CN109731016A - A kind of Chinese medicine composition for treating breast cancer and preparation method thereof and drug - Google Patents
A kind of Chinese medicine composition for treating breast cancer and preparation method thereof and drug Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating breast cancer and preparation method thereof and drugs；Being intended to provide one kind has effects that nourishing and fit keeping function, promotes longevity, strengthens the body resistance to consolidate the constitution; can be enhanced patient with breast cancer's body immunity, mitigate chemotherapeutics side effect, improve patient quality of life composition; technical points include 15-25 parts of mulberry tree Phellinus; 5-15 parts of east keyhole bacterium; 15-25 parts of ganoderma capense; 15-25 parts of pine needles; 15-25 parts, 15-25 parts of rainbow conk, 15-25 parts of tinder fungus of the white soul sesame in Tibet; 15-25 parts of red sesame; 5-15 parts of Poria cocos, 5-15 parts of Lasiosphaera fenzlii, 5-15 parts of sulfur bacteria; bitter white hoof 5-15 parts, 5-15 parts of ganoderma lipsiense；Belong to pharmaceutical technology field.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions, specifically, be a kind of Chinese medicine composition for treating treatment breast cancer, this
Invention further relates to the preparation method of the Chinese medicine composition, belongs to pharmaceutical technology field.
Background technique
Breast cancer is common one of the malignant tumour of women, and disease incidence is rising year by year, and the trend with rejuvenation.
Since the cause of disease is unclear and the state of an illness is swift and violent, clinical treatment mode mainly cuts off adjuvant chemotherapy, but postoperative and outcome using operation
Still poor, the mean survival time (MST) of patient, is lower than 2.5 years.Chemotherapeutics adverse reaction is heavier, and is easy to produce drug resistance, thus
Drug effect is reduced, the life cycle of patient is reduced, even results in treatment failure.
And traditional Chinese medicine is instructed by the experience accumulation of more than one thousand years and modern study, in the existence matter for improving patient with breast cancer
Amount mitigates the toxic side effect of Radiotherapy chemotherapy, adjusts immune function, inhibits tumour growth, prevents from recurring, and the band tumor for extending patient is raw
Depositing phase etc. has apparent advantage, is increasingly subject to the concern and attention of domestic and international tumour circle.
Since Chinese medicine compound prescription dosage is big, decoction process is more troublesome and time-consuming, and people, which are often busy with work, cannot be considered in terms of,
This takes Chinese medicine to people and brings very big puzzlement.
Summary of the invention
In view of the above-mentioned problems, the first purpose of the invention is to provide a kind of nourishing and fit keeping function, promoting longevity, strengthening the body resistance to consolidate the constitution
Effect, the immunity that patient with breast cancer's body can be enhanced, the side effect for mitigating chemotherapeutics, the quality of life for improving patient
Deng, and the composition having no adverse reaction.
A second object of the present invention is to provide a kind of preparation methods containing above-mentioned composition.
Third object of the present invention is to provide containing the above-mentioned drug containing above-mentioned composition.
To solve first technical problem, first technical solution provided by the invention is such that
A kind of Chinese medicine composition for treating breast cancer, is made of the bulk pharmaceutical chemicals of following weight parts: 15-25 parts of mulberry tree Phellinus,
5-15 parts of east keyhole bacterium, 15-25 parts of ganoderma capense, 15-25 parts of pine needles, 15-25 parts of the white soul sesame in Tibet, rainbow conk 15-
25 parts, 15-25 parts of tinder fungus, 15-25 parts of red sesame, 5-15 parts of Poria cocos, 5-15 parts of Lasiosphaera fenzlii, 5-15 parts of sulfur bacteria, bitter white hoof
5-15 parts, 5-15 parts of ganoderma lipsiense.
Further, above-mentioned a kind of Chinese medicine composition for treating breast cancer, is made of: mulberry the bulk pharmaceutical chemicals of following weight parts
Phellinus 18-22 parts of tree, 7-12 parts of Dong Fangshuankong bacterium, 18-22 parts of ganoderma capense, 18-22 parts of pine needles, the white soul sesame in Tibet
18-22 parts, 18-22 parts of rainbow conk, 18-22 parts of tinder fungus, 18-22 parts of red sesame, 9-12 parts of Poria cocos, 9-12 parts of Lasiosphaera fenzlii, Sulfur
9-12 parts of bacterium, bitter white hoof 9-12 parts, 9-12 parts of ganoderma lipsiense.
Further, above-mentioned a kind of Chinese medicine composition for treating breast cancer, is made: mulberry of the bulk pharmaceutical chemicals of following weight parts
15 parts of Phellinus of tree, 15 parts of Dong Fangshuankong bacterium, 15 parts of ganoderma capense, 25 parts of pine needles, 15 parts of the white soul sesame in Tibet, rainbow conk 25
Part, 15 parts of tinder fungus, 25 parts of red sesame, 5 parts of Poria cocos, 15 parts of Lasiosphaera fenzlii, 5 parts of sulfur bacteria, bitter white 15 parts of hoof, ganoderma lipsiense 5
Part.
Further, above-mentioned a kind of Chinese medicine composition for treating breast cancer, is made of: mulberry the bulk pharmaceutical chemicals of following weight parts
20 parts of Phellinus of tree, 10 parts of Dong Fangshuankong bacterium, 20 parts of ganoderma capense, 20 parts of pine needles, 20 parts of the white soul sesame in Tibet, rainbow conk 20
Part, 20 parts of tinder fungus, 20 parts of red sesame, 10 parts of Poria cocos, 10 parts of Lasiosphaera fenzlii, 10 parts of sulfur bacteria, bitter white 10 parts of hoof, ganoderma lipsiense
10 parts.
Further, above-mentioned a kind of Chinese medicine composition for treating breast cancer, is made of: mulberry the bulk pharmaceutical chemicals of following weight parts
25 parts of Phellinus of tree, 5 parts of Dong Fangshuankong bacterium, 25 parts of ganoderma capense, 15 parts of pine needles, 25 parts of the white soul sesame in Tibet, 15 parts of rainbow conk,
25 parts of tinder fungus, 15 parts of red sesame, 15 parts of Poria cocos, 5 parts of Lasiosphaera fenzlii, 15 parts of sulfur bacteria, bitter white 5 parts of hoof, 15 parts of ganoderma lipsiense.
Second technical solution provided by the invention is to treat the preparation method of the Chinese medicine composition of breast cancer:
(1) bulk pharmaceutical chemicals weight number described in accordance with the claim 1 weighs Chinese medicine, cleans；
(2) by each raw medicinal material, dry 5~10h is mixed, until moisture is about 6% by medicinal material at 50~65 DEG C respectively
It is ground into fine powder, it is spare after crossing 100~150 meshes.
(3) fine medicinal material powder is added in hopper, carries out 0.5~1.5h of ultramicro grinding using vacuum pneumatic breaking-wall cell machine,
Micro mist is collected after crossing 300 meshes.
Third technical solution provided by the invention is the drug of the Chinese medicine composition containing above-mentioned treatment breast cancer, described
Chinese medicine composition and customary adjuvant of the drug containing above-mentioned treatment breast cancer.
Further, the drug of above-mentioned a kind of Chinese medicine composition for treating breast cancer, the pharmaceutical dosage form are combination
The dosage form of object is tablet or capsule or granule.
The present invention provides each component:
Mulberry tree Phellinus: Phellinus is a kind of medicinal fungi for parasitizing mulberry tree, because having the function of unique anticancer etc.,
It is efficient in biology field for cancer recognized by the current world as the hot spot of domestic and international the world of medicine and health products trade research
Highest fungi.Traditional Chinese Medicine thinks, Phellinus is sweet flat, bitterly, returns liver, bladder meridian, have relieving the five internal organs, a surname's intestines gas, hemostasis,
The functions such as softening hard masses, toxin expelling rush down blood, leukorrhagia, amenorrhoea, splenasthenic diarrhea etc. for treating metrorrhagia, blood strangury, rectal prolapse.Modern pharmacological research
Show that Phellinus active constituent is mainly polysaccharide, terpene, flavonoids etc., have improve immunity, antifatigue, the anti-hardening of liver protection,
The effects of anticancer.Its antitumor mechanism is mainly cancer cell specific induction of apoptosis, and enhancing immune system promotes immune response, inhibits cell
Metabolism, and large dosage is for a long time using also without any side effects to human body, moreover it is possible to alleviate Radiotherapy chemotherapy side effect.
East keyhole bacterium: Dong Fangshuankong bacterium, alias east bolt bacterium, ash band bolt bacterium, white crane bacterium are subordinate to Basidiomycota, agaric
Guiding principle, Aphyllophorales, Polyporaceae, keyhole Pseudomonas.It is grown on broad leaf tree dry wood, rotten wood or sleeper, is distributed in from temperate zone
Into the various forest ecosystems in the torrid zone, China, Japan, India etc. are national to be distributed, China be distributed widely in Jilin,
The ground such as Jiangsu, Guangdong And Hainan.Pharmacological research show Dong Fangshuankong mushroom entity main active substances be mostly triterpene, protein,
Polysaccharide, amino acid etc. have the effects that antitumor, antibacterial, increase immunity, cure mainly cough phlegm asthma, pulmonary tuberculosis, fatigue synthesis
Sign, cancer etc..
Ganoderma capense: ganoderma capense is the mycelium of ganoderma lucidum subgenus fungi ganoderma capense, also known as Ganoderma capuse, Bao Zhi, is bracket fungus
Section Ganoderma fungi.The chemical component of ganoderma capense have polysaccharide, purine, pyrimidine, PEARLITOL 25C, alkaloid, agglutinin, protein,
Amino acid, fatty acid and mineral element abundant etc..Studies have shown that ganoderma capense extract has immunological regulation, antitumor, anti-ageing
Always, the activity of cardiovascular system, liver detoxification, calmness, hypoglycemic etc. is adjusted.Animal experiment study proves that ganoderma capense mentions
Taking object to have can significantly reduce mda content in mouse tissue and mitochondria, promote in the tissue such as red blood cell, liver, brain
The activity of the antioxidases such as SOD, glutathione mitigates hepatic lipid peroxidation degree, improves Membrane Fluidity, removes rouge
Fat is sour and generates antioxidation.
Pine needles: pine needles is the drying fructification of Polyporaceae Phellinus macro fungi, alias pine
Phellinus, loose whiterot fungi, Huang Zhi, pine needle Linzhi, Ganoderma applanatum etc., are distributed in the ground such as northeast, Hebei, Sichuan." legendary god of farming's book on Chinese herbal medicine
Through " once recorded: Huang Zhi, it is sweet in flavor, flat, evil trusted subordinate five is cured mainly, benefit temper, tranquilizing the mind, eats make light of one's life by commiting suicide long.Studies have shown that pine needles
Containing polysaccharide, phenols, terpene and polypeptide active substance, there are the function such as immunological regulation, anti-oxidant, antiviral and anti-fibrosis
Effect.Meanwhile pine needles also has the antitumaous effect for inhibiting kinds cancer cell to be grown on or shift, mechanism of action is logical
It crosses the Apoptosis of mitochondria mediation, the number of ways such as transfer is inhibited to realize, this inhibiting effect only has an impact to cancer cell.
The white soul sesame in Tibet: plain boiled pork ganoderma lucidum is also known as Ganoderma, Bai Xinling sesame, is that the son of On Polyporaceae ganoderma lucidum is real
Body.The so-called white soul sesame in Tibet is a kind of distinctive ganoderma lucidum new varieties for being grown in plateau band in fact, because its meat is snow-white
Color is well-known, and effect is significantly larger than Common ganoderma lucidum, and yield is extremely rare, and price is more expensive." Jingzhubencao " was once recorded；
White soul sesame is warm-natured in Tibet, bitter, have effects that anti anoxia, invigorating qi for tranquilization, it is relieving cough and asthma, promote longevity, cure mainly Hypoxic
Altitude sickness, insufficiency of vital energy and blood, neurasthenia, palpitation and dizziness, mental-tranquilization, relieving cough and asthma, coronary heart disease, hepatitis, hypertension and a variety of
Leukopenia caused by reason.Modern pharmacological studies have shown that the white soul sesame in Tibet can be with separation and Extraction a to structure novel
Triterpene compound --- GL22, this is a kind of marvellous compound, it is able to suppress a kind of albumen, causes the steady of cuorin
The decline of state level, so as to cause the exception of the cell mitochondrial in close relations with cuorin, finally causes cancer cell death.
Rainbow conk: rainbow conk is sweet in flavor, flat, return heart, spleen, liver and kidney channel, has the function such as clearing heat and detoxicating, invigorating the spleen to clear away damp pathogen, relieving cough and asthma
Effect, mainly treating bronchitis, hepatitis, cirrhosis, breast cancer etc..Cloud Siberian cocklebur main active is coriolan and polysaccharide-peptide, it
Not only have immunological regulation and hepatoprotective and cholagogic effects, also have antitumor, anti-oxidant, anti-aging, reducing blood lipid, QI invigorating removing toxic substances and
The effects of analgesia.Studies have shown that polysaccharide-peptide can not only enhance the immunocompetence of body by humoral immunity, cellular immunity,
Connect killing tumor cell, moreover it is possible to which killing tumor cell is directly participated in by cytotoxic effect.
Tinder fungus: tinder fungus popular name wood hoof, tree base belong to Basidiomycota, Basidiomycetes, Aphyllophorales, more
Hole
Cordycepps heterophyta macro fungi.It is widely distributed in more than ten provinces such as China Hebei, Shaanxi, Heilungkiang, Yunnan,
It is the common perennial domestomycetes in broad leaf tree forest zone.The wooden hoof is with a long history as folk medicine, and medicinal part is fructification, has
Disperse accumulation silt effect, for treating cancer of the esophagus, gastric cancer, breast cancer, uterine cancer etc..Studies have shown that tinder fungus primary chemical
Ingredient is polysaccharide, glycoside, cumarin, phytosterol etc., and crude extract has antitumor, anti-oxidant, the work such as enhancing immune function
Property.Zoopery proves that ligroin extraction, chloroform extract, the methanolic extract of tinder fungus fructification have centainly
Function of tumor inhibition, wherein the inhibiting effect of ligroin extraction is most significant, and tumour inhibiting rate is up to 56.29%.
Red sesame: ganoderma lucidum is the drying fructification of On Polyporaceae red sesame or purple sesame, is the rare tonic Chinese herbal medicine of China's tradition
Material has effects that strengthen the body resistance to consolidate the constitution, promote longevity.Clinically be mainly used for treat hepatitis, chronic bronchitis, indigestion,
The diseases such as neurasthenia, coronary heart disease, hyperlipidemia, hypertension, leukopenia, breast cancer.Domestic and foreign scholars are for ganoderma lucidum
Chemical component has carried out systematic research, it is found that it mainly contains sterol, triterpene, polysaccharide, alkaloid, furan derivatives, amino
The ingredients such as acid protein and nucleosides.Pharmacological research shows that red sesame triterpenes has apparent anticancer, strengthen immunity, liver protection shield
The multiple pharmacological effects such as liver.
Poria cocos: Poria cocos is dry sclerotia also known as Yu Ling, Fu spirit, Wan Linggui, Fu of Polyporaceae transverse hole fungus category fungi Poria cocos
Tu, Yun Ling, pine potato etc..Poria cocos more is depended on pinaceae plant Japanese red pine or Pinus massoniana root and is grown, and is mainly distributed on Yunnan Province of China, expensive
The ground such as state, Guangdong, Guangxi.Shennong's Herbal was once recorded；Poria cocos nature and flavor are sweet, light, flat, return heart, lung, spleen, kidney channel, have Li Shui
The effect of excreting dampness, invigorating the spleen calming heart.Clinic is usually used in treating edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, the mind not
Peace, insomnia of palpitating with fear etc..In recent years, research finds to contain triterpenes, steroid, protein, polysaccharide and other classes in Poria cocos
Close object.Modern pharmacology research shows that Poria cocos has and adjusts many-sided pharmacology work such as immune function, antitumor, anti-inflammatory, anti-aging
With, there are also anti-cirrhosis, mitigate poisoning by kanamycin ear damage, anti-delayed allergy the effects of.
Lasiosphaera fenzlii: Lasiosphaera fenzlii acrid flavour is mild-natured, enters lung channel, there is detumescence, hemostasis, removing toxic substances and other effects, for abscess of throat and it is various go out
Blood.Lasiosphaera fenzlii is extensive in distribution in China, abundance.Since 20th century, the antibacterial and anticancer of the world of medicine's extensive concern Lasiosphaera fenzlii preparation
Activity.Research shows that Lasiosphaera fenzlii mainly contain steroidal compounds, terpenoid, amino acid, fatty acid and polysaccharide, protein and
Polypeptide etc. has the effects that anti-inflammatory, cough-relieving, hemostasis, antitumor, scavenging activated oxygen, antiproliferative and anti-rush cell division.Cell
It is demonstrated experimentally that the active peptides in fresh Lasiosphaera fenzlii can inhibit the proliferation of human breast cancer cell MDA-MA-231.
Sulfur bacteria: laetiporus sulphureus belongs to Aphyllophorales Polyporaceae Sulfur Pseudomonas macro fungi, and Chinese nickname is sulphur color
The mutation of pore fungi vermilion, cockscomb bacterium, salmon bacterium, sets and spends bacterium, salmon mushroom etc. red vulcanized ester, is born in the needles trunk such as larch
Base portion is also given birth in the broad-leaveds butt such as robur sometimes, causes butt bulk brown rot, the fresh vermilion in surface, or with yellow
Vermilion, bacterial context trout is yellowish pink, and meat is flexible when young, bleach after dry and crisp belong in, low form mushroom, be distributed mainly on
The areas such as China Hebei, Henan, Sichuan, Gansu, Tibet, Xinjiang.Studies have shown that the main active of sulfur bacteria is polysaccharide
Substance has antitumor, antiviral, anti-aging, reducing blood lipid, protecting liver and expelling toxin, promotes nucleic acid and Protein synthesis etc. more
Kind biological effect.
Bitter white hoof: bitter white hoof also known as Ali red, fungus of larch, quinine fungus are the medicinal quasi- layer hole of On Polyporaceae
The fructification of bacterium.It has it is relieving cough and asthma, dispelling wind and eliminating dampness, detumescence relieves the pain, diuresis, and the effects of antidoting against snake bite, clinic is usually used in treating
The diseases such as gastrointestinal disease, cancer, bronchial asthma, night sweat.Modern pharmacological research proves that bitter white hoof chemical component is mainly more
Sugar, terpene, linear paraffin etc. have the effects that antitumor, strengthen immunity, scavenging activated oxygen.Animal experiment study discovery,
Its water extract can increase the anti-stress ability of mouse, extend antifatigue and hypoxia endurance time, have good benefiting action.
Ganoderma lipsiense: ganoderma lipsiense alias artist's conk, the flat ganoderma lucidum of artist's conk, flat mesh ganoderma lucidum belong to Eumycota, Basidiomycotina, layer
Bacterium
Guiding principle, Polyporaceae, Ganoderma.Ganoderma lipsiense is widely distributed in China, mainly in northeast, northwest, East China, China
South, each provinces and regions in southwest.Studies have shown that ganoderma lipsiense have anticancer, it is antitumor, anti-oxidant, anti-aging, adjust immunity, disappear
The bioactivity such as scorching antibacterial, hypoglycemic and liver protection.Zoopery proves that ganoderma lipsiense extract may be by inhibiting tumor tissues
The generations of medium vessels and the cell cycle is adjusted to inhibit the hyper-proliferative of tumour cell, to realize the inhibition to three negative breast cancer
Effect.
Compared with prior art, technical solution provided by the invention has following technological merit:
The present invention is by the present invention by mulberry tree Phellinus, Dong Fangshuankong bacterium, ganoderma capense, pine needles, the white soul sesame in Tibet, cloud
Sesame has effects that nourishing and fit keeping function, promotes longevity, strengthens the body resistance to consolidate the constitution by prescription compatibility, synergy, and breast cancer trouble can be enhanced
The immunity of person's body, the side effect for mitigating chemotherapeutics, the quality of life for improving patient etc., and have no adverse reaction.
2, technical solution provided by the invention not only can be improved patient's immunity can also inhibit cancer cell growth and
Expand, but its mechanism of action is different from doctor trained in Western medicine anticarcinogen, and indirect kill cancer cell, but by increasing macrophage
Phagocytosis, promotes the formation of immunoglobulin, increasing leukocyte, improve the transformation rate of lymph and improve body itself
Disease resistance or enhancing body to the tolerance of radiotherapy, chemotherapy, to achieve the purpose that resist cancer cell.
3, advantage of the invention uses vacuum pneumatic cell wall breaking technology, and a variety of mushroom cell-wall breaking ratios is made to be up to 90%
More than, effective component dissolution rate greatly improves, and not only saves the trouble of patient's decocting herb, but also good in taste, biological utilisation
It spends high, easy to carry etc..
Specific embodiment
Claim of the invention is described in further detail combined with specific embodiments below.
Embodiment 1
A kind of Chinese medicine composition for treating breast cancer provided by the invention, is made: mulberry tree of the bulk pharmaceutical chemicals of following weight parts
18 parts of Phellinus, 12 parts of Dong Fangshuankong bacterium, 18 parts of ganoderma capense, 22 parts of pine needles, 18 parts of the white soul sesame in Tibet, 22 parts of rainbow conk,
18 parts of tinder fungus, 22 parts of red sesame, 9 parts of Poria cocos, 12 parts of Lasiosphaera fenzlii, 9 parts of sulfur bacteria, bitter white 12 parts of hoof, 9 parts of ganoderma lipsiense.
Embodiment 2
A kind of Chinese medicine composition for treating breast cancer provided by the invention, is made: mulberry tree of the bulk pharmaceutical chemicals of following weight parts
22 parts of Phellinus, 7 parts of Dong Fangshuankong bacterium, 22 parts of ganoderma capense, 18 parts of pine needles, 22 parts of the white soul sesame in Tibet, 18 parts of rainbow conk, wood
22 parts of hoof shelf fungus, 18 parts of red sesame, 12 parts of Poria cocos, 9 parts of Lasiosphaera fenzlii, 12 parts of sulfur bacteria, bitter white 9 parts of hoof, 12 parts of ganoderma lipsiense.
Embodiment 3
A kind of Chinese medicine composition for treating breast cancer provided by the invention, is made: mulberry tree of the bulk pharmaceutical chemicals of following weight parts
15 parts of Phellinus, 15 parts of Dong Fangshuankong bacterium, 15 parts of ganoderma capense, 25 parts of pine needles, 15 parts of the white soul sesame in Tibet, 25 parts of rainbow conk,
15 parts of tinder fungus, 25 parts of red sesame, 5 parts of Poria cocos, 15 parts of Lasiosphaera fenzlii, 5 parts of sulfur bacteria, bitter white 15 parts of hoof, 5 parts of ganoderma lipsiense.
Embodiment 4
A kind of Chinese medicine composition for treating breast cancer provided by the invention, is made: above-mentioned of the bulk pharmaceutical chemicals of following weight parts
A kind of Chinese medicine composition for treating breast cancer, be made of the bulk pharmaceutical chemicals of following weight parts: 20 parts of mulberry tree Phellinus, Dong Fangshuankong bacterium
10 parts, 20 parts of ganoderma capense, 20 parts of pine needles, 20 parts of the white soul sesame in Tibet, 20 parts of rainbow conk, 20 parts of tinder fungus, red sesame
20 parts, 10 parts of Poria cocos, 10 parts of Lasiosphaera fenzlii, 10 parts of sulfur bacteria, bitter white 10 parts of hoof, 10 parts of ganoderma lipsiense.
Embodiment 5
A kind of Chinese medicine composition for treating breast cancer provided by the invention, is made of: mulberry tree the bulk pharmaceutical chemicals of following weight parts
25 parts of Phellinus, 5 parts of Dong Fangshuankong bacterium, 25 parts of ganoderma capense, 15 parts of pine needles, 25 parts of the white soul sesame in Tibet, 15 parts of rainbow conk, wood
25 parts of hoof shelf fungus, 15 parts of red sesame, 15 parts of Poria cocos, 5 parts of Lasiosphaera fenzlii, 15 parts of sulfur bacteria, bitter white 5 parts of hoof, 15 parts of ganoderma lipsiense.
The preparation method of the Chinese medicine composition of any one treatment breast cancer in embodiment 1 to 5, successively includes following steps
It is rapid:
(1) Chinese medicine is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；
It (2) by medicinal material drying to moisture is about respectively 6%, mixing, by pulverizing medicinal materials at fine powder (crossing 100~150 mesh),
It is spare.
(3) fine medicinal material powder is added in hopper, is pulverized using vacuum pneumatic breaking-wall cell machine, collect micro mist
(cross 300 mesh) to get.
For the ease of taking, the Chinese medicine composition for the treatment of breast cancer provided by the invention can be with the acceptable auxiliary material of medicine
It is prepared into tablet or capsule or granule.
In order to confirm the curative effect of the traditional chinese medicine composition of the invention treatment breast cancer, with by micro mist made from 3 method of embodiment, into
Go following animal experiment study:
1 experimental material
1.1 animals and drug
Balb/c-n/n nude mice, male and female are impartial, weight (16~20) g, and purchase Guangdong Medical Lab Animal Center provides, and close
Lattice card SCXK (Guangdong) 2013-0002.Mulberry tree Phellinus, Dong Fangshuankong bacterium, ganoderma capense, pine needles, the white soul sesame in Tibet, cloud
Sesame, tinder fungus etc. are purchased from medicinal material source area；Cyclophosphamide (Hengrui Medicine Co., Ltd., Jiangsu Prov., lot number:
12052325).MCF-7 Human Breast Cancer Cells strain (Co., Ltd, Nanjing Keygen Biotech).
1.2 main agents and instrument
Mouse IL-2, IL-4, IL-6, IFN-γ ELISA detection kit: An Di Bioisystech Co., Ltd.Automatically
Microplate reader: Shanghai Seiko Industrial Co., Ltd.；Micropipettor: German Eppendorf company.
2 experimental methods
2.1 tumor cell cultures use routine RPMI1640 culture medium by MCF-7 cell inoculation in T75 Tissue Culture Flask,
It is placed in 5%CO2, in 37 DEG C of constant incubator, logarithmic growth phase cell is as inoculating cell.
The foundation pancreatin of 2.2 bearing mouse models at single cell suspension, puts the MCF-1 cell dissociation of logarithmic growth phase
Enter centrifuge with 1000r/min centrifugation 10 minutes, discard supernatant, adjustment cell concentration is 1 × 107/ml, is inoculated in a nude mice left side
Side armpit is subcutaneous, every inoculation 0.2ml.
2.3 groupings and 32 mouse of administration are divided into 4 groups by weight randomization, every group 8, Chinese medicine composition it is high (4g/kg,
Ig), low dose group (2g/kg, ig), cyclophosphamide positive drug control group (0.03g/kg, ip) and model control group are (isometric
Physiological saline), it is administered once daily, successive administration 14 days.
2.4 observation index are measured in 2 hours after the last administration, remove mouse spleen, and grinding prepares splenocyte suspension, are centrifuged
Take supernatant.According to enzyme linked immunological kit specification measurement nude mice spleen in IL-2, IL-4, IL-6, IFN-γ content.
2.5 statistical analysis are analyzed and processed with SPSS20.0 software, and each numerical value is with mean ± standard deviationTable
Show, comparison among groups are examined using t.
3 experimental results
The measurement result composition group of 3.1 each group mouse spleen IL-2, IL-6 contents can significantly improve tumor-bearing mice serum
Middle IL-2 is horizontal, and has obvious dose-effect relationship, obvious with cyclophosphamide comparative advantages, and difference has statistical significance (table 1).
Compared with positive group, composition high dose group just can significantly reduce body IL-6 level, and difference has statistical significance (table
1)。
1 each group mouse spleen IL-2, IL-6 content of table measurement result (N=10)
The * P < 0.05 compared with model group, * * P < 0.01；#P < 0.05, ##P < 0.01 compared with positive group.
3.2 each group mouse spleen IL-4, IFN-γ content measurement result composition group significantly improve tumor bearing nude mice blood
The level of clear middle IL-4, IFN-γ, compare, improving the standard for composition group IL-4 is not obvious, and difference does not have with positive group
Statistical significance, and improving the standard for IFN-γ is substantially better than positive group in composition group, difference have statistical significance (see
Table 2).
2 each group mouse spleen IL-4 of table, IFN-γ content measurement result (N=8)
The * P < 0.05 compared with model group, * * P < 0.01；#P < 0.05, ##P < 0.01 compared with positive group.
4. experiment conclusion
It is horizontal that body IL-2, IFN-γ can be improved in composition, to promote T cell and the proliferation of NK cell and anti-tumor living
Property, body IL-6 level is reduced, body's immunity is adjusted and the proliferation of tumour cell is inhibited to have certain effect.Study table
It is bright, Thl cell Major Secretory IL-2, IFN-γ etc., Th2 cell Major Secretory IL-4, IL-6, if body is in anti-well
Tumor immune functional state, Th1 cell will be dominant.And composition group can significantly improve body IL-2, IFN-γ level,
It is horizontal to reduce IL-6, Th1 cell proportion is made to take advantage, enhances human body immune function, to play preferable antitumor action.
The above content is specific preferred embodiment is combined, further detailed description of the invention, cannot recognize
Fixed specific implementation of the invention is only limited to these instructions.Without departing from the inventive concept of the premise, it can also make several
Simple deduction or replace all shall be regarded as belonging to present invention scope of patent protection determined by the appended claims.
Claims (8)
1. a kind of Chinese medicine composition for treating breast cancer, which is characterized in that be made of the bulk pharmaceutical chemicals of following weight parts: mulberry tree Phellinus
15-25 parts, 5-15 parts of Dong Fangshuankong bacterium, 15-25 parts of ganoderma capense, 15-25 parts of pine needles, 15-25 parts of the white soul sesame in Tibet,
15-25 parts of rainbow conk, 15-25 parts of tinder fungus, 15-25 parts of red sesame, 5-15 parts of Poria cocos, 5-15 parts of Lasiosphaera fenzlii, 5-15 parts of sulfur bacteria,
Bitter white hoof 5-15 parts, 5-15 parts of ganoderma lipsiense.
2. a kind of Chinese medicine composition for treating breast cancer according to claim 1, which is characterized in that by following weight parts
Bulk pharmaceutical chemicals composition: 18-22 parts of mulberry tree Phellinus, 7-12 parts of Dong Fangshuankong bacterium, 18-22 parts of ganoderma capense, 18-22 parts of pine needles,
18-22 parts of the white soul sesame in Tibet, 18-22 parts of rainbow conk, 18-22 parts of tinder fungus, 18-22 parts of red sesame, 9-12 parts of Poria cocos, Lasiosphaera fenzlii
9-12 parts, 9-12 parts of sulfur bacteria, bitter white hoof 9-12 parts, 9-12 parts of ganoderma lipsiense.
3. a kind of Chinese medicine composition for treating breast cancer according to claim 1, which is characterized in that by following weight parts
Bulk pharmaceutical chemicals are made: 15 parts of mulberry tree Phellinus, 15 parts of Dong Fangshuankong bacterium, and 15 parts of ganoderma capense, 25 parts of pine needles, the white soul sesame in Tibet
15 parts, 25 parts of rainbow conk, 15 parts of tinder fungus, 25 parts of red sesame, 5 parts of Poria cocos, 15 parts of Lasiosphaera fenzlii, 5 parts of sulfur bacteria, bitter white 15 parts of hoof,
5 parts of ganoderma lipsiense.
4. a kind of Chinese medicine composition for treating breast cancer according to claim 1, which is characterized in that by following weight parts
Bulk pharmaceutical chemicals composition: 20 parts of mulberry tree Phellinus, 10 parts of Dong Fangshuankong bacterium, 20 parts of ganoderma capense, 20 parts of pine needles, the white soul sesame in Tibet
20 parts, 20 parts of rainbow conk, 20 parts of tinder fungus, 20 parts of red sesame, 10 parts of Poria cocos, 10 parts of Lasiosphaera fenzlii, 10 parts of sulfur bacteria, bitter white hoof 10
Part, 10 parts of ganoderma lipsiense.
5. a kind of Chinese medicine composition for treating breast cancer according to claim 1, which is characterized in that by following weight parts
Bulk pharmaceutical chemicals composition: 25 parts of mulberry tree Phellinus, 5 parts of Dong Fangshuankong bacterium, 25 parts of ganoderma capense, 15 parts of pine needles, the white soul sesame in Tibet
25 parts, 15 parts of rainbow conk, 25 parts of tinder fungus, 15 parts of red sesame, 15 parts of Poria cocos, 5 parts of Lasiosphaera fenzlii, 15 parts of sulfur bacteria, bitter white 5 parts of hoof,
15 parts of ganoderma lipsiense.
6. the method for preparing the Chinese medicine composition for the treatment of breast cancer described in claim 1, which is characterized in that including following step
It is rapid:
(1) bulk pharmaceutical chemicals weight number described in accordance with the claim 1 weighs Chinese medicine, cleans；
(2) by each raw medicinal material, dry 5~10h is mixed, until moisture is about 6% by pulverizing medicinal materials at 50~65 DEG C respectively
It is spare after crossing 100~150 meshes at fine powder.
(3) fine medicinal material powder is added in hopper, carries out 0.5~1.5h of ultramicro grinding using vacuum pneumatic breaking-wall cell machine, crosses 300
Micro mist is collected after mesh.
7. a kind of drug for the Chinese medicine composition for treating breast cancer, which is characterized in that the drug is containing in claim 1 to 5
The Chinese medicine composition and customary adjuvant of any one treatment breast cancer.
8. a kind of drug of Chinese medicine composition for treating breast cancer according to claim 7, which is characterized in that the medicine
Agent type is that the dosage form of composition is tablet or capsule or granule.
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| CN201910143019.4A CN109731016A (en) | 2019-02-26 | 2019-02-26 | A kind of Chinese medicine composition for treating breast cancer and preparation method thereof and drug |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12005092B2 (en) * | 2021-12-22 | 2024-06-11 | Laura Mann Kevehazi | Herbal composition for breast cancer prevention |
| CN119215085A (en) * | 2024-10-18 | 2024-12-31 | 黑龙江省中医药科学院 | Composition for alleviating gastrointestinal reactions and enhancing appetite in cancer patients after chemotherapy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1614010A (en) * | 2004-10-29 | 2005-05-11 | 天津同春和坊食品有限公司 | Vacuum pneumatic plant cell wall breaking process and apparatus |
-
2019
- 2019-02-26 CN CN201910143019.4A patent/CN109731016A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1614010A (en) * | 2004-10-29 | 2005-05-11 | 天津同春和坊食品有限公司 | Vacuum pneumatic plant cell wall breaking process and apparatus |
Non-Patent Citations (2)
| Title |
|---|
| 张文彭 等: "《药用真菌治肿瘤》", 30 November 2014, 北京：中国中医药出版社 * |
| 王艳 等: "真空气流植物细胞破壁技术在灵芝药材提取前处理中的应用", 《天津中医药大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12005092B2 (en) * | 2021-12-22 | 2024-06-11 | Laura Mann Kevehazi | Herbal composition for breast cancer prevention |
| CN119215085A (en) * | 2024-10-18 | 2024-12-31 | 黑龙江省中医药科学院 | Composition for alleviating gastrointestinal reactions and enhancing appetite in cancer patients after chemotherapy |
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