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CN109924485A - A kind of slimming health food and preparation method thereof containing hyaluronic acid - Google Patents

A kind of slimming health food and preparation method thereof containing hyaluronic acid Download PDF

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Publication number
CN109924485A
CN109924485A CN201910250227.4A CN201910250227A CN109924485A CN 109924485 A CN109924485 A CN 109924485A CN 201910250227 A CN201910250227 A CN 201910250227A CN 109924485 A CN109924485 A CN 109924485A
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China
Prior art keywords
hyaluronic acid
hyaluronate
weight
health food
salt
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Inventor
宋永民
宫衍革
冯晓毅
刘栋
甄文博
姜秀敏
郭学平
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Huaxi Biotechnology Co Ltd
Shandong Bloomage Hyinc Biopharm Co Ltd
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Huaxi Biotechnology Co Ltd
Shandong Bloomage Hyinc Biopharm Co Ltd
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Abstract

The present invention provides a kind of slimming health foods containing hyaluronic acid, it is formed by hyaluronate shell contents of parcel object, the raw material including following parts by weight: L-carnitine 5-20, Teng's Huang berry extract 10-30, Lotus Leafextract 5-30, tea polyphenols 1-20, vitamin 0.1-10, dietary fiber 1-30, dextrin 0.1-20, chondroitin sulfate 0.1-20, glucosamine salt 0.1-20, collagen 0.1-20, conjugated linoleic acid glyceride 0.1-20, hyaluronate 0.1-30.Above-mentioned hyaluronate is polymer hyaluronic acid salt and the combination of 20:1-1:20 in mass ratio of low molecular weight hyaluronic acid salt.The molecular weight of the high molecular weight hyaluronic acid salt is 1000KDa-3000 KDa, and the molecular weight of low-molecular-weight hyaluronic acid salt is 1KDa-800 KDa.Above-mentioned slimming health food has effects that weight-reducing, protection movable joint and reduces cutis laxa.

Description

A kind of slimming health food and preparation method thereof containing hyaluronic acid
Technical field
The invention belongs to field of food, and in particular to a kind of health food containing hyaluronic acid.
Background technique
Obesity refers to that body fat is excessive or abnormal stacking, is caused by the excessive metabolic imbalance of Energy intaking, is metabolic disorder Syndrome.Obesity not only influences pretty figure, makes troubles to life, can also cause soft tissue of joint damage, fecundity decline And the illnesss such as mental handicape, heart disease, diabetes, atherosclerosis, fatty liver, gall stone, oedema, gout.
Currently, the people of the nearly one third in the whole world is overweight or fat, Chinese population of being obese is also in explosive sharp increase, by fat band The related disease come has emerged one after another.Obesity has seriously affected daily life and health.Therefore, slimming drug, Food and health care product come into being, and are liked by numerous obese patients.Weight-reducing market is made a general survey of, drug toxic side effect is big, relies on Property it is strong, food produces little effect, takes effect slowly, and promotes and diet products that sales volume is best are health care product, especially L-carnitine Health food.According to investigations, internationally renowned brand Australia Swisse, Blackmores, U.S. GNC, domestic famous brand name soup minister times Strong, Kombi spy, amendment, at least 70% slimming health food is with L-carnitine for main slimming ingredient.
L-carnitine (L-carnitine), also known as l-carnitine or transliteration Carnitine are that one kind promotes adipose conversion for energy Amino acid, have no toxic and side effect to human body.L-carnitine is functioned primarily as carrier and will be grown in the form of fatty acyl carnitine Chain fatty acid transports in mitochondria, and beta oxidation is carried out in mitochondria, to generate energy.L-carnitine is removed as fat Fortune work, which needs that a large amount of aerobic exercises is cooperated to convert the energy into heat, to be excreted.Lost weight with L-carnitine, it is necessary to which cooperation is appropriate Movement, keep on a diet.All L-carnitine slimming health foods on the market all have ignored a bit at present, and a large amount of movements are to people Body joint injury is huge.Obese people, weight is big, and movement burden is big, and joint damage is bigger.At least adhere to daily in weight loss procedures Aerobic exercise one hour, day by day, joint damage can not look down upon.
Hyaluronic acid (HA) is a kind of straight chain polymer polysaccharide, is made of glucuronic acid and N-acetylglucosamine Dissacharide units repeat to be formed by connecting with glycosidic bond.HA is widely present in people and vertebrate body, is composition extracellular matrix One of several glycosaminoglycans.Content is most in the dermal layer of the skin and knuckle synovia of people, has water conservation, lubrication, without sensitization With the property of the macromolecule polysaccharides such as good biocompatibility.HA is taken orally through digesting and assimilating, internal HA synthesis can be obviously increased Precursor increases the HA synthetic quantity of skin, joint and its hetero-organization.Continuous netted knot is mutually wound between HA strand Structure, hydrone are functioned by polar bond, and HA molecule is absorbed and keeps thousands of times of own wt of moisture, by the world It is known as best " natural moisturizing factor ".The water-retaining property of HA can make human skin water profit full glossy.
The disclosure of the invention of 103284146 A of Publication No. CN L-carnitine tea polyphenol tablet and preparation method thereof, left-handed meat Alkali tea polyphenol tablet is formed by the components simple combination tabletting such as L-carnitine-L-tartrate, Lotus Leafextract, tea polyphenols, fat-reducing effect Obvious but L-carnitine intake is big, increases the kidney burden of user.In addition, not full abdomen effect, slimmer can only be strong Row reduces appetite, increases stomach lining friction, it is easy to cause mucosal lesion.
A kind of semi-permeable membrane water suction weight-reducing abrasive net-balloon for stomach capsule of the patented invention of 105476735 A of Publication No. CN, including acid resistance And the semi-transparent sacculus of water penetration, hyaluronic acid particles are coated in semi-transparent sacculus.Semi-transparent sacculus is by silica gel, acid-resistant epoxy Rouge, acidproof carboxymethyl cellulose are mixed.By hyaluronic acid water swelling, user is made to generate satiety, reduces appetite. The invention need to take orally the high molecular materials such as silica gel, epoxy resin, and to human body, there are potential harms, and pass through radiopaque mark Note object pays close attention to semi-transparent sacculus in the position of human body at any time, and to human life health, there are security risks.
Summary of the invention
Satiety cannot be led to the problem of for current diet food and balloon material is unsafe, and the present invention provides one kind The health food containing hyaluronic acid with weight losing function, raw material are raw-food material, safe and non-toxic, have stronger full abdomen Sense, and cutis laxa caused by weight-reducing can be effectively reduced.
To achieve the above object, the present invention adopts the following technical scheme that.
A kind of slimming health food containing hyaluronic acid is formed by hyaluronate shell contents of parcel object, including following The raw material of parts by weight is made:
L-carnitine 5-20, Teng's Huang berry extract 10-30, Lotus Leafextract 5-30, tea polyphenols 1-20, vitamin 0.1-10, meals Eat fiber 1-30, dextrin 0.1-20, chondroitin sulfate 0.1-20, glucosamine salt 0.1-20, collagen 0.1-20, conjugation Linoleic acid or its ester 0.1-20, hyaluronate 0.1-30.
Preferably, the raw material including following parts by weight is made: L-carnitine 5-15, Teng's Huang berry extract 10-20, lotus leaf mention Take object 10-20, tea polyphenols 5-15, vitamin 0.5-5, dietary fiber 5-25, dextrin 1-15, chondroitin sulfate 1-5, aminoglucose Sugared salt 1-15, collagen 1-15, conjugated linoleic acid or its ester 1-15, hyaluronate 1-25.
It is furthermore preferred that being made of raw material from the following weight: L-carnitine 5-10, Teng's Huang berry extract 10-20, lotus leaf mention Take object 10-15, tea polyphenols 5-10, vitamin 0.5-5, dietary fiber 10-20, dextrin 5-10, chondroitin sulfate 1-5, amino Portugal Grape sugar salt 5-10, collagen 5-10, conjugated linoleic acid or its ester 1-5, hyaluronate 1-5.
Above-mentioned hyaluronate is the combination of polymer hyaluronic acid salt and low molecular weight hyaluronic acid salt.The high molecular weight The mass ratio of hyaluronate and low-molecular-weight hyaluronic acid salt is 20:1-1:20;Preferably 15:1-1:15;More preferably 10: 1。
The molecular weight of the high molecular weight hyaluronic acid salt is 1000 KDa-3000 KDa, low-molecular-weight hyaluronic acid salt Molecular weight be 1 KDa-800 KDa.
Preferably, the molecular weight of high molecular weight hyaluronic acid salt be 1500KDa-2500KDa, low-molecular-weight hyaluronic acid or The molecular weight of its salt is 1KDa-500 KDa.
It is furthermore preferred that the molecular weight of high molecular weight hyaluronic acid or its salt is 1500KDa-2000KDa, low molecular weight is transparent The molecular weight of matter acid or its salt is 1KDa-300 KDa.
Above-mentioned hyaluronate can choose food and the acceptable hyaluronate of pharmaceutical field, such as sodium salt, sylvite, zinc Salt, magnesium salts, calcium salt etc..
A kind of preparation method of above-mentioned slimming health food, comprising the following steps:
(1) powder of L-carnitine, tea polyphenols, vitamin, glucosamine salt, collagen is uniformly mixed, be sieved to obtain powder Last I;The powder of Teng's Huang berry extract, Lotus Leafextract, dietary fiber is uniformly mixed, be sieved to obtain powder II;
(2) powder I is uniformly mixed with powder II, suitable quantity of water is added, stirs evenly;Chondroitin sulfate is added, is stirred evenly; It is eventually adding dextrin, obtains dough object, dry after granulation, sieving obtains solid particle I;
(3) conjugated linoleic acid or its ester are smeared into the surface solid particle I, obtains contents particles;
(4) contents particles are added in hyaluronate gel, are stirred evenly;Then it pelletizes, is dry, sieving obtains solid Grain II;
(5) by solid particle II cyclonic separation, core-shell structure particles, i.e. slimming health food finished product are obtained.
In step (1), the fineness of the powder is 100-400 mesh.
In step (2), the weight ratio of all raw materials and water is 1:1-10:1;Preferably 1:1-8:1;Most preferably 6:1.Institute Stating drying temperature is 35-65 DEG C;Drying time is 2-8h.The partial size of the solid particle I is 10-20 mesh.
In step (4), in the hyaluronate gel, the weight ratio of hyaluronate and water is 1:1-1:100;It is preferred that 1:5-1:50, most preferably 1:10.Drying temperature is 25-65 DEG C;Drying time is 1-20h.
In step (5), the partial size of the core-shell structure particles is 1-10 mesh.
It preferably, further include the process for polishing core-shell structure particles in step (5).
The invention has the following advantages:
The hyaluronic acid that the present invention has compounds shell, and satiety, drop can be generated by the strong water sorption of hyaluronate Hunger caused by low slimmer is reduced as caloric intake.Cooperated by the hyaluronic acid of different molecular weight, makes product outer layer Sustained release envelope is formed, the hyaluronic acid of high molecular weight absorbs water to form network architecture offer shielding action, the hyalomitome of low molecular weight Acid is embedded in the gap of network architecture.After the hyaluronic acid of low molecular weight is digested absorption, shell forms hole, to make to have Component diffusion or release are imitated, such structure can reduce destruction of the gastric juice to effective component, improve effective dense in enteron aisle Degree and absorption.Meanwhile hyaluronic acid gel can also protect stomach lining and repair slight gastric mucosa.The present invention can be with Caused by alleviation is antifatigue because being seriously worn caused by largely moving in weight loss procedures joint, and reduction is because of quick weight-lossing Cutis laxa keeps skin-tightening smooth flexible while weight-reducing.
In preparation method of the invention, contents particles are sufficiently wrapped up using conjugated linoleic acid or its ester, it can be effective Prevent during the preparation process contents particles absorb water and be destroyed in hyaluronic acid derivatives;Again using cyclonic separation by it is extra not The hyaluronic acid of contents of parcel composition granule removes.
Slimming health food of the invention can be applied to people to lose weight, reduce while reducing caloric intake hungry Sense reduces damage of the high-intensity exercise to joint, has a good slow releasing function to effective component, at the same with move and diet phase In conjunction with having the effect of preferably controlling weight.
Detailed description of the invention
Fig. 1 is the preparation flow schematic diagram of slimming health food;
Fig. 2 is the In-vitro release curves of functional component L-carnitine in slimming health food finished product S4, C2, C3, C4.
Specific embodiment
Below with reference to embodiment, the present invention will be further described, but the present invention is not limited by the following examples.
The preparation of 1 slimming health food containing hyaluronic acid of embodiment
(1) by the powder of L-carnitine 15g, 10 g of tea polyphenols, 5 g of vitamin, 5 g of glucosamine salt, 10 g of collagen 400 meshes are crossed respectively to be uniformly mixed, and obtain powder I;By 10 g of Teng's Huang berry extract, 10 g of Lotus Leafextract, 10 g of dietary fiber Powder sieve with 100 mesh sieve respectively uniformly mixed, obtain powder II;
(2) powder I is uniformly mixed with powder II, 10g water is added, stirs evenly;Chondroitin sulfate 10g is added, stirring is equal It is even;It is eventually adding 5g dextrin, obtains dough object, 35 DEG C of 8 h of drying, 20 meshes excessively obtain solid particle I after granulation;
(3) 5g conjugated linoleic acid glyceride is smeared on the surface solid particle I, obtains contents particles;
(4) 5g purified water will be added in 5g Sodium Hyaluronate (1000 KDa:800 KDa=20:1), obtains gel;By content Grain is added in hyaluronic acid sodium gel, stirs evenly;Then granulation, 25 DEG C of 20 h of drying, 10 meshes excessively obtain solid particle II;
(5) by solid particle II cyclonic separation, core-shell structure particles are obtained, slimming health food finished product S1 is obtained after polishing.
The preparation of 2 slimming health food containing hyaluronic acid of embodiment
(1) by the powder of L-carnitine 5g, 5 g of tea polyphenols, 3 g of vitamin, 10 g of glucosamine salt, 10 g of collagen point 200 meshes are not crossed to be uniformly mixed, and obtain powder I;By the powder of 10 g of Teng's Huang berry extract, 10 g of Lotus Leafextract, 7 g of dietary fiber End is crossed 200 meshes respectively and is uniformly mixed, and powder II is obtained;
(2) powder I is uniformly mixed with powder II, 10g water is added, stirs evenly;Chondroitin sulfate 5g is added, stirring is equal It is even;It is eventually adding 5g dextrin, obtains dough object, 65 DEG C of 2 h of drying, 15 meshes excessively obtain solid particle I after granulation;
(3) 10g conjugated linoleic acid glyceride is smeared on the surface solid particle I, obtains contents particles;
(4) 200g purified water will be added in 20g Sodium Hyaluronate (3000 KDa:1 KDa=1:20), obtains gel;By content Grain is added in hyaluronic acid sodium gel, stirs evenly;Then granulation, 35 DEG C of 15 h of drying, 5 meshes excessively obtain solid particle II;
(5) by solid particle II cyclonic separation, core-shell structure particles are obtained, slimming health food finished product S2 is obtained after polishing.
The preparation of 3 slimming health food containing hyaluronic acid of embodiment
(1) by the powder of L-carnitine 10g, 10 g of tea polyphenols, 1 g of vitamin, 6 g of glucosamine salt, 5 g of collagen point It does not sieve with 100 mesh sieve uniformly mixed, obtains powder I;By the powder of Teng's Huang berry extract 20g, 15 g of Lotus Leafextract, dietary fiber 13g End sieves with 100 mesh sieve uniformly mixed respectively, obtains powder II;
(2) powder I is uniformly mixed with powder II, 12g water is added, stirs evenly;Chondroitin sulfate 5g is added, stirring is equal It is even;It is eventually adding 5g dextrin, obtains dough object, 55 DEG C of 3 h of drying, 15 meshes excessively obtain solid particle I after granulation;
(3) 5g conjugated linoleic acid glyceride is smeared on the surface solid particle I, obtains contents particles;
(4) 250g purified water will be added in 5g Sodium Hyaluronate (2000 KDa:500KDa=15:1), obtains gel;By content Grain is added in hyaluronic acid sodium gel, stirs evenly;Then granulation, 55 DEG C of 5 h of drying, 10 meshes excessively obtain solid particle II;
(5) by solid particle II cyclonic separation, core-shell structure particles are obtained, slimming health food finished product S3 is obtained after polishing.
The preparation of 4 slimming health food containing hyaluronic acid of embodiment
(1) powder of L-carnitine 8g, 10 g of tea polyphenols, 2 g of vitamin, glucosamine salt 8g, 8 g of collagen are distinguished It crosses 300 meshes to be uniformly mixed, obtains powder I;By the powder of 18 g of Teng's Huang berry extract, 18 g of Lotus Leafextract, 12 g of dietary fiber End sieves with 100 mesh sieve uniformly mixed respectively, obtains powder II;
(2) powder I is uniformly mixed with powder II, 15g water is added, stirs evenly;2 g of chondroitin sulfate is added, stirring is equal It is even;6 g dextrin are eventually adding, dough object is obtained, 48 DEG C of 5 h of drying, 10 meshes excessively obtain solid particle I after granulation;
(3) 4g conjugated linoleic acid glyceride is smeared on the surface solid particle I, obtains contents particles;
(4) 30 g purified waters will be added in 3g Sodium Hyaluronate (1800 KDa:200 KDa=10:1), obtains gel;By content Particle is added in hyaluronic acid sodium gel, stirs evenly;Then granulation, 40 DEG C of 10 h of drying, 4 meshes excessively obtain solid particle II;
(5) by solid particle II cyclonic separation, core-shell structure particles are obtained, slimming health food finished product S4 is obtained after polishing.
The preparation of 1 slimming health food of comparative example
Contents particles are prepared with raw material weight according to step (1)-(3) in embodiment 4, as control sample C1;
According in embodiment 4 method and raw material weight prepare slimming health food finished product, difference be using only molecular weight The Sodium Hyaluronate of 1800 KDa, as control sample C2;
According in embodiment 4 method and raw material weight prepare slimming health food finished product, difference be using only molecular weight The Sodium Hyaluronate of 200 KDa, as control sample C3.
The preparation of 2 slimming health food of comparative example
(1) L-carnitine 8g, 10 g of tea polyphenols, 2 g of vitamin, glucosamine salt 8g, collagen 8 g, Teng Huangguo are mentioned Take 18 g of object, 18 g of Lotus Leafextract, 12 g of dietary fiber, 2 g of chondroitin sulfate, 6 g of dextrin, Sodium Hyaluronate (1800 KDa:200 KDa=10:1) 3g is uniformly mixed, 15g water is added, obtains dough object, and 40 DEG C of 10 h of drying after granulation, 4 meshes of mistake obtain To solid particle;
(2) solid particles surface is smeared into 4g conjugated linoleic acid glyceride, obtains slimming health food finished product C4.
5 slow release effect of embodiment
The experiment of health food finished product release in vitro L-carnitine, according to " Chinese Pharmacopoeia " (2015 editions), the measurement release of 0931 method Degree.Preceding 2h is with the HCl(simulate the gastric juice of the pH value 1.2 of 150mL) it is dissolution medium, the sodium phosphate of 50mL0.2M is added in 2h Solution makes solution ph be converted to 6.8(simulated intestinal fluid), temperature is 37 ± 0.5 DEG C, and revolving speed 50r/min is operated according to methods, and is being opened Begin after release 0.5,1,2,4,6,8,12 and timing sampling for 24 hours.Sample volume is 1mL, is supplemented in time into stripping rotor after sampling The fresh dissolution medium of equivalent equality of temperature.According to the content of the method detection L-carnitine of GB 29989-2013, with ultraviolet spectrometry light The absorbance for spending instrument measurement 412nm, calculates total release percentage, and it is as shown in Figure 2 to draw release profiles.As shown in Figure 2, C4 without Sustained release envelope, L-carnitine rate of release are most fast always.Test initial stage, since C2 sustained release envelope is polymer hyaluronic acid sodium (molecular weight is 1800 KDa) molecular gap is big, and L-carnitine rate of release is only slower than C4;C3 sustained release envelope is that low molecule is transparent Matter acid sodium (molecular weight is 200 KDa) molecular gap is minimum, and L-carnitine rate of release is most slow;S4 sustained release envelope has high and low point Sub- Sodium Hyaluronate mixing composition, molecular gap are between C2 and C3, and L-carnitine rate of release is also between C2 and C3. But Sodium Hyaluronate is easy to be degraded, and the lower degradation speed of molecular weight is faster, so C3 L-carnitine is released after about 2 hours Speed is put more than C2, and S4 L-carnitine rate of release becomes most slow after this.
The verifying of 6 weight losing function of embodiment
1 materials and methods
1.1 sample
By control sample C1, the control sample C4 in comparative example 2 in the sample S4 obtained in embodiment 4 and comparative example 1 and not Placebo containing any functional component carries out the test of safety and weight losing function, and human oral's recommended dose is 2 times a day, often Secondary 2.
1.2 study subject
Subject's male or female, Simple Obesity, by physical examination, without dysfunctions such as the obvious heart, liver, gallbladder, kidneys;
1.2.1 subject's selection criteria: adult BMI >=30, or total fat percentage reach male > 25%, female > 30% it is voluntary by Examination person;
1.2.2 exclusion criteria
1.2.2.1 merge intentionally, liver, gallbladder, the serious diseases such as kidney and hemopoietic system, mental patient;
1.2.2.2 article related with tested function is taken in a short time, influences the judgement person to result;
1.2.2.3 not by edible tested material is provided, can not determining effect or data, umbra does not ring effect and safety judgement person.
1.3 test method
The standard of being included in will be met and guarantee 208 volunteers of compatibility test, is randomly divided into S4, C1, C4, blank control group (placebo).Each tested group is taken sample by recommended dose, and continuous 60 days.Original eating habit is not changed during test, just Normal diet daily after complete second of tested material half an hour, uses treadmill with identical speed running 50min.
1.4 key instrument
Sebum thickness measurer, body composition analysis instrument, treadmill, Corneometer CM825 moisture of skin tester: Germany Courage-Khazaka company, MPA580 skin elasticity analyzer: German Courage-Khazaka company.
2 observation index: indices are in test-meal on-test and terminate each survey once.
2.1 safety observations
2.1.1 ordinary circumstance: spirit, sleep, diet, stool and urine, blood pressure, heart rate etc.;
2.1.2 Blood routine examination: red blood cell count(RBC), hemoglobin, white blood cell count(WBC);
2.1.3 routine urinalysis (including urine ketone bodies) and stool routine examination;
2.1.4 Biochemical Indexes: albumin (ALB), total protein (TP), glutamic-oxalacetic transaminease (AST), glutamic-pyruvic transaminase (ALT), Urea nitrogen (BUN), creatinine (Cr), uric acid (UA), blood glucose (GLU), triglycerides (TG), total cholesterol (CHOL);
2.1.5 other adverse reaction observations.
2.2 effect of weight reducing indexs
2.2.1 weight: emptying stool and urine, take off one's shoes before measurement, wears same clothes in same weight when body weight determination before and after test-meal Scale measurement;
2.2.2 bioelectrical impedance analysis: measurement human body body fat rate;
2.2.3 stratum corneum lipids measure: measurement site: mid-point on the outside of right deltoid muscle lower edge arm, right angulus inferior scapulae, 3cm by right navel, Right volume Ant sup;
2.2.4 girth diameter measures:
2.2.4.1 waistline: the abdomen perimeter of flat navel;
2.2.4.2 hip circumference: the perimeter with two sides greater trochanter of femur level;
2.2.5 analysis of experimental data: front and back difference is taken in calculating, carries out single factor test variance using Duncan method with SPSS software and divides Analysis.
2.3 lubricating joint efficiency indexes
2.3.1 knee joint rest pain: normal 0 point;Mild pain does not influence work 1 and divides;Compared with severe pain, rest 2 is not influenced Point;Severe pain influences 3 points of sleep;
2.3.2 motion of knee joint pain: normal 0 point;It is upper downstairs to have symptom, bend and stretch no influence 1 and divide;Above downstairs there is symptom, squatting down has Influence 2 points;Pain 3 is divided when walking;
2.3.3 tenderness: normal 0 point;Pain 1 is divided when weight;Pain 2 is divided when moderate is pressed;Pain 3 is divided when slight pressure;
2.3.4 swelling: normal 0 point;Slightly swollen, Xiyan understands 1 point;Soft tissue swelling, Xiyan do not know 2 points;Xiyan does not know 3 Point;
2.3.5 morning stiffness: normal 0 point;Bend and stretch stiff but 1 point of (< 10min) recovery quickly;It is stiff, the time is short (10min-20min) It can restore 2 points;The stiff, long period (> 20min) restores 3 points;
2.3.6 knee joint bending: knee joint can be 0-120 ° 0 point of normal activity;Knee joint bending is up to 90-119 ° 1 point;Knee joint Bending only reaches 20-89 ° 2 points;20 ° 3 points of knee joint bending degree <;
2.3.7 walking ability: there is no limit 0 point for maximum walking distance;Maximum walking distance is more than 1000m, but is restricted 1 point; Maximum walking distance is more than 800m, less than 1000m, is restricted 2 points;Maximum walking distance is more than 500m, less than 800m, is restricted 3 points;Maximum walking distance is more than 300m, less than 500m, is restricted 4 points;Maximum walking distance is more than 100m, less than 300m, by 5 points of limitation;Maximum walking distance is more than 100m, is restricted 6 points;
2.3.8 statistical analysis: carrying out t- inspection using SPSS software, carries out one-way analysis of variance with Duncan method.
2.4 reduce cutis laxa efficiency index
2.4.1 skin moisture content measures: forehead glabella skin;
2.4.1.1 functional attributes
Skin moisture content measurement, measurement site are forehead glabella skin.All subjects enter test wrapper in 30 minutes before survey It is quiet to be measured in border.Distilled water is dipped in cleaning cotton balls under rest state and cleans tested position, is dried rear 15min and is carried out moisture Measurement, the measurement work of test front and back are operated by same instrument, the same person, control 22 DEG C of room temperature, humidity 40%-50%;
2.4.2 skin elasticity measures:
2.4.2.1 testing procedure
Interregional every 2cm on subject, belly, the measurement of same subject is completed by the same survey crew.Wherein, R2 is Thick elasticity, R5 are net elasticity, and R7 is bioelastic, and elasticity indexes show that skin elasticity is better closer to 1.
2.4.3 statistical method
One-way analysis of variance is carried out with SPSS software using Duncan method.
3 results
3.1 ordinary circumstance
Initial trial crowd blank control group 52, male/female number ratio are 14/38, and the age is 35.12 ± 10.38 years old;C1 group 52, male/female number ratio is 14/38, and the age is 35.46 ± 10.28 years old;C4 group 52, male/female number ratio is 14/38, Age is 36.34 ± 10.62 years old;S4 group 52, male/female number ratio is 14/38, and the age is 35.72 ± 10.42 years old.
Test-meal test front and back, subject's spirit, sleep, diet, stool and urine situation no abnormality seen.
3.2 safety observations Indexs measures
3.2.1 blood pressure, heart rate, routine urinalysis, stool routine examination, blood routine and Biochemical Indexes: it the results are shown in Table 1.It can by table 1 See, test-meal front and back indices are in the normal range.
Subject's Indexs measure result (x ± s) before and after 1 test-meal of table
3.2.2 other obvious adverse reactions are had no during test-meal.
3.3 effect of weight reducing observation index
3.3.1 weight, body fat total amount and fat percentage measurement
Weight, body fat total amount, fat percentage difference (x ± s) before and after 2 test-meal of table
Note: same column difference letter represents the horizontal upper significant difference of p=0.05 in table.
From the data in table 2, it can be seen that blank control group three weight, total amount of body fat and Rate of body lipid indexs before and after the test It is almost unchanged;Compared with blank control group, C1, C4 and S4 group have significant decrease;With the C1 group phase for not adding hyaluronic acid Than each index of C4 and S4 group has significant decrease;And S4 group significant effect is best better than C4.This illustrates, before same amount of exercise It puts, product fat-reducing effect is more preferable after the hyaluronic acid of same effective component addition different molecular weight;Using side of the invention The product effect of method preparation prepares the fat-reducing effect of product better than conventional mixing method.
3.3.2 subcutaneous fat thickness measuring
Subcutaneous fat thickness difference (x ± s) before and after 3 test-meal of table
Note: same column difference letter represents the horizontal upper significant difference of p=0.05 in table.
By 3 numerical value of table it is found that blank control group 4 fat thickness before and after experiment are almost unchanged;With blank control group It compares, C1, C4 and S4 group have significant decrease;Compared with the C1 group for not adding hyaluronic acid, each index of S4 group has significant drop It is low;Compared with the products C 4 being routinely mixed with, each index of S4 group has significant decrease.This explanation, identical effective component add Add hyaluronic acid that fat thickness can be effectively reduced;It can using the product that product prepared by the method for the present invention is obtained than conventional method To significantly reduce fat thickness.
3.3.3 girth diameter measurement result
Girth diameter difference (x ± s) before and after 4 test-meal of table
Note: same column difference letter represents the horizontal upper significant difference of p=0.05 in table.
From the data in table 4, it can be seen that blank control group waistline and hip circumference before experiment is almost unchanged;With blank control group phase Than C1, C4 and S4 group have significant decrease;Compared with the C1 group for not adding hyaluronic acid, C4 group and each index of S4 group have aobvious Writing reduces;Compared with the products C 4 being routinely mixed with, each index of S4 group has significant decrease.This explanation, it is identical effectively at Point, addition hyaluronic acid is more effective to reduction waistline and hip circumference;Using the product of the method for the present invention preparation to waistline and hip circumference Reduce more effective.
By every effect of weight reducing observation index (weight, body fat total amount and fat percentage measurement;Subcutaneous fat depth Degree measurement;Girth diameter measurement) measurement result it is found that C1, C4 and S4 group slimming health food cooperate moderate exercise have effect of weight reducing, But S4 group effect of weight reducing is most significant, and C4 group fat-reducing effect takes second place, and C1 group fat-reducing effect is worst.Hyaluronic acid water swelling increases Satiety can make subject take in less food.In addition, S4 group, which is hyaluronic acid as shell, wraps up other functional components, Low-molecular-weight hyaluronic acid salt is gradually absorbed or degrades in stomach, and functional component is not easy the destruction that is decomposed, into enteron aisle after this A little functional components play effect of weight reducing through hyaluronic acid macromolecular network structure, and hyaluronic acid shell slows down functional component Rate of release extends the action time of functional component, increases the utilization rate of functional component.Hyaluronic acid and other in C4 group Ingredient is blended, and hyaluronic acid only plays the role of full abdomen herein, so fat-reducing effect is worse than S4 group.Without hyalomitome in C1 group Acid, no satiety is also without sustained release envelope, so fat-reducing effect is worst.
3.4 lubricating joint efficiency indexes
5 lubricating joint efficacy outcomes (x ± s) of table
Note: different lowercases are represented with the horizontal upper significant difference of column data p=0.05 in table;Different capitalizations represent in table The horizontal upper significant difference of the data p=0.05 that goes together.
Result is observed by 5 lubricating joint efficiency index of table it is found that the symptom integral before the test of each experimental group is without significance difference It is different;And there is significant joint injury exacerbation in blank control group after testing;S4 group significantly improves joint lubrication state.C1 group Slimming health food cooperation moderate exercise is lost weight, and movable joint damage is serious.Compared with blank control, the weight-reducing of C4 and S4 group Health food cooperation moderate exercise is lost weight, and not only without damage movable joint, protects movable joint instead, wherein S4 group subtracts Fertile health food Saving cortilage effect is more preferable.This is because hyaluronic acid has the effect of lubricating joint Saving cortilage, aminoglucose The effect of sugared hydrochloride, chondroitin sulfate nutritious joint Saving cortilage.Hyaluronic acid shell slows down aminoglucose in S4 group The rate of release of sugared hydrochloride and chondroitin sulfate extends the action time of aminoglucose hydrochloride and chondroitin sulfate, The utilization rate of aminoglucose hydrochloride and chondroitin sulfate is increased, so closing in the weight loss procedures of cooperation moderate exercise Section is not damaged the undamaged portion before alleviating instead not only.Hyaluronic acid and other ingredients are blended in C4 group, no sustained release Shell, so, although joint is not impaired, alleviating journey to undamaged portion before in the weight loss procedures of cooperation moderate exercise It spends small.Without hyaluronic acid in C1 group, so joint injury is serious, but because there is amino in the weight loss procedures of cooperation moderate exercise Glucosamine salt hydrochlorate and chondroitin sulfate are so joint injury is slightly lighter than blank control group.
3.5 reduce cutis laxa efficiency index
6 moisture of skin of table and Resilience Results (x ± s)
Moisture difference R2 difference
Blank control group 0.08±0.02a -0.01±0.05a
C1 group -8.62±0.13b -0.13±0.04b
C4 group 3.49±0.11c 0.05±0.03a
S4 group 3.44±0.13c 0.15±0.03c
Note: same column difference letter represents the horizontal upper significant difference of p=0.05 in table.
From the data in table 6, it can be seen that blank control group has almost no change in skin moisture content and elasticity after 60 days;However, C1 group skin moisture content and elastic conspicuousness decline, illustrate to take C1 group slimming health food for a long time and cooperate moderate exercise, Moisture of skin is substantially reduced while cutting fat, it may appear that phenomena such as having dry skin, be dark yellow, matt, simultaneously because weight It reduces and serious cutis laxa phenomenon occurs.Compared with blank control, C4 group and S4 group significantly increase moisture content of skin, explanation It takes C4 and S4 group slimming health food for a long time and cooperates moderate exercise, moisture of skin obviously increases while cutting fat, meeting There is phenomena such as skin water profit, smooth.Compared with blank control, C4 group does not significantly improve skin elasticity, and S4 group significantly increases Strong skin elasticity, illustrates that skin elasticity can be significantly improved by taking S4 for a long time, is not in common since quick weight-lossing is brought Cutis laxa phenomenon.
From the above results, it takes S4 group slimming health food for a long time and cooperates moderate exercise, while cutting fat Moisture of skin obviously increases, it may appear that phenomena such as skin water moistens, is smooth, while skin elasticity can be significantly improved again, be not in Common quick weight-lossing bring cutis laxa phenomenon.This is because collagen is improved the effect of skin elasticity, in S4 group Hyaluronic acid shell slows down the rate of release of collagen, extends the action time of collagen, increases collagen Utilization rate, so in weight loss procedures, not only no relaxation is not more flexible instead for skin.Hyaluronic acid and other ingredients in C4 group It is blended, no sustained release envelope, so, although skin does not relax, skin elasticity increase rate is little in weight loss procedures.C1 Without hyaluronic acid, no sustained release envelope in group, so collagen utilization rate is low, and cutis laxa is obvious in weight loss procedures.

Claims (10)

1. a kind of slimming health food containing hyaluronic acid, which is characterized in that it is formed by hyaluronate shell contents of parcel object, Raw material including following parts by weight is made:
L-carnitine 5-20, Teng's Huang berry extract 10-30, Lotus Leafextract 5-30, tea polyphenols 1-20, vitamin 0.1-10, meals Eat fiber 1-30, dextrin 0.1-20, chondroitin sulfate 0.1-20, glucosamine salt 0.1-20, collagen 0.1-20, conjugation Linoleic acid or its ester 0.1-20, hyaluronate 0.1-30.
2. slimming health food according to claim 1, which is characterized in that the hyaluronate is macromolecule hyalomitome The combination of hydrochlorate and low molecular weight hyaluronic acid salt;The molecular weight of the high molecular weight hyaluronic acid salt is 1000KDa-3000 KDa, the molecular weight of low-molecular-weight hyaluronic acid salt are 1KDa-800 KDa;
The mass ratio of the high molecular weight hyaluronic acid salt and low-molecular-weight hyaluronic acid salt is 20:1-1:20;Preferably 15:1- 1:15;More preferably 10:1.
3. slimming health food according to claim 1, which is characterized in that the hyaluronate be selected from sodium salt, sylvite, Zinc salt, magnesium salts or calcium salt.
4. slimming health food according to claim 1 to 3, which is characterized in that the raw material system including following parts by weight At: L-carnitine 5-15, Teng's Huang berry extract 10-20, Lotus Leafextract 10-20, tea polyphenols 5-15, vitamin 0.5-5, diet Fiber 5-25, dextrin 1-15, chondroitin sulfate 1-5, glucosamine salt 1-15, collagen 1-15, conjugated linoleic acid or its Ester 1-15, hyaluronate 1-25.
5. slimming health food according to claim 1 to 3, which is characterized in that by the raw material system of following parts by weight At: L-carnitine 5-10, Teng's Huang berry extract 10-20, Lotus Leafextract 10-15, tea polyphenols 5-10, vitamin 0.5-5, diet Fiber 10-20, dextrin 5-10, chondroitin sulfate 1-5, glucosamine salt 5-10, collagen 5-10, conjugated linoleic acid or its Ester 1-5, hyaluronate 1-5.
6. a kind of preparation method of slimming health food a method as claimed in any one of claims 1 to 5, which is characterized in that including following step It is rapid:
(1) powder of L-carnitine, tea polyphenols, vitamin, glucosamine salt, collagen is uniformly mixed, be sieved to obtain powder Last I;The powder of Teng's Huang berry extract, Lotus Leafextract, dietary fiber is uniformly mixed, be sieved to obtain powder II;
(2) powder I is uniformly mixed with powder II, suitable quantity of water is added, stirs evenly;Chondroitin sulfate is added, is stirred evenly; It is eventually adding dextrin, obtains dough object, dry after granulation, sieving obtains solid particle I;
(3) conjugated linoleic acid or its ester are smeared into the surface solid particle I, obtains contents particles;
(4) contents particles are added in hyaluronate gel, are stirred evenly;Then it pelletizes, is dry, sieving obtains solid Grain II;
(5) by solid particle II cyclonic separation, slimming health food finished product is obtained.
7. preparation method according to claim 6, which is characterized in that in step (2), the weight ratio of all raw materials and water is 1:1-10:1;Preferably 1:1-8:1;Most preferably 6:1;
In step (4), in the hyaluronate gel, the weight ratio of hyaluronate and water is 1:1-1:100;It is preferred that 1:5- 1:50, most preferably 1:10.
8. preparation method according to claim 6, which is characterized in that in step (2), the drying temperature is 35-65 DEG C; Drying time is 2-8h;
In step (4), drying temperature is 25-65 DEG C;Drying time is 1-20h.
9. preparation method according to claim 6, which is characterized in that in step (1), the fineness of the powder is 100- 400 mesh;
In step (2), the partial size of the solid particle I is 10-20 mesh;
In step (5), the partial size of the core-shell structure particles is 1-10 mesh.
10. preparation method according to claim 6, which is characterized in that step further includes throwing core-shell structure particles in (5) The process of light.
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