CN109953975A - A kind of preparation method of slow-release polysaccharide-based Capsules - Google Patents
A kind of preparation method of slow-release polysaccharide-based Capsules Download PDFInfo
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- CN109953975A CN109953975A CN201910150439.5A CN201910150439A CN109953975A CN 109953975 A CN109953975 A CN 109953975A CN 201910150439 A CN201910150439 A CN 201910150439A CN 109953975 A CN109953975 A CN 109953975A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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Abstract
The invention belongs to medical material preparation technical fields, and in particular to a kind of preparation method of slow-release polysaccharide-based Capsules.The present invention obtains modified konjac glucomannan using konjaku glucomannan as raw material, it is blended with polysaccharide algin and sodium carboxymethylcellulose, it adds the mixed glue of glycerol and water and obtains mixed serum, it is crosslinked by calcification twice, finally obtained slow-release polysaccharide-based Capsules, initial oxidation polysaccharide konjaku glucomannan of the present invention is broken polysaccharide molecular weight, to reduce dissolved adhesiveness and improve its solid content, oxidized konjac glucomannan is carried out under the action of phosphate followed by soybean protein cross-linking modified, improve stability, therefore the residence time is long in gastric juice, complex reaction is carried out followed by calcium ion and modified konjac glucomannan surface and sequestering group, generate insoluble complex, improve tolerance of the capsule in gastric juice, calcification processing improves the molding integrality of capsule twice, before wide application Scape.
Description
Technical field
The invention belongs to medical material preparation technical fields, and in particular to a kind of preparation of slow-release polysaccharide-based Capsules
Method.
Background technique
Capsule has very extensive application in medicine, health care product and functional food industry, is present drug and function
One of energy most common dosage form of food.Capsules are usually cap, two section of body being prepared by gelatin, glycerol and other auxiliary materials
Capsule shells composition.Capsules shell is the main outer packaging material for filling drug, health food, is taken together with endocytosis object into vivo, is subtracted
Light entrance trouble, increases curative effect.Capsule shells make drug keep activity, from the influence of the sunlight, air, light of nature etc.,
And some drugs can also be avoided to discharge in inappropriate position, generate adverse reaction.Because it is with good appearance, conducive to covering
Lid content drug odor, fully absorbs insulation blocking, and convenient for meeting positioning, delayed release requirement, preparation process is simple, powder charge
Many advantages, such as easy to use, and be widely used.
Domestic Capsules are classified by raw material at present, are broadly divided into animal-protein-gelatins capsule and plant capsule.Absolutely
Most of Capsules are mostly using animal gelatin as raw material, and animal gelatin is mainly the bone by extracting in animal osteoderm
Glue, hide glue are made.Production of the Quality Safety of animal-protein-gelatins vulnerable to animal species, animal health condition and gelatin material
It is influenced with logistics environment, disease especially may be mutually infected between different plant species, in addition, existing gelatin hollow capsule exists easily
The problems such as crisp, easy adherency, and used by limitation.The raw material of plant hollow capsule is mainly polyol, such as: cellulose,
Starch and its derivative etc..Study at present it is commonplace be with cellulose plant hollow capsule as main component, but by
It is nonnutritive in cellulose, and cellulose hollow capsule so has that disintegration time is longer and production technology is more complex, because
And most drugs can not be suitable for.In recent years, the life of Capsules is prepared using hydroxypropyl methyl cellulose as primary raw material
There are glue ratio of water to material is larger during producing, water removal is more difficult, and glue paste silk is longer, and it is main with it that molding difficulty is big
The disintegration time limited of the Capsules of raw material preparation is longer, and therefore, occupation rate of market at present at home is not high.Starch price ten
It is point cheap, Capsules are prepared with very big attraction with it, domestic many producers have also applied for starch hollow capsule one after another
Patent, but due to starch viscosity is high, film forming is poor, film toughness not by force, poor water retention property, bad mechanical performance the features such as so that
Starch base capsule is difficult to compare favourably with animal gelatin capsule, while being easy the moisture absorption again, and more demanding to preservation condition, the shelf-life is not
It is long.So the product that can form industrialized production is few although the patent about starch capsule is more.In addition, existing market
On Capsules it is general itself do not have slow release, majority is to be reprocessed into capsule, glue after content to be made to sustained-release dosage type
Capsule quickly dissolves after entering gastric juice, can only play sustained release performance by the slow-released carrier skeleton of content.In recent years, market
On also there are a small number of Capsules with sustained release performance, but its sustained release performance is poor, and stomach floatability is bad, cannot be effective
Extend residence time of the content in gastric juice, good stomach sustained release performance can not be obtained.
Therefore, a kind of Capsules can be developed to be of great significance to solve the deficiencies in the prior art.
Summary of the invention
Present invention mainly solves the technical issues of, for common plant polyose base rubber capsule material at present, that there are hygroscopicity is strong
Lead to that storage stability is poor, dissolved adhesiveness causes greatly difficult forming and sustained release performance poor, and stomach floatability is bad, it cannot
Effectively extend residence time of the content in gastric juice, the defect of good stomach sustained release performance can not be obtained, provides a kind of slow
Release the preparation method of type polysaccharide-based Capsules.
In order to solve the above-mentioned technical problem, the technical scheme adopted by the invention is that:
The specific preparation step of slow-release polysaccharide-based Capsules are as follows:
(1) capsule die is immersed in mixed glue solution, stands dipping 10~15 seconds, lifts capsule die after dipping, from
Open mixed glue solution and repeatedly overturning spin coating handle 3~5 times, then it is 30% that spin coating treated capsule die, which is immersed mass fraction,
Calcium gluconate solution in, calcification crosslinking Treatment；
(2) after to above-mentioned calcification crosslinking Treatment, it is dried to obtain a calcification capsule, then a calcification capsule is moved into quality
In the calcium chloride solution that score is 20%, secondary calcification crosslinking Treatment, after secondary calcification processing, vacuum drying, demoulding, i.e.,
Obtain slow-release polysaccharide-based Capsules；
The preparation step of mixed serum are as follows:
Will modified konjac glucomannan and algin and sodium carboxymethylcellulose mix after obtain mixture, then by mixture and
It is fitted into reaction kettle after glycerol and water mixing, is stirred 15~20min at 60~70 DEG C and obtains mixed glue solution；
The preparation step of modified konjac glucomannan are as follows:
(1) konjaku glucomannan and water are mixed and is packed into beaker, stand 30~40min of swelling, then quality point is added into beaker
The hydrogen peroxide that number is 30% is added the dehydrated alcohol with quality such as water after stirring 40~50min of oxidation reaction, stands and separate
To sediment；
(2) soy bean proteinous soln that mass fraction is 30% being heated to 75~80 DEG C, heat preservation is heat-treated 15~20min, then
By after heat treatment soy bean proteinous soln and above-mentioned sediment mix and be fitted into reaction kettle, then poly phosphorus is added into reaction kettle
Sour sodium, is stirred to react 30~40min；
(3) after to above-mentioned be stirred to react, then dehydrated alcohol is added into reaction kettle, staticly settles 1 after stirring 15~20min
~2h is separated by filtration to obtain filter residue, and the ethanol solution for being 75% with mass fraction is dried in vacuo after rinsing filter residue 3~5 times, obtains
Modified konjac glucomannan.
In the specific preparation step (1) of slow-release polysaccharide-based Capsules, time of calcification crosslinking Treatment is 15~
20min。
In the specific preparation step (2) of slow-release polysaccharide-based Capsules, time of secondary calcification crosslinking Treatment is 15~
20min。
In the preparation step of mixed serum, the quality of modified konjac glucomannan and algin and sodium carboxymethylcellulose
Than for 20:10:1.
In the preparation step of mixed serum, the mass ratio of mixture and glycerol and water is 1:1:20.
In the preparation step (1) of modified konjac glucomannan, the mass ratio of konjaku glucomannan and water is 1:5.
In the preparation step (1) of modified konjac glucomannan, the additional amount for the hydrogen peroxide that mass fraction is 30% is konjaku Portugal
3~5 times of sweet glycan quality.
In the preparation step (2) of modified konjac glucomannan, the quality of soy bean proteinous soln and sediment after heat treatment
Than being the 1~2% of sediment quality for the additional amount of 5:1, sodium polyphosphate.
In the preparation step (3) of modified konjac glucomannan, the additional amount and soy bean proteinous soln volume phase of dehydrated alcohol
Deng.
The method have the benefit that:
(1) present invention first using plant polyose konjaku glucomannan as raw material, by its with after hydrogen peroxide oxidation again through soybean egg
White modification obtains modified konjac glucomannan, then of the invention by modified konjac glucomannan and another plant polyose brown alga
Glue and sodium carboxymethylcellulose are blended, and add glycerol and water and mix glue, obtain mixed serum, impregnate die of capsule with mixed serum
Tool, and after spin coating processing, it is crosslinked by calcification twice, finally obtained slow-release polysaccharide-based Capsules, the present invention is first with day
Right plant polyose konjaku glucomannan is broken polysaccharide molecular weight its oxidation modification, molecule as raw material by hydrogen peroxide
Amount reduces and molecules align becomes more orderly, thus reduce dissolved adhesiveness and improve its solid content, but after oxidation modification
The polar group of generation increases the hygroscopicity of konjaku glucomannan, and therefore, the present invention is followed by soybean protein in phosphoric acid
Oxidized konjac glucomannan has been carried out under the action of salt it is cross-linking modified, it is modified, it is hydroxyl on oxidized konjac glucomannan, big
Sulfydryl on legumin respectively with phosphate group reaction forming, then intramolecular or the intermolecular strong hydrogen bond, covalently of foring
Key effect forms spacial framework, and stability improves, therefore the residence time is long in gastric juice, and dredges in modified product
Water key is aligned in film surface to be stretched to aerial, and when it is dissolved in water, hydrophobic grouping is inside it far from water, when heating, makes
Protein three-dimensional conformation changes, and hydrophobic grouping is exposed, in air-water interface, hydrophobic grouping in modified product molecule
It stretches in the air, hydrophilic radical is then maintained at the water surface, therefore the hydrophobic performance of modified konjaku glucomannan improves, hygroscopicity
It can also be reduced, then modified konjac glucomannan and another plant polyose algin are blended the present invention, are soaked with mold
Calcification twice is carried out to mixed glue solution by calcium gluconate and calcium chloride after glue, utilizes calcium ion and modified konjac glucomannan
Surface and sequestering group carry out complex reaction, generate insoluble complex, improve tolerance of the capsule in gastric juice, while benefit
Ion-exchange reactions is realized with the sodium ion in calcium ion and algin, to form the alginic acid of sour slightly solubility in capsule surface
Calcium gel improves tolerance of the capsule of the present invention in gastric juice again, and twice calcification processing improve capsule at
Type integrality is conducive to production and goes on smoothly, and final slow-release polysaccharide-based Capsules hydroscopicity produced by the present invention is low, saves
Stability is good, and dissolved adhesiveness is low, and molding is easy, and stomach floatability is good, the increased retention in gastric juice, before wide application
Scape.
Specific embodiment
Konjaku glucomannan and water are mixed for 1:5 in mass ratio and are packed into beaker, stands 30~40min of swelling, then to burning
The hydrogen peroxide that the mass fraction that 3~5 times of konjaku glucomannan quality are added in cup is 30%, after stirring 40~50min of oxidation reaction
The dehydrated alcohol with quality such as water, standing and isolated sediment is added；The soy bean proteinous soln that mass fraction is 30% is added
Heat is warming up to 75~80 DEG C, heat preservation 15~20min of heat treatment, then by after heat treatment soy bean proteinous soln and above-mentioned sediment press
Mass ratio is that 5:1 is mixed and is fitted into reaction kettle, then the sodium polyphosphate of sediment quality 1~2% is added into reaction kettle, is stirred
Mix 30~40min of reaction；After to above-mentioned be stirred to react, then addition and the isometric nothing of soy bean proteinous soln into reaction kettle
Water-ethanol staticly settles 1~2h after stirring 15~20min, is separated by filtration to obtain filter residue, and the ethyl alcohol for being 75% with mass fraction is molten
Liquid is dried in vacuo after rinsing filter residue 3~5 times, obtains modified konjac glucomannan；By above-mentioned modified konjac glucomannan and brown alga
Glue and sodium carboxymethylcellulose are to obtain mixture after 20:10:1 mixing in mass ratio, then by mixture and glycerol and water
In mass ratio to be fitted into reaction kettle after 1:1:20 mixing, 15~20min is stirred at 60~70 DEG C and obtains mixed glue solution；
Capsule die is immersed in above-mentioned mixed glue solution, dipping 10~15 seconds is stood, capsule die is lifted after dipping, is left mixed
Close glue and repeatedly overturning spin coating handle 3~5 times, then spin coating treated capsule die is immersed into mass fraction for 30% Portugal
In grape saccharic acid calcium solution, 15~20min of calcification crosslinking Treatment；After to above-mentioned calcification crosslinking Treatment, it is dried to obtain a calcium
Change capsule, then calcification capsule is moved into the calcium chloride solution that mass fraction is 20%, secondary calcification crosslinking Treatment 15~
20min, after secondary calcification processing, vacuum drying, demoulding are to get slow-release polysaccharide-based Capsules.
Embodiment 1
The preparation of sediment:
Konjaku glucomannan and water are mixed for 1:5 in mass ratio and are packed into beaker, stands swelling 30min, then be added into beaker
The hydrogen peroxide that the mass fraction that 3 times of konjaku glucomannan quality is 30% is added and the quality such as water after stirring oxidation reaction 40min
Dehydrated alcohol, stand and isolated sediment.
The preparation of modified konjac glucomannan:
The soy bean proteinous soln that mass fraction is 30% is heated to 75 DEG C, heat preservation heat treatment 15min, then will be after heat treatment
Soy bean proteinous soln and above-mentioned sediment be in mass ratio that 5:1 is mixed and is fitted into reaction kettle, then be added into reaction kettle it is heavy
The sodium polyphosphate of starch quality 1%, is stirred to react 30min；After to above-mentioned be stirred to react, then into reaction kettle be added and
The isometric dehydrated alcohol of soy bean proteinous soln staticly settles 1h after stirring 15min, is separated by filtration to obtain filter residue, with quality point
Number is dried in vacuo after rinsing filter residue 3 times for 75% ethanol solution, obtains modified konjac glucomannan.
The preparation of mixed glue solution:
It is in mass ratio to be obtained after 20:10:1 is mixed by above-mentioned modified konjac glucomannan and algin and sodium carboxymethylcellulose
In mass ratio it is to be fitted into reaction kettle after 1:1:20 is mixed to mixture, then by mixture and glycerol and water, is stirred at 60 DEG C
It mixes mixing 15min and obtains mixed glue solution.
The preparation of slow-release polysaccharide-based Capsules:
Capsule die is immersed in above-mentioned mixed glue solution, dipping 10 seconds is stood, capsule die is lifted after dipping, is left mixed
Close glue and repeatedly overturning spin coating handle 3 times, then spin coating treated capsule die is immersed into mass fraction for 30% glucose
In sour calcium solution, calcification crosslinking Treatment 15min；After to above-mentioned calcification crosslinking Treatment, it is dried to obtain a calcification capsule, then
Calcification capsule is moved into the calcium chloride solution that mass fraction is 20%, secondary calcification crosslinking Treatment 15min, secondary calcification
After treatment, vacuum drying, demoulding are to get slow-release polysaccharide-based Capsules.
Embodiment 2
The preparation of sediment:
Konjaku glucomannan and water are mixed for 1:5 in mass ratio and are packed into beaker, stands swelling 35min, then be added into beaker
The hydrogen peroxide that the mass fraction that 4 times of konjaku glucomannan quality is 30% is added and the quality such as water after stirring oxidation reaction 45min
Dehydrated alcohol, stand and isolated sediment.
The preparation of modified konjac glucomannan:
The soy bean proteinous soln that mass fraction is 30% is heated to 77 DEG C, heat preservation heat treatment 18min, then will be after heat treatment
Soy bean proteinous soln and above-mentioned sediment be in mass ratio that 5:1 is mixed and is fitted into reaction kettle, then be added into reaction kettle it is heavy
The sodium polyphosphate of starch quality 1%, is stirred to react 35min；After to above-mentioned be stirred to react, then into reaction kettle be added and
The isometric dehydrated alcohol of soy bean proteinous soln staticly settles 1h after stirring 17min, is separated by filtration to obtain filter residue, with quality point
Number is dried in vacuo after rinsing filter residue 4 times for 75% ethanol solution, obtains modified konjac glucomannan.
The preparation of mixed glue solution:
It is in mass ratio to be obtained after 20:10:1 is mixed by above-mentioned modified konjac glucomannan and algin and sodium carboxymethylcellulose
In mass ratio it is to be fitted into reaction kettle after 1:1:20 is mixed to mixture, then by mixture and glycerol and water, is stirred at 65 DEG C
It mixes mixing 17min and obtains mixed glue solution.
The preparation of slow-release polysaccharide-based Capsules:
Capsule die is immersed in above-mentioned mixed glue solution, dipping 13 seconds is stood, capsule die is lifted after dipping, is left mixed
Close glue and repeatedly overturning spin coating handle 4 times, then spin coating treated capsule die is immersed into mass fraction for 30% glucose
In sour calcium solution, calcification crosslinking Treatment 17min；After to above-mentioned calcification crosslinking Treatment, it is dried to obtain a calcification capsule, then
Calcification capsule is moved into the calcium chloride solution that mass fraction is 20%, secondary calcification crosslinking Treatment 17min, secondary calcification
After treatment, vacuum drying, demoulding are to get slow-release polysaccharide-based Capsules.
Embodiment 3
The preparation of sediment:
Konjaku glucomannan and water are mixed for 1:5 in mass ratio and are packed into beaker, stands swelling 40min, then be added into beaker
The hydrogen peroxide that the mass fraction that 5 times of konjaku glucomannan quality is 30% is added and the quality such as water after stirring oxidation reaction 50min
Dehydrated alcohol, stand and isolated sediment.
The preparation of modified konjac glucomannan:
The soy bean proteinous soln that mass fraction is 30% is heated to 80 DEG C, heat preservation heat treatment 20min, then will be after heat treatment
Soy bean proteinous soln and above-mentioned sediment be in mass ratio that 5:1 is mixed and is fitted into reaction kettle, then be added into reaction kettle it is heavy
The sodium polyphosphate of starch quality 2%, is stirred to react 40min；After to above-mentioned be stirred to react, then into reaction kettle be added and
The isometric dehydrated alcohol of soy bean proteinous soln staticly settles 2h after stirring 20min, is separated by filtration to obtain filter residue, with quality point
Number is dried in vacuo after rinsing filter residue 5 times for 75% ethanol solution, obtains modified konjac glucomannan.
The preparation of mixed glue solution:
It is in mass ratio to be obtained after 20:10:1 is mixed by above-mentioned modified konjac glucomannan and algin and sodium carboxymethylcellulose
In mass ratio it is to be fitted into reaction kettle after 1:1:20 is mixed to mixture, then by mixture and glycerol and water, is stirred at 70 DEG C
It mixes mixing 20min and obtains mixed glue solution.
The preparation of slow-release polysaccharide-based Capsules:
Capsule die is immersed in above-mentioned mixed glue solution, dipping 15 seconds is stood, capsule die is lifted after dipping, is left mixed
Close glue and repeatedly overturning spin coating handle 5 times, then spin coating treated capsule die is immersed into mass fraction for 30% glucose
In sour calcium solution, calcification crosslinking Treatment 20min；After to above-mentioned calcification crosslinking Treatment, it is dried to obtain a calcification capsule, then
Calcification capsule is moved into the calcium chloride solution that mass fraction is 20%, secondary calcification crosslinking Treatment 20min, secondary calcification
After treatment, vacuum drying, demoulding are to get slow-release polysaccharide-based Capsules.
Comparative example 1: it is essentially identical with the preparation method of example 1, it has only the difference is that sediment is not added.
Comparative example 2: it is essentially identical with the preparation method of example 2, it has only the difference is that modified konjac glucomannan is not added.
Comparative example 3: the Capsules of Shanghai City company production.
Capsules in slow-release polysaccharide-based Capsules produced by the present invention and comparative example are detected, detection knot
Fruit is as shown in table 1:
Friability measurement
Capsules each 60 in slow-release polysaccharide-based Capsules produced by the present invention and comparative example are taken respectively, are placed in surface
It in ware, and is put into the drier for filling saturated solution of magnesium sulfate, sets 26 DEG C of ± 2 DEG C of constant temperature for 24 hours, take out, immediately respectively by grain
It is put into the glass tube (internal diameter 25mm, a length of 2600mm) stood upright on plank (thickness 2cm), by cylindrical counterweight (material
It freely falls from glass nozzle for polytetrafluoroethylene (PTFE), diameter 23mm, weight 22g ± 0.2g), whether is ruptured depending on capsule, if any
Rupture, must not exceed 5.
Moisture retention measurement
Capsules in slow-release polysaccharide-based Capsules produced by the present invention and comparative example are placed in 6h under normal temperature environment, then
It is tested using moisture teller.
1 performance measurement result of table
From the data in table 1, it can be seen that slow-release polysaccharide-based Capsules viscosity produced by the present invention is low, good film-forming property has good
Moisture retention and stability can be complied fully with Capsules standard in " Chinese Pharmacopoeia ", be guaranteed it in gastric juice with long-time storage
In do not rupture and be not disintegrated, disintegratable discharges drug in intestinal juice, and material is safe and non-toxic, from a wealth of sources, has wide use
Prospect.
Claims (9)
1. a kind of preparation method of slow-release polysaccharide-based Capsules, it is characterised in that specific preparation step are as follows:
(1) capsule die is immersed in mixed glue solution, stands dipping 10~15 seconds, lifts capsule die after dipping, from
Open mixed glue solution and repeatedly overturning spin coating handle 3~5 times, then it is 30% that spin coating treated capsule die, which is immersed mass fraction,
Calcium gluconate solution in, calcification crosslinking Treatment；
(2) after to above-mentioned calcification crosslinking Treatment, it is dried to obtain a calcification capsule, then a calcification capsule is moved into quality
In the calcium chloride solution that score is 20%, secondary calcification crosslinking Treatment, after secondary calcification processing, vacuum drying, demoulding, i.e.,
Obtain slow-release polysaccharide-based Capsules；
The preparation step of the mixed serum are as follows:
Will modified konjac glucomannan and algin and sodium carboxymethylcellulose mix after obtain mixture, then by mixture and
It is fitted into reaction kettle after glycerol and water mixing, is stirred 15~20min at 60~70 DEG C and obtains mixed glue solution；
The preparation step of the modified konjac glucomannan are as follows:
(1) konjaku glucomannan and water are mixed and is packed into beaker, stand 30~40min of swelling, then quality point is added into beaker
The hydrogen peroxide that number is 30% is added the dehydrated alcohol with quality such as water after stirring 40~50min of oxidation reaction, stands and separate
To sediment；
(2) soy bean proteinous soln that mass fraction is 30% being heated to 75~80 DEG C, heat preservation is heat-treated 15~20min, then
By after heat treatment soy bean proteinous soln and above-mentioned sediment mix and be fitted into reaction kettle, then poly phosphorus is added into reaction kettle
Sour sodium, is stirred to react 30~40min；
(3) after to above-mentioned be stirred to react, then dehydrated alcohol is added into reaction kettle, staticly settles 1 after stirring 15~20min
~2h is separated by filtration to obtain filter residue, and the ethanol solution for being 75% with mass fraction is dried in vacuo after rinsing filter residue 3~5 times, obtains
Modified konjac glucomannan.
2. a kind of preparation method of slow-release polysaccharide-based Capsules according to claim 1, it is characterised in that: described slow
It releases in the specific preparation step (1) of type polysaccharide-based Capsules, the time of calcification crosslinking Treatment is 15~20min.
3. a kind of preparation method of slow-release polysaccharide-based Capsules according to claim 1, it is characterised in that: described slow
It releases in the specific preparation step (2) of type polysaccharide-based Capsules, the time of secondary calcification crosslinking Treatment is 15~20min.
4. a kind of preparation method of slow-release polysaccharide-based Capsules according to claim 1, it is characterised in that: described mixed
In the preparation step for closing slurries, the mass ratio of modified konjac glucomannan and algin and sodium carboxymethylcellulose is 20:10:
1。
5. a kind of preparation method of slow-release polysaccharide-based Capsules according to claim 1, it is characterised in that: described mixed
In the preparation step for closing slurries, the mass ratio of mixture and glycerol and water is 1:1:20.
6. a kind of preparation method of slow-release polysaccharide-based Capsules according to claim 1, it is characterised in that: described to change
Property konjaku glucomannan preparation step (1) in, the mass ratio of konjaku glucomannan and water is 1:5.
7. a kind of preparation method of slow-release polysaccharide-based Capsules according to claim 1, it is characterised in that: described to change
In the preparation step (1) of property konjaku glucomannan, the additional amount for the hydrogen peroxide that mass fraction is 30% is konjaku glucomannan quality
3~5 times.
8. a kind of preparation method of slow-release polysaccharide-based Capsules according to claim 1, it is characterised in that: described to change
Property konjaku glucomannan preparation step (2) in, the mass ratio of soy bean proteinous soln and sediment after heat treatment is 5:1, more
The additional amount of polyphosphate sodium is the 1~2% of sediment quality.
9. a kind of preparation method of slow-release polysaccharide-based Capsules according to claim 1, it is characterised in that: described to change
In the preparation step (3) of property konjaku glucomannan, the additional amount and soy bean proteinous soln volume of dehydrated alcohol are equal.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1561971A (en) * | 2004-03-30 | 2005-01-12 | 湖北工学院 | Plant hard hollow capsule and its preparng method |
| CN1739488A (en) * | 2005-08-02 | 2006-03-01 | 武汉工业学院 | High performance composite hollow konjaku capsule and its prepn process |
-
2019
- 2019-02-28 CN CN201910150439.5A patent/CN109953975A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1561971A (en) * | 2004-03-30 | 2005-01-12 | 湖北工学院 | Plant hard hollow capsule and its preparng method |
| CN1739488A (en) * | 2005-08-02 | 2006-03-01 | 武汉工业学院 | High performance composite hollow konjaku capsule and its prepn process |
Non-Patent Citations (2)
| Title |
|---|
| 周君: "氧化魔芋葡甘聚糖-大豆蛋白硬空心胶囊囊材的研究", 《湖北工业大学硕士学位论文》 * |
| 张珂等: "海藻酸钠/CMC/KGM复合膜的制备及性能", 《印染》 * |
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