CN109996872A - 一种用于治疗肿瘤的egfr单域抗体cart及其应用 - Google Patents
一种用于治疗肿瘤的egfr单域抗体cart及其应用 Download PDFInfo
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- CN109996872A CN109996872A CN201780064335.1A CN201780064335A CN109996872A CN 109996872 A CN109996872 A CN 109996872A CN 201780064335 A CN201780064335 A CN 201780064335A CN 109996872 A CN109996872 A CN 109996872A
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- A61K39/464403—Receptors for growth factors
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
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Abstract
提供了一种EGFR单域抗体改造的CART细胞，所述CART细胞可用于治疗肿瘤。还提供了人源化的EGFR单域抗体基因及其编码的单域抗体，EGFR CAR基因及其编码的EGFR CAR嵌合抗原受体，以及含有EGFR CAR基因的慢病毒载体Pre‑Lenti‑EF1‑EGFR CAR。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/093652 WO2019014891A1 (zh) | 2017-07-20 | 2017-07-20 | 一种用于治疗肿瘤的egfr单域抗体cart及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109996872A true CN109996872A (zh) | 2019-07-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780064335.1A Pending CN109996872A (zh) | 2017-07-20 | 2017-07-20 | 一种用于治疗肿瘤的egfr单域抗体cart及其应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN109996872A (zh) |
| WO (1) | WO2019014891A1 (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105384825A (zh) * | 2015-08-11 | 2016-03-09 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| CN106636003A (zh) * | 2017-01-24 | 2017-05-10 | 北京普瑞金科技有限公司 | 一种全人源化EGFRvIII嵌合抗原受体T细胞及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1934259A2 (en) * | 2005-10-11 | 2008-06-25 | Ablynx N.V. | Nanobodies and polypeptides against egfr and igf-ir |
| AU2013221672B2 (en) * | 2012-02-13 | 2017-11-09 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
-
2017
- 2017-07-20 CN CN201780064335.1A patent/CN109996872A/zh active Pending
- 2017-07-20 WO PCT/CN2017/093652 patent/WO2019014891A1/zh active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105384825A (zh) * | 2015-08-11 | 2016-03-09 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| WO2017025038A1 (en) * | 2015-08-11 | 2017-02-16 | Nanjing Legend Biotech Co., Ltd. | Chimeric antigen receptors based on single-domain antibodies and methods of use thereof |
| CN106636003A (zh) * | 2017-01-24 | 2017-05-10 | 北京普瑞金科技有限公司 | 一种全人源化EGFRvIII嵌合抗原受体T细胞及其制备方法 |
Non-Patent Citations (3)
| Title |
|---|
| ANDREA BELL等: "Differential tumor-targeting abilities of three single-domain antibody formats", 《CANCER LETTERS》 * |
| IAN M. TOMLINSON等: "The Repertoire of Human Germline VH Sequences Reveals about Fifty Groups of VH Segments with Different Hypervariable Loops", 《J. MOL. BIOL.》 * |
| 张曼泽等: "嵌合抗原受体修饰的T细胞在实体肿瘤治疗中的研究进展", 《免疫学杂志》 * |
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| Publication number | Publication date |
|---|---|
| WO2019014891A1 (zh) | 2019-01-24 |
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