequential line charts of another embodiment of layout of applicant's self-treatment disk 40 with reference now to Fig. 8 A, 8B and 8C.With reference to figure 8A, the first of tinnitus treatment or regional #1 are at an A opening entry, and some A is preferably the original position or the reset position of specified recorded trace, as previously described in reference to Figure 6.Reset position or original position are shown as t on time coordinate
0, as shown in the figure, on line chart, increase from left to right.By B point beginning, show a series of subdivisions of regional #2, i.e. 2-1,2-2...2-n.The persistent period of each phase shift that increases progressively of the persistent period of the subdivision of zone #2 and patient individual draft is corresponding.As top described in conjunction with Fig. 1 and 2, the quantity of incremental steps is that specific patient selects with suitable manner by the clinicist or the doctor physician that participate in, and wherein, in a treatment fragment or scope, incremental steps is added to 180 degree at least.In a preferred embodiment, the applicant successfully adopts the phase shift steps that increases progressively of 6 degree, and each incremental steps continues preset time, for example one minute.Similarly, the applicant adopts the incremental steps of 20 degree, and each incremental steps continues ten minutes, has obtained reflection preferably in the patient.Shown in Fig. 8 A, first patient treatment of self-treatment disk 40 in regional #2 is recorded in t
2Finish, and subsequently or multiple regional #1 treatment can be from time t
2Extend to t
3, or the like.
[0045] with reference now to Fig. 8 B, regional #1 can comprise aforesaid by the extraneous tinnitus treatment tone f that determines in the patient oneself mensuration program
1In this embodiment, in regional # 3, s phase shift treatment begins with a series of phase shifts that increase progressively of patient treatment tone, and the skew that increases progressively is illustrated as part 3-1,3-2...3-n.Another embodiment of applicant's phase shift tinnitus treatment can comprise for example a series of nine incremental steps of increments with 20 degree, and each increment continues 10 minutes, and total treatment time is 90 minutes.Shown in Fig. 8 B, prime area # 3 can follow second area # 3 after treatment time, has just described above the treatment phase place equals.
[0046] shown in Fig. 8 C, the patient self-treatment disk can comprise the area for treatment of any amount, shown in area for treatment # 4, regional # 5 and regional #6.As mentioned above, shown in Fig. 3 A, 3B and 3C, because the intravital tinnitus tone instantaneous phase of patient can not be used current existing electronics or acoustic instrument is measured or determine in most of the cases, between patient's tinnitus tone and the extraneous treatment tinnitus tone that generates phase cancellation will be arranged.Thereby according to applicant's phase shift tinnitus treatment draft, patient's treatment can be handled in several modes by the clinicist, so that obtain required patient treatment response.This can comprise the quantity of regulating the phase shift steps that increases progressively, for example 2-2 or ... 3-2..., obtain to reduce and final phase shift sequence causes the tinnitus treatment tone I (t) that generates in the external world and the anti-phase counteracting between patient's tinnitus tone P (t) to concern, shown in Fig. 3 A, 3B and 3C.
[0047] as known at medical domain, the intravital tinnitus condition of people has the many different forms and the very large origin cause of formation of many difference.For simple investigation, can be 10/083,088 coherent reference with reference to top US application number to the tinnitus treatment literature of medical science.Though there is not the method for known healing tinnitus,, invalid substantially and stand the people of tinnitus misery for those medicines, though painful alleviating is temporary transient, also be significant.
[0048] application number of mentioning in the above is the patient's clinical effectiveness that discloses in 10/083,088 the coherent reference application from 28 patients' not visible one step 180 degree s phase shift treatment drafts researchs.In this research, 7 patients (25%) have experienced splendid result, and what reached tinnitus loudness reduces to be higher than 90%.15 patients (greater than 54%) have experienced or the result of " very good " or " good ", have obtained tinnitus loudness and have reduced 50% temporary transient alleviation at least.Should believe that utilize 6 degree phase shift fragment drafts above-mentioned, for example, each fragment continues one minute at least, compares with the technology that at application number is description in 10/083,088, will obtain improved basically result.
[0049], be that others according to applicant's new treatment draft generate and utilize the logic diagram about the objective patient data of the effect of the phase shift tinnitus treatment draft of particular patient shown in the figure with reference now to Fig. 9.
[0050] brick 70 has been illustrated screening sequence, and this program is used for determining whether certain tinnitus patient is the fit person of single-frequency s phase shift treatment.As mentioned above, medical science in most of the cases can not be told reason definite or similar patient's tinnitus condition, can not accurately describe the structure that causes specific patient's tinnitus condition.
[0051] shown in brick 72, if the patient is shown as mono-frequency tinnitus, for example it and drug use are irrelevant, the patient is required the extraneous tone from sound generator that generates of his/her tinnitus tone utilization is carried out self-typing so, wherein can handle the extraneous tone that generates and make it to be complementary with subjective patient's tinnitus tone of determining.As mentioned above, preferably, patient oneself typing program repeats repeatedly to guarantee accuracy on not visible basis.After this, shown in brick 74, in an independent treatment part, the patient is subjective, and the treatment tone of determining increases progressively phase shift, via 180 complete at least degree skews, thereby with the tone that the external world generates become with patient's tinnitus tone anti-phase, waveform eliminates relation.
[0052] displacement bias tinnitus treatment draft thereafter is shown in brick 76, and the patient can accept PET or MRI brain scan program determines objectively the effect that s phase shift treatment makes the brain activity at auditory cortex relevant with patient's tinnitus condition reduce, make it to minimize or eliminate.Should be realized that, as shown in Figure 9, to a certain degree, as from brick 70 and brick 72 to shown in the dotted line of brick 76, before the patient accepts s phase shift treatment and all need to carry out brain scan afterwards.Shown in brick 78, the patient is accepted brain scan data that a certain moment before or after the phase shift tinnitus treatment obtains carry out medical inspection and can help the clinicist in brick 79, to change or revise s phase shift treatment draft at patient individual.Whether decision needs this adjustment in brick 77.
[0053] as mentioned above, for tinnitus, the current therapeutic treatment that does not have forever to cure patient's tinnitus condition.Thereby, after the improvement phase shift tinnitus treatment of implementing the applicant, though specific mono-frequency tinnitus patient reduces substantially or temporarily eliminated his/her tinnitus condition, its aftereffect generally can only continue the limited time, several hrs or several days, or under individual cases, be tens days.Thereby, use objective brain scan data can help the clinicist to distinguish patient's Heal Thyself situation, shown in brick 80.As top described with reference to figure 4 and 5, according to a further aspect in the invention, self-treatment disk 40 can carry out being made among the clinical tinnitus treatment at specific qualified patient, thereby when their situation needed this continuation to treat, they can utilize self-treatment disk at home easily.
[0054] though described a plurality of embodiment of applicant at the new apparatus and method of tinnitus treatment, it is illustrative that but the technical staff in medical science and audiology field can recognize described embodiment, and can carry out other change and modification and do not depart from the appended scope of the present invention that claim embodied to described preferred embodiment.
[0055] description carried out of front only is in order to illustrate and describe embodiments of the invention.Rather than in order to invent eliminating or to be limited to disclosed any accurate form.Consider top instruction, can carry out many modifications and variations.Scope of the present invention will be limited by following claim.
Claims (8)
1. be used for the treatment of mono-frequency tinnitus patient's modifying device, comprise:
Sound generator has selectable frequency and amplitude output wave controller;
Amplifier is used for the output of described sound generator is imposed on tinnitus patient audibly, and thus, the patient subjectively determines his/her tinnitus tone according to frequency and amplitude, and
Phase-shift network, be used for and increase progressively skew by the subjective output wave of selecting that is generated of patient, to be complementary with described patient's tinnitus tone and amplitude, thereby reach 180 degree phase shifts by a plurality of fragments that increase progressively with respect to the predetermined starting point of generation ripple, have the output wave of selecting the described generation of skew to realize that the sound of described patient's tinnitus tone offsets.
2. according to the device of claim 1, the wherein said phase-shift network that is used to generate a plurality of successive angle recruitments comprises the numerical range that can manually select relevant with described sound generator.
3. according to the device of claim 1, the phase-shift network that wherein is used to generate a plurality of successive angle recruitments comprises the automatic sequencing switch.
4. according to the device of claim 1, also comprise electronic logger, be used for when the phase shift by described a plurality of predetermined angulars of the described output wave of described sound generator is offset continuously, generate the record of output wave, thereby realize reducing or offsetting of described patient's tinnitus tone, wherein said record is the tinnitus treatment sound sequence.
5. according to the device of claim 4, wherein, described tinnitus treatment sound sequence is noted with the clinical s phase shift treatment of patient, thereby the described treatment sound sequence that is recorded can be used in Heal Thyself thereafter by described patient.
6. according to the device of claim 4, wherein, the record of described patient's tinnitus treatment sound sequence comprises the electronics stored record, and comprises memory access apparatus, is used for selectively described patient's tinnitus treatment sound sequence data being sent to movably memorizer.
7. according to the device of claim 4, also comprise online communication transmitters,, selectively described patient's tinnitus treatment sound sequence record is sent to remote location by addressable communication link.
8. according to the device of claim 1, wherein, described phase-shift network comprises also that scale is controlled and limits each angle phase shift sequence, makes it to equal the angular deflections of 6 degree with respect to the predetermined point of the waveform of described generation, and limits each segmental persistent period and equal one minute at least.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34027101P | 2001-12-18 | 2001-12-18 | |
| US60/340,271 | 2001-12-18 | ||
| US10/083,088 US20020133147A1 (en) | 1993-09-24 | 2002-02-26 | Removable tip for laser device |
| US10/083,088 | 2002-02-26 | ||
| US10/319,281 | 2002-12-12 | ||
| US10/319,281 US6846284B2 (en) | 2001-12-18 | 2002-12-12 | Method and apparatus for treatment of mono-frequency tinnitus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200710141924 Division CN101229090A (en) | 2001-12-18 | 2002-12-13 | Method and apparatus for treatment of mono-frequency tinnitus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1620264A CN1620264A (en) | 2005-05-25 |
| CN100340205C true CN100340205C (en) | 2007-10-03 |
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| CNB02828187XA Expired - Fee Related CN100340205C (en) | 2001-12-18 | 2002-12-13 | Method and apparatus for treatment of mono-frequency tinnitus |
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| Country | Link |
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| CN (1) | CN100340205C (en) |
| IL (1) | IL162629A0 (en) |
| MX (1) | MXPA04006099A (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE102013013278A1 (en) * | 2013-08-08 | 2015-02-12 | Forschungszentrum Jülich GmbH | Apparatus and method for calibrating an acoustic desynchronizing neurostimulation |
| CN119257590A (en) * | 2024-12-09 | 2025-01-07 | 杭州爱华仪器有限公司 | Tinnitus diagnosis module and tinnitus treatment system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403262A (en) * | 1993-03-09 | 1995-04-04 | Microtek Medical, Inc. | Minimum energy tinnitus masker |
| US5795287A (en) * | 1996-01-03 | 1998-08-18 | Symphonix Devices, Inc. | Tinnitus masker for direct drive hearing devices |
| US6210321B1 (en) * | 1999-07-29 | 2001-04-03 | Adm Tronics Unlimited, Inc. | Electronic stimulation system for treating tinnitus disorders |
-
2002
- 2002-12-13 IL IL16262902A patent/IL162629A0/en unknown
- 2002-12-13 CN CNB02828187XA patent/CN100340205C/en not_active Expired - Fee Related
- 2002-12-13 MX MXPA04006099A patent/MXPA04006099A/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403262A (en) * | 1993-03-09 | 1995-04-04 | Microtek Medical, Inc. | Minimum energy tinnitus masker |
| US5795287A (en) * | 1996-01-03 | 1998-08-18 | Symphonix Devices, Inc. | Tinnitus masker for direct drive hearing devices |
| US6210321B1 (en) * | 1999-07-29 | 2001-04-03 | Adm Tronics Unlimited, Inc. | Electronic stimulation system for treating tinnitus disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04006099A (en) | 2005-03-31 |
| CN1620264A (en) | 2005-05-25 |
| IL162629A0 (en) | 2005-11-20 |
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