CN109984957A - A kind of facial masks for whitening faces and removing spots liquid and preparation method thereof - Google Patents
A kind of facial masks for whitening faces and removing spots liquid and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of facial masks for whitening faces and removing spots liquid and preparation method thereof, which includes following component: Trenaxmine, niacinamide, carnosine, allantoin, dipotassium glycyrrhizinate, glucan, panthenol, sodium lactate, glycine betaine, pyrrolidone sodium carboxylate, ethoxy urea, Sodium Hyaluronate, polyglutamic acid, thickener, EDETATE SODIUM, hydroxy phenylpropionyl amine benzoic acid, antiseptic and antibiotic agent, polyalcohol and deionized water.The facial masks for whitening faces and removing spots liquid has outstanding stability and skin compatibility, has apparent whitening effect, mild to skin, has broad application prospects.
Description
Technical field
The present invention relates to a kind of cosmetics and preparation method thereof, it is more particularly related to a kind of whitening spot-removing face
Film liquid and preparation method thereof.
Background technique
There are many facial masks for whitening faces and removing spots type on the market at present, but stability due to product composition and various composition it
Between compatibility the problems such as, facial masks for whitening faces and removing spots liquid on the market is mostly one or two kinds of whitening spot-removings into assignment system, and because of beauty
The physicochemical characteristic of white nti-freckle ingredient causes stability poor, thus has a single function and effect is unstable, to the variation because of living environment
Increase etc. dermal melanin caused by various extraneous factors or local a large amount of the problem of depositing cannot quickly and effectively solve.
For example, a kind of stain removing skin care aloe product disclosed in Chinese invention patent CN 1191057C, since it is only dispelled containing whitening
Spot facial mask liquid freeze-dried powder, arbutin, vitamin B3With this few effective active composition of allantoin, therefore only have dispel
Complicated skin problem can not be treated and be improved to the effect of spot, anti-acne and moisturizing.The present invention be by long-term summary of experience with
Constantly practice evaluation carries out scientific compounding on existing beauty and skin care component base, with formed it is a kind of have multi-efficiency and
The facial masks for whitening faces and removing spots liquid of obvious effect.
Summary of the invention
The purpose of the present invention is to provide a kind of facial mask liquid with quick, significant whitening effect and its preparation sides
Method, to solve problems of the prior art.
The technical solution adopted in the present invention: a kind of facial masks for whitening faces and removing spots liquid includes following component by weight percentage:
Trenaxmine 0.05%~2.00%, niacinamide 0.10%~5.00%, carnosine 0.01%~1.00%, allantoin
0.05%~1.00%, dipotassium glycyrrhizinate 0.05%~2.00%, glucan 0.01%~3.00%, panthenol 0.05%~
3.00%, sodium lactate 0.05%~2.50%, glycine betaine 0.05%~5.00%, pyrrolidone sodium carboxylate 0.05%~
7.50%, ethoxy urea 0.10%~5.00%, Sodium Hyaluronate 0.01%~1.00%, polyglutamic acid 0.01%~
1.00%, thickener 0.04%~5.00%, EDETATE SODIUM 0.01%~0.50%, hydroxy phenylpropionyl amine benzoic acid 0.01%~
0.50%, antiseptic and antibiotic agent 0.1%~5.00%, polyalcohol 2.25%~20.00%, deionized water 30.00%~
97.00%.
By weight percentage include following component as preferred embodiment:
Trenaxmine 0.07%~1.50%, niacinamide 0.50%~3.00%, carnosine 0.04%~0.08%, allantoin
0.06%~0.08%, dipotassium glycyrrhizinate 0.07%~1.50%, glucan 0.05%~2.00%, panthenol 1.00%~
2.00%, sodium lactate 1.00%~2.00%, glycine betaine 2.00%~3.00%, pyrrolidone sodium carboxylate 3.00%~
5.50%, ethoxy urea 2.50%~3.50%, Sodium Hyaluronate 0.05%~0.70%, polyglutamic acid 0.50%~
0.70%, thickener 1.00%~3.00%, EDETATE SODIUM 0.10%~0.30%, hydroxy phenylpropionyl amine benzoic acid 0.10%~
0.30%, antiseptic and antibiotic agent 2.00%~4.00%, polyalcohol 5.00%~15.00%, deionized water 45.00%~
60.00%.
By weight percentage include following component as preferred embodiment:
Trenaxmine 1.20%, niacinamide 2.00%, carnosine 0.06%, allantoin 0.07%, dipotassium glycyrrhizinate 1.00%, Portugal
Glycan 1.50%, panthenol 1.50%, sodium lactate 1.20%, glycine betaine 2.50%, pyrrolidone sodium carboxylate 5.50%, ethoxy urea
3.00%, Sodium Hyaluronate 0.55%, polyglutamic acid 0.600%, thickener 3.00%, EDETATE SODIUM 0.20%, hydroxyphenyl third
Acid amides benzoic acid 0.20%, antiseptic and antibiotic agent 3.92%, polyalcohol 13.00%, deionized water 59.00%.
As preferred embodiment, the thickener be selected from hydroxyethyl cellulose, xanthan gum, bulbil glue, carbomer,
Acrylic acid (ester) class/one or more of alkylol acrylic acid (ester) class cross-linked polymer and gelatin；The anti-corrosive antibacterial
Agent is selected from methyl hydroxybenzoate, Nipasol, Bis(hydroxymethyl)imidazolidinyl urea, phenoxetol, pentanediol, hexylene glycol and to hydroxyl
One or more of acetophenone；The polyalcohol is selected from one of butanediol, propylene glycol, glycerol and methyl propanediol.
In the present invention, the thickener is selected from hydroxyethyl cellulose, xanthan gum, bulbil glue, carbomer, acrylic acid
(ester) class/one of alkylol acrylic acid (ester) class cross-linked polymer and gelatin or a variety of；The antiseptic and antibiotic agent choosing
From methyl hydroxybenzoate, Nipasol, Bis(hydroxymethyl)imidazolidinyl urea, phenoxetol, pentanediol, hexylene glycol, para hydroxybenzene second
One of ketone or two or more mixing；The polyalcohol is in butanediol, propylene glycol, glycerol, methyl propanediol
One or more.
The present invention further protects a kind of preparation method of above-mentioned facial masks for whitening faces and removing spots liquid, comprising the following steps:
(1) each ingredient is weighed by weight percentage；
(2) deionized water is put into vacuum emulsification pot, is warming up to 95 DEG C of heat preservations and is cooled to 75 DEG C after twenty minutes；
(3) EDETATE SODIUM is put into deionized water under stiring, by thickener, Sodium Hyaluronate, polyglutamic acid and more
It is put into after the mixing of first alcohol, is kept for 60~75 DEG C of temperature, stirring is to being uniformly dissolved；
(4) 45~50 DEG C are cooled to, Trenaxmine, niacinamide, allantoin, dipotassium glycyrrhizinate, glucan, panthenol, sweet tea are put into
Dish alkali, stirring is to being uniformly dissolved；
(5) 35~45 DEG C are cooled to, carnosine, sodium lactate, pyrrolidone sodium carboxylate, ethoxy urea, hydroxy phenylpropionyl are put into
Amine benzoic acid, antiseptic and antibiotic agent, stirring is to being uniformly dissolved；
(6) it is evacuated to -0.06MPa, it stirs 20 minutes；
(7) vacuum, discharging are excluded.
Facial masks for whitening faces and removing spots liquid of the present invention contain by Trenaxmine, niacinamide, carnosine, allantoin, dipotassium glycyrrhizinate,
The effective active compositions such as glucan.Wherein Trenaxmine is a kind of protease inhibitors, and energy protease inhibition urges peptide bond hydrolysis
Change effect, so that the activity of such as rising property protease enzyme is prevented, and then inhibit the epidermal cell function at blackspot position
Confusion, and inhibit melanin enhancement factor group, then thoroughly break off the way occurred because of the melanin that ultraviolet light irradiates and is formed
Diameter, so as to be effectively prevented and improve the pigment deposition of skin.Niacinamide is a kind of stable water soluble ingredient, molecular weight
It is small, skin cuticula can be permeated rapidly, melanin is inhibited to transport to epidermis, inhibit obscure color spot to generate, while there is anti-saccharification
Function can make the dark yellow colour of skin become white and moist clear.Carnosine is a kind of natural, it is anti-oxidant, inhibit free radical and
Metal ion cause lipid oxidation have obvious action, melanin can be significantly reduced and formed.Allantoin, dipotassium glycyrrhizinate,
The substantially reduced skin of glucan energy mitigates the light reaction of skin day, reduces black because of the emergency reaction mechanism generated after ultraviolet light irradiation
The generation of pigment, and accelerate cytothesis, cuticula is accelerated to fall off, to promote skin renewal.
Facial masks for whitening faces and removing spots liquid of the present invention uses hydroxyethyl cellulose, xanthan gum, bulbil glue, carbomer, third
One of olefin(e) acid (ester) class/alkylol acrylate (class) cross-linked polymer, gelatin are a variety of as thickener, they have
Higher transparency, thickening capabilities can make stable thick liquid, Neng Gouwen after being dissolved in the water under few additive
Active constituent in fixed and dispensing formulations helps to promote impression when facial mask uses, and has good compatibility with skin.
Meanwhile various effective active components of the present invention and these thickeners all have good compatibility.
In the present invention, the facial masks for whitening faces and removing spots liquid, by Trenaxmine, niacinamide, carnosine, allantoin, glycyrrhizic acid two
Potassium, glucan composition whitening spot-removing combination, it is complementary mutually to promote, whitening spot-removing effect when being apparently higher than single use is played, then
Cooperate polyalcohol by sodium lactate, pyrrolidone sodium carboxylate, glycine betaine, ethoxy urea element, opens skin absorbing path, promote skin
Skin absorbs, and generates quick, apparent whitening effect on the skin.
The selected Multiple components of facial masks for whitening faces and removing spots liquid of the present invention carry out scientific compounding, take full advantage of each in formula
The effect of concertedness and compatibility of ingredient, Multiple components mutually cooperate with promoting, greatly improving formula, make product formula
Stability, the reliability of effect and quick effective problem are all solved perfectly.
Specific embodiment
Embodiment one:
Each ingredient is weighed according to following weight percents:
Each ingredient is weighed by weight percentage, deionized water is put into vacuum emulsification pot, is warming up to 95 DEG C and is kept the temperature 20 points
It is cooled to 75 DEG C after clock, puts into EDETATE SODIUM into deionized water under stiring, by hydroxyethyl cellulose, Sodium Hyaluronate, gathers
Glutamic acid is put into after mixing with butanediol, is kept for 60~75 DEG C of temperature, stirring is to being uniformly dissolved；45~50 DEG C are cooled to, investment
Glycerol, Trenaxmine, niacinamide, allantoin, dipotassium glycyrrhizinate, glucan, panthenol, glycine betaine, stirring is to being uniformly dissolved；It is cooled to
35~45 DEG C, put into carnosine, sodium lactate, pyrrolidone sodium carboxylate, ethoxy urea, hydroxy phenylpropionyl amine benzoic acid, phenoxy group second
Alcohol, hexylene glycol, methyl hydroxybenzoate, stirring is to being uniformly dissolved；It is evacuated to -0.06MPa, it stirs 20 minutes；Exclude vacuum, discharging.
Indices test is carried out to obtained facial masks for whitening faces and removing spots liquid, test result is shown in Table 1 and test example 1, test example 2.
Embodiment two:
Each ingredient is weighed according to following weight percents:
Each ingredient is weighed by weight percentage, deionized water is put into vacuum emulsification pot, is warming up to 95 DEG C and is kept the temperature 20 points
It is cooled to 75 DEG C after clock, puts into EDETATE SODIUM into deionized water under stiring, by carbomer, Sodium Hyaluronate, polyglutamic acid
It is put into after being mixed with methyl propanediol, is kept for 60~75 DEG C of temperature, stirring is to being uniformly dissolved；45~50 DEG C are cooled to, is put into sweet
Oil, Trenaxmine, niacinamide, allantoin, dipotassium glycyrrhizinate, glucan, panthenol, glycine betaine, stirring is to being uniformly dissolved；It is cooled to 35
~45 DEG C, investment carnosine, sodium lactate, pyrrolidone sodium carboxylate, ethoxy urea, hydroxy phenylpropionyl amine benzoic acid, phenoxetol,
Parahydroxyacet-ophenone, hexylene glycol, stirring is to being uniformly dissolved；It is evacuated to -0.06MPa, after arginine is dissolved in process water
Vacuum emulsification pot is sucked, is stirred 30 minutes；Exclude vacuum, discharging.Indices are carried out to obtained facial masks for whitening faces and removing spots liquid
Test, test result are shown in Table 1 and test example 1, test example 2.
Embodiment three:
Each ingredient is weighed according to following weight percents:
Each ingredient is weighed by weight percentage, deionized water is put into vacuum emulsification pot, is warming up to 95 DEG C and is kept the temperature 20 points
It is cooled to 75 DEG C after clock, puts into EDETATE SODIUM into deionized water under stiring, by hydroxyethyl cellulose, xanthan gum, hyalomitome
It is put into after sour sodium, polyglutamic acid and mixed with propylene glycol, is kept for 60~75 DEG C of temperature, stirring is to being uniformly dissolved；It is cooled to 45~50
DEG C, put into glycerol, methyl hydroxybenzoate, Trenaxmine, niacinamide, allantoin, dipotassium glycyrrhizinate, glucan, panthenol, glycine betaine, stirring
To being uniformly dissolved；35~45 DEG C are cooled to, carnosine, sodium lactate, pyrrolidone sodium carboxylate, ethoxy urea, hydroxy phenylpropionyl are put into
Amine benzoic acid, phenoxetol, pentanediol, hexylene glycol, stirring is to being uniformly dissolved；It is evacuated to -0.06MPa, is stirred 30 minutes；
Exclude vacuum, discharging.Indices test is carried out to obtained facial masks for whitening faces and removing spots liquid, test result is shown in Table 1 and test example
1, test example 2.
1 performance test of test case
Facial masks for whitening faces and removing spots liquid made from 1-3 of the embodiment of the present invention is subjected to indices test, test result is shown in Table 1.
The indices test result of 2 facial masks for whitening faces and removing spots liquid of table
1 patch test of test example
1. tested material: facial masks for whitening faces and removing spots liquid prepared by embodiment 1.
2. negative control: deionized water.
3. subject: totally 30 people, male 0 people, 30 people of female the age 19-45 years old, meet subject and volunteer inclusion criteria.
4. patch method: selecting qualified spot tester, with enclosed patch test method, about by tested material and negative control
0.020mL-0.025mL (semifluid) is dripped in spot tester, and external application special adhesive tape is pasted on subject back, removes after 24 hours
Tested material, observation dermoreaction in 0.5,24,48 hour after removing respectively, by " cosmetics safety technical specification " (version in 2015)
Dermoreaction grade scale records its result.Test result is shown in Table 2:
2 human skin patch test result of table
Human skin patch test result is shown: 0 there is skin adverse reaction in 30 people；Illustrate that whitening of the invention is dispelled
Spot facial mask liquid uses safe.
2 whitening spot-removing effect test of test example
1. sample sets: facial masks for whitening faces and removing spots liquid prepared by embodiment 1.
2. control group: control group is commercially available facial masks for whitening faces and removing spots liquid.
3. subject: totally 30 people, male 0 people, 30 people of female the age 32-57 years old, meet subject and volunteer inclusion criteria.
4. the principle of dermal melanin and ferroheme test:
Mexameter MX18 is the principle (RGB) based on spectral absorption, by measuring the illumination of specific wavelength in human body
Volume reflection after on skin determines the content of melanin and ferroheme in skin.The transmitter of instrument probe issues wavelength difference
It is radiated at skin surface for the light of tri- kinds of wavelength of 568nm, 660nm and 880nm, recipient measures the light of skin reflex.Due to hair
It is certain for penetrating the amount of light, therefore can measure the amount for the light being absorbed by the skin, and measures containing for dermal melanin and ferroheme
Amount.The measurement range of instrument is 0-999, and measurement numerical value is higher, illustrates that the content of melanin and ferroheme is higher in skin.
5. test method:
Before subject smears sample, first experiment position is cleaned, smears sample after drying.The left and right cheek of subject is successively
Cycle labeling: the area of 4 × 4cm size is as tested region and blank control region；Subject is daily sooner or later in Experimental Area
Twice using tested material, during experiment, subject cannot smear any other cosmetics in Test sites.Subject continuously makes
After tested material one week, two weeks, three weeks and four weeks, same time subject cleans position is smeared weekly, is used by tester
The content at position is smeared in Mexameter MX18 tester and the measurement of MicroSkin II Multi-functional skin mirror image analysis system.
Every is surveyed five times, is averaged.It the results are shown in Table 3.
Melanin reduced rate (%)=[the secondary melanin content (%)-for the first time melanin content (%)] ÷ melanin for the first time
Content (%) × 100%
Relative melanin reduced rate (the %)=secondary sample sets melanin reduced rate (%)-this time compares 5 groups of pigments and reduces
Rate (%)
3 each group tested material Comparative result table of table
As shown in Table 3, sample sets and control group are reduced using rear melanin content, and over time in incremental
Trend, and sample sets melanin content lowers rate and is substantially better than control group, after four weeks, relative melanin reduced rate reaches
42.1%, it is seen that the freckle effect of sample sets is substantially better than control group, and effect is lasting for light spot, it was demonstrated that the whitening of this hair is dispelled
Spot facial mask liquid is substantially better than similar product.
The obtained facial masks for whitening faces and removing spots liquid of embodiment 2~3, which is used, as active ingredients carries out people according to the above method
Body skin patch test and whitening spot-removing effect test, obtain the test result similar with above-mentioned test result.
Facial masks for whitening faces and removing spots liquid of the present invention contain by Trenaxmine, niacinamide, carnosine, allantoin, dipotassium glycyrrhizinate,
The effective active compositions such as glucan.Wherein Trenaxmine is a kind of protease inhibitors, and energy protease inhibition urges peptide bond hydrolysis
Change effect, so that the activity of such as rising property protease enzyme is prevented, and then inhibit the epidermal cell function at blackspot position
Confusion, and inhibit melanin enhancement factor group, then thoroughly break off the way occurred because of the melanin that ultraviolet light irradiates and is formed
Diameter, so as to be effectively prevented and improve the pigment deposition of skin.Niacinamide is a kind of stable water soluble ingredient, molecular weight
It is small, skin cuticula can be permeated rapidly, melanin is inhibited to transport to epidermis, inhibit obscure color spot to generate, while there is anti-saccharification
Function can make the dark yellow colour of skin become white and moist clear.Carnosine is a kind of natural, it is anti-oxidant, inhibit free radical and
Metal ion cause lipid oxidation have obvious action, melanin can be significantly reduced and formed.Allantoin, dipotassium glycyrrhizinate,
The substantially reduced skin of glucan energy mitigates the light reaction of skin day, reduces black because of the emergency reaction mechanism generated after ultraviolet light irradiation
The generation of pigment, and accelerate cytothesis, cuticula is accelerated to fall off, to promote skin renewal.
Facial masks for whitening faces and removing spots liquid of the present invention uses hydroxyethyl cellulose, xanthan gum, bulbil glue, carbomer, third
One of olefin(e) acid (ester) class/alkylol acrylate (class) cross-linked polymer, gelatin are a variety of as thickener, they have
Higher transparency, thickening capabilities can make stable thick liquid, Neng Gouwen after being dissolved in the water under few additive
Active constituent in fixed and dispensing formulations helps to promote impression when facial mask uses, and has good compatibility with skin.
Meanwhile various effective active components of the present invention and these thickeners all have good compatibility.
Using methyl hydroxybenzoate, Nipasol, Bis(hydroxymethyl)imidazolidinyl urea, phenoxetol, pentanediol, hexylene glycol,
One of parahydroxyacet-ophenone or two or more antiseptic and antibiotic agents flexibly compound, it can be ensured that product is in shelf-life and validity period
Interior stability guarantees that product is not polluted by external microbe when in use and rotten or quality is caused to decline.
Polyalcohol used is that secondary solvent increases product stability and shelf-life in formula, has infiltration keratoderma,
Moisturizing water lock increase simultaneously facial mask liquid be functional component infiltrate into skin base layer hair acted on by whitening spot-removing.Arginine is to neutralize
Agent and pH adjusting agent.
The selected Multiple components of facial masks for whitening faces and removing spots liquid of the present invention carry out scientific compounding, take full advantage of each in formula
The effect of concertedness and compatibility of ingredient, Multiple components mutually cooperate with promoting, greatly improving formula, make product formula
Stability, the reliability of effect and quick effective problem are all solved perfectly.Product pH value, bacterial content and heavy metal
The indices such as content meet the quality requirement of skin care item.
Claims (5)
1. a kind of facial masks for whitening faces and removing spots liquid, which is characterized in that by weight percentage include following component:
Trenaxmine 0.05%~2.00%, niacinamide 0.10%~5.00%, carnosine 0.01%~1.00%, allantoin 0.05%~
1.00%, dipotassium glycyrrhizinate 0.05%~2.00%, glucan 0.01%~3.00%, panthenol 0.05%~3.00%, sodium lactate 0.05%
~2.50%, glycine betaine 0.05%~5.00%, pyrrolidone sodium carboxylate 0.05%~7.50%, ethoxy urea 0.10%~5.00%, thoroughly
Bright matter acid sodium 0.01%~1.00%, polyglutamic acid 0.01%~1.00%, thickener 0.04%~5.00%, EDTA disodium 0.01%~
0.50%, hydroxy phenylpropionyl amine benzoic acid 0.01%~0.50%, antiseptic and antibiotic agent 0.10%~5.00%, polyalcohol 2.25%~
20.00%, deionized water 30.00%~97.00%.
2. facial masks for whitening faces and removing spots liquid according to claim 1, which is characterized in that by weight percentage include following component:
Trenaxmine 0.07%~1.50%, niacinamide 0.50%~3.00%, carnosine 0.04%~0.08%, allantoin 0.06%~
0.08%, dipotassium glycyrrhizinate 0.07%~1.50%, glucan 0.05%~2.00%, panthenol 1.00%~2.00%, sodium lactate 1.00%
~2.00%, glycine betaine 2.00%~3.00%, pyrrolidone sodium carboxylate 3.00%~5.50%, ethoxy urea 2.50%~3.50%, thoroughly
Bright matter acid sodium 0.05%~0.70%, polyglutamic acid 0.50%~0.70%, thickener 1.00%~3.00%, EDTA disodium 0.10%~
0.30%, hydroxy phenylpropionyl amine benzoic acid 0.10%~0.30%, antiseptic and antibiotic agent 2.00%~4.00%, polyalcohol 5.00%~
15.00%, deionized water 45.00%~60.00%.
3. facial masks for whitening faces and removing spots liquid according to claim 2, which is characterized in that by weight percentage include following component:
Trenaxmine 1.20%, niacinamide 2.00%, carnosine 0.06%, allantoin 0.07%, dipotassium glycyrrhizinate 1.00%, glucan
1.50%, panthenol 1.50%, sodium lactate 1.20%, glycine betaine 2.50%, pyrrolidone sodium carboxylate 5.50%, ethoxy urea 3.00%, thoroughly
Bright matter acid sodium 0.55%, polyglutamic acid 0.600%, thickener 3.00%, EDTA disodium 0.20%, hydroxy phenylpropionyl amine benzoic acid
0.20%, antiseptic and antibiotic agent 3.92%, polyalcohol 13.00%, deionized water 59.00%.
4. facial masks for whitening faces and removing spots liquid according to claim 1, which is characterized in that the thickener is selected from hydroxy ethyl fiber
Element, xanthan gum, bulbil glue, carbomer, in acrylic acid (ester) class/alkylol acrylic acid (ester) class cross-linked polymer and gelatin
It is one or more of；The antiseptic and antibiotic agent is selected from methyl hydroxybenzoate, Nipasol, Bis(hydroxymethyl)imidazolidinyl urea, phenoxy group
One or more of ethyl alcohol, pentanediol, hexylene glycol and parahydroxyacet-ophenone；The polyalcohol be selected from butanediol, propylene glycol,
One or more of glycerol and methyl propanediol.
5. a kind of preparation method of the facial masks for whitening faces and removing spots liquid as described in any one of claim 1-4 claim, including it is following
Step:
(1) each ingredient is weighed by weight percentage；
(2) deionized water is put into vacuum emulsification pot, is warming up to 95 DEG C of heat preservations and is cooled to 75 DEG C after twenty minutes；
(3) EDETATE SODIUM is put into deionized water under stiring, by thickener, Sodium Hyaluronate, polyglutamic acid and polyalcohol
It is put into after mixing, is kept for 60 ~ 75 DEG C of temperature, stirring is to being uniformly dissolved；
(4) 45 ~ 50 DEG C are cooled to, Trenaxmine, niacinamide, allantoin, dipotassium glycyrrhizinate, glucan, panthenol, glycine betaine are put into,
Stirring is to being uniformly dissolved；
(5) 35 ~ 45 DEG C are cooled to, carnosine, sodium lactate, pyrrolidone sodium carboxylate, ethoxy urea, hydroxy phenylpropionyl amine benzene first are put into
Acid, antiseptic and antibiotic agent, stirring is to being uniformly dissolved；
(6) it is evacuated to -0.06MPa, is stirred 20 minutes；
(7) vacuum, discharging are excluded.
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| CN109908035A (en) * | 2019-04-25 | 2019-06-21 | 山西纳安生物科技有限公司 | A kind of freckle-removing mask based on peony seed oil |
| CN110559205A (en) * | 2019-09-26 | 2019-12-13 | 敖丽英 | Facial mask liquid capable of controlling oil and shrinking pores and preparation method thereof |
| CN110623882A (en) * | 2019-10-21 | 2019-12-31 | 广州艾蓓生物科技有限公司 | Whitening and freckle removing mask and preparation method thereof |
| CN110917051A (en) * | 2019-11-07 | 2020-03-27 | 泉后(广州)生物科技研究院有限公司 | Whitening essence and preparation method thereof |
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| CN109908035A (en) * | 2019-04-25 | 2019-06-21 | 山西纳安生物科技有限公司 | A kind of freckle-removing mask based on peony seed oil |
| CN110559205A (en) * | 2019-09-26 | 2019-12-13 | 敖丽英 | Facial mask liquid capable of controlling oil and shrinking pores and preparation method thereof |
| CN110623882A (en) * | 2019-10-21 | 2019-12-31 | 广州艾蓓生物科技有限公司 | Whitening and freckle removing mask and preparation method thereof |
| CN110917051A (en) * | 2019-11-07 | 2020-03-27 | 泉后(广州)生物科技研究院有限公司 | Whitening essence and preparation method thereof |
| CN110934812A (en) * | 2019-12-19 | 2020-03-31 | 广州市玉鑫化妆品有限公司 | Skin whitening and brightening freeze-dried tablet and preparation method thereof |
| CN115243669A (en) * | 2020-03-06 | 2022-10-25 | 西姆莱斯股份公司 | Avenanthramide compositions with enhanced solubility comprising 4-hydroxybenzophenones |
| JP2023516454A (en) * | 2020-03-06 | 2023-04-19 | シムライズ アーゲー | Avenanthramide Compositions Containing 4-Hydroxyphenone With Improved Solubility |
| CN111643423A (en) * | 2020-06-28 | 2020-09-11 | 广州市澳莱化妆品有限公司 | Formula and preparation method of whitening and repairing mask |
| CN111773151A (en) * | 2020-07-06 | 2020-10-16 | 广东职业技术学院 | Whitening and freckle-removing antioxidant emulsion and preparation method thereof |
| CN111773151B (en) * | 2020-07-06 | 2023-01-10 | 广东职业技术学院 | Whitening and freckle-removing antioxidant emulsion and preparation method thereof |
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