CN1097601A - The medicine and the preparation technology thereof of treatment tinea pedis - Google Patents

Abstract

A kind of medicine and preparation technology thereof who treats tinea pedis is main component with propolis, Lac regis apis, Venenum apis, is equipped with compositions such as ketoconazole, Alumen, salicylic acid again.This medicine has safety non-toxic, nonirritant, inhibition tinea bacteria growing, anti-inflammatory anti-itch analgesia, promotes the histiocyte regeneration function, dermatophytes is had extremely strong killing action.Its preparation technology is simple, cheap, easy to use, formulation rate is little, is suitable for all tinea pedis patients and uses, and special efficacy is arranged.

Description

The medicine and the preparation technology thereof of treatment tinea pedis

The present invention relates to a kind of medicine and preparation technology thereof who treats tinea pedis, belong to medicine and make the field.

Tinea pedis (being commonly called as beriberi, tinea pedis) is that crowd's sickness rate in a kind of sickness rate very high multiple cutaneous disease, especially underground labour, the soldier of army, athlete, ironworker, southern vast town and country, subtropical zone, the torrid zone is more concentrated and the residence is high.Add the cross infection of common plunge bath, public slippers etc., cause the people of 60-70% to suffer from this disease.Pruritus is scratched water blood Tianjin stream behind the skin unbearably if then moist erosion in affected part of bacterial infection, toe edema, the dense blood and slime of outflow and frowziness are arranged between ill initial stage toe.This is sick brings very big influence for life, work and study of patient, must hospitalization when serious, but do not have special-effect.China's traditional medicine thinks that these cause of disease taste two form or occupy for a long time wetland or water slurry dipping through damp invasion of lower energizer, and noxious dampness is contaminated due to the skin.Doctor trained in Western medicine is then thought to be caused by fungal infection.Drug therapys such as at present clinical " JIAOXIAN YICIJING " " zinci undecylenatis compositum " commonly used, " Compound Flavescent Sophora and Salicylic Acid Powder ", " daktarin ", " beriberi paste ", " Cortex Pseudolaricis tincture ", though can be temporarily antipruritic, slow down symptom, large usage quantity also has recurrence in a short time.Some medicine is bigger as zests such as " Cortex Pseudolaricis tincture ", " JIAOXIAN YICIJING " in addition, and pain is brought very big misery to the patient unbearably during use.Also do not see this sick specific medicament of treatment up to now.

Purpose of the present invention is exactly that a kind of consumption is less, price is lower and provide at the deficiency in the above-mentioned background technology, can suppress fungal infection, the medicine and the preparation technology thereof of anti-inflammation, antipruritic deodorant treatment tinea pedis.

The technical solution that realizes the object of the invention is such: contain propolis 2.5-5.0 gram, Lac regis apis 0.8-3.0 gram, ketoconazole 0.8-3.0 gram, benzoic acid 3.0-7.0 gram, boric acid 10.0-19.0 gram, Alumen 10.0-19.0 gram, tannic acid 10.0-19.0 gram, sodium chloride 15.0-27.0 gram, salicylic acid 15.0-27.0 gram, Venenum apis 0.001-0.005 gram in the medicine of the present invention.Its preparation technology be by consumption with propolis in-8 ℃-0 ℃ temperature after freezing 5-16 hour levigation cross 120 mesh sieves, add ketoconazole, benzoic acid, boric acid, Alumen, tannic acid, sodium chloride, the mixing of salicylic acid levigation more according to quantity, add the even encapsulation of lyophilizing royal jelly and Venenum apis fine powder grinding again and get final product.

Below in conjunction with embodiment the present invention is done an explanation.

At first with the propolis of 2.5-5.0 gram under-8 ℃-0 ℃ temperature freezing 7-12 hour, grind and cross 120 mesh sieves after making it crisp firmly, again the salicylic acid fine powder of the sodium chloride of the tannic acid of the Alumen of the boric acid of the benzoic acid of the ketoconazole of 0.9-2.8 gram, 3.2-6.7 gram, 10.5-18.0 gram, 10.5-18.0 gram, 10.5-18.0 gram, 15.2-25.0 gram, 15.5-25.0 gram is added and mix, add in above mixed powder again that lyophilizing royal jelly 0.8-3.0 gram and Venenum apis 0.001-0.005 restrain, encapsulate behind the fine powder mix homogeneously and get final product.

The effect of contained each composition in this medicine:

Propolis: contain flavone, flavonol, flavanone, Quercetin, cinnamic acid, cinnamyl alcohol, vanillin, caffeic acid and 5-hydroxyl 2-7-dimethoxy flavone, 5-7-dihydroxy-2,4-dimethoxy flavone and ferulic acid etc.Propolis has antibacterial, fungus, virus and suppresses and killing action, can also antiinflammatory, analgesia, antipruritic, promote tissue regeneration.

Lac regis apis: contain 10-hydroxyl decanoic acid (having another name called Royal Jelly acid) and active polypeptide etc.Lac regis apis has the growth promoter of promotion and rejuvenation effect, and old and feeble and impaired histiocyte is replaced by new cell, makes cell function normalization.

Benzoic acid, boric acid, salicylic acid, tannic acid: anti-tinea bacterium is all arranged, suppress the effect of its growth, but and horny layer softening confluent monolayer cells.

Sodium chloride: can anticorrosion antiinflammatory.

Alumen: have astringent therapy, bacteriostasis.

Ketoconazole: can suppress the tinea bacteria growing, treatment dermatophytes sexuality is dyed.

Venenum apis: can make local anesthesia, and can increase antibody.

Every experimental result that medicine of the present invention carries out through the Traditional Chinese Medicine Research Institute, Shanxi Province is as follows:

One, acute toxicity testing: stomach is irritated by 0.2 milliliter/20 grams (be equivalent to be grown up dosage 100 times) in each 10 fasting (can't help water) of ICR strain white mice male and female of getting 18-22 gram back of spending the night, and observes all no abnormal reaction in 7 days.Through all no abnormal discoveries of important organ such as the anatomic observation heart, liver, spleen, lung, kidneys.

Two, pharmacodynamic experiment:

1, experimental technique stimulates and allergic experiment with the Mus skin of back routinely, and this medicine does not cause skin erythema, edema, does not cause skin erosion.Carry out also non-toxic reaction of skin acute toxicity testing with rabbit.

2, the damaged skin after the wound (operation cut) is had no stimulation, and the effect of rapid hemostasis, promotion skin healing is arranged.

3, adhere to this medicine and stick on the culture dish of the various antibacterials of inoculation and cultivated 24 hours with soaking the scraps of paper, conclusion is can suppress from the effect of the isolated white epidermis trichophyton of tinea pedis patient skin.

4, experimental results show that with white mice acetic acid twisting method this medicine has significant analgesic activity.

158 examples are observed in clinical practice altogether, and obvious effective rate is 98%, and recovery from illness rapidly after the medication does not have recurrence in 1 year.Show as antipruritic, pain relieving, only ooze out, the very fast healing of damaged skin, the disease of casting off a skin in the week takes a turn for the better, recovery from illness.Clean both feet before the patient sleeps, this drug powder is coated with touches in the affected part.The lighter's medication 1 gram, weight person's medication 2-4 gram can be fully recovered.

The present invention is Main Ingredients and Appearance owing to having adopted honeybee series of products such as propolis, royal jelly and bee venom, be equipped with again the medicines such as ketoconazole, alum, salicylic acid, have safety non-toxic, nonirritant, inhibition tinea bacteria growing, anticorrosion anti-inflammatory, deodorizing, relieving iching by astringing analgesia, promote the histocyte regeneration function, dermatophyte is had extremely strong killing action. This pharmaceutical preparation is simple, cheap, formulation rate is few, easy to use, be suitable for all tinea pedis disease patients effect, and special curative effect arranged.

Claims (3)

1, a kind of medicine for the treatment of tinea pedis, comprising benzoic acid, salicylic acid, the invention is characterized in and contain propolis 2.5-5.0 gram, Lac regis apis 0.8-3.0 gram, ketoconazole 0.8-3.0 gram, benzoic acid 3.0-7.0 gram, boric acid 10.0-19.0 gram, Alumen 10.0-19.0 gram, tannic acid 10.0-19.0 gram, sodium chloride 15.0-27.0 gram, salicylic acid 15.0-27.0 gram, Venenum apis 0.001-0.005 gram in this medicine.

2, medicine according to claim 1 is characterized in that described propolis is the lyophilizing propolis; Lac regis apis is a frozen dry roral jelly.

3, a kind of technology for preparing the medicine for the treatment of tinea pedis, comprise mixing, levigation operation, it is characterized in that propolis with 2.5-5.0 gram in-8 ℃-0 ℃ temperature after freezing 5-16 hour levigation cross 120 mesh sieves, add ketoconazole 0.8-3.0 gram, benzoic acid 3.0-7.0 gram, boric acid 10.0-19.0 gram, Alumen 10.0-19.0 gram, tannic acid 10.0-19.0 gram, sodium chloride 15.0-27.0 gram, salicylic acid 15.0-27.0 gram levigation again and mix, add frozen dry roral jelly 0.8-3.0 gram at last and Venenum apis 0.001-0.005 gram fine powder grinds even.